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The map label for this gene is apt

Identifier: 77458037

GI number: 77458037

Start: 2023103

End: 2023651

Strand: Reverse

Name: apt

Synonym: Pfl01_1810

Alternate gene names: 77458037

Gene position: 2023651-2023103 (Counterclockwise)

Preceding gene: 77458038

Following gene: 77458031

Centisome position: 31.43

GC content: 61.02

Gene sequence:

>549_bases
ATGGTCTTCGACTCCTTCGACATCAAATCCCTGATCCGCCCCGTGATCGACTTCCCGAAACCGGGCGTGATCTTTCGCGA
CATCACCCCGCTGTTCCAGTCGCCCAAGGCCCTGCGCCTGGTGATGGACAGCTTCGCCCACCGCTATGTTGAAGCCGACT
TCACCCACATCGGCGCGATGGATGCGCGTGGTTTCCTGATCGGTTCGGTGCTGGCTTATCAACTGAACAAGCCGCTGGTG
CTGTTCCGCAAGCAAGGCAAACTGCCGGCGGACGTGCTGGCCGAAGGTTACGCGACCGAGTACGGCGAAGCGTTCCTCGA
AGTGCACGCCGACAGCCTGTGCGAAGGCGATTCGGTGGTGATGTTCGATGACCTGATCGCCACCGGCGGCACGCTGATCG
CGGCGGCCAACCTGATCCGCCGCATGGGCGCCCGCGTTCATGAAGCGGCGGCGATCATTGATCTGCCGGAGCTGGGTGGT
TCGCAGCGTCTTGAGGACATGGGGATTCCGACGTTCTGCCTGACGCAGTTTGCGTTGACTGATAAATAA

Upstream 100 bases:

>100_bases
CGGCGGCTCGCTCGAAGTCTGATCTCGACCCGCGGCCGAGCGTATCGTTTCAGCCGCGGGTATACTGCGCCGTTTGCAGC
CCTGCCAGGACACCTCGACG

Downstream 100 bases:

>100_bases
TCAGCCCCGCGCCTCGATCGTTCCCACGCTCCGCGTGGGAACGATCAAACACCGAAGATTACAGTCCCATCTGCTTGCTG
ATGATCTCGTTCATCACTTC

Product: adenine phosphoribosyltransferase

Products: NA

Alternate protein names: APRT

Number of amino acids: Translated: 182; Mature: 182

Protein sequence:

>182_residues
MVFDSFDIKSLIRPVIDFPKPGVIFRDITPLFQSPKALRLVMDSFAHRYVEADFTHIGAMDARGFLIGSVLAYQLNKPLV
LFRKQGKLPADVLAEGYATEYGEAFLEVHADSLCEGDSVVMFDDLIATGGTLIAAANLIRRMGARVHEAAAIIDLPELGG
SQRLEDMGIPTFCLTQFALTDK

Sequences:

>Translated_182_residues
MVFDSFDIKSLIRPVIDFPKPGVIFRDITPLFQSPKALRLVMDSFAHRYVEADFTHIGAMDARGFLIGSVLAYQLNKPLV
LFRKQGKLPADVLAEGYATEYGEAFLEVHADSLCEGDSVVMFDDLIATGGTLIAAANLIRRMGARVHEAAAIIDLPELGG
SQRLEDMGIPTFCLTQFALTDK
>Mature_182_residues
MVFDSFDIKSLIRPVIDFPKPGVIFRDITPLFQSPKALRLVMDSFAHRYVEADFTHIGAMDARGFLIGSVLAYQLNKPLV
LFRKQGKLPADVLAEGYATEYGEAFLEVHADSLCEGDSVVMFDDLIATGGTLIAAANLIRRMGARVHEAAAIIDLPELGG
SQRLEDMGIPTFCLTQFALTDK

Specific function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family

Homologues:

Organism=Homo sapiens, GI4502171, Length=174, Percent_Identity=41.3793103448276, Blast_Score=130, Evalue=7e-31,
Organism=Homo sapiens, GI71773201, Length=126, Percent_Identity=43.6507936507937, Blast_Score=102, Evalue=2e-22,
Organism=Escherichia coli, GI1786675, Length=170, Percent_Identity=46.4705882352941, Blast_Score=157, Evalue=3e-40,
Organism=Caenorhabditis elegans, GI17509087, Length=181, Percent_Identity=39.7790055248619, Blast_Score=126, Evalue=8e-30,
Organism=Saccharomyces cerevisiae, GI6323619, Length=172, Percent_Identity=31.3953488372093, Blast_Score=86, Evalue=5e-18,
Organism=Saccharomyces cerevisiae, GI6320649, Length=162, Percent_Identity=30.8641975308642, Blast_Score=72, Evalue=6e-14,
Organism=Drosophila melanogaster, GI17136334, Length=167, Percent_Identity=38.3233532934132, Blast_Score=97, Evalue=5e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): APT_PSEPF (Q3KFA3)

Other databases:

- EMBL:   CP000094
- RefSeq:   YP_347542.1
- HSSP:   P07741
- ProteinModelPortal:   Q3KFA3
- SMR:   Q3KFA3
- STRING:   Q3KFA3
- GeneID:   3716416
- GenomeReviews:   CP000094_GR
- KEGG:   pfo:Pfl01_1810
- eggNOG:   COG0503
- HOGENOM:   HBG703830
- OMA:   GILFYDI
- ProtClustDB:   PRK02304
- BioCyc:   PFLU205922:PFL_1810-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00004
- InterPro:   IPR005764
- InterPro:   IPR000836
- TIGRFAMs:   TIGR01090

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.7

Molecular weight: Translated: 19979; Mature: 19979

Theoretical pI: Translated: 4.82; Mature: 4.82

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVFDSFDIKSLIRPVIDFPKPGVIFRDITPLFQSPKALRLVMDSFAHRYVEADFTHIGAM
CCCCCCCHHHHHHHHHCCCCCCEEHHCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCC
DARGFLIGSVLAYQLNKPLVLFRKQGKLPADVLAEGYATEYGEAFLEVHADSLCEGDSVV
CCCHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEE
MFDDLIATGGTLIAAANLIRRMGARVHEAAAIIDLPELGGSQRLEDMGIPTFCLTQFALT
EEHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCHHHHCCCCHHHHHHHHHC
DK
CC
>Mature Secondary Structure
MVFDSFDIKSLIRPVIDFPKPGVIFRDITPLFQSPKALRLVMDSFAHRYVEADFTHIGAM
CCCCCCCHHHHHHHHHCCCCCCEEHHCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCC
DARGFLIGSVLAYQLNKPLVLFRKQGKLPADVLAEGYATEYGEAFLEVHADSLCEGDSVV
CCCHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEE
MFDDLIATGGTLIAAANLIRRMGARVHEAAAIIDLPELGGSQRLEDMGIPTFCLTQFALT
EEHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCHHHHCCCCHHHHHHHHHC
DK
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA