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The map label for this gene is tauD [C]

Identifier: 77456441

GI number: 77456441

Start: 253352

End: 254272

Strand: Direct

Name: tauD [C]

Synonym: Pfl01_0213

Alternate gene names: 77456441

Gene position: 253352-254272 (Clockwise)

Preceding gene: 77456439

Following gene: 77456444

Centisome position: 3.94

GC content: 62.76

Gene sequence:

>921_bases
ATGAGCAATGCCGCACTCGCTGTAAAACCCGCTGTCCACGCGCTGGACATTCATCCGGTGGCCGGCCGTATCGGCGCCGA
AATCCGTGGCGTGCACTTGTCCGGTGAGCTGGATGCCGCGACGGTTGAAGCCATTCAACAGGCGCTGATCCAGTACAAGG
TCGTGTTCTTCCGCGAGCAGACCCAGCTCGACGATCAACGTCAGGAAGCCTTCGCGCATCTGCTCGGCGAGCCCGTGGCG
CACCCGACCGTGCCGTCCCGCGAGGGTACCCGTTACCTCCTGGAACTGGACGGCGCCGAAGGGCAGCGCGCCAACTCGTG
GCACACCGACGTGACCTTCGTCGATGCCTACCCGAAAGCCTCGATCCTGCGCTCGGTGGTGGCCCCGGCGTTCGGTGGCG
ACACGCTGTGGGCGAACACCGCGACCGCGTACAACGAACTGCCGACCGAGTTGCGCGAGCTGGCAGACAAACTGGTGGCT
GTGCACAGCAACGAATACGACTACGCCGCCGTGAAGCCGGACGTGTCGGCGGAGAAGCTTGAGCGCTATCGCAAGATCTT
CACCTCTACCGTCTACGAAACCGAGCACCCGGTGGTCCGCGTGCACCCGATCAGCGGCGAAAAGAGCTTGCTGCTGGGGC
ATTTCGTCAAACGCATCAAGGGCTATTCCCAGGCCGATTCGGCGCACCTGTTCGGCTTGCTGCAAAGTCATGTGATCCGT
CAGGAGAACGTCGTGCGCTGGCGCTGGAAGGCCGGTGATGTGGCGATCTGGGATAACCGCTCGACCCAGCATTACGCGAT
TGATGATTACGGCACTCAGGATCGGGTGGTGCGTCGGGTAACGCTCAAAGGGGAAGTGCCGGTCGGGGCGAATGGGCAGC
GTAGCCAGACCATCAAAGGGGCTGAGATCGTCGGCGTTTGA

Upstream 100 bases:

>100_bases
CGTCAAAGAAGCATGTCAATATCTATTAGATGTAAATGGAATATAGATAGAGCGTTGTTTCGCTGCCGTCCAACCGCAAG
CAGTCGATGAGGGTCTATCC

Downstream 100 bases:

>100_bases
TAACTGATCGTTCCCACGTCGAGGCGTCGAACCGTCTGCGTGGGAATGCCTCAATGGACGCTCTGCGTCCGCTTTGGGAC
GCGGAGCGTCCCGGGCTGCA

Product: taurine dioxygenase

Products: Aminoacetaldehyde; CO2; H+; Sulfite; Succinate [C]

Alternate protein names: NA

Number of amino acids: Translated: 306; Mature: 305

Protein sequence:

>306_residues
MSNAALAVKPAVHALDIHPVAGRIGAEIRGVHLSGELDAATVEAIQQALIQYKVVFFREQTQLDDQRQEAFAHLLGEPVA
HPTVPSREGTRYLLELDGAEGQRANSWHTDVTFVDAYPKASILRSVVAPAFGGDTLWANTATAYNELPTELRELADKLVA
VHSNEYDYAAVKPDVSAEKLERYRKIFTSTVYETEHPVVRVHPISGEKSLLLGHFVKRIKGYSQADSAHLFGLLQSHVIR
QENVVRWRWKAGDVAIWDNRSTQHYAIDDYGTQDRVVRRVTLKGEVPVGANGQRSQTIKGAEIVGV

Sequences:

>Translated_306_residues
MSNAALAVKPAVHALDIHPVAGRIGAEIRGVHLSGELDAATVEAIQQALIQYKVVFFREQTQLDDQRQEAFAHLLGEPVA
HPTVPSREGTRYLLELDGAEGQRANSWHTDVTFVDAYPKASILRSVVAPAFGGDTLWANTATAYNELPTELRELADKLVA
VHSNEYDYAAVKPDVSAEKLERYRKIFTSTVYETEHPVVRVHPISGEKSLLLGHFVKRIKGYSQADSAHLFGLLQSHVIR
QENVVRWRWKAGDVAIWDNRSTQHYAIDDYGTQDRVVRRVTLKGEVPVGANGQRSQTIKGAEIVGV
>Mature_305_residues
SNAALAVKPAVHALDIHPVAGRIGAEIRGVHLSGELDAATVEAIQQALIQYKVVFFREQTQLDDQRQEAFAHLLGEPVAH
PTVPSREGTRYLLELDGAEGQRANSWHTDVTFVDAYPKASILRSVVAPAFGGDTLWANTATAYNELPTELRELADKLVAV
HSNEYDYAAVKPDVSAEKLERYRKIFTSTVYETEHPVVRVHPISGEKSLLLGHFVKRIKGYSQADSAHLFGLLQSHVIRQ
ENVVRWRWKAGDVAIWDNRSTQHYAIDDYGTQDRVVRRVTLKGEVPVGANGQRSQTIKGAEIVGV

Specific function: Catalyzes The Conversion Of Taurine And Alpha Ketoglutarate To Sulfite, Aminoacetaldehyde And Succinate. Required For The Utilization Of Taurine (2-Aminoethanesulfonic Acid) As An Alternative Sulfur Source. Pentane-Sulfonic Acid, 3- (N-Morpholino)Propanes

COG id: COG2175

COG function: function code Q; Probable taurine catabolism dioxygenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tfdA dioxygenase family [H]

Homologues:

Organism=Escherichia coli, GI1786565, Length=281, Percent_Identity=37.0106761565836, Blast_Score=181, Evalue=4e-47,
Organism=Saccharomyces cerevisiae, GI6322971, Length=303, Percent_Identity=27.3927392739274, Blast_Score=96, Evalue=5e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003819 [H]

Pfam domain/function: PF02668 TauD [H]

EC number: 1.14.11.17 [C]

Molecular weight: Translated: 33933; Mature: 33801

Theoretical pI: Translated: 6.86; Mature: 6.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.3 %Met     (Translated Protein)
0.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
0.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNAALAVKPAVHALDIHPVAGRIGAEIRGVHLSGELDAATVEAIQQALIQYKVVFFREQ
CCCCCEEECCCEEEEECCCHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHEEECH
TQLDDQRQEAFAHLLGEPVAHPTVPSREGTRYLLELDGAEGQRANSWHTDVTFVDAYPKA
HHCCHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCEEEEECCCHH
SILRSVVAPAFGGDTLWANTATAYNELPTELRELADKLVAVHSNEYDYAAVKPDVSAEKL
HHHHHHHHCCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCHHHH
ERYRKIFTSTVYETEHPVVRVHPISGEKSLLLGHFVKRIKGYSQADSAHLFGLLQSHVIR
HHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHC
QENVVRWRWKAGDVAIWDNRSTQHYAIDDYGTQDRVVRRVTLKGEVPVGANGQRSQTIKG
CCCEEEEEEECCCEEEECCCCCCEEEECCCCCHHHEEEEEEEECCCCCCCCCCCCCCCCC
AEIVGV
EEEECC
>Mature Secondary Structure 
SNAALAVKPAVHALDIHPVAGRIGAEIRGVHLSGELDAATVEAIQQALIQYKVVFFREQ
CCCCEEECCCEEEEECCCHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHEEECH
TQLDDQRQEAFAHLLGEPVAHPTVPSREGTRYLLELDGAEGQRANSWHTDVTFVDAYPKA
HHCCHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCEEEEECCCHH
SILRSVVAPAFGGDTLWANTATAYNELPTELRELADKLVAVHSNEYDYAAVKPDVSAEKL
HHHHHHHHCCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCHHHH
ERYRKIFTSTVYETEHPVVRVHPISGEKSLLLGHFVKRIKGYSQADSAHLFGLLQSHVIR
HHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHC
QENVVRWRWKAGDVAIWDNRSTQHYAIDDYGTQDRVVRRVTLKGEVPVGANGQRSQTIKG
CCCEEEEEEECCCEEEECCCCCCEEEECCCCCHHHEEEEEEEECCCCCCCCCCCCCCCCC
AEIVGV
EEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: Ascorbate. [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2-Oxoglutarate; O2; Taurine [C]

Specific reaction: 2-Oxoglutarate + O2 + Taurine --> Aminoacetaldehyde + CO2 + H+ + Sulfite + Succinate [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]