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The map label for this gene is cvrA [H]

Identifier: 77457251

GI number: 77457251

Start: 1186924

End: 1188732

Strand: Reverse

Name: cvrA [H]

Synonym: Pfl01_1024

Alternate gene names: 77457251

Gene position: 1188732-1186924 (Counterclockwise)

Preceding gene: 77457259

Following gene: 77457244

Centisome position: 18.46

GC content: 63.96

Gene sequence:

>1809_bases
ATGAACGAGCAGCAAATTCTGTTGGCTTTCGGTGGTATCGGTGCCGCCGCGCTGGGCTGCCAATGGCTCGCCTGGCGCCT
GAAGCTGCCGGCGATTCTGTTTCTGCTGCTGACCGGCATTCTGGCGGGCCCCGTGCTGGGCTGGCTCGACCCTCAGGAAA
TGTTCGGCCCGCTGCTGATGCCGCTGGTGTCGCTGGCGGTGGCGCTGATTCTGTTTGAAGGCAGCCTGACCCTGCACCTG
TCGGAGTGGCGCGAGATCGGCAGCGTCGTGCATCGGCTGGTGACCCTTGGCGCGCTCTCGACCTGGATCGTGATTGCGGT
CGCGACCCACTGGCTGCTGGGCTTCGACTGGTTGCTCGCCATCCTCTTCGGCAGTCTGACCCTGGTCACCGGGCCGACCG
TGATCGTGCCGATGCTGCGCGTGGTGCGGCCGAAGGCTTCGATCGCCAATATCCTGCGCTGGGAAGGGATTGTGATCGAC
CCGATCGGCGCGCTGCTCGCGGTGGTGGTCTACAGCTTCATCATTGCTCGGGCCGAAGGCCATGGCCTGGAACAGAGCCT
GCTGACATTTGGCGGGGTGATTGTCTGCGGCAGCGCGTTCGGCGTCGCCGGTGGCTGGCTGCTCGGCACGATCATCCGGC
GCCAATGGTTGCCGGAGTATTTGCACAATCTGGCATCGCTCGCCGCGGTGCTGGGGATATTCATCGCCGCCAACCAGGTC
ATGCACGAATCCGGTCTGCTGGCGGTGACGCTGATGGGCATGTGGCTGGCGAACATGAAGGGCGTGGATGTGCGGCACAT
CCTGCACTTCAAGGAAAACCTCAGCGTGTTGCTGATTTCCGGGTTATTCATCCTGCTGGCGGCACGACTGGACCTCAACG
CGCTGATCGGTCTCGGGCCGCTGGTGTTGATTCTGTTGCTGGTGATCCAGTTGATCGCCCGGCCGCTGAACGTGGTGCTG
AGTACCGCCGGTTCGAGTCTGAGCTGGCGTGAGCGTGCACTGTTGTGCTGGATTGCCCCGCGCGGGATCGTCGCGGCGGC
GGTCTCGGCGATCTTTGCGATTCGCCTGGATGAAGCGGGCCATGAAGGCGCGCTGTTGCTGGTGCCGCTGACCTTCGCCG
TGATCATCGGCACCGTCGTGCTGCAAAGTGCGACTGCCCGGCCCCTGGCCCGACTGTTGAAAGTTGCGGAACCAGCGCCC
AGCGGCTTCCTGATCGTCGGGGCGAACGGGCCTGCGCGCCTGCTCGGCAAGTCGCTGCAGCAGTTGGGCAGCCGGGTGCT
GCTGACGGATTCAAGCTGGGAAAATATCCGGGCGGCGCGCATGGAAGGCTTGCCGACCTACTTTGGCAATCCGGCCTCGC
AGCACGCCGATGCACATCTGGACCTAGTCGGGCTGGGGCATTTGCTGGCGCTGTCACCGTCGGGCGAACTCAATACGCTG
GCAGCCATGCGCTTTCGTCATGACTTCGGCCATCAACGATTGTTCGGGCTCGCCAGTGGTCAGGAAAGCCGTCGCAGCGA
CAAGCACCGCGCCAGCCTCGAACATCGCGGCAATCAACTGGGTAACGAAGCGCTGACTTACGCCAGACTGGCCAGCCAAC
TGGGTCAGGGCGCCGATCTGTACAGCACGACGCTGACGGACGGATTTGGCTGGGACGATTACCGGGCGCTGCATGGCAAC
CGCGCGACACTGCTGTTCATGCGCGATGACAGCGGCTGGGTGCATGTCGTGTCGCCGGAAACCGTGCTGAAACCTGGGCC
GGGGTGGACGCTGGTGGCGCTGATTCAGCCGGAGAGCGTCAACGCCTGA

Upstream 100 bases:

>100_bases
CAAGACACGCAGGCTTGGCACTGCGCGCAAATAAAGAGTGAACGGTTGAAATGGCCGCTAGTCTTTCATAGCCCGCTATT
TCAAGGAACAGGGAGCTTCA

Downstream 100 bases:

>100_bases
CCGGCCGGATCGCGACTCGGTGCTGGATCAGGCCGCGAAACCCGGCAGCACCGGCACCGGACGCTTGTCATCATCAATGG
CAACGAAGCTGAACTGCCCG

Product: Sodium/hydrogen exchanger

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 602; Mature: 602

Protein sequence:

>602_residues
MNEQQILLAFGGIGAAALGCQWLAWRLKLPAILFLLLTGILAGPVLGWLDPQEMFGPLLMPLVSLAVALILFEGSLTLHL
SEWREIGSVVHRLVTLGALSTWIVIAVATHWLLGFDWLLAILFGSLTLVTGPTVIVPMLRVVRPKASIANILRWEGIVID
PIGALLAVVVYSFIIARAEGHGLEQSLLTFGGVIVCGSAFGVAGGWLLGTIIRRQWLPEYLHNLASLAAVLGIFIAANQV
MHESGLLAVTLMGMWLANMKGVDVRHILHFKENLSVLLISGLFILLAARLDLNALIGLGPLVLILLLVIQLIARPLNVVL
STAGSSLSWRERALLCWIAPRGIVAAAVSAIFAIRLDEAGHEGALLLVPLTFAVIIGTVVLQSATARPLARLLKVAEPAP
SGFLIVGANGPARLLGKSLQQLGSRVLLTDSSWENIRAARMEGLPTYFGNPASQHADAHLDLVGLGHLLALSPSGELNTL
AAMRFRHDFGHQRLFGLASGQESRRSDKHRASLEHRGNQLGNEALTYARLASQLGQGADLYSTTLTDGFGWDDYRALHGN
RATLLFMRDDSGWVHVVSPETVLKPGPGWTLVALIQPESVNA

Sequences:

>Translated_602_residues
MNEQQILLAFGGIGAAALGCQWLAWRLKLPAILFLLLTGILAGPVLGWLDPQEMFGPLLMPLVSLAVALILFEGSLTLHL
SEWREIGSVVHRLVTLGALSTWIVIAVATHWLLGFDWLLAILFGSLTLVTGPTVIVPMLRVVRPKASIANILRWEGIVID
PIGALLAVVVYSFIIARAEGHGLEQSLLTFGGVIVCGSAFGVAGGWLLGTIIRRQWLPEYLHNLASLAAVLGIFIAANQV
MHESGLLAVTLMGMWLANMKGVDVRHILHFKENLSVLLISGLFILLAARLDLNALIGLGPLVLILLLVIQLIARPLNVVL
STAGSSLSWRERALLCWIAPRGIVAAAVSAIFAIRLDEAGHEGALLLVPLTFAVIIGTVVLQSATARPLARLLKVAEPAP
SGFLIVGANGPARLLGKSLQQLGSRVLLTDSSWENIRAARMEGLPTYFGNPASQHADAHLDLVGLGHLLALSPSGELNTL
AAMRFRHDFGHQRLFGLASGQESRRSDKHRASLEHRGNQLGNEALTYARLASQLGQGADLYSTTLTDGFGWDDYRALHGN
RATLLFMRDDSGWVHVVSPETVLKPGPGWTLVALIQPESVNA
>Mature_602_residues
MNEQQILLAFGGIGAAALGCQWLAWRLKLPAILFLLLTGILAGPVLGWLDPQEMFGPLLMPLVSLAVALILFEGSLTLHL
SEWREIGSVVHRLVTLGALSTWIVIAVATHWLLGFDWLLAILFGSLTLVTGPTVIVPMLRVVRPKASIANILRWEGIVID
PIGALLAVVVYSFIIARAEGHGLEQSLLTFGGVIVCGSAFGVAGGWLLGTIIRRQWLPEYLHNLASLAAVLGIFIAANQV
MHESGLLAVTLMGMWLANMKGVDVRHILHFKENLSVLLISGLFILLAARLDLNALIGLGPLVLILLLVIQLIARPLNVVL
STAGSSLSWRERALLCWIAPRGIVAAAVSAIFAIRLDEAGHEGALLLVPLTFAVIIGTVVLQSATARPLARLLKVAEPAP
SGFLIVGANGPARLLGKSLQQLGSRVLLTDSSWENIRAARMEGLPTYFGNPASQHADAHLDLVGLGHLLALSPSGELNTL
AAMRFRHDFGHQRLFGLASGQESRRSDKHRASLEHRGNQLGNEALTYARLASQLGQGADLYSTTLTDGFGWDDYRALHGN
RATLLFMRDDSGWVHVVSPETVLKPGPGWTLVALIQPESVNA

Specific function: Participates in control of cell volume in low-osmolarity conditions [H]

COG id: COG0025

COG function: function code P; NhaP-type Na+/H+ and K+/H+ antiporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK C-terminal domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR016169
- InterPro:   IPR006037
- InterPro:   IPR005170 [H]

Pfam domain/function: PF03471 CorC_HlyC; PF00999 Na_H_Exchanger; PF02080 TrkA_C [H]

EC number: NA

Molecular weight: Translated: 64681; Mature: 64681

Theoretical pI: Translated: 8.19; Mature: 8.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNEQQILLAFGGIGAAALGCQWLAWRLKLPAILFLLLTGILAGPVLGWLDPQEMFGPLLM
CCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
PLVSLAVALILFEGSLTLHLSEWREIGSVVHRLVTLGALSTWIVIAVATHWLLGFDWLLA
HHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ILFGSLTLVTGPTVIVPMLRVVRPKASIANILRWEGIVIDPIGALLAVVVYSFIIARAEG
HHHCCHHHHCCCHHHHHHHHHHCCHHHHHHHHHHCCEEECHHHHHHHHHHHHHHHHHCCC
HGLEQSLLTFGGVIVCGSAFGVAGGWLLGTIIRRQWLPEYLHNLASLAAVLGIFIAANQV
CCHHHHHHHHCCHHEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MHESGLLAVTLMGMWLANMKGVDVRHILHFKENLSVLLISGLFILLAARLDLNALIGLGP
HHHCCHHHHHHHHHHHHCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHH
LVLILLLVIQLIARPLNVVLSTAGSSLSWRERALLCWIAPRGIVAAAVSAIFAIRLDEAG
HHHHHHHHHHHHHHHHHHHHHCCCCCCCHHCCEEEEEECCCHHHHHHHHHHHHHEECCCC
HEGALLLVPLTFAVIIGTVVLQSATARPLARLLKVAEPAPSGFLIVGANGPARLLGKSLQ
CCCCEEEHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHH
QLGSRVLLTDSSWENIRAARMEGLPTYFGNPASQHADAHLDLVGLGHLLALSPSGELNTL
HHCCEEEEECCCHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEECCHHEEECCCCCHHHH
AAMRFRHDFGHQRLFGLASGQESRRSDKHRASLEHRGNQLGNEALTYARLASQLGQGADL
HHHHHHHHCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
YSTTLTDGFGWDDYRALHGNRATLLFMRDDSGWVHVVSPETVLKPGPGWTLVALIQPESV
HHHHCCCCCCCCCHHHHCCCCEEEEEEECCCCEEEEECCCCEECCCCCCEEEEEECCCCC
NA
CC
>Mature Secondary Structure
MNEQQILLAFGGIGAAALGCQWLAWRLKLPAILFLLLTGILAGPVLGWLDPQEMFGPLLM
CCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
PLVSLAVALILFEGSLTLHLSEWREIGSVVHRLVTLGALSTWIVIAVATHWLLGFDWLLA
HHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ILFGSLTLVTGPTVIVPMLRVVRPKASIANILRWEGIVIDPIGALLAVVVYSFIIARAEG
HHHCCHHHHCCCHHHHHHHHHHCCHHHHHHHHHHCCEEECHHHHHHHHHHHHHHHHHCCC
HGLEQSLLTFGGVIVCGSAFGVAGGWLLGTIIRRQWLPEYLHNLASLAAVLGIFIAANQV
CCHHHHHHHHCCHHEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MHESGLLAVTLMGMWLANMKGVDVRHILHFKENLSVLLISGLFILLAARLDLNALIGLGP
HHHCCHHHHHHHHHHHHCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHH
LVLILLLVIQLIARPLNVVLSTAGSSLSWRERALLCWIAPRGIVAAAVSAIFAIRLDEAG
HHHHHHHHHHHHHHHHHHHHHCCCCCCCHHCCEEEEEECCCHHHHHHHHHHHHHEECCCC
HEGALLLVPLTFAVIIGTVVLQSATARPLARLLKVAEPAPSGFLIVGANGPARLLGKSLQ
CCCCEEEHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHH
QLGSRVLLTDSSWENIRAARMEGLPTYFGNPASQHADAHLDLVGLGHLLALSPSGELNTL
HHCCEEEEECCCHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEECCHHEEECCCCCHHHH
AAMRFRHDFGHQRLFGLASGQESRRSDKHRASLEHRGNQLGNEALTYARLASQLGQGADL
HHHHHHHHCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
YSTTLTDGFGWDDYRALHGNRATLLFMRDDSGWVHVVSPETVLKPGPGWTLVALIQPESV
HHHHCCCCCCCCCHHHHCCCCEEEEEEECCCCEEEEECCCCEECCCCCCEEEEEECCCCC
NA
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12620739 [H]