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The map label for this gene is nhaA [H]

Identifier: 77457461

GI number: 77457461

Start: 1405305

End: 1406492

Strand: Reverse

Name: nhaA [H]

Synonym: Pfl01_1234

Alternate gene names: 77457461

Gene position: 1406492-1405305 (Counterclockwise)

Preceding gene: 77457463

Following gene: 77457460

Centisome position: 21.85

GC content: 63.3

Gene sequence:

>1188_bases
TTGCCTCTGCGTAGCACTTTCACGCGTTTCTTTCAGTTGGAAGCTGCCAGCGGTCTGTTACTGATCGCCGCGGCCATCCT
GGCTCTAATCATCAACAACTCGCCGCTGTCGTGGTTGTACAACGGCCTGCTCGACACCCCGGTGGTGGCGCAGATCGGCG
CGTTGAAAATCGCCAAACCCCTGCTGCTGTGGATCAACGACGGCCTGATGGCGCTGTTCTTCCTGCTGATCGGCCTGGAA
GTGAAGCGCGAAGTGCTCGACGGTCAGCTGTCGAAACCATCGCAGATCGTCCTGCCCGGTGCGGCCGCAATTGGCGGCAT
GCTGGTGCCGGCGCTGATCTACTGGTTCCTCAACCGTGACAACCCGGCAGCCCTCGACGGCTGGGCGATTCCGACCGCCA
CCGACATCGCCTTCGCCCTTGGCGTACTGGCCTTGCTCGGCAAGCGCGTGCCGGTATCGCTGAAGCTGTTTCTCATGACC
CTGGCGATCATCGATGACCTCGGCGCCATCGTGATCATCGCGATCTTCTATTCCGGCGAACTCTCGACCCTGTCGCTGGG
CCTTGCGGCGGCGTGCATTGCGGCGCTGGTAGCGATGAACCGGCTCGGGGTGGTCAAGCTCGGGCCATACATGATCATTG
GTCTGATCCTCTGGGTATGCGTGCTCAAGAGCGGTGTCCACGCGACGCTGGCCGGCGTAACCCTGGCGTTCTGCATCCCG
CTGCGCACGAAAAACGCCGAACCTTCGCCGCTGCTGACCCTCGAACACGCGCTGCACCCGTGGGTCGCTTACGGCATTCT
GCCGCTGTTTGCCTTCGCCAACGCAGGTCTGTCGCTGAGCGGCGTGACTGTCGAGAGCTTCACCCACCACGTGCCGATGG
GCATCGCCGTCGGCCTGCTGCTGGGCAAGACCCTCGGCGTGTTCGGCCTGACCTGGCTCGCCGTCAAGACCGGCATCGCC
GCCCTGCCCCAAGGTGCCAATTGGGGCCAGGTGCTGGGCGTGGCGATCCTCTGCGGGATCGGCTTCACCATGAGCCTGTT
TGTCGGCTCCCTGGCATTCGTGCCGGGTGCCAGTGAATACGCCGGGATGGACCGGATGGGCATTCTCACCGGGTCGGTGT
TTGCGGCATTGATCGGTTATGCGGTGACGGCGGCTGCGAGTAGAAAGAACACCGCGCTGCCTTCCTGA

Upstream 100 bases:

>100_bases
TGTAACCATATATAACAAAAAAGAATATAACTTTTGTTTTAACAACTAACGGTACGGGTTAGGGTGTCCCACCTTTTGAC
TTTAACGATGGAGAGCGACC

Downstream 100 bases:

>100_bases
TGCCGTAGCGAACAATCCCCACGTCTTTAGGGATACGTCCTACAGCCACGATTTTCCTGCTTCGTTAACGTCGTGCAGCC
CCTTGCGAGGGGTTGCCGAT

Product: pH-dependent sodium/proton antiporter

Products: Na (I) [Periplasm]; Proton [Cytoplasm] [C]

Alternate protein names: Sodium/proton antiporter nhaA [H]

Number of amino acids: Translated: 395; Mature: 394

Protein sequence:

>395_residues
MPLRSTFTRFFQLEAASGLLLIAAAILALIINNSPLSWLYNGLLDTPVVAQIGALKIAKPLLLWINDGLMALFFLLIGLE
VKREVLDGQLSKPSQIVLPGAAAIGGMLVPALIYWFLNRDNPAALDGWAIPTATDIAFALGVLALLGKRVPVSLKLFLMT
LAIIDDLGAIVIIAIFYSGELSTLSLGLAAACIAALVAMNRLGVVKLGPYMIIGLILWVCVLKSGVHATLAGVTLAFCIP
LRTKNAEPSPLLTLEHALHPWVAYGILPLFAFANAGLSLSGVTVESFTHHVPMGIAVGLLLGKTLGVFGLTWLAVKTGIA
ALPQGANWGQVLGVAILCGIGFTMSLFVGSLAFVPGASEYAGMDRMGILTGSVFAALIGYAVTAAASRKNTALPS

Sequences:

>Translated_395_residues
MPLRSTFTRFFQLEAASGLLLIAAAILALIINNSPLSWLYNGLLDTPVVAQIGALKIAKPLLLWINDGLMALFFLLIGLE
VKREVLDGQLSKPSQIVLPGAAAIGGMLVPALIYWFLNRDNPAALDGWAIPTATDIAFALGVLALLGKRVPVSLKLFLMT
LAIIDDLGAIVIIAIFYSGELSTLSLGLAAACIAALVAMNRLGVVKLGPYMIIGLILWVCVLKSGVHATLAGVTLAFCIP
LRTKNAEPSPLLTLEHALHPWVAYGILPLFAFANAGLSLSGVTVESFTHHVPMGIAVGLLLGKTLGVFGLTWLAVKTGIA
ALPQGANWGQVLGVAILCGIGFTMSLFVGSLAFVPGASEYAGMDRMGILTGSVFAALIGYAVTAAASRKNTALPS
>Mature_394_residues
PLRSTFTRFFQLEAASGLLLIAAAILALIINNSPLSWLYNGLLDTPVVAQIGALKIAKPLLLWINDGLMALFFLLIGLEV
KREVLDGQLSKPSQIVLPGAAAIGGMLVPALIYWFLNRDNPAALDGWAIPTATDIAFALGVLALLGKRVPVSLKLFLMTL
AIIDDLGAIVIIAIFYSGELSTLSLGLAAACIAALVAMNRLGVVKLGPYMIIGLILWVCVLKSGVHATLAGVTLAFCIPL
RTKNAEPSPLLTLEHALHPWVAYGILPLFAFANAGLSLSGVTVESFTHHVPMGIAVGLLLGKTLGVFGLTWLAVKTGIAA
LPQGANWGQVLGVAILCGIGFTMSLFVGSLAFVPGASEYAGMDRMGILTGSVFAALIGYAVTAAASRKNTALPS

Specific function: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons [H]

COG id: COG3004

COG function: function code P; Na+/H+ antiporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nhaA Na(+)/H(+) (TC 2.A.33) antiporter family [H]

Homologues:

Organism=Escherichia coli, GI1786201, Length=374, Percent_Identity=56.951871657754, Blast_Score=373, Evalue=1e-104,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023171
- InterPro:   IPR004670 [H]

Pfam domain/function: PF06965 Na_H_antiport_1 [H]

EC number: NA

Molecular weight: Translated: 41247; Mature: 41116

Theoretical pI: Translated: 8.88; Mature: 8.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLRSTFTRFFQLEAASGLLLIAAAILALIINNSPLSWLYNGLLDTPVVAQIGALKIAKP
CCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHHH
LLLWINDGLMALFFLLIGLEVKREVLDGQLSKPSQIVLPGAAAIGGMLVPALIYWFLNRD
HHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHCCC
NPAALDGWAIPTATDIAFALGVLALLGKRVPVSLKLFLMTLAIIDDLGAIVIIAIFYSGE
CCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
LSTLSLGLAAACIAALVAMNRLGVVKLGPYMIIGLILWVCVLKSGVHATLAGVTLAFCIP
HHHHHHHHHHHHHHHHHHHHCCCEEEECHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHEE
LRTKNAEPSPLLTLEHALHPWVAYGILPLFAFANAGLSLSGVTVESFTHHVPMGIAVGLL
CCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHCCCCEECCCCHHHHHHHCHHHHHHHHH
LGKTLGVFGLTWLAVKTGIAALPQGANWGQVLGVAILCGIGFTMSLFVGSLAFVPGASEY
HHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
AGMDRMGILTGSVFAALIGYAVTAAASRKNTALPS
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
PLRSTFTRFFQLEAASGLLLIAAAILALIINNSPLSWLYNGLLDTPVVAQIGALKIAKP
CCHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHHH
LLLWINDGLMALFFLLIGLEVKREVLDGQLSKPSQIVLPGAAAIGGMLVPALIYWFLNRD
HHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHCCC
NPAALDGWAIPTATDIAFALGVLALLGKRVPVSLKLFLMTLAIIDDLGAIVIIAIFYSGE
CCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
LSTLSLGLAAACIAALVAMNRLGVVKLGPYMIIGLILWVCVLKSGVHATLAGVTLAFCIP
HHHHHHHHHHHHHHHHHHHHCCCEEEECHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHEE
LRTKNAEPSPLLTLEHALHPWVAYGILPLFAFANAGLSLSGVTVESFTHHVPMGIAVGLL
CCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHCCCCEECCCCHHHHHHHCHHHHHHHHH
LGKTLGVFGLTWLAVKTGIAALPQGANWGQVLGVAILCGIGFTMSLFVGSLAFVPGASEY
HHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
AGMDRMGILTGSVFAALIGYAVTAAASRKNTALPS
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Na (I) [Cytoplasm]; Proton [Periplasm] [C]

Specific reaction: Na (I) [Cytoplasm] + 2 Proton [Periplasm] = Na (I) [Periplasm] + 2 Proton [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA