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The map label for this gene is mdaB [H]

Identifier: 77456946

GI number: 77456946

Start: 845967

End: 846557

Strand: Direct

Name: mdaB [H]

Synonym: Pfl01_0718

Alternate gene names: 77456946

Gene position: 845967-846557 (Clockwise)

Preceding gene: 77456944

Following gene: 77456947

Centisome position: 13.14

GC content: 58.88

Gene sequence:

>591_bases
ATGAAAAAAGTGCTGTTGCTCAATGGCGGTAAAAAATTCGCCCACTCCGACGGTCGCTACAACACCACCTTGCACGAAGC
GGCGCTGAGCGTGCTGGATCGTGGCGGTGTCGACGTCAAGACCACCTTCATCGACGAGGGTTACGACATCGCCGAAGAAG
TCGCCAAATTCCTCTGGGCCGACGTGATCATTTATCAGATGCCGGGCTGGTGGATGGGCGCGCCGTGGACCGTGAAAAAG
TACATCGACGAAGTCTTTACCGAAGGCCACGGCAGCCTCTACGCCAGCGACGGTCGCACCCGTTCCGATTCCTCGCAGAA
GTACGGCAGCGGTGGTCTGATCCACGGCAAGCAATACATGCTGTCGCTGACCTGGAACGCACCGCAGCAGGCGTTCGATG
ACCCGACCGACTTCTTCGAAGCCAAAGGCGTGGACGCCGTGTACTTCCCGTTCCACAAGGCCAATCAGTTCCTCGGCATG
ACCGGCCTGCCGACCTTCCTCTGCGTGGACGTGATGAAACGCCCGAACATCGAAGCGGATGTGGCGCGTTACGAGCAGCA
TCTGACCGAGGTGTTTGGCCTCAAGGCCTGA

Upstream 100 bases:

>100_bases
ATTCCGCGCGAGGCGGATCGCTAATCTGCCGCCATTCAATTTTTCCCCTTCTCCATCCAGCGCTCTGCGCTGCGCATCGG
AATCCGATCGAGGCTCTCCC

Downstream 100 bases:

>100_bases
CGCTCGGCTACTATCGAAGGCCTTAGCTTGCGCAGCAGGCCTTTCGATTCGAGGACATCCGTGAAAGCCAGATCCGATGA
GTTGCAGATTTTCGTCTGCG

Product: NAD(P)H dehydrogenase (quinone)

Products: NADP; a reduced quinone; reduced acceptor [C]

Alternate protein names: NA

Number of amino acids: Translated: 196; Mature: 196

Protein sequence:

>196_residues
MKKVLLLNGGKKFAHSDGRYNTTLHEAALSVLDRGGVDVKTTFIDEGYDIAEEVAKFLWADVIIYQMPGWWMGAPWTVKK
YIDEVFTEGHGSLYASDGRTRSDSSQKYGSGGLIHGKQYMLSLTWNAPQQAFDDPTDFFEAKGVDAVYFPFHKANQFLGM
TGLPTFLCVDVMKRPNIEADVARYEQHLTEVFGLKA

Sequences:

>Translated_196_residues
MKKVLLLNGGKKFAHSDGRYNTTLHEAALSVLDRGGVDVKTTFIDEGYDIAEEVAKFLWADVIIYQMPGWWMGAPWTVKK
YIDEVFTEGHGSLYASDGRTRSDSSQKYGSGGLIHGKQYMLSLTWNAPQQAFDDPTDFFEAKGVDAVYFPFHKANQFLGM
TGLPTFLCVDVMKRPNIEADVARYEQHLTEVFGLKA
>Mature_196_residues
MKKVLLLNGGKKFAHSDGRYNTTLHEAALSVLDRGGVDVKTTFIDEGYDIAEEVAKFLWADVIIYQMPGWWMGAPWTVKK
YIDEVFTEGHGSLYASDGRTRSDSSQKYGSGGLIHGKQYMLSLTWNAPQQAFDDPTDFFEAKGVDAVYFPFHKANQFLGM
TGLPTFLCVDVMKRPNIEADVARYEQHLTEVFGLKA

Specific function: Unknown

COG id: COG2249

COG function: function code R; Putative NADPH-quinone reductase (modulator of drug activity B)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: To H.influenzae HI_0648 and S.pombe SPAC5H10.05c [H]

Homologues:

Organism=Escherichia coli, GI1789406, Length=193, Percent_Identity=62.6943005181347, Blast_Score=261, Evalue=3e-71,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003680 [H]

Pfam domain/function: PF02525 Flavodoxin_2 [H]

EC number: NA

Molecular weight: Translated: 22002; Mature: 22002

Theoretical pI: Translated: 5.93; Mature: 5.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKVLLLNGGKKFAHSDGRYNTTLHEAALSVLDRGGVDVKTTFIDEGYDIAEEVAKFLWA
CCEEEEEECCCEECCCCCCCCHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHH
DVIIYQMPGWWMGAPWTVKKYIDEVFTEGHGSLYASDGRTRSDSSQKYGSGGLIHGKQYM
HHHEECCCCCCCCCCHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCCCCCEEECCEEE
LSLTWNAPQQAFDDPTDFFEAKGVDAVYFPFHKANQFLGMTGLPTFLCVDVMKRPNIEAD
EEEEECCCHHHCCCCHHHHHHCCCCEEEECHHHHCHHCCCCCCHHHHHHHHHHCCCCHHH
VARYEQHLTEVFGLKA
HHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKKVLLLNGGKKFAHSDGRYNTTLHEAALSVLDRGGVDVKTTFIDEGYDIAEEVAKFLWA
CCEEEEEECCCEECCCCCCCCHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHH
DVIIYQMPGWWMGAPWTVKKYIDEVFTEGHGSLYASDGRTRSDSSQKYGSGGLIHGKQYM
HHHEECCCCCCCCCCHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCCCCCEEECCEEE
LSLTWNAPQQAFDDPTDFFEAKGVDAVYFPFHKANQFLGMTGLPTFLCVDVMKRPNIEAD
EEEEECCCHHHCCCCHHHHHHCCCCEEEECHHHHCHHCCCCCCHHHHHHHHHHCCCCHHH
VARYEQHLTEVFGLKA
HHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NADPH; a quinone; Acceptor; NADPH [C]

Specific reaction: NADPH + a quinone = NADP + a reduced quinone Acceptor + NADPH = reduced acceptor + NADP [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]