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The map label for this gene is trpF

Identifier: 77458124

GI number: 77458124

Start: 2168355

End: 2168969

Strand: Direct

Name: trpF

Synonym: Pfl01_1897

Alternate gene names: 77458124

Gene position: 2168355-2168969 (Clockwise)

Preceding gene: 77458123

Following gene: 77458125

Centisome position: 33.68

GC content: 63.09

Gene sequence:

>615_bases
ATGTCAGCCGTTCGCAGCAAGATTTGCGGGATTACCCGCATAGAAGATGCGTTGGCAGCCGTCGAGGCCGGGGCCGATGC
CATTGGTTTTGTGTTCTACGCTAAAAGTCCCCGGGCCGTGACCGTGCAGCAGGCGCGGTCGATCATCGCCGCCTTGCCAC
CGTTCGTGACCACGGTCGGGCTGTTCGTCAATGCCAGCCGTTGCGAGCTCGGGGAAATCCTCGATGCCGTGCCGCTGGAT
CTGCTGCAGTTCCATGGCGACGAAACCGCCGCCGAGTGTGAGGGCTGGCACCGGCCGTACATCAAGGCCTTGCGGGTCAA
GGCGGGCGATAACATTGCCGCTGCCTGCGATGCCTACCCGAGCGCCAGCGGCGTGCTGCTCGACACTTATGTCGAAGGCG
TGCCCGGCGGAACCGGCGAAGCGTTCGACTGGTCATTGATTCCGCAAGGCTTGAGCAAACCGTTGATTCTGGCCGGCGGC
CTGACGCCGGAGAACGTCGCCGATGCGATAGCCCGGGTGCGGCCGTATGCCGTGGATGTCAGCGGCGGGGTAGAGGCGAG
CAAGGGCATCAAGGATCACGCAAAGATTCGTGCATTCATCAACGCCGTACGCTGA

Upstream 100 bases:

>100_bases
CATTTCCTTACGGGTTTCGCGGAACTTGACGGCTGACGCCCTCGAACGCATTTGTTACCATCCGGGACTTTCTCGGATTT
GCCTTGGGGTTTTTATCGAC

Downstream 100 bases:

>100_bases
TGTGACGGCTGGCAGACTGCCGCCGTCCACAGCTCTGTAGAAAAGAGGCTGAGGGTCTTTTCGGGGTGTGCGCAGGTCAG
TTCCGCTGACCCGGCAGTCC

Product: N-(5'-phosphoribosyl)anthranilate isomerase

Products: NA

Alternate protein names: PRAI

Number of amino acids: Translated: 204; Mature: 203

Protein sequence:

>204_residues
MSAVRSKICGITRIEDALAAVEAGADAIGFVFYAKSPRAVTVQQARSIIAALPPFVTTVGLFVNASRCELGEILDAVPLD
LLQFHGDETAAECEGWHRPYIKALRVKAGDNIAAACDAYPSASGVLLDTYVEGVPGGTGEAFDWSLIPQGLSKPLILAGG
LTPENVADAIARVRPYAVDVSGGVEASKGIKDHAKIRAFINAVR

Sequences:

>Translated_204_residues
MSAVRSKICGITRIEDALAAVEAGADAIGFVFYAKSPRAVTVQQARSIIAALPPFVTTVGLFVNASRCELGEILDAVPLD
LLQFHGDETAAECEGWHRPYIKALRVKAGDNIAAACDAYPSASGVLLDTYVEGVPGGTGEAFDWSLIPQGLSKPLILAGG
LTPENVADAIARVRPYAVDVSGGVEASKGIKDHAKIRAFINAVR
>Mature_203_residues
SAVRSKICGITRIEDALAAVEAGADAIGFVFYAKSPRAVTVQQARSIIAALPPFVTTVGLFVNASRCELGEILDAVPLDL
LQFHGDETAAECEGWHRPYIKALRVKAGDNIAAACDAYPSASGVLLDTYVEGVPGGTGEAFDWSLIPQGLSKPLILAGGL
TPENVADAIARVRPYAVDVSGGVEASKGIKDHAKIRAFINAVR

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0135

COG function: function code E; Phosphoribosylanthranilate isomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpF family

Homologues:

Organism=Escherichia coli, GI87081863, Length=205, Percent_Identity=32.6829268292683, Blast_Score=93, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6320210, Length=216, Percent_Identity=32.4074074074074, Blast_Score=91, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TRPF_PSEPF (Q3KF16)

Other databases:

- EMBL:   CP000094
- RefSeq:   YP_347629.1
- ProteinModelPortal:   Q3KF16
- SMR:   Q3KF16
- STRING:   Q3KF16
- GeneID:   3716314
- GenomeReviews:   CP000094_GR
- KEGG:   pfo:Pfl01_1897
- eggNOG:   COG0135
- HOGENOM:   HBG554803
- OMA:   SKICGIT
- ProtClustDB:   PRK01222
- BioCyc:   PFLU205922:PFL_1897-MONOMER
- HAMAP:   MF_00135_B
- InterPro:   IPR013785
- InterPro:   IPR001240
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70

Pfam domain/function: PF00697 PRAI; SSF51366 RibP_bind_barrel

EC number: =5.3.1.24

Molecular weight: Translated: 21362; Mature: 21230

Theoretical pI: Translated: 5.28; Mature: 5.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAVRSKICGITRIEDALAAVEAGADAIGFVFYAKSPRAVTVQQARSIIAALPPFVTTVG
CCHHHHHHCCHHHHHHHHHHHHCCCCEEEEEEEECCCCEEEHHHHHHHHHHHHHHHHHHH
LFVNASRCELGEILDAVPLDLLQFHGDETAAECEGWHRPYIKALRVKAGDNIAAACDAYP
HHHCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCHHHHHHHHCCCCCEEECCCCCC
SASGVLLDTYVEGVPGGTGEAFDWSLIPQGLSKPLILAGGLTPENVADAIARVRPYAVDV
CCCCEEHHHHHCCCCCCCCCCCCHHHCCCCCCCCEEEECCCCHHHHHHHHHHHCCEEEEC
SGGVEASKGIKDHAKIRAFINAVR
CCCCCCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
SAVRSKICGITRIEDALAAVEAGADAIGFVFYAKSPRAVTVQQARSIIAALPPFVTTVG
CHHHHHHCCHHHHHHHHHHHHCCCCEEEEEEEECCCCEEEHHHHHHHHHHHHHHHHHHH
LFVNASRCELGEILDAVPLDLLQFHGDETAAECEGWHRPYIKALRVKAGDNIAAACDAYP
HHHCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCHHHHHHHHCCCCCEEECCCCCC
SASGVLLDTYVEGVPGGTGEAFDWSLIPQGLSKPLILAGGLTPENVADAIARVRPYAVDV
CCCCEEHHHHHCCCCCCCCCCCCHHHCCCCCCCCEEEECCCCHHHHHHHHHHHCCEEEEC
SGGVEASKGIKDHAKIRAFINAVR
CCCCCCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA