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The map label for this gene is gltA [H]

Identifier: 77457836

GI number: 77457836

Start: 1797909

End: 1799198

Strand: Reverse

Name: gltA [H]

Synonym: Pfl01_1609

Alternate gene names: 77457836

Gene position: 1799198-1797909 (Counterclockwise)

Preceding gene: 77457849

Following gene: 77457832

Centisome position: 27.94

GC content: 59.15

Gene sequence:

>1290_bases
ATGGCTGACAAAAAAGCGCAGTTGATCATCGAGGGCGCAGCCCCCGTCGAGCTGCCCATTTTAACCGGCACCGTTGGTCC
CGATGTTATCGATGTTCGGGGCCTGACGGCCACGGGCCGCTTCACTTTCGACCCCGGTTTCATGTCGACCGCTTCCTGCG
AATCGAAGATCACCTATATCGACGGCGACAACGGCATCCTGCTGCACCGCGGCTACCCGATCGAACAGCTGGCTGAAAAG
TCGGACTACCTGGAAACCTGCTACCTGCTGCTGAACGGCGAATTGCCGACTGCAGAGCAAAAGGCCCAGTTCGTCGGCAC
CGTGAAGAACCACACCATGGTTCACGAGCAGCTGAAAACCTTCTTCAACGGCTTCCGCCGTGACGCCCACCCGATGGCTG
TCATGTGTGGTGTAGTCGGCGCCCTCTCGGCCTTCTACCACGACTCCCTCGACATCAATAACCCGCAGCATCGCGAAATC
TCCGCGATCCGCCTGGTTGCCAAGATGCCGACCCTGGCCGCGATGGTTTACAAGTACTCCATGGGCCAACCCATGATGTA
CCCGCGCAACGACCTGTCGTACGCGGAAAACTTCCTGCACATGATGTTCAACACCCCGTGCGAGATCAAACCGATCAGCC
CGGTACTCGCCAAGGCCATGGACCGGATCTTCATCCTCCACGCCGACCACGAGCAGAACGCCTCGACCTCCACCGTGCGT
CTGGCGGGCTCCTCGGGTGCCAACCCGTTCGCCTGTATCGCCGCCGGCATCGCCGCACTGTGGGGCCCTGCCCACGGCGG
TGCGAACGAAGCCGTGCTGACCATGCTCGATGAAATCGGCGATGTTTCGAACATCGACAAGTTCATCGCCAAGGCCAAGG
ACAAGAACGATCCGTTCAAACTGATGGGCTTCGGTCACCGCGTCTACAAGAACCGCGACCCTCGCGCGACTGTCATGAAG
CAGACCTGCGACGAAGTGCTGAAGGAACTGGGCATCCAGAACGACCCGCAACTCGAACTGGCCATGCGCCTGGAAGAGAT
CGCCCTGACCGATCCGTACTTCATCGAGCGCTCGCTGTACCCGAACGTCGACTTCTACTCGGGGATCATCCTCAAGGCGA
TCGGCATTCCGACCAGCATGTTCACTGTGATCTTCGCCCTGGCACGTACTGTCGGCTGGATTTCGCACTGGAAGGAAATG
CTCTCAAGCCCGTACAAGATTGGCCGTCCGCGTCAGCTGTACACTGGTTATGAGTCGCGGGATATCACCAAGCTGGAAGA
CCGCAAATAA

Upstream 100 bases:

>100_bases
AGACTTTAGGCAAATTGACATTCGAATTTATCTCACTATAGTGGTGCGGGCCCTGCGTGGGGGGTCTGTCTGATGATTTC
AAGCATAAATAGGAGGCCAC

Downstream 100 bases:

>100_bases
GAGCTGTCTTGCGATAGCGTCTTAGCGTTTTACCGGGAACGGCCTCCATGTGAATGGGGGCCGTTTTTCGTTTTGGGCAT
CTCAGCGGCCTTTGGGCCGA

Product: type II citrate synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 429; Mature: 428

Protein sequence:

>429_residues
MADKKAQLIIEGAAPVELPILTGTVGPDVIDVRGLTATGRFTFDPGFMSTASCESKITYIDGDNGILLHRGYPIEQLAEK
SDYLETCYLLLNGELPTAEQKAQFVGTVKNHTMVHEQLKTFFNGFRRDAHPMAVMCGVVGALSAFYHDSLDINNPQHREI
SAIRLVAKMPTLAAMVYKYSMGQPMMYPRNDLSYAENFLHMMFNTPCEIKPISPVLAKAMDRIFILHADHEQNASTSTVR
LAGSSGANPFACIAAGIAALWGPAHGGANEAVLTMLDEIGDVSNIDKFIAKAKDKNDPFKLMGFGHRVYKNRDPRATVMK
QTCDEVLKELGIQNDPQLELAMRLEEIALTDPYFIERSLYPNVDFYSGIILKAIGIPTSMFTVIFALARTVGWISHWKEM
LSSPYKIGRPRQLYTGYESRDITKLEDRK

Sequences:

>Translated_429_residues
MADKKAQLIIEGAAPVELPILTGTVGPDVIDVRGLTATGRFTFDPGFMSTASCESKITYIDGDNGILLHRGYPIEQLAEK
SDYLETCYLLLNGELPTAEQKAQFVGTVKNHTMVHEQLKTFFNGFRRDAHPMAVMCGVVGALSAFYHDSLDINNPQHREI
SAIRLVAKMPTLAAMVYKYSMGQPMMYPRNDLSYAENFLHMMFNTPCEIKPISPVLAKAMDRIFILHADHEQNASTSTVR
LAGSSGANPFACIAAGIAALWGPAHGGANEAVLTMLDEIGDVSNIDKFIAKAKDKNDPFKLMGFGHRVYKNRDPRATVMK
QTCDEVLKELGIQNDPQLELAMRLEEIALTDPYFIERSLYPNVDFYSGIILKAIGIPTSMFTVIFALARTVGWISHWKEM
LSSPYKIGRPRQLYTGYESRDITKLEDRK
>Mature_428_residues
ADKKAQLIIEGAAPVELPILTGTVGPDVIDVRGLTATGRFTFDPGFMSTASCESKITYIDGDNGILLHRGYPIEQLAEKS
DYLETCYLLLNGELPTAEQKAQFVGTVKNHTMVHEQLKTFFNGFRRDAHPMAVMCGVVGALSAFYHDSLDINNPQHREIS
AIRLVAKMPTLAAMVYKYSMGQPMMYPRNDLSYAENFLHMMFNTPCEIKPISPVLAKAMDRIFILHADHEQNASTSTVRL
AGSSGANPFACIAAGIAALWGPAHGGANEAVLTMLDEIGDVSNIDKFIAKAKDKNDPFKLMGFGHRVYKNRDPRATVMKQ
TCDEVLKELGIQNDPQLELAMRLEEIALTDPYFIERSLYPNVDFYSGIILKAIGIPTSMFTVIFALARTVGWISHWKEML
SSPYKIGRPRQLYTGYESRDITKLEDRK

Specific function: Tricarboxylic acid cycle. [C]

COG id: COG0372

COG function: function code C; Citrate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the citrate synthase family [H]

Homologues:

Organism=Homo sapiens, GI38327625, Length=418, Percent_Identity=26.7942583732057, Blast_Score=120, Evalue=2e-27,
Organism=Escherichia coli, GI1786939, Length=422, Percent_Identity=72.7488151658768, Blast_Score=663, Evalue=0.0,
Organism=Escherichia coli, GI1786527, Length=370, Percent_Identity=31.8918918918919, Blast_Score=156, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI17555174, Length=402, Percent_Identity=26.865671641791, Blast_Score=110, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6325257, Length=411, Percent_Identity=25.5474452554745, Blast_Score=105, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6324328, Length=378, Percent_Identity=25.6613756613757, Blast_Score=102, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6319850, Length=365, Percent_Identity=25.7534246575342, Blast_Score=99, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24640126, Length=423, Percent_Identity=26.7139479905437, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24640124, Length=423, Percent_Identity=26.7139479905437, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI21356863, Length=359, Percent_Identity=26.4623955431755, Blast_Score=104, Evalue=9e-23,

Paralogues:

None

Copy number: 624 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016142
- InterPro:   IPR016143
- InterPro:   IPR002020
- InterPro:   IPR016141
- InterPro:   IPR019810
- InterPro:   IPR010953 [H]

Pfam domain/function: PF00285 Citrate_synt [H]

EC number: =2.3.3.1 [H]

Molecular weight: Translated: 47713; Mature: 47581

Theoretical pI: Translated: 6.65; Mature: 6.65

Prosite motif: PS00480 CITRATE_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADKKAQLIIEGAAPVELPILTGTVGPDVIDVRGLTATGRFTFDPGFMSTASCESKITYI
CCCCCCEEEEECCCCEEEEEEECCCCCCEEEECCCEECCEEEECCCCCCCCCCCCEEEEE
DGDNGILLHRGYPIEQLAEKSDYLETCYLLLNGELPTAEQKAQFVGTVKNHTMVHEQLKT
ECCCCEEEECCCCHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHHHHHHHHHH
FFNGFRRDAHPMAVMCGVVGALSAFYHDSLDINNPQHREISAIRLVAKMPTLAAMVYKYS
HHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
MGQPMMYPRNDLSYAENFLHMMFNTPCEIKPISPVLAKAMDRIFILHADHEQNASTSTVR
CCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCEEEEEECCCCCCCCCCEEE
LAGSSGANPFACIAAGIAALWGPAHGGANEAVLTMLDEIGDVSNIDKFIAKAKDKNDPFK
EECCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHCCCCCCEE
LMGFGHRVYKNRDPRATVMKQTCDEVLKELGIQNDPQLELAMRLEEIALTDPYFIERSLY
EEECCHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCHHHHHCCC
PNVDFYSGIILKAIGIPTSMFTVIFALARTVGWISHWKEMLSSPYKIGRPRQLYTGYESR
CCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHCCCCCC
DITKLEDRK
CCCCCCCCC
>Mature Secondary Structure 
ADKKAQLIIEGAAPVELPILTGTVGPDVIDVRGLTATGRFTFDPGFMSTASCESKITYI
CCCCCEEEEECCCCEEEEEEECCCCCCEEEECCCEECCEEEECCCCCCCCCCCCEEEEE
DGDNGILLHRGYPIEQLAEKSDYLETCYLLLNGELPTAEQKAQFVGTVKNHTMVHEQLKT
ECCCCEEEECCCCHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHHHHHHHHHH
FFNGFRRDAHPMAVMCGVVGALSAFYHDSLDINNPQHREISAIRLVAKMPTLAAMVYKYS
HHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
MGQPMMYPRNDLSYAENFLHMMFNTPCEIKPISPVLAKAMDRIFILHADHEQNASTSTVR
CCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCEEEEEECCCCCCCCCCEEE
LAGSSGANPFACIAAGIAALWGPAHGGANEAVLTMLDEIGDVSNIDKFIAKAKDKNDPFK
EECCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHCCCCCCEE
LMGFGHRVYKNRDPRATVMKQTCDEVLKELGIQNDPQLELAMRLEEIALTDPYFIERSLY
EEECCHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCHHHHHCCC
PNVDFYSGIILKAIGIPTSMFTVIFALARTVGWISHWKEMLSSPYKIGRPRQLYTGYESR
CCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHCCCCCC
DITKLEDRK
CCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2507528; 10984043 [H]