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The map label for this gene is sdhA [H]

Identifier: 77457839

GI number: 77457839

Start: 1800303

End: 1802075

Strand: Direct

Name: sdhA [H]

Synonym: Pfl01_1612

Alternate gene names: 77457839

Gene position: 1800303-1802075 (Clockwise)

Preceding gene: 77457838

Following gene: 77457840

Centisome position: 27.96

GC content: 59.62

Gene sequence:

>1773_bases
ATGGCTAACATTCCAACGATTTCTTTCGACGCCATCATTATTGGTGGCGGCGGTGCCGGCATGCGCGCAGCGCTGCAACT
GGCACAGGGCGGTCACAAGACTGCCGTGATCACCAAGGTTTTCCCGACCCGTTCGCACACTGTGTCCGCACAGGGCGGGA
TCACCTGCGCCATCGCTTCGGCCGACCCGAACGATGACTGGCGCTGGCACATGTACGATACCGTCAAGGGTTCCGACTAC
ATCGGTGACCAGGACGCTATCGAATACATGTGTCAGGAAGGCCCGGCTGCCGTTTTCGAGCTGGACCACATGGGTCTGCC
GTTCTCGCGTACCGAGCAAGGCCGTATCTACCAGCGTCCGTTCGGCGGTCAGTCGAAGGATTACGGTAAAGGCGGGCAGG
CTGCCCGCACCTGCGCCGCTTCCGACCGTACCGGTCACGCGCTGCTGCACACCCTTTATCAGGGCAACCTGAAAGCCGGT
ACCACGTTCCTGAACGAGTACTACGCTGTCGACCTGGTGAAAAACCAGGAAGGCGAATTCGTCGGTGTGATCGCGATCTG
CATCGAAACCGGCGAAACCACCTACATCCGCGCCAAAGCCACCGTACTGGCTACCGGCGGTGCAGGTCGTATCTATGCAT
CCACCACCAACGCCCTGATCAACACCGGTGACGGCGTCGGCATGGCTCTGCGTGCTGGCGTGCCGGTACAAGACATCGAA
ATGTGGCAGTTCCACCCGACCGGCATCGCCGGCGCCGGTGTACTGGTGACCGAAGGTTGCCGTGGTGAAGGTGGTTACCT
GATCAACAAGCACGGCGAGCGTTTCATGGAGCGTTATGCTCCGAACGCCAAAGACCTTGCCGGTCGTGACGTGGTTGCCC
GTTCGATGGTTAAAGAGATCATCGCCGGTAATGGTTGCGGTCCGAATGGCGACCACGTGATGCTCAAACTCGACCACCTG
GGCGAGGAAGTGCTGCACAGCCGTCTGCCAGGCATCTGCGAACTGTCGAAGACTTTCGCACACGTTGATCCGGTGGTTGC
TCCGGTTCCGGTTGTTCCGACTTGCCACTACATGATGGGCGGCGTTGCCACCAACATTCATGGCCAGGCGATCACCCAGG
ACGCCGAAGGCGTGGATCAGATCATTCCTGGTCTGTTCGCGGTAGGTGAAGTGGCTTGCGTATCGGTTCACGGTGCCAAC
CGTCTGGGCGGCAACTCGCTGCTCGACCTGGTGGTATTCGGCCGCGCTGCCGGCCTGCACCTGGAGAAGGCGCTGACCGA
CGGCATCGAATACGACGACGCTACCGAAGCCGACATCGAAGCTGCCCTGGCACGTCTGAACGCCCTGAACAACCGTACCG
ACGGCGAAGACGTCGCTACCCTGCGTCGCGAGCTGCAAAGCTGCATGCAGAACTACTTCGGTGTATTCCGTACCGGCGAA
TACATGCAGAAGGGTATTGCCCAGCTGGCCGATCTGCGCAAGCGCATCGCCAACGTGAAGATCAACGACAAGTCGCAGGC
GTTCAACACTGCCCGTATCGAAGCGCTGGAACTGCAAAACCTGCTGGAAGTGGCTGAAGCTACCGCCATCGCTGCCGAAG
TACGTAAAGAGTCCCGCGGTGCTCACGCCCGTGAAGACTTCGAAGATCGTGACGACGAAAACTGGCTGTGCCACACCCTG
TACTTCCCGGGTGAGAAACGCGTCGCCAAGCGTGCCGTGAACTTCTCGCCGAAGACTGTTCCGACTTTCGAACCTAAAGT
CCGGACTTATTAA

Upstream 100 bases:

>100_bases
GTCCGCGACTGCAGTACGTTTCCTTTTCCAGGCAGTATGCGGCGTCGCGATGTTCGCTTACTTCGTCTGGGGTGTGCAGA
TTCTCTGGGGTATCTGATTC

Downstream 100 bases:

>100_bases
GGGTGACCGCCATGTTGCAAGTCAGTGTTTATCGTTACAACCCTGATCAGGACGCTGCGCCGTTCATGCAGGAATTCCAG
GTTGATACCGGTGGTAAAGA

Product: succinate dehydrogenase flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 590; Mature: 589

Protein sequence:

>590_residues
MANIPTISFDAIIIGGGGAGMRAALQLAQGGHKTAVITKVFPTRSHTVSAQGGITCAIASADPNDDWRWHMYDTVKGSDY
IGDQDAIEYMCQEGPAAVFELDHMGLPFSRTEQGRIYQRPFGGQSKDYGKGGQAARTCAASDRTGHALLHTLYQGNLKAG
TTFLNEYYAVDLVKNQEGEFVGVIAICIETGETTYIRAKATVLATGGAGRIYASTTNALINTGDGVGMALRAGVPVQDIE
MWQFHPTGIAGAGVLVTEGCRGEGGYLINKHGERFMERYAPNAKDLAGRDVVARSMVKEIIAGNGCGPNGDHVMLKLDHL
GEEVLHSRLPGICELSKTFAHVDPVVAPVPVVPTCHYMMGGVATNIHGQAITQDAEGVDQIIPGLFAVGEVACVSVHGAN
RLGGNSLLDLVVFGRAAGLHLEKALTDGIEYDDATEADIEAALARLNALNNRTDGEDVATLRRELQSCMQNYFGVFRTGE
YMQKGIAQLADLRKRIANVKINDKSQAFNTARIEALELQNLLEVAEATAIAAEVRKESRGAHAREDFEDRDDENWLCHTL
YFPGEKRVAKRAVNFSPKTVPTFEPKVRTY

Sequences:

>Translated_590_residues
MANIPTISFDAIIIGGGGAGMRAALQLAQGGHKTAVITKVFPTRSHTVSAQGGITCAIASADPNDDWRWHMYDTVKGSDY
IGDQDAIEYMCQEGPAAVFELDHMGLPFSRTEQGRIYQRPFGGQSKDYGKGGQAARTCAASDRTGHALLHTLYQGNLKAG
TTFLNEYYAVDLVKNQEGEFVGVIAICIETGETTYIRAKATVLATGGAGRIYASTTNALINTGDGVGMALRAGVPVQDIE
MWQFHPTGIAGAGVLVTEGCRGEGGYLINKHGERFMERYAPNAKDLAGRDVVARSMVKEIIAGNGCGPNGDHVMLKLDHL
GEEVLHSRLPGICELSKTFAHVDPVVAPVPVVPTCHYMMGGVATNIHGQAITQDAEGVDQIIPGLFAVGEVACVSVHGAN
RLGGNSLLDLVVFGRAAGLHLEKALTDGIEYDDATEADIEAALARLNALNNRTDGEDVATLRRELQSCMQNYFGVFRTGE
YMQKGIAQLADLRKRIANVKINDKSQAFNTARIEALELQNLLEVAEATAIAAEVRKESRGAHAREDFEDRDDENWLCHTL
YFPGEKRVAKRAVNFSPKTVPTFEPKVRTY
>Mature_589_residues
ANIPTISFDAIIIGGGGAGMRAALQLAQGGHKTAVITKVFPTRSHTVSAQGGITCAIASADPNDDWRWHMYDTVKGSDYI
GDQDAIEYMCQEGPAAVFELDHMGLPFSRTEQGRIYQRPFGGQSKDYGKGGQAARTCAASDRTGHALLHTLYQGNLKAGT
TFLNEYYAVDLVKNQEGEFVGVIAICIETGETTYIRAKATVLATGGAGRIYASTTNALINTGDGVGMALRAGVPVQDIEM
WQFHPTGIAGAGVLVTEGCRGEGGYLINKHGERFMERYAPNAKDLAGRDVVARSMVKEIIAGNGCGPNGDHVMLKLDHLG
EEVLHSRLPGICELSKTFAHVDPVVAPVPVVPTCHYMMGGVATNIHGQAITQDAEGVDQIIPGLFAVGEVACVSVHGANR
LGGNSLLDLVVFGRAAGLHLEKALTDGIEYDDATEADIEAALARLNALNNRTDGEDVATLRRELQSCMQNYFGVFRTGEY
MQKGIAQLADLRKRIANVKINDKSQAFNTARIEALELQNLLEVAEATAIAAEVRKESRGAHAREDFEDRDDENWLCHTLY
FPGEKRVAKRAVNFSPKTVPTFEPKVRTY

Specific function: Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; the fumarate reductase is used in anaerobic growth, and the succinate dehydrogenase is used in aerobic growth [H]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=588, Percent_Identity=52.0408163265306, Blast_Score=585, Evalue=1e-167,
Organism=Escherichia coli, GI1786942, Length=589, Percent_Identity=69.1001697792869, Blast_Score=810, Evalue=0.0,
Organism=Escherichia coli, GI1790597, Length=574, Percent_Identity=42.8571428571429, Blast_Score=419, Evalue=1e-118,
Organism=Escherichia coli, GI1788928, Length=569, Percent_Identity=32.5131810193322, Blast_Score=220, Evalue=2e-58,
Organism=Caenorhabditis elegans, GI17550100, Length=527, Percent_Identity=55.0284629981025, Blast_Score=577, Evalue=1e-165,
Organism=Caenorhabditis elegans, GI17505833, Length=531, Percent_Identity=54.0489642184557, Blast_Score=569, Evalue=1e-162,
Organism=Saccharomyces cerevisiae, GI6322416, Length=555, Percent_Identity=55.4954954954955, Blast_Score=599, Evalue=1e-172,
Organism=Saccharomyces cerevisiae, GI6322701, Length=592, Percent_Identity=52.7027027027027, Blast_Score=599, Evalue=1e-172,
Organism=Saccharomyces cerevisiae, GI6320788, Length=483, Percent_Identity=27.3291925465839, Blast_Score=96, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6322511, Length=310, Percent_Identity=25.8064516129032, Blast_Score=84, Evalue=4e-17,
Organism=Drosophila melanogaster, GI17137288, Length=546, Percent_Identity=55.8608058608059, Blast_Score=588, Evalue=1e-168,
Organism=Drosophila melanogaster, GI24655642, Length=546, Percent_Identity=55.8608058608059, Blast_Score=588, Evalue=1e-168,
Organism=Drosophila melanogaster, GI24655647, Length=546, Percent_Identity=55.8608058608059, Blast_Score=588, Evalue=1e-168,
Organism=Drosophila melanogaster, GI24663005, Length=610, Percent_Identity=48.0327868852459, Blast_Score=547, Evalue=1e-156,

Paralogues:

None

Copy number: 1900 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 1360 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 1100 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR013027
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR011281
- InterPro:   IPR014006 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 63584; Mature: 63452

Theoretical pI: Translated: 5.93; Mature: 5.93

Prosite motif: PS00504 FRD_SDH_FAD_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANIPTISFDAIIIGGGGAGMRAALQLAQGGHKTAVITKVFPTRSHTVSAQGGITCAIAS
CCCCCCEEEEEEEEECCCHHHHHHHHHHCCCCCEEEEEEEECCCCCEEECCCCEEEEEEC
ADPNDDWRWHMYDTVKGSDYIGDQDAIEYMCQEGPAAVFELDHMGLPFSRTEQGRIYQRP
CCCCCCCEEEEEEECCCCCCCCCHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCEEECC
FGGQSKDYGKGGQAARTCAASDRTGHALLHTLYQGNLKAGTTFLNEYYAVDLVKNQEGEF
CCCCCCCCCCCCCHHHHHHCCCCCHHHHHHHHHCCCCCCCHHHHHCEEEEEEEECCCCCE
VGVIAICIETGETTYIRAKATVLATGGAGRIYASTTNALINTGDGVGMALRAGVPVQDIE
EEEEEEEEECCCEEEEEEEEEEEEECCCCEEEEECCCCEEECCCCCCEEEECCCCHHHCE
MWQFHPTGIAGAGVLVTEGCRGEGGYLINKHGERFMERYAPNAKDLAGRDVVARSMVKEI
EEEECCCCCCCCCEEEECCCCCCCCEEECCHHHHHHHHHCCCCHHHCCHHHHHHHHHHHH
IAGNGCGPNGDHVMLKLDHLGEEVLHSRLPGICELSKTFAHVDPVVAPVPVVPTCHYMMG
HCCCCCCCCCCEEEEEHHHCCHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHC
GVATNIHGQAITQDAEGVDQIIPGLFAVGEVACVSVHGANRLGGNSLLDLVVFGRAAGLH
CEEECCCCCEECCCCCCHHHHHHHHHHHCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCH
LEKALTDGIEYDDATEADIEAALARLNALNNRTDGEDVATLRRELQSCMQNYFGVFRTGE
HHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHH
YMQKGIAQLADLRKRIANVKINDKSQAFNTARIEALELQNLLEVAEATAIAAEVRKESRG
HHHHHHHHHHHHHHHHHCCEECCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
AHAREDFEDRDDENWLCHTLYFPGEKRVAKRAVNFSPKTVPTFEPKVRTY
CCCCCCCCCCCCCCEEEEEEECCCHHHHHHHHCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
ANIPTISFDAIIIGGGGAGMRAALQLAQGGHKTAVITKVFPTRSHTVSAQGGITCAIAS
CCCCCEEEEEEEEECCCHHHHHHHHHHCCCCCEEEEEEEECCCCCEEECCCCEEEEEEC
ADPNDDWRWHMYDTVKGSDYIGDQDAIEYMCQEGPAAVFELDHMGLPFSRTEQGRIYQRP
CCCCCCCEEEEEEECCCCCCCCCHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCEEECC
FGGQSKDYGKGGQAARTCAASDRTGHALLHTLYQGNLKAGTTFLNEYYAVDLVKNQEGEF
CCCCCCCCCCCCCHHHHHHCCCCCHHHHHHHHHCCCCCCCHHHHHCEEEEEEEECCCCCE
VGVIAICIETGETTYIRAKATVLATGGAGRIYASTTNALINTGDGVGMALRAGVPVQDIE
EEEEEEEEECCCEEEEEEEEEEEEECCCCEEEEECCCCEEECCCCCCEEEECCCCHHHCE
MWQFHPTGIAGAGVLVTEGCRGEGGYLINKHGERFMERYAPNAKDLAGRDVVARSMVKEI
EEEECCCCCCCCCEEEECCCCCCCCEEECCHHHHHHHHHCCCCHHHCCHHHHHHHHHHHH
IAGNGCGPNGDHVMLKLDHLGEEVLHSRLPGICELSKTFAHVDPVVAPVPVVPTCHYMMG
HCCCCCCCCCCEEEEEHHHCCHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHC
GVATNIHGQAITQDAEGVDQIIPGLFAVGEVACVSVHGANRLGGNSLLDLVVFGRAAGLH
CEEECCCCCEECCCCCCHHHHHHHHHHHCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCH
LEKALTDGIEYDDATEADIEAALARLNALNNRTDGEDVATLRRELQSCMQNYFGVFRTGE
HHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHH
YMQKGIAQLADLRKRIANVKINDKSQAFNTARIEALELQNLLEVAEATAIAAEVRKESRG
HHHHHHHHHHHHHHHHHCCEECCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
AHAREDFEDRDDENWLCHTLYFPGEKRVAKRAVNFSPKTVPTFEPKVRTY
CCCCCCCCCCCCCCEEEEEEECCCHHHHHHHHCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]