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The map label for this gene is aqpZ [H]

Identifier: 77457653

GI number: 77457653

Start: 1601556

End: 1602251

Strand: Reverse

Name: aqpZ [H]

Synonym: Pfl01_1426

Alternate gene names: 77457653

Gene position: 1602251-1601556 (Counterclockwise)

Preceding gene: 77457654

Following gene: 77457651

Centisome position: 24.89

GC content: 64.8

Gene sequence:

>696_bases
ATGTCTCTTTTCAAACGTTCAGTCACTGAGTTGTTGGGTACGTTCTGGTTGGTGTTGGGCGGCTGCGGCAGTGCGGTCAT
TGCCGCGTCTTCACCCTTGGGAATCGGCGTGCTGGGGGTCGCCCTGGCGTTCGGTCTGACGGTGTTGACCATGGCGTTTG
CCATCGGCCACATCAGCGGCTGTCACCTCAACCCGGCCGTGTCGGTCGGTCTGGTCGTCGGCGGTCGGTTCCCGGCCAAG
GAACTGCCTGCCTACGTCATCGCCCAGGTGCTCGGCGGGATTCTGGCAGCGGCCCTGCTCTACCACATCGCCAGCGGCAA
GGAAGGTTTCGACATCGCCGCGGGCCTTGCCTCAAACGGTTATGGCGAACACTCGCCGGGCAAATACTCGATGGCGTCCG
GCTTCGTCACCGAACTGGTGATGACCGCCATGTTCGTGGTGATCATCCTCGGCGCCACCGACAAGCGCGCTCCGGCAGGA
CTGGCACCGATCGCCATCGGCCTGGCCCTGACGCTGATCCACCTGATCTCGATTCCGGTGACCAACACCTCGGTCAACCC
GGCCCGCAGCACGGGCCCGGCGCTGATGGTCGGCGGCTGGGCCATCGCCCAGTTGTGGATGTTCTGGGTCGCGCCGCTGC
TCGGTGCGGTGGTCGGCGGCGTGCTCTATCGCTGGCTGGGCAAGGAAGACAGCTGA

Upstream 100 bases:

>100_bases
TGCTGTAATCAGCGAAGGCTCCGGAACGGAACCTGTCGTAAATCTGCAGGGAAGCATCACTCGATGCAGTCTCGATAGCA
CGCCTATCAAGGACTCTGTC

Downstream 100 bases:

>100_bases
AGGAGCCGGCGAGGATCAGGCTTGCCGATACGGCAAGGCGTTCCTCGCCTCTTCGGCATAGGCCAGCACACCGGCGCGCT
CCTGGTGCAGGAAGTCTTTG

Product: aquaporin Z

Products: H2O [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 231; Mature: 230

Protein sequence:

>231_residues
MSLFKRSVTELLGTFWLVLGGCGSAVIAASSPLGIGVLGVALAFGLTVLTMAFAIGHISGCHLNPAVSVGLVVGGRFPAK
ELPAYVIAQVLGGILAAALLYHIASGKEGFDIAAGLASNGYGEHSPGKYSMASGFVTELVMTAMFVVIILGATDKRAPAG
LAPIAIGLALTLIHLISIPVTNTSVNPARSTGPALMVGGWAIAQLWMFWVAPLLGAVVGGVLYRWLGKEDS

Sequences:

>Translated_231_residues
MSLFKRSVTELLGTFWLVLGGCGSAVIAASSPLGIGVLGVALAFGLTVLTMAFAIGHISGCHLNPAVSVGLVVGGRFPAK
ELPAYVIAQVLGGILAAALLYHIASGKEGFDIAAGLASNGYGEHSPGKYSMASGFVTELVMTAMFVVIILGATDKRAPAG
LAPIAIGLALTLIHLISIPVTNTSVNPARSTGPALMVGGWAIAQLWMFWVAPLLGAVVGGVLYRWLGKEDS
>Mature_230_residues
SLFKRSVTELLGTFWLVLGGCGSAVIAASSPLGIGVLGVALAFGLTVLTMAFAIGHISGCHLNPAVSVGLVVGGRFPAKE
LPAYVIAQVLGGILAAALLYHIASGKEGFDIAAGLASNGYGEHSPGKYSMASGFVTELVMTAMFVVIILGATDKRAPAGL
APIAIGLALTLIHLISIPVTNTSVNPARSTGPALMVGGWAIAQLWMFWVAPLLGAVVGGVLYRWLGKEDS

Specific function: Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response

COG id: COG0580

COG function: function code G; Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MIP/aquaporin (TC 1.A.8) family [H]

Homologues:

Organism=Homo sapiens, GI4502179, Length=227, Percent_Identity=37.4449339207048, Blast_Score=122, Evalue=2e-28,
Organism=Homo sapiens, GI4502183, Length=231, Percent_Identity=36.3636363636364, Blast_Score=116, Evalue=2e-26,
Organism=Homo sapiens, GI37694062, Length=234, Percent_Identity=34.6153846153846, Blast_Score=115, Evalue=4e-26,
Organism=Homo sapiens, GI4755125, Length=232, Percent_Identity=34.4827586206897, Blast_Score=115, Evalue=5e-26,
Organism=Homo sapiens, GI4502181, Length=232, Percent_Identity=33.6206896551724, Blast_Score=114, Evalue=6e-26,
Organism=Homo sapiens, GI6912506, Length=227, Percent_Identity=33.4801762114537, Blast_Score=110, Evalue=1e-24,
Organism=Homo sapiens, GI157266307, Length=243, Percent_Identity=32.0987654320988, Blast_Score=101, Evalue=4e-22,
Organism=Homo sapiens, GI4826645, Length=247, Percent_Identity=31.9838056680162, Blast_Score=97, Evalue=1e-20,
Organism=Homo sapiens, GI86792455, Length=195, Percent_Identity=34.3589743589744, Blast_Score=95, Evalue=6e-20,
Organism=Homo sapiens, GI22538420, Length=244, Percent_Identity=30.7377049180328, Blast_Score=87, Evalue=9e-18,
Organism=Homo sapiens, GI45446752, Length=215, Percent_Identity=33.953488372093, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI4502187, Length=243, Percent_Identity=28.8065843621399, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI310133356, Length=177, Percent_Identity=29.3785310734463, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI310114181, Length=177, Percent_Identity=29.3785310734463, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1787101, Length=231, Percent_Identity=71.4285714285714, Blast_Score=295, Evalue=3e-81,
Organism=Escherichia coli, GI1790362, Length=256, Percent_Identity=28.515625, Blast_Score=82, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI71993722, Length=237, Percent_Identity=32.9113924050633, Blast_Score=103, Evalue=6e-23,
Organism=Caenorhabditis elegans, GI17558372, Length=243, Percent_Identity=29.6296296296296, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI71992966, Length=241, Percent_Identity=29.8755186721992, Blast_Score=83, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17531431, Length=245, Percent_Identity=31.0204081632653, Blast_Score=77, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17531429, Length=245, Percent_Identity=31.0204081632653, Blast_Score=77, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI212646268, Length=275, Percent_Identity=26.1818181818182, Blast_Score=74, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI71994009, Length=243, Percent_Identity=25.1028806584362, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24652747, Length=221, Percent_Identity=35.2941176470588, Blast_Score=123, Evalue=1e-28,
Organism=Drosophila melanogaster, GI45551084, Length=221, Percent_Identity=35.2941176470588, Blast_Score=123, Evalue=1e-28,
Organism=Drosophila melanogaster, GI19922038, Length=225, Percent_Identity=34.2222222222222, Blast_Score=93, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24652751, Length=225, Percent_Identity=34.2222222222222, Blast_Score=92, Evalue=2e-19,
Organism=Drosophila melanogaster, GI17136672, Length=228, Percent_Identity=28.9473684210526, Blast_Score=88, Evalue=4e-18,
Organism=Drosophila melanogaster, GI45550503, Length=226, Percent_Identity=26.9911504424779, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24762342, Length=198, Percent_Identity=29.7979797979798, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24762344, Length=225, Percent_Identity=30.6666666666667, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24762346, Length=225, Percent_Identity=30.6666666666667, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24762348, Length=225, Percent_Identity=30.6666666666667, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI20130305, Length=225, Percent_Identity=30.6666666666667, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012269
- InterPro:   IPR000425
- InterPro:   IPR022357 [H]

Pfam domain/function: PF00230 MIP [H]

EC number: NA

Molecular weight: Translated: 23555; Mature: 23424

Theoretical pI: Translated: 8.71; Mature: 8.71

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00221 MIP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLFKRSVTELLGTFWLVLGGCGSAVIAASSPLGIGVLGVALAFGLTVLTMAFAIGHISG
CCHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
CHLNPAVSVGLVVGGRFPAKELPAYVIAQVLGGILAAALLYHIASGKEGFDIAAGLASNG
CCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCC
YGEHSPGKYSMASGFVTELVMTAMFVVIILGATDKRAPAGLAPIAIGLALTLIHLISIPV
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCC
TNTSVNPARSTGPALMVGGWAIAQLWMFWVAPLLGAVVGGVLYRWLGKEDS
CCCCCCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SLFKRSVTELLGTFWLVLGGCGSAVIAASSPLGIGVLGVALAFGLTVLTMAFAIGHISG
CHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
CHLNPAVSVGLVVGGRFPAKELPAYVIAQVLGGILAAALLYHIASGKEGFDIAAGLASNG
CCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCC
YGEHSPGKYSMASGFVTELVMTAMFVVIILGATDKRAPAGLAPIAIGLALTLIHLISIPV
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCC
TNTSVNPARSTGPALMVGGWAIAQLWMFWVAPLLGAVVGGVLYRWLGKEDS
CCCCCCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: H2O [Periplasm] [C]

Specific reaction: H2O [Periplasm] = H2O [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12534463 [H]