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The map label for this gene is atoC [H]

Identifier: 77457761

GI number: 77457761

Start: 1722523

End: 1723914

Strand: Direct

Name: atoC [H]

Synonym: Pfl01_1534

Alternate gene names: 77457761

Gene position: 1722523-1723914 (Clockwise)

Preceding gene: 77457760

Following gene: 77457762

Centisome position: 26.75

GC content: 63.94

Gene sequence:

>1392_bases
ATGGGCATCAAGGTTCTGCTGGTCGAGGATGACCGCTCGTTGCGCGAAGCGCTGGCCGATACGCTGCTGCTGGCCGGTCA
CGACTATCACGCGGTGGGTTCGGCCGAAGAGGCGCTGAACGCGGTCGAGCGCGAAGCGTTCAGTCTGGTGGTCAGTGACG
TCAACATGCCGGGCATGGACGGCCATCAATTGCTCGGCCTGCTGCGCGCACGGCAACCGCAATTGCCGGTGCTGCTGATG
ACCGCCCATGGCGCGGTCGAGCGCGCGGTCGATGCCATGCGCCAGGGCGCGGCGGATTATCTGGTCAAGCCGTTCGAGCC
CAAGGCTCTGCTGGATCTGGTAGCGCGTCACGCCTTGGGCAGCCTTGTCGCCAGCGACGCCGAAGGGCCGGTCGCGGTCG
AGCCGGCCAGTGCTCAATTGCTGGATCTGGCGGCGCGGGTCGCACGCAGTGATTCCACCGTGCTGATTTCCGGCGAGTCC
GGCACCGGCAAGGAAGTGCTGGCGCGCTACATCCACCAGCAATCCCATCGTGCCAGTCAGCCGTTCATTGCGATCAACTG
CGCGGCGATCCCCGACAACATGCTCGAAGCCACCCTGTTCGGTCATGAAAAAGGCTCGTTCACTGGCGCCATCGCGGCCC
AGGCTGGCAAGTTCGAACAGGCGGACGGCGGCACCATTCTGCTCGATGAAATTTCCGAAATGCCCCTGGGTCTGCAAGCC
AAGCTGTTGCGGGTGTTGCAGGAGCGGGAAGTGGAACGGGTCGGCGCACGCAAGCCGATCACCCTCGATATTCGCGTGGT
GGCGACCACCAACCGCGATCTGGCCGGTGAAGTGGCGGCGGGGCGATTCCGTGAAGACCTCTATTATCGTCTGTCGGTAT
TTCCGCTGGCCTGGCGTCCGTTGCGCGAGCGCACCGCCGATATCCTGCCGCTGGCCGAGCGTCTGTTGGCCAAACACGTC
AATAAAATGAAGCACGCGATGGCGAAGTTCTCGTCCGAGGCGCAAGCGTGCCTGATCGGTTATCCGTGGCCGGGCAACGT
GCGCGAGCTGGATAATGCGGTCCAGCGGGCCTTGATTCTCCAGCAGGGCGGGTTGATCCAGCCGCAGGATTTCTGTCTCT
CCGGGCCTGCGCTGTTTGCGCCATTGCCAGCGGTGGTGCCGGTTGCGCCGGTCATTCGTGAAGTCGAAATCGAGGTGGAT
TCGGCCGGTGCGCTGGGCGATGACCTGCGTCGCCGGGAGTTCCAGATGATCATCGACACCCTGCGTACCGAGCGCGGCCG
ACGCAAGGAAGCCGCCGAAAAACTCGGCATCAGCCCGCGCACCCTGCGGTACAAACTGGCGCAAATGCGCGATGCGGGCA
TGGATGTCGAAGGCTACCTGTTCGCCACCTGA

Upstream 100 bases:

>100_bases
ATCAGGGAGAATTGCAGCTGCGTTCGCGGGTCGGGCGCGGTACGTGCGCGCAGGTCATCCTGCCGTTGTTTTCTGCTGTA
CAGGGAGCTGAGTGAAGGTC

Downstream 100 bases:

>100_bases
CGGGTGGCGCAAACGTTTGAAACGGCTTTTTCTGAAAGCGGTGCCCATGAGCTGGCACCGTTGTTGCTAACACCTGAGTA
CCCGCCGAGTGAGTGTCAAA

Product: two component, sigma-54 specific, Fis family transcriptional regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 463; Mature: 462

Protein sequence:

>463_residues
MGIKVLLVEDDRSLREALADTLLLAGHDYHAVGSAEEALNAVEREAFSLVVSDVNMPGMDGHQLLGLLRARQPQLPVLLM
TAHGAVERAVDAMRQGAADYLVKPFEPKALLDLVARHALGSLVASDAEGPVAVEPASAQLLDLAARVARSDSTVLISGES
GTGKEVLARYIHQQSHRASQPFIAINCAAIPDNMLEATLFGHEKGSFTGAIAAQAGKFEQADGGTILLDEISEMPLGLQA
KLLRVLQEREVERVGARKPITLDIRVVATTNRDLAGEVAAGRFREDLYYRLSVFPLAWRPLRERTADILPLAERLLAKHV
NKMKHAMAKFSSEAQACLIGYPWPGNVRELDNAVQRALILQQGGLIQPQDFCLSGPALFAPLPAVVPVAPVIREVEIEVD
SAGALGDDLRRREFQMIIDTLRTERGRRKEAAEKLGISPRTLRYKLAQMRDAGMDVEGYLFAT

Sequences:

>Translated_463_residues
MGIKVLLVEDDRSLREALADTLLLAGHDYHAVGSAEEALNAVEREAFSLVVSDVNMPGMDGHQLLGLLRARQPQLPVLLM
TAHGAVERAVDAMRQGAADYLVKPFEPKALLDLVARHALGSLVASDAEGPVAVEPASAQLLDLAARVARSDSTVLISGES
GTGKEVLARYIHQQSHRASQPFIAINCAAIPDNMLEATLFGHEKGSFTGAIAAQAGKFEQADGGTILLDEISEMPLGLQA
KLLRVLQEREVERVGARKPITLDIRVVATTNRDLAGEVAAGRFREDLYYRLSVFPLAWRPLRERTADILPLAERLLAKHV
NKMKHAMAKFSSEAQACLIGYPWPGNVRELDNAVQRALILQQGGLIQPQDFCLSGPALFAPLPAVVPVAPVIREVEIEVD
SAGALGDDLRRREFQMIIDTLRTERGRRKEAAEKLGISPRTLRYKLAQMRDAGMDVEGYLFAT
>Mature_462_residues
GIKVLLVEDDRSLREALADTLLLAGHDYHAVGSAEEALNAVEREAFSLVVSDVNMPGMDGHQLLGLLRARQPQLPVLLMT
AHGAVERAVDAMRQGAADYLVKPFEPKALLDLVARHALGSLVASDAEGPVAVEPASAQLLDLAARVARSDSTVLISGESG
TGKEVLARYIHQQSHRASQPFIAINCAAIPDNMLEATLFGHEKGSFTGAIAAQAGKFEQADGGTILLDEISEMPLGLQAK
LLRVLQEREVERVGARKPITLDIRVVATTNRDLAGEVAAGRFREDLYYRLSVFPLAWRPLRERTADILPLAERLLAKHVN
KMKHAMAKFSSEAQACLIGYPWPGNVRELDNAVQRALILQQGGLIQPQDFCLSGPALFAPLPAVVPVAPVIREVEIEVDS
AGALGDDLRRREFQMIIDTLRTERGRRKEAAEKLGISPRTLRYKLAQMRDAGMDVEGYLFAT

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=460, Percent_Identity=41.304347826087, Blast_Score=336, Evalue=2e-93,
Organism=Escherichia coli, GI1790437, Length=456, Percent_Identity=41.8859649122807, Blast_Score=325, Evalue=3e-90,
Organism=Escherichia coli, GI1788905, Length=365, Percent_Identity=43.8356164383562, Blast_Score=287, Evalue=1e-78,
Organism=Escherichia coli, GI1790299, Length=472, Percent_Identity=37.5, Blast_Score=283, Evalue=2e-77,
Organism=Escherichia coli, GI87082117, Length=218, Percent_Identity=55.9633027522936, Blast_Score=251, Evalue=8e-68,
Organism=Escherichia coli, GI1789087, Length=407, Percent_Identity=38.8206388206388, Blast_Score=249, Evalue=3e-67,
Organism=Escherichia coli, GI87082152, Length=270, Percent_Identity=46.6666666666667, Blast_Score=232, Evalue=3e-62,
Organism=Escherichia coli, GI1789233, Length=312, Percent_Identity=42.6282051282051, Blast_Score=228, Evalue=4e-61,
Organism=Escherichia coli, GI1786524, Length=265, Percent_Identity=44.5283018867925, Blast_Score=208, Evalue=5e-55,
Organism=Escherichia coli, GI87081872, Length=312, Percent_Identity=39.1025641025641, Blast_Score=203, Evalue=2e-53,
Organism=Escherichia coli, GI1787583, Length=316, Percent_Identity=37.6582278481013, Blast_Score=200, Evalue=2e-52,
Organism=Escherichia coli, GI1789828, Length=274, Percent_Identity=32.4817518248175, Blast_Score=140, Evalue=2e-34,
Organism=Escherichia coli, GI87081858, Length=317, Percent_Identity=31.8611987381703, Blast_Score=134, Evalue=1e-32,
Organism=Escherichia coli, GI87082012, Length=124, Percent_Identity=37.0967741935484, Blast_Score=79, Evalue=8e-16,
Organism=Escherichia coli, GI1789809, Length=108, Percent_Identity=36.1111111111111, Blast_Score=72, Evalue=7e-14,
Organism=Escherichia coli, GI1786784, Length=173, Percent_Identity=31.2138728323699, Blast_Score=69, Evalue=8e-13,
Organism=Escherichia coli, GI1788191, Length=113, Percent_Identity=37.1681415929204, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1790552, Length=114, Percent_Identity=37.719298245614, Blast_Score=66, Evalue=5e-12,
Organism=Escherichia coli, GI1789402, Length=209, Percent_Identity=27.7511961722488, Blast_Score=65, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 50399; Mature: 50268

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGIKVLLVEDDRSLREALADTLLLAGHDYHAVGSAEEALNAVEREAFSLVVSDVNMPGMD
CCEEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCC
GHQLLGLLRARQPQLPVLLMTAHGAVERAVDAMRQGAADYLVKPFEPKALLDLVARHALG
HHHHHHHHHCCCCCCCEEEEECCHHHHHHHHHHHCCCHHHCCCCCCCHHHHHHHHHHHHH
SLVASDAEGPVAVEPASAQLLDLAARVARSDSTVLISGESGTGKEVLARYIHQQSHRASQ
HHHHCCCCCCEEECCCHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCC
PFIAINCAAIPDNMLEATLFGHEKGSFTGAIAAQAGKFEQADGGTILLDEISEMPLGLQA
CEEEEEEEECCCHHHHHHHCCCCCCCCCCHHHHCCCCCCCCCCCEEEEECHHCCCCCHHH
KLLRVLQEREVERVGARKPITLDIRVVATTNRDLAGEVAAGRFREDLYYRLSVFPLAWRP
HHHHHHHHHHHHHHCCCCCEEEEEEEEEECCCCCCCHHHHHHHHHHHHHEEEECCCCCHH
LRERTADILPLAERLLAKHVNKMKHAMAKFSSEAQACLIGYPWPGNVRELDNAVQRALIL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHH
QQGGLIQPQDFCLSGPALFAPLPAVVPVAPVIREVEIEVDSAGALGDDLRRREFQMIIDT
HCCCCCCCHHHHCCCCHHHCCCCHHHHHHHHHHEEEEEECCCCCCHHHHHHHHHHHHHHH
LRTERGRRKEAAEKLGISPRTLRYKLAQMRDAGMDVEGYLFAT
HHHHCCHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCEEEEC
>Mature Secondary Structure 
GIKVLLVEDDRSLREALADTLLLAGHDYHAVGSAEEALNAVEREAFSLVVSDVNMPGMD
CEEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCC
GHQLLGLLRARQPQLPVLLMTAHGAVERAVDAMRQGAADYLVKPFEPKALLDLVARHALG
HHHHHHHHHCCCCCCCEEEEECCHHHHHHHHHHHCCCHHHCCCCCCCHHHHHHHHHHHHH
SLVASDAEGPVAVEPASAQLLDLAARVARSDSTVLISGESGTGKEVLARYIHQQSHRASQ
HHHHCCCCCCEEECCCHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCC
PFIAINCAAIPDNMLEATLFGHEKGSFTGAIAAQAGKFEQADGGTILLDEISEMPLGLQA
CEEEEEEEECCCHHHHHHHCCCCCCCCCCHHHHCCCCCCCCCCCEEEEECHHCCCCCHHH
KLLRVLQEREVERVGARKPITLDIRVVATTNRDLAGEVAAGRFREDLYYRLSVFPLAWRP
HHHHHHHHHHHHHHCCCCCEEEEEEEEEECCCCCCCHHHHHHHHHHHHHEEEECCCCCHH
LRERTADILPLAERLLAKHVNKMKHAMAKFSSEAQACLIGYPWPGNVRELDNAVQRALIL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHH
QQGGLIQPQDFCLSGPALFAPLPAVVPVAPVIREVEIEVDSAGALGDDLRRREFQMIIDT
HCCCCCCCHHHHCCCCHHHCCCCHHHHHHHHHHEEEEEECCCCCCHHHHHHHHHHHHHHH
LRTERGRRKEAAEKLGISPRTLRYKLAQMRDAGMDVEGYLFAT
HHHHCCHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]