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The map label for this gene is cvrA [H]

Identifier: 77456674

GI number: 77456674

Start: 506031

End: 507773

Strand: Reverse

Name: cvrA [H]

Synonym: Pfl01_0446

Alternate gene names: 77456674

Gene position: 507773-506031 (Counterclockwise)

Preceding gene: 77456675

Following gene: 77456673

Centisome position: 7.89

GC content: 63.51

Gene sequence:

>1743_bases
TTGAATGCGACGACCATCAACAGCCTGTTCTTGATCGGCGCGTTGCTGGTAGGCGCAAGCATTCTTGTCAGCTCCCTGTC
TTCCCGTCTCGGCATCCCGATTCTGGTGATCATTCTCGCGGTCGGCATGAGTGCCGGGGTCGATGGCGGCGGCATCATTT
TCGATAACTACCCGACGGCCTATCTGGTCGGCAACCTCGCACTGGCAGTGATCCTGCTCGACGGTGGCTTGCGCACCCGG
GTGTCCAGTTTCCGCGTGGCGTTGTGGCCGGCCTTGTCGCTGGCCACGGTCGGTGTCCTTATCACCACCGGCCTCACCGG
CATGGCCGCCGCGTGGCTGTTTGATCTCAATCTGATCCAAGGCCTGCTGATCGGCGCTATCGTCGGTTCCACGGACGCCG
CGGCGGTGTTCTCGCTGCTCGGCGGAAAGGGCCTGAACGAACGGGTGACCGCCAGCCTGGAAATCGAATCCGGCAGCAAC
GACCCGATGGCGGTGTTCCTCACCGTGACCCTGATCGACATGCTCGCCAGCGGCCAGACCGGTCTGCACTGGAGCCTGCT
GACCCACCTGATCCGCGAGTTTGGCATTGGCGGTGTGATCGGCCTGGGTGGCGGCTGGCTGATGCTGCAACTGGTCAACC
GGATCAACCTGGCCACCGGTCTGTATCCGATTCTGGTGATCGCCGGCGGGCTGGTGGTGTTCGCCCTGACCAACGCCCTG
CACGGCAGCGGTTTCCTCGCCGTGTACCTGTGCGGTCTGGTGATCGGCAACCGCCCGGTGCGCAGCCGTCATGGCATTCT
GCACATGCTCGACGGCATGGCGTGGCTGGCGCAGATCGGCATGTTCCTGGTGCTGGGCCTGCTGGTCACCCCGCATGACT
TGCTGCCGATCGCCCTGCCTGCGCTGGGTCTGGCGCTGTGGATGATTCTGTTCGCTCGGCCGCTATCGGTGCTGGTCGGG
CTGCTGCCGTTCAAGGCCTTCCATGGCCGCGAAAAGGCGTTCATTTCCTGGGTCGGCCTGCGTGGCGCGGTGCCGATCAT
TCTGGCGGTGTTCCCGCTGATGGCCGGGCTGCCGAATGCGCAGCTGTACTTCAACCTCGCGTTCTTCATCGTGCTGGTGT
CGCTGCTGGTGCAGGGCACGAGCCTGCCGTGGGTGGCCAAGCTGCTCAAAGTGACGGTACCGCCGGAGCCGGCGCCGATT
TCCCGCGCCGCCCTCGAAGTGCACGTCACCAGCGAGTGGGAACTGTTCGTTTACAAGCTCGGCGCGGAAAAATGGTGCAT
CGGTTCGCCCCTGCGCGAACTGAAAATGCCCGAAGGCACCCGTATCGCCGCCCTGTTTCGCGGTCAGCAACTGCTCCATC
CGTCGGGTAGTACGGTGCTGGAAGTCGATGATTTGCTGTGTGTCATCGGCCATGAGCACAACCTGCCGGCCCTCGGAAAA
CTGTTCAGCCAGGCGCCGCAACGCGGCCTCGATCTGCGCTTCTTCGGCGATTTCGTACTCGAAGGAGACGCCCAGCTCAA
AGCGGTTGCCGCCCTGTACGGCCTGCCGGCCGAAGGCATCGATCCAGACATGACCCTGGGCCACTTCATTGCCCAGAAAG
TCGGCGGTGCACCGATCGTTGGCGACCAGGTGGAATGGAACAACACCCACTGGACGGTTGCGGTCATGGACGGGAACAAG
ATCGGCAAAGTGGGCGTCAGATTCCCCGAAGGAAGTCGCCCGGGCCCCGGGCTCTTCCTCTAA

Upstream 100 bases:

>100_bases
AAACCTTTTTGACAGCATCACATTTCAACAGGTTAGAATCGCTGGCACGCAGACTGCATGGTCAGTTTGTGCCCGTCTTT
CCGCTTCTGGAGTACTGCCT

Downstream 100 bases:

>100_bases
ACTGCGTCCACTCTCACTTGCTTGACCGGTCTCTATGCCTACCCTGCGCTCCTTTTTCGTCGCGGCCCTGCTGGGCCTGA
GTCTCACTGTCGGCCCGCTG

Product: potassium/proton antiporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 580; Mature: 580

Protein sequence:

>580_residues
MNATTINSLFLIGALLVGASILVSSLSSRLGIPILVIILAVGMSAGVDGGGIIFDNYPTAYLVGNLALAVILLDGGLRTR
VSSFRVALWPALSLATVGVLITTGLTGMAAAWLFDLNLIQGLLIGAIVGSTDAAAVFSLLGGKGLNERVTASLEIESGSN
DPMAVFLTVTLIDMLASGQTGLHWSLLTHLIREFGIGGVIGLGGGWLMLQLVNRINLATGLYPILVIAGGLVVFALTNAL
HGSGFLAVYLCGLVIGNRPVRSRHGILHMLDGMAWLAQIGMFLVLGLLVTPHDLLPIALPALGLALWMILFARPLSVLVG
LLPFKAFHGREKAFISWVGLRGAVPIILAVFPLMAGLPNAQLYFNLAFFIVLVSLLVQGTSLPWVAKLLKVTVPPEPAPI
SRAALEVHVTSEWELFVYKLGAEKWCIGSPLRELKMPEGTRIAALFRGQQLLHPSGSTVLEVDDLLCVIGHEHNLPALGK
LFSQAPQRGLDLRFFGDFVLEGDAQLKAVAALYGLPAEGIDPDMTLGHFIAQKVGGAPIVGDQVEWNNTHWTVAVMDGNK
IGKVGVRFPEGSRPGPGLFL

Sequences:

>Translated_580_residues
MNATTINSLFLIGALLVGASILVSSLSSRLGIPILVIILAVGMSAGVDGGGIIFDNYPTAYLVGNLALAVILLDGGLRTR
VSSFRVALWPALSLATVGVLITTGLTGMAAAWLFDLNLIQGLLIGAIVGSTDAAAVFSLLGGKGLNERVTASLEIESGSN
DPMAVFLTVTLIDMLASGQTGLHWSLLTHLIREFGIGGVIGLGGGWLMLQLVNRINLATGLYPILVIAGGLVVFALTNAL
HGSGFLAVYLCGLVIGNRPVRSRHGILHMLDGMAWLAQIGMFLVLGLLVTPHDLLPIALPALGLALWMILFARPLSVLVG
LLPFKAFHGREKAFISWVGLRGAVPIILAVFPLMAGLPNAQLYFNLAFFIVLVSLLVQGTSLPWVAKLLKVTVPPEPAPI
SRAALEVHVTSEWELFVYKLGAEKWCIGSPLRELKMPEGTRIAALFRGQQLLHPSGSTVLEVDDLLCVIGHEHNLPALGK
LFSQAPQRGLDLRFFGDFVLEGDAQLKAVAALYGLPAEGIDPDMTLGHFIAQKVGGAPIVGDQVEWNNTHWTVAVMDGNK
IGKVGVRFPEGSRPGPGLFL
>Mature_580_residues
MNATTINSLFLIGALLVGASILVSSLSSRLGIPILVIILAVGMSAGVDGGGIIFDNYPTAYLVGNLALAVILLDGGLRTR
VSSFRVALWPALSLATVGVLITTGLTGMAAAWLFDLNLIQGLLIGAIVGSTDAAAVFSLLGGKGLNERVTASLEIESGSN
DPMAVFLTVTLIDMLASGQTGLHWSLLTHLIREFGIGGVIGLGGGWLMLQLVNRINLATGLYPILVIAGGLVVFALTNAL
HGSGFLAVYLCGLVIGNRPVRSRHGILHMLDGMAWLAQIGMFLVLGLLVTPHDLLPIALPALGLALWMILFARPLSVLVG
LLPFKAFHGREKAFISWVGLRGAVPIILAVFPLMAGLPNAQLYFNLAFFIVLVSLLVQGTSLPWVAKLLKVTVPPEPAPI
SRAALEVHVTSEWELFVYKLGAEKWCIGSPLRELKMPEGTRIAALFRGQQLLHPSGSTVLEVDDLLCVIGHEHNLPALGK
LFSQAPQRGLDLRFFGDFVLEGDAQLKAVAALYGLPAEGIDPDMTLGHFIAQKVGGAPIVGDQVEWNNTHWTVAVMDGNK
IGKVGVRFPEGSRPGPGLFL

Specific function: Participates in control of cell volume in low-osmolarity conditions [H]

COG id: COG3263

COG function: function code P; NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK C-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI87081854, Length=573, Percent_Identity=66.8411867364747, Blast_Score=699, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018421
- InterPro:   IPR006153
- InterPro:   IPR018422
- InterPro:   IPR016169
- InterPro:   IPR006037
- InterPro:   IPR005170 [H]

Pfam domain/function: PF03471 CorC_HlyC; PF00999 Na_H_Exchanger; PF02080 TrkA_C [H]

EC number: NA

Molecular weight: Translated: 61384; Mature: 61384

Theoretical pI: Translated: 7.20; Mature: 7.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNATTINSLFLIGALLVGASILVSSLSSRLGIPILVIILAVGMSAGVDGGGIIFDNYPTA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCEEECCCCHH
YLVGNLALAVILLDGGLRTRVSSFRVALWPALSLATVGVLITTGLTGMAAAWLFDLNLIQ
HHHHHHHHEEHEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
GLLIGAIVGSTDAAAVFSLLGGKGLNERVTASLEIESGSNDPMAVFLTVTLIDMLASGQT
HHHHHHHHCCCHHHHHHHHHCCCCCCCCEEEEEEEECCCCCCEEEHHHHHHHHHHHCCCC
GLHWSLLTHLIREFGIGGVIGLGGGWLMLQLVNRINLATGLYPILVIAGGLVVFALTNAL
CCCHHHHHHHHHHHCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HGSGFLAVYLCGLVIGNRPVRSRHGILHMLDGMAWLAQIGMFLVLGLLVTPHDLLPIALP
CCCCHHHHHHHHHHHCCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
ALGLALWMILFARPLSVLVGLLPFKAFHGREKAFISWVGLRGAVPIILAVFPLMAGLPNA
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHEEEECCCCHHHHHHHHHHHHHCCCCC
QLYFNLAFFIVLVSLLVQGTSLPWVAKLLKVTVPPEPAPISRAALEVHVTSEWELFVYKL
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCEEEEEEE
GAEKWCIGSPLRELKMPEGTRIAALFRGQQLLHPSGSTVLEVDDLLCVIGHEHNLPALGK
CCCCCCCCCCHHHCCCCCCCEEEEECCCCCEECCCCCEEEECCCEEEEECCCCCCCHHHH
LFSQAPQRGLDLRFFGDFVLEGDAQLKAVAALYGLPAEGIDPDMTLGHFIAQKVGGAPIV
HHHHCHHCCCCEEEECCEEECCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCEE
GDQVEWNNTHWTVAVMDGNKIGKVGVRFPEGSRPGPGLFL
CCCEEECCCEEEEEEEECCCCCCEEEECCCCCCCCCCCCC
>Mature Secondary Structure
MNATTINSLFLIGALLVGASILVSSLSSRLGIPILVIILAVGMSAGVDGGGIIFDNYPTA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCEEECCCCHH
YLVGNLALAVILLDGGLRTRVSSFRVALWPALSLATVGVLITTGLTGMAAAWLFDLNLIQ
HHHHHHHHEEHEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
GLLIGAIVGSTDAAAVFSLLGGKGLNERVTASLEIESGSNDPMAVFLTVTLIDMLASGQT
HHHHHHHHCCCHHHHHHHHHCCCCCCCCEEEEEEEECCCCCCEEEHHHHHHHHHHHCCCC
GLHWSLLTHLIREFGIGGVIGLGGGWLMLQLVNRINLATGLYPILVIAGGLVVFALTNAL
CCCHHHHHHHHHHHCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HGSGFLAVYLCGLVIGNRPVRSRHGILHMLDGMAWLAQIGMFLVLGLLVTPHDLLPIALP
CCCCHHHHHHHHHHHCCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
ALGLALWMILFARPLSVLVGLLPFKAFHGREKAFISWVGLRGAVPIILAVFPLMAGLPNA
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHEEEECCCCHHHHHHHHHHHHHCCCCC
QLYFNLAFFIVLVSLLVQGTSLPWVAKLLKVTVPPEPAPISRAALEVHVTSEWELFVYKL
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCEEEEEEE
GAEKWCIGSPLRELKMPEGTRIAALFRGQQLLHPSGSTVLEVDDLLCVIGHEHNLPALGK
CCCCCCCCCCHHHCCCCCCCEEEEECCCCCEECCCCCEEEECCCEEEEECCCCCCCHHHH
LFSQAPQRGLDLRFFGDFVLEGDAQLKAVAALYGLPAEGIDPDMTLGHFIAQKVGGAPIV
HHHHCHHCCCCEEEECCEEECCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCEE
GDQVEWNNTHWTVAVMDGNKIGKVGVRFPEGSRPGPGLFL
CCCEEECCCEEEEEEEECCCCCCEEEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA