Click here to switch to the map view.

The map label for this gene is hcrC [H]

Identifier: 77458024

GI number: 77458024

Start: 2003498

End: 2004952

Strand: Reverse

Name: hcrC [H]

Synonym: Pfl01_1797

Alternate gene names: 77458024

Gene position: 2004952-2003498 (Counterclockwise)

Preceding gene: 77458031

Following gene: 77458023

Centisome position: 31.14

GC content: 62.82

Gene sequence:

>1455_bases
GTGATCCAGTTTTTACTTAACCAGGAACTCCGTAGCGAGCACGCCCTGGACCCGAACCTGACTGTGCTCAACTACCTGCG
CGAACACGTGGGTAAATCCGGCACCAAAGAAGGCTGCGCCAGCGGTGACTGCGGCGCGTGTACGGTGGTGGTCGGCGAGT
TGCAGACGGATGACGATGGCCGCGAGCACATTCGCTATCGCAGCCTCAACTCGTGTCTGACGTTCGTTTCGTCGCTGCAC
GGCAAGCAATTGATCAGCGTCGAAGACCTCAAGCACAAGGGCGAACTGCACAGCGTGCAGAAAGCCATGGTCGAGTGCCA
CGGTTCGCAGTGCGGTTTCTGCACCCCCGGTTTCGTGATGTCGCTGTTCGCCCTGCAAAAGAACAGCGATGCACCGGATC
AGGCCAAGGCCCACGAAGCGCTGGCCGGCAACCTCTGCCGCTGCACCGGCTACCGGCCGATCCTGGCCGCCGCTGAACAA
TCCTGCTGCGGCAAGCAACCGGACCAGTTCGACGCCCGTGAAGCCGAAACCATCGCCCGCCTCAAAGCCATTGCTCCGAC
GTCGATCGGCGAACTCAACAGCGGCGACAAACGCTGCCTGGTGCCGCTGACCGTGGCCGATCTGGCCGATCTCTACGACG
CTTATCCACAGGCCCGCCTGCTGGCCGGCGGCACCGATCTGGCACTGGAAGTCACTCAGTTCCACCGCACGTTGCCGGTG
ATGATCTACGTCGGCAACGTCGCCGAAATGAAGCGCATCGAGCACTTCGATGACCGCATCGAAATCGGCGCCGCCACCGC
CCTCTCCGACTGCTACGAAGCGCTGAACGCCGAGTACCCGGATTTCGGCGAACTGCTGCACCGCTTCGCCTCCCTGCAGA
TCCGCAACCAGGGCACTTTGGGCGGCAACATCGGCAACGCCTCGCCGATTGGTGACTCGCCACCGCTGCTGATCGCCCTC
GGCGCGCAGATCGTGCTGTGCAAGGGCGAGACCCGCCGCACGCTGGCCCTCGAGGATTACTTCATCGATTACCGGGTCAC
CGCGCGTCAGGAAAGCGAGTTCATCGAGAAAATCATCGTGCCGCGCGCCACGACCGAGCAGCGCTTCCGCGCCTACAAAG
TCTCCAAGCGTCTGGACGACGACATCTCTGCCGTCTGCGCCGCGTTCAACCTGCGGGTCGAGAACGGCGTGATCACCGAC
GCCCGCGTCGCCTTCGGTGGCATGGCTGCGATCCCGAAACGCGCCGCTCATTGCGAAGCCGTGCTGCTCGGCCAGCCGTT
CAACAACGCTGTGGTCGAACGTGCCTGCACCGCGCTGGGCGAGGATTTCACCCCGCTCTCGGACTTCCGCGCCAGCAAGG
AATACCGCCTGCTCAGCGCGCAGAACCTGCTGCGCAAATACTTCATCGAACTGCAAACACCGCACATCGAGACTCGGGTG
ACCGCTTATGTCTAA

Upstream 100 bases:

>100_bases
TTTCCTGACCTTTAAGTCAGAAAACCATTGACCGAAAAGTCAGACCTGCTAAATTCGGCTCAAGTCGCTCAACAACAATA
ATGAGTCTGCGAGGCCTTCC

Downstream 100 bases:

>100_bases
TCATCACGGCGTAGAGAAAACGCAAGCTGAACTGGCTGAACTGTTCGCCAAAGACCTGACCACCGGCGTCGGCCGCAGCG
TCAAGCACGACAGCGCCGCC

Product: molybdopterin dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 484; Mature: 484

Protein sequence:

>484_residues
MIQFLLNQELRSEHALDPNLTVLNYLREHVGKSGTKEGCASGDCGACTVVVGELQTDDDGREHIRYRSLNSCLTFVSSLH
GKQLISVEDLKHKGELHSVQKAMVECHGSQCGFCTPGFVMSLFALQKNSDAPDQAKAHEALAGNLCRCTGYRPILAAAEQ
SCCGKQPDQFDAREAETIARLKAIAPTSIGELNSGDKRCLVPLTVADLADLYDAYPQARLLAGGTDLALEVTQFHRTLPV
MIYVGNVAEMKRIEHFDDRIEIGAATALSDCYEALNAEYPDFGELLHRFASLQIRNQGTLGGNIGNASPIGDSPPLLIAL
GAQIVLCKGETRRTLALEDYFIDYRVTARQESEFIEKIIVPRATTEQRFRAYKVSKRLDDDISAVCAAFNLRVENGVITD
ARVAFGGMAAIPKRAAHCEAVLLGQPFNNAVVERACTALGEDFTPLSDFRASKEYRLLSAQNLLRKYFIELQTPHIETRV
TAYV

Sequences:

>Translated_484_residues
MIQFLLNQELRSEHALDPNLTVLNYLREHVGKSGTKEGCASGDCGACTVVVGELQTDDDGREHIRYRSLNSCLTFVSSLH
GKQLISVEDLKHKGELHSVQKAMVECHGSQCGFCTPGFVMSLFALQKNSDAPDQAKAHEALAGNLCRCTGYRPILAAAEQ
SCCGKQPDQFDAREAETIARLKAIAPTSIGELNSGDKRCLVPLTVADLADLYDAYPQARLLAGGTDLALEVTQFHRTLPV
MIYVGNVAEMKRIEHFDDRIEIGAATALSDCYEALNAEYPDFGELLHRFASLQIRNQGTLGGNIGNASPIGDSPPLLIAL
GAQIVLCKGETRRTLALEDYFIDYRVTARQESEFIEKIIVPRATTEQRFRAYKVSKRLDDDISAVCAAFNLRVENGVITD
ARVAFGGMAAIPKRAAHCEAVLLGQPFNNAVVERACTALGEDFTPLSDFRASKEYRLLSAQNLLRKYFIELQTPHIETRV
TAYV
>Mature_484_residues
MIQFLLNQELRSEHALDPNLTVLNYLREHVGKSGTKEGCASGDCGACTVVVGELQTDDDGREHIRYRSLNSCLTFVSSLH
GKQLISVEDLKHKGELHSVQKAMVECHGSQCGFCTPGFVMSLFALQKNSDAPDQAKAHEALAGNLCRCTGYRPILAAAEQ
SCCGKQPDQFDAREAETIARLKAIAPTSIGELNSGDKRCLVPLTVADLADLYDAYPQARLLAGGTDLALEVTQFHRTLPV
MIYVGNVAEMKRIEHFDDRIEIGAATALSDCYEALNAEYPDFGELLHRFASLQIRNQGTLGGNIGNASPIGDSPPLLIAL
GAQIVLCKGETRRTLALEDYFIDYRVTARQESEFIEKIIVPRATTEQRFRAYKVSKRLDDDISAVCAAFNLRVENGVITD
ARVAFGGMAAIPKRAAHCEAVLLGQPFNNAVVERACTALGEDFTPLSDFRASKEYRLLSAQNLLRKYFIELQTPHIETRV
TAYV

Specific function: Catalyzes reductive dehydroxylation of 4-hydroxybenzoyl- CoA. Reaction is not reversible [H]

COG id: COG4630

COG function: function code F; Xanthine dehydrogenase, iron-sulfur cluster and FAD-binding subunit A

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 2Fe-2S ferredoxin-type domain [H]

Homologues:

Organism=Homo sapiens, GI91823271, Length=490, Percent_Identity=31.0204081632653, Blast_Score=203, Evalue=3e-52,
Organism=Homo sapiens, GI71773480, Length=529, Percent_Identity=27.2211720226843, Blast_Score=152, Evalue=9e-37,
Organism=Escherichia coli, GI1789231, Length=271, Percent_Identity=28.7822878228782, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1786480, Length=161, Percent_Identity=34.7826086956522, Blast_Score=90, Evalue=4e-19,
Organism=Escherichia coli, GI1789232, Length=140, Percent_Identity=38.5714285714286, Blast_Score=86, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI17540638, Length=541, Percent_Identity=30.1293900184843, Blast_Score=227, Evalue=1e-59,
Organism=Caenorhabditis elegans, GI32566215, Length=169, Percent_Identity=43.1952662721894, Blast_Score=140, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI17539860, Length=156, Percent_Identity=44.2307692307692, Blast_Score=138, Evalue=7e-33,
Organism=Drosophila melanogaster, GI17737937, Length=492, Percent_Identity=34.349593495935, Blast_Score=249, Evalue=4e-66,
Organism=Drosophila melanogaster, GI24647199, Length=495, Percent_Identity=28.4848484848485, Blast_Score=152, Evalue=6e-37,
Organism=Drosophila melanogaster, GI24647201, Length=489, Percent_Identity=26.3803680981595, Blast_Score=140, Evalue=2e-33,
Organism=Drosophila melanogaster, GI24647197, Length=491, Percent_Identity=27.0875763747454, Blast_Score=139, Evalue=4e-33,
Organism=Drosophila melanogaster, GI24647193, Length=498, Percent_Identity=27.3092369477912, Blast_Score=137, Evalue=1e-32,
Organism=Drosophila melanogaster, GI24647195, Length=314, Percent_Identity=29.6178343949045, Blast_Score=124, Evalue=2e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002888
- InterPro:   IPR006058
- InterPro:   IPR017606
- InterPro:   IPR012675
- InterPro:   IPR001041 [H]

Pfam domain/function: PF00111 Fer2; PF01799 Fer2_2 [H]

EC number: =1.3.99.20 [H]

Molecular weight: Translated: 53132; Mature: 53132

Theoretical pI: Translated: 5.92; Mature: 5.92

Prosite motif: PS00197 2FE2S_FER_1 ; PS51085 2FE2S_FER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.5 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
3.5 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIQFLLNQELRSEHALDPNLTVLNYLREHVGKSGTKEGCASGDCGACTVVVGELQTDDDG
CCHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEEECCCCCCH
REHIRYRSLNSCLTFVSSLHGKQLISVEDLKHKGELHSVQKAMVECHGSQCGFCTPGFVM
HHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHCCHHHHHHHHHHHHCCCCCCCCCHHHHH
SLFALQKNSDAPDQAKAHEALAGNLCRCTGYRPILAAAEQSCCGKQPDQFDAREAETIAR
HHHHHHCCCCCCHHHHHHHHHHCCCCEECCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHH
LKAIAPTSIGELNSGDKRCLVPLTVADLADLYDAYPQARLLAGGTDLALEVTQFHRTLPV
HHHHCCCCCCCCCCCCCEEEEEEHHHHHHHHHHHCCCCEEEECCCCCEEEHHHHHCCCEE
MIYVGNVAEMKRIEHFDDRIEIGAATALSDCYEALNAEYPDFGELLHRFASLQIRNQGTL
EEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHEEECCCCCC
GGNIGNASPIGDSPPLLIALGAQIVLCKGETRRTLALEDYFIDYRVTARQESEFIEKIIV
CCCCCCCCCCCCCCCEEEEECCEEEEECCCCCCEEEEEEEEEEEEEECHHHHHHHHHHHC
PRATTEQRFRAYKVSKRLDDDISAVCAAFNLRVENGVITDARVAFGGMAAIPKRAAHCEA
CCCCHHHHHHHHHHHHHCCHHHHHHHHHHHEEECCCCEECHHHHHCCHHHCCHHHHCCCE
VLLGQPFNNAVVERACTALGEDFTPLSDFRASKEYRLLSAQNLLRKYFIELQTPHIETRV
EEECCCCHHHHHHHHHHHHCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCEE
TAYV
EEEC
>Mature Secondary Structure
MIQFLLNQELRSEHALDPNLTVLNYLREHVGKSGTKEGCASGDCGACTVVVGELQTDDDG
CCHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEEECCCCCCH
REHIRYRSLNSCLTFVSSLHGKQLISVEDLKHKGELHSVQKAMVECHGSQCGFCTPGFVM
HHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHCCHHHHHHHHHHHHCCCCCCCCCHHHHH
SLFALQKNSDAPDQAKAHEALAGNLCRCTGYRPILAAAEQSCCGKQPDQFDAREAETIAR
HHHHHHCCCCCCHHHHHHHHHHCCCCEECCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHH
LKAIAPTSIGELNSGDKRCLVPLTVADLADLYDAYPQARLLAGGTDLALEVTQFHRTLPV
HHHHCCCCCCCCCCCCCEEEEEEHHHHHHHHHHHCCCCEEEECCCCCEEEHHHHHCCCEE
MIYVGNVAEMKRIEHFDDRIEIGAATALSDCYEALNAEYPDFGELLHRFASLQIRNQGTL
EEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHEEECCCCCC
GGNIGNASPIGDSPPLLIALGAQIVLCKGETRRTLALEDYFIDYRVTARQESEFIEKIIV
CCCCCCCCCCCCCCCEEEEECCEEEEECCCCCCEEEEEEEEEEEEEECHHHHHHHHHHHC
PRATTEQRFRAYKVSKRLDDDISAVCAAFNLRVENGVITDARVAFGGMAAIPKRAAHCEA
CCCCHHHHHHHHHHHHHCCHHHHHHHHHHHEEECCCCEECHHHHHCCHHHCCHHHHCCCE
VLLGQPFNNAVVERACTALGEDFTPLSDFRASKEYRLLSAQNLLRKYFIELQTPHIETRV
EEECCCCHHHHHHHHHHHHCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCEE
TAYV
EEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9490068 [H]