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The map label for this gene is hflK [H]

Identifier: 77456753

GI number: 77456753

Start: 607720

End: 608889

Strand: Direct

Name: hflK [H]

Synonym: Pfl01_0525

Alternate gene names: 77456753

Gene position: 607720-608889 (Clockwise)

Preceding gene: 77456752

Following gene: 77456754

Centisome position: 9.44

GC content: 61.54

Gene sequence:

>1170_bases
ATGGCTTGGAATGAGCCGGGTGGCAACTCGAACAATCAGGATCCTTGGGGTGGCAAGCGTCGCAACAACGGCGACCGCAA
GGGACCGCCGGATCTCGACGAGGCCTTCCGAAAGCTGCAGGAAAGCCTGAACGGGTTGTTCGGTGGTGGAAAAAAACGCG
GTGATGACGGTGGTGGCTCGGGCAAGAGCGGCGGCTTCGGCGGCCTGCTCGGCATCGGCCTTGTCGTGCTGGCGGCCGTC
TGGCTGTACAGCGCGGTGTATGTCGTGGACGAGCAGGAGCAAGCCGTGGTGCTGCGCTTCGGCAAGTACTACGAGACTGT
CGGTCCCGGCCTGAACATCTACTTCCCGCCGATCGACAAGAAGTACATGGAGAACGTCACGCGTGAGCGTGCCTACACCA
AGCAGGGCCAGATGCTGACCGAAGACGAGAACATCGTCGAAGTGCCGCTGACCGTGCAGTACAAGATCAGCAACCTGCAG
GACTTCGTGCTGAACGTCGACCAGCCGGAAATCAGCCTGCAACATGCGACCGACAGTGCGCTGCGCCATGTGGTGGGCTC
CACCGCGATGGACCAGGTGCTGACCGAAGGTCGTGAGCTGATGGCCAGCGAGATCAAGGAGCGCCTGCAGCGCTTCCTCG
ATACCTATCGCACCGGTATCACGGTCACCCAGGTCAACGTACAGAGCGCAGCGGCACCGCGTGAAGTGCAGGAAGCCTTC
GATGACGTGATCCGCGCCCGTGAAGACGAGCAGCGTTCGCGCAACCAGGCTGAAACCTACGCCAACGGCGTGGTGCCGGA
AGCCCGTGGTCAGGCCCAGCGTATCCTCGAAGATGCCAACGGTTACCGTGACGAAACGGTCTCGCGCGCCAAGGGTGAGG
CGGATCGCTTCACCAAACTGGTTGCCGAGTATCGCAAGGCGCCCGAGGTCACTCGTCAGCGTCTGTACCTGGACACCATG
CAGGAAGTCTTCAGCAGCACCAGCAAGGTACTCGTGACCGGCAACAAGAACGGCCAGAGCAACCTGCTTTACCTGCCGCT
GGACAAGATGATTCAGAACAGTTCGGGCAGCAATGCACCGGTCACCGGTTCGGCTGCCGCCAGCAACAACACGGACGCTA
CGCCGCATGTCACTGACCTGCCACAGTCGCGTACAAGGGAGACCCGCTGA

Upstream 100 bases:

>100_bases
ATAAAAGCCTGACAAAGCGGTTGTGCCGCAACGGCAGGCATTCTGTAGCATTGGTCGGCGCGCCGTGGGTGCGTCTTTGC
TTTATCAGATGGAGAGCGCT

Downstream 100 bases:

>100_bases
TGAGCAATAAATCGCTGATCGCCCTGATCGTTGGCGTTGTTGTGGTACTGGTTGGCTGGAACTGCTTCTACATCGTCGCT
CAGACCGAGCGCGCGGTGTT

Product: HflK

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 389; Mature: 388

Protein sequence:

>389_residues
MAWNEPGGNSNNQDPWGGKRRNNGDRKGPPDLDEAFRKLQESLNGLFGGGKKRGDDGGGSGKSGGFGGLLGIGLVVLAAV
WLYSAVYVVDEQEQAVVLRFGKYYETVGPGLNIYFPPIDKKYMENVTRERAYTKQGQMLTEDENIVEVPLTVQYKISNLQ
DFVLNVDQPEISLQHATDSALRHVVGSTAMDQVLTEGRELMASEIKERLQRFLDTYRTGITVTQVNVQSAAAPREVQEAF
DDVIRAREDEQRSRNQAETYANGVVPEARGQAQRILEDANGYRDETVSRAKGEADRFTKLVAEYRKAPEVTRQRLYLDTM
QEVFSSTSKVLVTGNKNGQSNLLYLPLDKMIQNSSGSNAPVTGSAAASNNTDATPHVTDLPQSRTRETR

Sequences:

>Translated_389_residues
MAWNEPGGNSNNQDPWGGKRRNNGDRKGPPDLDEAFRKLQESLNGLFGGGKKRGDDGGGSGKSGGFGGLLGIGLVVLAAV
WLYSAVYVVDEQEQAVVLRFGKYYETVGPGLNIYFPPIDKKYMENVTRERAYTKQGQMLTEDENIVEVPLTVQYKISNLQ
DFVLNVDQPEISLQHATDSALRHVVGSTAMDQVLTEGRELMASEIKERLQRFLDTYRTGITVTQVNVQSAAAPREVQEAF
DDVIRAREDEQRSRNQAETYANGVVPEARGQAQRILEDANGYRDETVSRAKGEADRFTKLVAEYRKAPEVTRQRLYLDTM
QEVFSSTSKVLVTGNKNGQSNLLYLPLDKMIQNSSGSNAPVTGSAAASNNTDATPHVTDLPQSRTRETR
>Mature_388_residues
AWNEPGGNSNNQDPWGGKRRNNGDRKGPPDLDEAFRKLQESLNGLFGGGKKRGDDGGGSGKSGGFGGLLGIGLVVLAAVW
LYSAVYVVDEQEQAVVLRFGKYYETVGPGLNIYFPPIDKKYMENVTRERAYTKQGQMLTEDENIVEVPLTVQYKISNLQD
FVLNVDQPEISLQHATDSALRHVVGSTAMDQVLTEGRELMASEIKERLQRFLDTYRTGITVTQVNVQSAAAPREVQEAFD
DVIRAREDEQRSRNQAETYANGVVPEARGQAQRILEDANGYRDETVSRAKGEADRFTKLVAEYRKAPEVTRQRLYLDTMQ
EVFSSTSKVLVTGNKNGQSNLLYLPLDKMIQNSSGSNAPVTGSAAASNNTDATPHVTDLPQSRTRETR

Specific function: HflC and HflK could encode or regulate a protease [H]

COG id: COG0330

COG function: function code O; Membrane protease subunits, stomatin/prohibitin homologs

Gene ontology:

Cell location: Membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the band 7/mec-2 family. HflK subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790616, Length=381, Percent_Identity=44.6194225721785, Blast_Score=269, Evalue=2e-73,
Organism=Escherichia coli, GI1786697, Length=286, Percent_Identity=25.5244755244755, Blast_Score=62, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI32564147, Length=243, Percent_Identity=26.7489711934156, Blast_Score=65, Evalue=4e-11,
Organism=Drosophila melanogaster, GI281365664, Length=198, Percent_Identity=27.2727272727273, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI281361633, Length=174, Percent_Identity=24.1379310344828, Blast_Score=66, Evalue=5e-11,
Organism=Drosophila melanogaster, GI62484448, Length=198, Percent_Identity=27.2727272727273, Blast_Score=65, Evalue=6e-11,
Organism=Drosophila melanogaster, GI281361631, Length=174, Percent_Identity=24.1379310344828, Blast_Score=65, Evalue=7e-11,
Organism=Drosophila melanogaster, GI24657857, Length=214, Percent_Identity=25.2336448598131, Blast_Score=65, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001107
- InterPro:   IPR010201
- InterPro:   IPR020980
- InterPro:   IPR001972 [H]

Pfam domain/function: PF01145 Band_7; PF12221 HflK_N [H]

EC number: NA

Molecular weight: Translated: 43000; Mature: 42869

Theoretical pI: Translated: 5.22; Mature: 5.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAWNEPGGNSNNQDPWGGKRRNNGDRKGPPDLDEAFRKLQESLNGLFGGGKKRGDDGGGS
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
GKSGGFGGLLGIGLVVLAAVWLYSAVYVVDEQEQAVVLRFGKYYETVGPGLNIYFPPIDK
CCCCCCHHHHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHCCCCEEEECCCCH
KYMENVTRERAYTKQGQMLTEDENIVEVPLTVQYKISNLQDFVLNVDQPEISLQHATDSA
HHHHHHHHHHHHHHCCCEEECCCCEEEECEEEEEECCCHHHHHHCCCCCCCHHHHHHHHH
LRHVVGSTAMDQVLTEGRELMASEIKERLQRFLDTYRTGITVTQVNVQSAAAPREVQEAF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEHHHHCCHHHHHHHH
DDVIRAREDEQRSRNQAETYANGVVPEARGQAQRILEDANGYRDETVSRAKGEADRFTKL
HHHHHHCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHH
VAEYRKAPEVTRQRLYLDTMQEVFSSTSKVLVTGNKNGQSNLLYLPLDKMIQNSSGSNAP
HHHHHHCHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCEEEEEHHHHHCCCCCCCCC
VTGSAAASNNTDATPHVTDLPQSRTRETR
CCCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
AWNEPGGNSNNQDPWGGKRRNNGDRKGPPDLDEAFRKLQESLNGLFGGGKKRGDDGGGS
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
GKSGGFGGLLGIGLVVLAAVWLYSAVYVVDEQEQAVVLRFGKYYETVGPGLNIYFPPIDK
CCCCCCHHHHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHCCCCEEEECCCCH
KYMENVTRERAYTKQGQMLTEDENIVEVPLTVQYKISNLQDFVLNVDQPEISLQHATDSA
HHHHHHHHHHHHHHCCCEEECCCCEEEECEEEEEECCCHHHHHHCCCCCCCHHHHHHHHH
LRHVVGSTAMDQVLTEGRELMASEIKERLQRFLDTYRTGITVTQVNVQSAAAPREVQEAF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEHHHHCCHHHHHHHH
DDVIRAREDEQRSRNQAETYANGVVPEARGQAQRILEDANGYRDETVSRAKGEADRFTKL
HHHHHHCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHH
VAEYRKAPEVTRQRLYLDTMQEVFSSTSKVLVTGNKNGQSNLLYLPLDKMIQNSSGSNAP
HHHHHHCHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCEEEEEHHHHHCCCCCCCCC
VTGSAAASNNTDATPHVTDLPQSRTRETR
CCCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]