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The map label for this gene is lig [H]

Identifier: 77457438

GI number: 77457438

Start: 1382705

End: 1384393

Strand: Reverse

Name: lig [H]

Synonym: Pfl01_1211

Alternate gene names: 77457438

Gene position: 1384393-1382705 (Counterclockwise)

Preceding gene: 77457439

Following gene: 77457437

Centisome position: 21.5

GC content: 64.06

Gene sequence:

>1689_bases
ATGAAAGACTTCGCCGGGTTGTACGCCGAACTCGACGCCACCACCTCCAGCAACGCCAAACTGGCGGCCATGCAAACCTA
CTTCGCCCAGGCGCAACCGCAGGATGCCGCTTGGGCGGTGTACTTCTTGTCCGGCGGTCGGCCGCGGCAACTGGTGCCGG
TGCGGATCCTGCGCGATCTCGCGGTCGAAATGTCCGGGTTGGCGCCATGGCTGTTCGAGGAGAGCTATCAAGCGGTCGGC
GACCTGGCGGAAACCATCTCGCTGGTGTTGCCGGAACATCCATACACCTCCGAGGCCGGCCTCGCCGAATGGATCGAAGA
CAAACTGCTGCCCCTGCGCGGTGAAACCCCGGAATACCTCGCCCATCAGTTGCCCGCACTGTGGGCGCAACTGGATCGGC
CGAGCCTGATGCTGTGCATCAAGTTGATCACCGGCAGCTTCCGGGTCGGCGTATCCAAGCTGCTGGTGACCCGCGCTCTG
GCTTCCATGGCCGGGCTCGACAGCAAGCGAGTGGCGCAACGGCTGGTGGGTTACACCGACCTGTCCAACCGGCCGAACGC
TGCCAGTTACCTGAAACTGATCGCCCCCGAATCCAGCGACGAGCATGCCCAGCGCGGCGGCCAGCCCTACCCGTTCTTCC
TCGCCCACGCGCTGGCGCAACCGGTGGAAACCTTCGAAGCCCTGCTCGGGCCTGCCAGTAACTGGCAGGTGGAATGGAAG
TGGGATGGCATTCGCGCGCAAGTGGTCAAGCGCGACGGAAAACTGTGGGTCTGGTCCCGGGGCGAAGAACTGGTCACCGA
ACGCTTTCCCGAACTCGACACACTGGTGCACGGGTTGCCCGACGGCACGGTGATCGACGGCGAAATCGTGGTCTGGAAAA
ACCGGCGCCCGGTCACCGAAGATGCTTTCGATCCGCAGTCGACAGAAGCTCCGGCGGTGCAACCCTTCGCGCTGTTGCAG
CAACGGATTGGCCGTAAATCGCTGGACCGGAAAATCCTTGAAGACGCGCCGGTGGTGGTACTCGCCTATGACCTGCTCGA
ATGGCAGGGCGAAGACTGGCGCAACCAGCCCCAGGCCAGACGTCGTGAGCAACTGGAGCAGGTCATCGCCCGCTGCAACA
ACCCGGTGCTGCTGCCTTCGCCGATTCTGACGGGTGATGACTGGTTCGACCTCGCCCGCCAGCGCGAAGCCTCCAGACGC
CTGGGGGTCGAAGGCATGATGCTCAAGGCCAGGGATGCGATGTATGGCGTCGGTCGCACCAAGGACATGGGCGTGTGGTG
GAAATGGAAGGTCGACCCGTTCAGCGTCGACGCGGTGCTGATCTACGCCCAGCGCGGTCATGGCCGGCGCGCCAGCCTCT
ACAGCGATTACACCTTTGCGGTGTGGGACGGCCCGCCCGGTGCCAGTGCGCGGGCGTTGGTGCCCTTCGCCAAGGCCTAT
TCTGGGCTGACCGACGCGGAAATGCGCGAAGTCGACAGCATCGTGCGCAAGACCACCGTGGAAAAATTCGGTCCGGTCAG
CAGCGTGAAGCCGAGCCTTGTGTTCGAACTGGGTTTCGAAGGCATCGCCCTCTCCCGTCGGCACAAGAGCGGCATCGCCG
TGCGCTTCCCGCGCATGCTGCGCTGGCGCCAGGACAAGACCGTGGACGAGGCCGACAGCCTGGCGACCCTGCAAAACCTG
TTGGTCTGA

Upstream 100 bases:

>100_bases
TGCGCGAGCAGGGTCTGGACGCACAGGGTTTCAACACCGAATACGGTGACGATGAGGAAGAGCTGCCTGCCGCCACGCCC
GCCGTTGCCGAGGTGCAACC

Downstream 100 bases:

>100_bases
CTCCTTCCCCCGATACTCCCCCTCACCCCGATCGTTCCCACGCTCCGCGTGGGAATGCCTCAATGGACGCTCTGCGTCCG
CTTTGGGACGCGGAGCGTCC

Product: ATP-dependent DNA ligase

Products: NA

Alternate protein names: Polydeoxyribonucleotide synthase [ATP] [H]

Number of amino acids: Translated: 562; Mature: 562

Protein sequence:

>562_residues
MKDFAGLYAELDATTSSNAKLAAMQTYFAQAQPQDAAWAVYFLSGGRPRQLVPVRILRDLAVEMSGLAPWLFEESYQAVG
DLAETISLVLPEHPYTSEAGLAEWIEDKLLPLRGETPEYLAHQLPALWAQLDRPSLMLCIKLITGSFRVGVSKLLVTRAL
ASMAGLDSKRVAQRLVGYTDLSNRPNAASYLKLIAPESSDEHAQRGGQPYPFFLAHALAQPVETFEALLGPASNWQVEWK
WDGIRAQVVKRDGKLWVWSRGEELVTERFPELDTLVHGLPDGTVIDGEIVVWKNRRPVTEDAFDPQSTEAPAVQPFALLQ
QRIGRKSLDRKILEDAPVVVLAYDLLEWQGEDWRNQPQARRREQLEQVIARCNNPVLLPSPILTGDDWFDLARQREASRR
LGVEGMMLKARDAMYGVGRTKDMGVWWKWKVDPFSVDAVLIYAQRGHGRRASLYSDYTFAVWDGPPGASARALVPFAKAY
SGLTDAEMREVDSIVRKTTVEKFGPVSSVKPSLVFELGFEGIALSRRHKSGIAVRFPRMLRWRQDKTVDEADSLATLQNL
LV

Sequences:

>Translated_562_residues
MKDFAGLYAELDATTSSNAKLAAMQTYFAQAQPQDAAWAVYFLSGGRPRQLVPVRILRDLAVEMSGLAPWLFEESYQAVG
DLAETISLVLPEHPYTSEAGLAEWIEDKLLPLRGETPEYLAHQLPALWAQLDRPSLMLCIKLITGSFRVGVSKLLVTRAL
ASMAGLDSKRVAQRLVGYTDLSNRPNAASYLKLIAPESSDEHAQRGGQPYPFFLAHALAQPVETFEALLGPASNWQVEWK
WDGIRAQVVKRDGKLWVWSRGEELVTERFPELDTLVHGLPDGTVIDGEIVVWKNRRPVTEDAFDPQSTEAPAVQPFALLQ
QRIGRKSLDRKILEDAPVVVLAYDLLEWQGEDWRNQPQARRREQLEQVIARCNNPVLLPSPILTGDDWFDLARQREASRR
LGVEGMMLKARDAMYGVGRTKDMGVWWKWKVDPFSVDAVLIYAQRGHGRRASLYSDYTFAVWDGPPGASARALVPFAKAY
SGLTDAEMREVDSIVRKTTVEKFGPVSSVKPSLVFELGFEGIALSRRHKSGIAVRFPRMLRWRQDKTVDEADSLATLQNL
LV
>Mature_562_residues
MKDFAGLYAELDATTSSNAKLAAMQTYFAQAQPQDAAWAVYFLSGGRPRQLVPVRILRDLAVEMSGLAPWLFEESYQAVG
DLAETISLVLPEHPYTSEAGLAEWIEDKLLPLRGETPEYLAHQLPALWAQLDRPSLMLCIKLITGSFRVGVSKLLVTRAL
ASMAGLDSKRVAQRLVGYTDLSNRPNAASYLKLIAPESSDEHAQRGGQPYPFFLAHALAQPVETFEALLGPASNWQVEWK
WDGIRAQVVKRDGKLWVWSRGEELVTERFPELDTLVHGLPDGTVIDGEIVVWKNRRPVTEDAFDPQSTEAPAVQPFALLQ
QRIGRKSLDRKILEDAPVVVLAYDLLEWQGEDWRNQPQARRREQLEQVIARCNNPVLLPSPILTGDDWFDLARQREASRR
LGVEGMMLKARDAMYGVGRTKDMGVWWKWKVDPFSVDAVLIYAQRGHGRRASLYSDYTFAVWDGPPGASARALVPFAKAY
SGLTDAEMREVDSIVRKTTVEKFGPVSSVKPSLVFELGFEGIALSRRHKSGIAVRFPRMLRWRQDKTVDEADSLATLQNL
LV

Specific function: DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair [H]

COG id: COG1793

COG function: function code L; ATP-dependent DNA ligase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent DNA ligase family [H]

Homologues:

Organism=Homo sapiens, GI4557719, Length=393, Percent_Identity=25.6997455470738, Blast_Score=96, Evalue=9e-20,
Organism=Caenorhabditis elegans, GI71985269, Length=466, Percent_Identity=25.9656652360515, Blast_Score=128, Evalue=9e-30,
Organism=Saccharomyces cerevisiae, GI6320038, Length=368, Percent_Identity=24.4565217391304, Blast_Score=90, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24762424, Length=371, Percent_Identity=27.2237196765499, Blast_Score=94, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022865
- InterPro:   IPR000977
- InterPro:   IPR012309
- InterPro:   IPR012310
- InterPro:   IPR016059
- InterPro:   IPR012308
- InterPro:   IPR012340
- InterPro:   IPR016027 [H]

Pfam domain/function: PF04679 DNA_ligase_A_C; PF01068 DNA_ligase_A_M; PF04675 DNA_ligase_A_N [H]

EC number: =6.5.1.1 [H]

Molecular weight: Translated: 63024; Mature: 63024

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: PS00687 ALDEHYDE_DEHYDR_GLU ; PS00697 DNA_LIGASE_A1 ; PS50160 DNA_LIGASE_A3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKDFAGLYAELDATTSSNAKLAAMQTYFAQAQPQDAAWAVYFLSGGRPRQLVPVRILRDL
CCCHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCHHHHHHHHH
AVEMSGLAPWLFEESYQAVGDLAETISLVLPEHPYTSEAGLAEWIEDKLLPLRGETPEYL
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCCCCCHHHH
AHQLPALWAQLDRPSLMLCIKLITGSFRVGVSKLLVTRALASMAGLDSKRVAQRLVGYTD
HHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCC
LSNRPNAASYLKLIAPESSDEHAQRGGQPYPFFLAHALAQPVETFEALLGPASNWQVEWK
CCCCCCHHHHEEEECCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEE
WDGIRAQVVKRDGKLWVWSRGEELVTERFPELDTLVHGLPDGTVIDGEIVVWKNRRPVTE
ECCEEEEEEECCCCEEEEECCHHHHHHHCCHHHHHHHCCCCCEEECCEEEEECCCCCCCC
DAFDPQSTEAPAVQPFALLQQRIGRKSLDRKILEDAPVVVLAYDLLEWQGEDWRNQPQAR
CCCCCCCCCCCCCCHHHHHHHHHCHHHHHHHHHHCCCEEEEEEHHHHCCCCCCCCCHHHH
RREQLEQVIARCNNPVLLPSPILTGDDWFDLARQREASRRLGVEGMMLKARDAMYGVGRT
HHHHHHHHHHHCCCCEECCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEHHHHHHCCCCC
KDMGVWWKWKVDPFSVDAVLIYAQRGHGRRASLYSDYTFAVWDGPPGASARALVPFAKAY
CCCCEEEEEECCCCCCCEEEEEEECCCCCCCEEECCEEEEEECCCCCCCCCHHHHHHHHH
SGLTDAEMREVDSIVRKTTVEKFGPVSSVKPSLVFELGFEGIALSRRHKSGIAVRFPRML
CCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCEEECCCCCCCCEEECHHHH
RWRQDKTVDEADSLATLQNLLV
HHHCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MKDFAGLYAELDATTSSNAKLAAMQTYFAQAQPQDAAWAVYFLSGGRPRQLVPVRILRDL
CCCHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCHHHHHHHHH
AVEMSGLAPWLFEESYQAVGDLAETISLVLPEHPYTSEAGLAEWIEDKLLPLRGETPEYL
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCCCCCHHHH
AHQLPALWAQLDRPSLMLCIKLITGSFRVGVSKLLVTRALASMAGLDSKRVAQRLVGYTD
HHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCC
LSNRPNAASYLKLIAPESSDEHAQRGGQPYPFFLAHALAQPVETFEALLGPASNWQVEWK
CCCCCCHHHHEEEECCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEE
WDGIRAQVVKRDGKLWVWSRGEELVTERFPELDTLVHGLPDGTVIDGEIVVWKNRRPVTE
ECCEEEEEEECCCCEEEEECCHHHHHHHCCHHHHHHHCCCCCEEECCEEEEECCCCCCCC
DAFDPQSTEAPAVQPFALLQQRIGRKSLDRKILEDAPVVVLAYDLLEWQGEDWRNQPQAR
CCCCCCCCCCCCCCHHHHHHHHHCHHHHHHHHHHCCCEEEEEEHHHHCCCCCCCCCHHHH
RREQLEQVIARCNNPVLLPSPILTGDDWFDLARQREASRRLGVEGMMLKARDAMYGVGRT
HHHHHHHHHHHCCCCEECCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEHHHHHHCCCCC
KDMGVWWKWKVDPFSVDAVLIYAQRGHGRRASLYSDYTFAVWDGPPGASARALVPFAKAY
CCCCEEEEEECCCCCCCEEEEEEECCCCCCCEEECCEEEEEECCCCCCCCCHHHHHHHHH
SGLTDAEMREVDSIVRKTTVEKFGPVSSVKPSLVFELGFEGIALSRRHKSGIAVRFPRML
CCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCEEECCCCCCCCEEECHHHH
RWRQDKTVDEADSLATLQNLLV
HHHCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA