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The map label for this gene is emrK [H]

Identifier: 77458104

GI number: 77458104

Start: 2141232

End: 2142281

Strand: Reverse

Name: emrK [H]

Synonym: Pfl01_1877

Alternate gene names: 77458104

Gene position: 2142281-2141232 (Counterclockwise)

Preceding gene: 77458113

Following gene: 77458103

Centisome position: 33.27

GC content: 62.86

Gene sequence:

>1050_bases
ATGCCTGCCCAACTCAAGCGTCGCCTGTTCATTTTCCTGCTGCTGGTCCTGCTGATTGCCGGGGGCTTTTTCGCCCATTG
GTTTTTCAAGGGACGCTTTTATGAAAGCACCGACAACGCCTATGTCCAGGGTGAAATCACCCGCGTGTCGAGCCAGTTGA
GCGCACGCATCGACGAAGTGCTGGTGCAGGACAACCAACATGTGGAAAAGGGCCAACTGCTGATCCGTCTCGAACCGAAT
GATTTCCGTCTGGCCGTCGATCGCGCCAACGCCGCCCTCGCCACCCGTGAGGCCGAGCGCCTGCAAGCCCAGAGCAAATT
GACCCAGCAAGCCAGCCTGATTGCCGCCAGCGACGCGCAAGTTGCCACCACCCAGGCAACGCTCGGCCGCTCGCAGGTGG
ATTTGTCGCGGGCAGAAACCCTGCGTAAACCCGGCTACGTCTCCGAGGAGCGGGTCACCACCCTCTCCGCCGACGCCCAT
ATCGCCCGCTCGCAAGTGGCCAAGGCCCAGGCCGATGCCCAGAGCCAGCGCCAGCAAGTCAACGCGCTGACCGCCGAGAT
CAAACGCCTCGATGCACAGATCGCCAACGCCCGTGCCGACCTCGCCCAGGCCGAACTGAACCTGACCCGCAGCGAAATCC
ACGCGCCGATCAGCGGCCTGATCGGCCAGCGTGCCGCGCGCAATGGGCAAGTGGTACAGGCCGGCGCCTATCTTTTGTCG
ATCGTCCCGGACGAAGACATCTGGGTGCAGGCCAATTTCAAGGAAACCCAGATCGGCCACATGCAGCCGGGCCAAAAGGC
CGAGCTGCTTTTCGATGCCTATGGCGATACGCCGGTCGAAGCCCGGGTCGACAGTCTGTTCGCCGCCTCTGGCGCGCAGT
TCAGCCTGTTGCCGCCGGACAACGCCACCGGCAACTTCACCAAGGTCGTGCAGCGGATTCCGGTCAAGCTGACCTTCAAG
GCCGATAACCCGCTGCACGGCAAGATCCGTCCGGGCATGTCCGTCACCGCCACCGTGAACATCAAAGACGCCCCTGACAA
TGGCCGGTGA

Upstream 100 bases:

>100_bases
AATGGCCGAATATCAACAGACGGCATTTACCGTTCATCGGCTGTATGCCAGATTCGCCTGCTGATAACTTTCCTTACAAT
TCCTCGACTACAGTTTGCCC

Downstream 100 bases:

>100_bases
TTCACTGATCCGCCCGGTCGGCGAACCGACCCGGCGGGACTGGATCGCGGTGATGAGCGTCATGCTTGGCGCCTTCATGG
CGGTGCTCGACATCCAGATC

Product: secretion protein HlyD

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 349; Mature: 348

Protein sequence:

>349_residues
MPAQLKRRLFIFLLLVLLIAGGFFAHWFFKGRFYESTDNAYVQGEITRVSSQLSARIDEVLVQDNQHVEKGQLLIRLEPN
DFRLAVDRANAALATREAERLQAQSKLTQQASLIAASDAQVATTQATLGRSQVDLSRAETLRKPGYVSEERVTTLSADAH
IARSQVAKAQADAQSQRQQVNALTAEIKRLDAQIANARADLAQAELNLTRSEIHAPISGLIGQRAARNGQVVQAGAYLLS
IVPDEDIWVQANFKETQIGHMQPGQKAELLFDAYGDTPVEARVDSLFAASGAQFSLLPPDNATGNFTKVVQRIPVKLTFK
ADNPLHGKIRPGMSVTATVNIKDAPDNGR

Sequences:

>Translated_349_residues
MPAQLKRRLFIFLLLVLLIAGGFFAHWFFKGRFYESTDNAYVQGEITRVSSQLSARIDEVLVQDNQHVEKGQLLIRLEPN
DFRLAVDRANAALATREAERLQAQSKLTQQASLIAASDAQVATTQATLGRSQVDLSRAETLRKPGYVSEERVTTLSADAH
IARSQVAKAQADAQSQRQQVNALTAEIKRLDAQIANARADLAQAELNLTRSEIHAPISGLIGQRAARNGQVVQAGAYLLS
IVPDEDIWVQANFKETQIGHMQPGQKAELLFDAYGDTPVEARVDSLFAASGAQFSLLPPDNATGNFTKVVQRIPVKLTFK
ADNPLHGKIRPGMSVTATVNIKDAPDNGR
>Mature_348_residues
PAQLKRRLFIFLLLVLLIAGGFFAHWFFKGRFYESTDNAYVQGEITRVSSQLSARIDEVLVQDNQHVEKGQLLIRLEPND
FRLAVDRANAALATREAERLQAQSKLTQQASLIAASDAQVATTQATLGRSQVDLSRAETLRKPGYVSEERVTTLSADAHI
ARSQVAKAQADAQSQRQQVNALTAEIKRLDAQIANARADLAQAELNLTRSEIHAPISGLIGQRAARNGQVVQAGAYLLSI
VPDEDIWVQANFKETQIGHMQPGQKAELLFDAYGDTPVEARVDSLFAASGAQFSLLPPDNATGNFTKVVQRIPVKLTFKA
DNPLHGKIRPGMSVTATVNIKDAPDNGR

Specific function: Unknown

COG id: COG1566

COG function: function code V; Multidrug resistance efflux pump

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI1788711, Length=345, Percent_Identity=33.3333333333333, Blast_Score=173, Evalue=2e-44,
Organism=Escherichia coli, GI1789041, Length=331, Percent_Identity=33.2326283987915, Blast_Score=165, Evalue=4e-42,
Organism=Escherichia coli, GI1790519, Length=312, Percent_Identity=28.2051282051282, Blast_Score=102, Evalue=4e-23,
Organism=Escherichia coli, GI87081951, Length=315, Percent_Identity=22.8571428571429, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI1790012, Length=232, Percent_Identity=26.2931034482759, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1790024, Length=238, Percent_Identity=26.890756302521, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1789900, Length=317, Percent_Identity=23.9747634069401, Blast_Score=68, Evalue=7e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005694
- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 38174; Mature: 38042

Theoretical pI: Translated: 9.32; Mature: 9.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
0.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
0.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPAQLKRRLFIFLLLVLLIAGGFFAHWFFKGRFYESTDNAYVQGEITRVSSQLSARIDEV
CCHHHHHHHHHHHHHHHHHHCHHHHHHHHCCEEEECCCCEEEEEHHHHHHHHHHHHHHHH
LVQDNQHVEKGQLLIRLEPNDFRLAVDRANAALATREAERLQAQSKLTQQASLIAASDAQ
HHCCCCCCCCCCEEEEECCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHEEECCCC
VATTQATLGRSQVDLSRAETLRKPGYVSEERVTTLSADAHIARSQVAKAQADAQSQRQQV
EEEHHHHHCCHHHHHHHHHHHCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHH
NALTAEIKRLDAQIANARADLAQAELNLTRSEIHAPISGLIGQRAARNGQVVQAGAYLLS
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCHHHHHHHHHCCCCCEEEECEEEEE
IVPDEDIWVQANFKETQIGHMQPGQKAELLFDAYGDTPVEARVDSLFAASGAQFSLLPPD
ECCCCCEEEEECCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHCCCCEEEEECCC
NATGNFTKVVQRIPVKLTFKADNPLHGKIRPGMSVTATVNIKDAPDNGR
CCCCHHHHHHHHCCEEEEEECCCCCCCCCCCCCEEEEEEEEECCCCCCC
>Mature Secondary Structure 
PAQLKRRLFIFLLLVLLIAGGFFAHWFFKGRFYESTDNAYVQGEITRVSSQLSARIDEV
CHHHHHHHHHHHHHHHHHHCHHHHHHHHCCEEEECCCCEEEEEHHHHHHHHHHHHHHHH
LVQDNQHVEKGQLLIRLEPNDFRLAVDRANAALATREAERLQAQSKLTQQASLIAASDAQ
HHCCCCCCCCCCEEEEECCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHEEECCCC
VATTQATLGRSQVDLSRAETLRKPGYVSEERVTTLSADAHIARSQVAKAQADAQSQRQQV
EEEHHHHHCCHHHHHHHHHHHCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHH
NALTAEIKRLDAQIANARADLAQAELNLTRSEIHAPISGLIGQRAARNGQVVQAGAYLLS
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCHHHHHHHHHCCCCCEEEECEEEEE
IVPDEDIWVQANFKETQIGHMQPGQKAELLFDAYGDTPVEARVDSLFAASGAQFSLLPPD
ECCCCCEEEEECCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHCCCCEEEEECCC
NATGNFTKVVQRIPVKLTFKADNPLHGKIRPGMSVTATVNIKDAPDNGR
CCCCHHHHHHHHCCEEEEEECCCCCCCCCCCCCEEEEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503 [H]