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The map label for this gene is cpxA [H]

Identifier: 77457708

GI number: 77457708

Start: 1661927

End: 1663267

Strand: Reverse

Name: cpxA [H]

Synonym: Pfl01_1481

Alternate gene names: 77457708

Gene position: 1663267-1661927 (Counterclockwise)

Preceding gene: 77457709

Following gene: 77457706

Centisome position: 25.83

GC content: 64.35

Gene sequence:

>1341_bases
GTGCGTTCATTGTTCTGGCGTATCCTCGCCAGCTTCTGGCTGGCCATCGCTCTGGTTGCAGGGCTTTCCATTCTGCTAGG
GCACATGCTCAACCAGGACGCGTGGATCCTCAGCCGCCATCCGGGCCTCAACACTCTGGCCGCGGAATGGACGCAGACTT
ACGAAGCCCAGGGCGAAAACGCCGCCCAGGACATCCTCGAACAGCGCAAGCGCCAGTACCACATCGACGTGCAAGTGCTG
AACGAAAGCGGCGACCCGGTGGTGCGCGGCACCTTCCCCCGGCGCGCGGCCGCCTTCGAGGCGCGGCAGAACAACGATGA
CCGACGCCTGCCATGGCGCCGTCTGACCGACGAATTCACCAGCGACAAAAGCGGCGACACCTACCTCTTCATCTATCGCA
TCCCGCACCCGGAACTCGACGCCTGGCACCGCGAAAGCCTGCTCTGGCCGTTGAGTGCACTGGGCATCGCGCTGGTGGTG
CTGACTCTGTTCAGCCTGCTGGTGACGTTTTCCATCACCCGGCCCCTCAGTCGCCTGCGCGGCGCGGTGCATGACCTCGG
CCAGACCACGTATCAGCAGAACAGCCTGGCGCAACTGGCCAACCGCCGCGATGAATTCGGTGTGCTGGCCAACGACTTCA
ACCGAATGGGCGCCCGTCTGCAAAGCCTGATCGGCAGTCAGCGCCAGTTGCTGCGCGATGTGTCCCACGAACTGCGTTCA
CCGCTGGCACGGCTGCGCATTGCCCTAGCTCTGGCCGAGCGTGCAAGCCCGGAAGAACGGGAAAAACTCTGGCCGCGCCT
GACCCGCGAGTGTGATCGGCTGGAAGCGTTGATCAGTGAAATTCTGGTGCTGGCACGGGTCGATGCCGACAACGCCAGCG
CCGAAGACGTGGATCTGAATGCCTTGCTCGCCACCCTGCAAAAGGATGCGCAGCTGGGCTCGCCGGAGCAGACCGTGCGT
CTGGAGGCCGAACCGGCACTCAATCTGACAGGCTGGCCGACCATGATCGAACGCGCCGTGGACAACCTGCTGCGCAATGC
CCAGCGCTTCAACCCGGTGGGGCAGTCGATTGAAATGCAGGCGTCACGTCAGGGCGAGCGGATCGTGGTCAGCGTGCGTG
ACCATGGGCCAGGGGTGCAGGCCGAACATCTGAGCCAGTTGGGCGAACCGTTTTATCGGGCGCCGGGGCAGACCGCTGCC
GGCCATGGCCTGGGACTGGCGATTGCCCGGCGGGCGGCGGAACGGCATGGCGGGACGCTGGTGCTGGCCAATCATCCGCA
GGGCGGGTTTGTGGCGAGTCTTGAATTGCCTCTCGTACCGGGGGCAGTTGTCCAACCATAA

Upstream 100 bases:

>100_bases
TGGAAAGCGCAGCAGCCGCAAAAGGCGCAATAATGTTCTAGCGTCACGCCCCGACCCAACGGCTCACCGCCGTTGGGTTT
TCTTTGTTTGAGGATTTTCT

Downstream 100 bases:

>100_bases
AACCAATGTGTCAGGCCTTTGCTGGCCACGCGCTGACAAACTCCGCCAGATCAACCTTCTCGGCCACCCGCGGTTCTTTC
TGCGGTGTGCCGAGGTACAG

Product: periplasmic sensor Signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 446; Mature: 446

Protein sequence:

>446_residues
MRSLFWRILASFWLAIALVAGLSILLGHMLNQDAWILSRHPGLNTLAAEWTQTYEAQGENAAQDILEQRKRQYHIDVQVL
NESGDPVVRGTFPRRAAAFEARQNNDDRRLPWRRLTDEFTSDKSGDTYLFIYRIPHPELDAWHRESLLWPLSALGIALVV
LTLFSLLVTFSITRPLSRLRGAVHDLGQTTYQQNSLAQLANRRDEFGVLANDFNRMGARLQSLIGSQRQLLRDVSHELRS
PLARLRIALALAERASPEEREKLWPRLTRECDRLEALISEILVLARVDADNASAEDVDLNALLATLQKDAQLGSPEQTVR
LEAEPALNLTGWPTMIERAVDNLLRNAQRFNPVGQSIEMQASRQGERIVVSVRDHGPGVQAEHLSQLGEPFYRAPGQTAA
GHGLGLAIARRAAERHGGTLVLANHPQGGFVASLELPLVPGAVVQP

Sequences:

>Translated_446_residues
MRSLFWRILASFWLAIALVAGLSILLGHMLNQDAWILSRHPGLNTLAAEWTQTYEAQGENAAQDILEQRKRQYHIDVQVL
NESGDPVVRGTFPRRAAAFEARQNNDDRRLPWRRLTDEFTSDKSGDTYLFIYRIPHPELDAWHRESLLWPLSALGIALVV
LTLFSLLVTFSITRPLSRLRGAVHDLGQTTYQQNSLAQLANRRDEFGVLANDFNRMGARLQSLIGSQRQLLRDVSHELRS
PLARLRIALALAERASPEEREKLWPRLTRECDRLEALISEILVLARVDADNASAEDVDLNALLATLQKDAQLGSPEQTVR
LEAEPALNLTGWPTMIERAVDNLLRNAQRFNPVGQSIEMQASRQGERIVVSVRDHGPGVQAEHLSQLGEPFYRAPGQTAA
GHGLGLAIARRAAERHGGTLVLANHPQGGFVASLELPLVPGAVVQP
>Mature_446_residues
MRSLFWRILASFWLAIALVAGLSILLGHMLNQDAWILSRHPGLNTLAAEWTQTYEAQGENAAQDILEQRKRQYHIDVQVL
NESGDPVVRGTFPRRAAAFEARQNNDDRRLPWRRLTDEFTSDKSGDTYLFIYRIPHPELDAWHRESLLWPLSALGIALVV
LTLFSLLVTFSITRPLSRLRGAVHDLGQTTYQQNSLAQLANRRDEFGVLANDFNRMGARLQSLIGSQRQLLRDVSHELRS
PLARLRIALALAERASPEEREKLWPRLTRECDRLEALISEILVLARVDADNASAEDVDLNALLATLQKDAQLGSPEQTVR
LEAEPALNLTGWPTMIERAVDNLLRNAQRFNPVGQSIEMQASRQGERIVVSVRDHGPGVQAEHLSQLGEPFYRAPGQTAA
GHGLGLAIARRAAERHGGTLVLANHPQGGFVASLELPLVPGAVVQP

Specific function: This protein is involved in several diverse cellular processes, such as the functioning of acetohydroxyacid synthetase I, in the biosynthesis of isoleucine and valine, the TraJ protein activation activity for tra gene expression in F plasmid, and the synt

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790346, Length=291, Percent_Identity=32.3024054982818, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI1787894, Length=338, Percent_Identity=31.3609467455621, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI1789403, Length=234, Percent_Identity=35.4700854700855, Blast_Score=117, Evalue=2e-27,
Organism=Escherichia coli, GI1786600, Length=228, Percent_Identity=31.140350877193, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI1788393, Length=271, Percent_Identity=28.7822878228782, Blast_Score=102, Evalue=7e-23,
Organism=Escherichia coli, GI1786783, Length=239, Percent_Identity=28.4518828451883, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI1789808, Length=228, Percent_Identity=29.8245614035088, Blast_Score=89, Evalue=5e-19,
Organism=Escherichia coli, GI1790551, Length=291, Percent_Identity=29.8969072164948, Blast_Score=89, Evalue=5e-19,
Organism=Escherichia coli, GI1790861, Length=297, Percent_Identity=30.6397306397306, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1790436, Length=214, Percent_Identity=33.1775700934579, Blast_Score=85, Evalue=9e-18,
Organism=Escherichia coli, GI87082128, Length=295, Percent_Identity=27.4576271186441, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1786912, Length=248, Percent_Identity=28.6290322580645, Blast_Score=75, Evalue=9e-15,
Organism=Escherichia coli, GI87081816, Length=293, Percent_Identity=29.0102389078498, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI145693157, Length=228, Percent_Identity=26.3157894736842, Blast_Score=72, Evalue=7e-14,
Organism=Escherichia coli, GI1789149, Length=280, Percent_Identity=25.3571428571429, Blast_Score=69, Evalue=8e-13,
Organism=Escherichia coli, GI1788279, Length=279, Percent_Identity=23.6559139784946, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI48994928, Length=227, Percent_Identity=24.6696035242291, Blast_Score=67, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 49736; Mature: 49736

Theoretical pI: Translated: 6.98; Mature: 6.98

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRSLFWRILASFWLAIALVAGLSILLGHMLNQDAWILSRHPGLNTLAAEWTQTYEAQGEN
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHCCCH
AAQDILEQRKRQYHIDVQVLNESGDPVVRGTFPRRAAAFEARQNNDDRRLPWRRLTDEFT
HHHHHHHHHHHHEEEEEEEECCCCCCEEECCCCHHHHHHHHHCCCCCCCCCHHHHHHHHC
SDKSGDTYLFIYRIPHPELDAWHRESLLWPLSALGIALVVLTLFSLLVTFSITRPLSRLR
CCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GAVHDLGQTTYQQNSLAQLANRRDEFGVLANDFNRMGARLQSLIGSQRQLLRDVSHELRS
HHHHHHHHHHHHHHHHHHHHCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PLARLRIALALAERASPEEREKLWPRLTRECDRLEALISEILVLARVDADNASAEDVDLN
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHH
ALLATLQKDAQLGSPEQTVRLEAEPALNLTGWPTMIERAVDNLLRNAQRFNPVGQSIEMQ
HHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHH
ASRQGERIVVSVRDHGPGVQAEHLSQLGEPFYRAPGQTAAGHGLGLAIARRAAERHGGTL
HCCCCCEEEEEEECCCCCCCHHHHHHHCCHHHCCCCCCCCCCCHHHHHHHHHHHHCCCEE
VLANHPQGGFVASLELPLVPGAVVQP
EEEECCCCCEEEEEECCCCCCCCCCC
>Mature Secondary Structure
MRSLFWRILASFWLAIALVAGLSILLGHMLNQDAWILSRHPGLNTLAAEWTQTYEAQGEN
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHCCCH
AAQDILEQRKRQYHIDVQVLNESGDPVVRGTFPRRAAAFEARQNNDDRRLPWRRLTDEFT
HHHHHHHHHHHHEEEEEEEECCCCCCEEECCCCHHHHHHHHHCCCCCCCCCHHHHHHHHC
SDKSGDTYLFIYRIPHPELDAWHRESLLWPLSALGIALVVLTLFSLLVTFSITRPLSRLR
CCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GAVHDLGQTTYQQNSLAQLANRRDEFGVLANDFNRMGARLQSLIGSQRQLLRDVSHELRS
HHHHHHHHHHHHHHHHHHHHCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PLARLRIALALAERASPEEREKLWPRLTRECDRLEALISEILVLARVDADNASAEDVDLN
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHH
ALLATLQKDAQLGSPEQTVRLEAEPALNLTGWPTMIERAVDNLLRNAQRFNPVGQSIEMQ
HHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHH
ASRQGERIVVSVRDHGPGVQAEHLSQLGEPFYRAPGQTAAGHGLGLAIARRAAERHGGTL
HCCCCCEEEEEEECCCCCCCHHHHHHHCCHHHCCCCCCCCCCCHHHHHHHHHHHHCCCEE
VLANHPQGGFVASLELPLVPGAVVQP
EEEECCCCCEEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]