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The map label for this gene is prsA [H]

Identifier: 77458207

GI number: 77458207

Start: 2261727

End: 2262680

Strand: Direct

Name: prsA [H]

Synonym: Pfl01_1980

Alternate gene names: 77458207

Gene position: 2261727-2262680 (Clockwise)

Preceding gene: 77458206

Following gene: 77458208

Centisome position: 35.13

GC content: 61.53

Gene sequence:

>954_bases
ATGAAGCTCAAAACCCTGTGTTGGCTGCTGACAGGCTGGTTGTCGGTGGGAATGGCGAACAATGAACCGGTGGCCGCCCG
GGTCAACGGCGAGGCGATTTCCGAGTTTCGCCTGGAACGTTTTTTCGCCGAGTACCTGGAAGATCAGGGCCGCGCCGTGG
CGAGCATCCGCAACCCCAAGGCCTATAAACAATTGCGTCAGGCCGCGCTGGACACGTTGATCGACAAGGAACTGCTCTGG
CAGGAATCGCGCAAGCGCGGGGTCAAGATCGATGAGCAAACCGTGCGCGAACAGGTCGAACGGACTCGCACCGCCATCGG
TGGCACCGACAAATTCCTCCAGCGTTTGCAGGACGCCGGTTTCGACGAGGCCTCGTTCACCGAGTACACCCACCGCGAAC
TGGCGGCGCAGCGGATGTTTGCCGAACTGACCCAAGTCCAGGCCCCGGACGAGCAGACGGTGCGGGCGTTTTTTGCAGAA
CACCGCGCTGAAATGGCCGCACCGGAGCAGGTCCAGGCCCGGCACATTCTGATCAAGGTTGCTGGCGATGCCGATGCCGC
CACGGTTGAAGCGGCACGGCTACGCTTGGAAGAGTTGCGTGCCGCTATCGCAGGGGGGCAAACCTTTGCTAGCGTCGCGC
AATCGGGATCGGAAGATGTCACCGCCAGCCAGGGCGGGGATCTGGGGTATTTCGCCCGTGGGCAAATGGTGCCGGCGTTT
GAAACGGCGGCGTTTGCCCTCAAGCCTGGTGAAGTCAGCGAAGCGGTGCGCACACCGTTCGGCTGGCATTTGATCTTTGT
CGAGAACCACAAGGAGGCGGCCGATGTCCCAGAGGAGCAAGGGCTGGAAACAGTCAGGGCGTACCTCGCCCGACAGCAAC
AGACCCAGGCTCGTCGTCAGGTGCTCGCGCAATTACGGGCAGAGAACAGGATCGAACGAATTGACGACGACTGA

Upstream 100 bases:

>100_bases
CGGGGCGCACGTGGTCACCGTTGACTTGCCCGACCAGCGTTTTTATCTGGTCGCTCCCTACAAACCGATTATTGCCACGC
CCTGACCGGAGGCCCTGATC

Downstream 100 bases:

>100_bases
AGGTTCCCCCCAATAGTGGGGAATGGCTTCGATGCCCATTCAGGTGCTTCCCCGTTTCTGGGGAACGGGGTACCGGGACG
AGCGGGCATTTCCATTCAAT

Product: PpiC-type peptidyl-prolyl cis-trans isomerase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 317; Mature: 317

Protein sequence:

>317_residues
MKLKTLCWLLTGWLSVGMANNEPVAARVNGEAISEFRLERFFAEYLEDQGRAVASIRNPKAYKQLRQAALDTLIDKELLW
QESRKRGVKIDEQTVREQVERTRTAIGGTDKFLQRLQDAGFDEASFTEYTHRELAAQRMFAELTQVQAPDEQTVRAFFAE
HRAEMAAPEQVQARHILIKVAGDADAATVEAARLRLEELRAAIAGGQTFASVAQSGSEDVTASQGGDLGYFARGQMVPAF
ETAAFALKPGEVSEAVRTPFGWHLIFVENHKEAADVPEEQGLETVRAYLARQQQTQARRQVLAQLRAENRIERIDDD

Sequences:

>Translated_317_residues
MKLKTLCWLLTGWLSVGMANNEPVAARVNGEAISEFRLERFFAEYLEDQGRAVASIRNPKAYKQLRQAALDTLIDKELLW
QESRKRGVKIDEQTVREQVERTRTAIGGTDKFLQRLQDAGFDEASFTEYTHRELAAQRMFAELTQVQAPDEQTVRAFFAE
HRAEMAAPEQVQARHILIKVAGDADAATVEAARLRLEELRAAIAGGQTFASVAQSGSEDVTASQGGDLGYFARGQMVPAF
ETAAFALKPGEVSEAVRTPFGWHLIFVENHKEAADVPEEQGLETVRAYLARQQQTQARRQVLAQLRAENRIERIDDD
>Mature_317_residues
MKLKTLCWLLTGWLSVGMANNEPVAARVNGEAISEFRLERFFAEYLEDQGRAVASIRNPKAYKQLRQAALDTLIDKELLW
QESRKRGVKIDEQTVREQVERTRTAIGGTDKFLQRLQDAGFDEASFTEYTHRELAAQRMFAELTQVQAPDEQTVRAFFAE
HRAEMAAPEQVQARHILIKVAGDADAATVEAARLRLEELRAAIAGGQTFASVAQSGSEDVTASQGGDLGYFARGQMVPAF
ETAAFALKPGEVSEAVRTPFGWHLIFVENHKEAADVPEEQGLETVRAYLARQQQTQARRQVLAQLRAENRIERIDDD

Specific function: Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins [H]

COG id: COG0760

COG function: function code O; Parvulin-like peptidyl-prolyl isomerase

Gene ontology:

Cell location: Cell membrane; Lipid-anchor (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PpiC domain [H]

Homologues:

Organism=Escherichia coli, GI1786238, Length=98, Percent_Identity=43.8775510204082, Blast_Score=72, Evalue=6e-14,

Paralogues:

None

Copy number: 400 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023059
- InterPro:   IPR000297
- InterPro:   IPR023058
- InterPro:   IPR015391
- InterPro:   IPR008880 [H]

Pfam domain/function: PF00639 Rotamase; PF09312 SurA_N [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 35506; Mature: 35506

Theoretical pI: Translated: 5.08; Mature: 5.08

Prosite motif: PS01096 PPIC_PPIASE_1 ; PS50198 PPIC_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLKTLCWLLTGWLSVGMANNEPVAARVNGEAISEFRLERFFAEYLEDQGRAVASIRNPK
CCHHHHHHHHHHHHHHCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCH
AYKQLRQAALDTLIDKELLWQESRKRGVKIDEQTVREQVERTRTAIGGTDKFLQRLQDAG
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHCC
FDEASFTEYTHRELAAQRMFAELTQVQAPDEQTVRAFFAEHRAEMAAPEQVQARHILIKV
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCHHHHHEEEEEEE
AGDADAATVEAARLRLEELRAAIAGGQTFASVAQSGSEDVTASQGGDLGYFARGQMVPAF
ECCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCCCCCEECCCCCCCCH
ETAAFALKPGEVSEAVRTPFGWHLIFVENHKEAADVPEEQGLETVRAYLARQQQTQARRQ
HHHHHEECCCHHHHHHCCCCCEEEEEEECCCHHHCCCHHCCHHHHHHHHHHHHHHHHHHH
VLAQLRAENRIERIDDD
HHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKLKTLCWLLTGWLSVGMANNEPVAARVNGEAISEFRLERFFAEYLEDQGRAVASIRNPK
CCHHHHHHHHHHHHHHCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCH
AYKQLRQAALDTLIDKELLWQESRKRGVKIDEQTVREQVERTRTAIGGTDKFLQRLQDAG
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHCC
FDEASFTEYTHRELAAQRMFAELTQVQAPDEQTVRAFFAEHRAEMAAPEQVQARHILIKV
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCHHHHHEEEEEEE
AGDADAATVEAARLRLEELRAAIAGGQTFASVAQSGSEDVTASQGGDLGYFARGQMVPAF
ECCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCCCCCEECCCCCCCCH
ETAAFALKPGEVSEAVRTPFGWHLIFVENHKEAADVPEEQGLETVRAYLARQQQTQARRQ
HHHHHEECCCHHHHHHCCCCCEEEEEEECCCHHHCCCHHCCHHHHHHHHHHHHHHHHHHH
VLAQLRAENRIERIDDD
HHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]