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The map label for this gene is atsA [H]

Identifier: 77456436

GI number: 77456436

Start: 246858

End: 248468

Strand: Reverse

Name: atsA [H]

Synonym: Pfl01_0208

Alternate gene names: 77456436

Gene position: 248468-246858 (Counterclockwise)

Preceding gene: 77456437

Following gene: 77456434

Centisome position: 3.86

GC content: 63.38

Gene sequence:

>1611_bases
ATGCCGCAACGTCCCAACTTTCTGGTGATTCTGGCCGATGACCTCGGCTTCTCCGACATCGGCGCGTTCGGCGGCGAAAT
CGCCACGCCGAACCTCGATGCCCTGGCCAACAATGGCCTGCGCCTGACCGATTTTCACACCGCACCGACCTGCTCGCCGA
CCCGCTCGATGCTGCTCACCGGCACCGATCACCACATCGCCGGCATCGGCACCATGGCCGAAACCCTGACCCCGGAGCTG
ATCGGCAAACCGGGTTACGAAGGCTATCTCAACGACCGCGTCGTCGCGCTGCCGGAGTTGCTGCGCGAGGCCGGTTACCA
GACCTTGATGAGCGGCAAATGGCACCTGGGCCTGACCGCCGAACTGGCGCCCCACGCCCGAGGTTTCGAGCGTTCGTTCT
CGCTGCTGCCCGGCGCGGCCAACCACTACGGATTCGAACCGACCTACGACGAACACACGCCCGGCCTGCTGAAATCCACT
CCGGCGCTGTACATCGAGGACGACACGTTCATCGACGAATTGCCGAAGGATTTCTATTCCTCCGACGCTTTCGGCGACAA
GCTGCTGCAGTACCTCAAGGAGCGCGATCAGAGCCGGCCGTTCTTCGCCTATCTGCCGTTTTCCGCGCCGCACTGGCCGC
TGCAGGCGCCCGCCGACATCGTCGAAAAATATCGCGGCCGCTACGACGCGGGGCCGGAAGTGCTGCGCCTCGAGCGTCTG
GAAAAACTCAAATCGCTGGGGCTGATCGAGCCGGATGTCGAACCGCATCCGCTGATCAAGCTGACCGCGCAATGGGGCGC
GCTGAGCGATGAACAAAAACGCATTTCCGCCCGGGCAATGGAAGTCTATGCAGCGATGGTCGAGCGCATGGACTGGAACA
TCGGGCGCGTCGTCGATTACCTGCGCCAGCAGGGCCAGCTCGACAACACCTTCATCCTGTTCATGTCCGACAACGGTGCC
GAAGGCGCGCTGCTGGAAGCCTTCCCCAAATTCGGTCCGGATCTGGTGACCTACCTGAGCCAGCACTACGACAACAGCCT
CGACAACATCGGCCGCGCCAATTCCTACGTCTGGTACGGGCCGAACTGGGCGCAGGTGGCGACCGCGCCGTCACGCCTGT
TCAAGGCGTTCACCACCGAGGGCGGGATTCGCGTTCCGGCGCTGCTGCACTATCCGCAACTGCCGCTGAAGGGACAGATC
AGCCACGGTTTCGGCACGGTGATGGACATCACGCCGACTATCCTCGATCTGGCCGGCGTGCGCCATCCCGGCAAGCAGTG
GCACGGCAAACCGGTGGCGCCGTTGCGTGGTAAATCGTGGCTGGGTTTCCTGTCCGGCGAGACGGCGCAGGTGCATGACG
AACACACCGTTACCGGTTGGGAATTGTTCGGGCGCCGGGCGATTCGGCAGGGTCAGTGGAAGGCGGTGTGGATCCCCGGG
CCAGTGGGGCCGGCGACCTGGCAGCTTTACGACCTGGGGAGTGATCCGGGGGAGATTCATGACCTGGCGTCGAGTCAGCC
GCAGAAGCTTGAAGCGCTGATCGAGCATTGGCAGCGGTATGTGGAGGAGACCGGGGTGATCTTGAGTGAGTCGCCGTTTC
AGCCGGATTGA

Upstream 100 bases:

>100_bases
TGCACGAGCTGACCAGTGACGACCATTACCAACCGAGCGTGCCGGTACAGATCCGTGATCTGCCGTTGTCGTTCATTGCC
TGCTGAACAGGAGCCTGTTG

Downstream 100 bases:

>100_bases
GATTTAGCTCAAGAGCTGCCCTCATCGGAACGCCGCCCGCCCAGCCCTCTCCCGGAGGGAGAGGGCTGGGGTGTTCCGCG
TTATACATCGACCTGAAATA

Product: sulfatase

Products: NA

Alternate protein names: AS; Aryl-sulfate sulphohydrolase [H]

Number of amino acids: Translated: 536; Mature: 535

Protein sequence:

>536_residues
MPQRPNFLVILADDLGFSDIGAFGGEIATPNLDALANNGLRLTDFHTAPTCSPTRSMLLTGTDHHIAGIGTMAETLTPEL
IGKPGYEGYLNDRVVALPELLREAGYQTLMSGKWHLGLTAELAPHARGFERSFSLLPGAANHYGFEPTYDEHTPGLLKST
PALYIEDDTFIDELPKDFYSSDAFGDKLLQYLKERDQSRPFFAYLPFSAPHWPLQAPADIVEKYRGRYDAGPEVLRLERL
EKLKSLGLIEPDVEPHPLIKLTAQWGALSDEQKRISARAMEVYAAMVERMDWNIGRVVDYLRQQGQLDNTFILFMSDNGA
EGALLEAFPKFGPDLVTYLSQHYDNSLDNIGRANSYVWYGPNWAQVATAPSRLFKAFTTEGGIRVPALLHYPQLPLKGQI
SHGFGTVMDITPTILDLAGVRHPGKQWHGKPVAPLRGKSWLGFLSGETAQVHDEHTVTGWELFGRRAIRQGQWKAVWIPG
PVGPATWQLYDLGSDPGEIHDLASSQPQKLEALIEHWQRYVEETGVILSESPFQPD

Sequences:

>Translated_536_residues
MPQRPNFLVILADDLGFSDIGAFGGEIATPNLDALANNGLRLTDFHTAPTCSPTRSMLLTGTDHHIAGIGTMAETLTPEL
IGKPGYEGYLNDRVVALPELLREAGYQTLMSGKWHLGLTAELAPHARGFERSFSLLPGAANHYGFEPTYDEHTPGLLKST
PALYIEDDTFIDELPKDFYSSDAFGDKLLQYLKERDQSRPFFAYLPFSAPHWPLQAPADIVEKYRGRYDAGPEVLRLERL
EKLKSLGLIEPDVEPHPLIKLTAQWGALSDEQKRISARAMEVYAAMVERMDWNIGRVVDYLRQQGQLDNTFILFMSDNGA
EGALLEAFPKFGPDLVTYLSQHYDNSLDNIGRANSYVWYGPNWAQVATAPSRLFKAFTTEGGIRVPALLHYPQLPLKGQI
SHGFGTVMDITPTILDLAGVRHPGKQWHGKPVAPLRGKSWLGFLSGETAQVHDEHTVTGWELFGRRAIRQGQWKAVWIPG
PVGPATWQLYDLGSDPGEIHDLASSQPQKLEALIEHWQRYVEETGVILSESPFQPD
>Mature_535_residues
PQRPNFLVILADDLGFSDIGAFGGEIATPNLDALANNGLRLTDFHTAPTCSPTRSMLLTGTDHHIAGIGTMAETLTPELI
GKPGYEGYLNDRVVALPELLREAGYQTLMSGKWHLGLTAELAPHARGFERSFSLLPGAANHYGFEPTYDEHTPGLLKSTP
ALYIEDDTFIDELPKDFYSSDAFGDKLLQYLKERDQSRPFFAYLPFSAPHWPLQAPADIVEKYRGRYDAGPEVLRLERLE
KLKSLGLIEPDVEPHPLIKLTAQWGALSDEQKRISARAMEVYAAMVERMDWNIGRVVDYLRQQGQLDNTFILFMSDNGAE
GALLEAFPKFGPDLVTYLSQHYDNSLDNIGRANSYVWYGPNWAQVATAPSRLFKAFTTEGGIRVPALLHYPQLPLKGQIS
HGFGTVMDITPTILDLAGVRHPGKQWHGKPVAPLRGKSWLGFLSGETAQVHDEHTVTGWELFGRRAIRQGQWKAVWIPGP
VGPATWQLYDLGSDPGEIHDLASSQPQKLEALIEHWQRYVEETGVILSESPFQPD

Specific function: Unknown

COG id: COG3119

COG function: function code P; Arylsulfatase A and related enzymes

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sulfatase family [H]

Homologues:

Organism=Homo sapiens, GI109389362, Length=416, Percent_Identity=28.3653846153846, Blast_Score=149, Evalue=9e-36,
Organism=Homo sapiens, GI38569405, Length=567, Percent_Identity=26.2786596119929, Blast_Score=139, Evalue=8e-33,
Organism=Homo sapiens, GI59797060, Length=556, Percent_Identity=26.4388489208633, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI38569407, Length=319, Percent_Identity=30.4075235109718, Blast_Score=132, Evalue=9e-31,
Organism=Homo sapiens, GI45430057, Length=498, Percent_Identity=27.5100401606426, Blast_Score=112, Evalue=1e-24,
Organism=Homo sapiens, GI4503899, Length=252, Percent_Identity=33.7301587301587, Blast_Score=102, Evalue=8e-22,
Organism=Homo sapiens, GI157266309, Length=141, Percent_Identity=36.1702127659575, Blast_Score=84, Evalue=4e-16,
Organism=Homo sapiens, GI146229331, Length=264, Percent_Identity=31.0606060606061, Blast_Score=82, Evalue=9e-16,
Organism=Homo sapiens, GI146229329, Length=264, Percent_Identity=31.0606060606061, Blast_Score=82, Evalue=9e-16,
Organism=Homo sapiens, GI6005990, Length=264, Percent_Identity=31.0606060606061, Blast_Score=82, Evalue=9e-16,
Organism=Homo sapiens, GI146229324, Length=264, Percent_Identity=31.0606060606061, Blast_Score=82, Evalue=9e-16,
Organism=Homo sapiens, GI53831991, Length=121, Percent_Identity=35.5371900826446, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI58743319, Length=119, Percent_Identity=37.8151260504202, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI71852584, Length=119, Percent_Identity=38.655462184874, Blast_Score=74, Evalue=5e-13,
Organism=Homo sapiens, GI71852586, Length=119, Percent_Identity=38.655462184874, Blast_Score=74, Evalue=5e-13,
Organism=Homo sapiens, GI31742482, Length=120, Percent_Identity=36.6666666666667, Blast_Score=73, Evalue=8e-13,
Organism=Escherichia coli, GI1790233, Length=438, Percent_Identity=27.8538812785388, Blast_Score=112, Evalue=9e-26,
Organism=Caenorhabditis elegans, GI115533416, Length=536, Percent_Identity=25.5597014925373, Blast_Score=113, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI115533418, Length=528, Percent_Identity=25, Blast_Score=103, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17559078, Length=264, Percent_Identity=29.9242424242424, Blast_Score=86, Evalue=5e-17,
Organism=Drosophila melanogaster, GI281363223, Length=518, Percent_Identity=26.2548262548263, Blast_Score=131, Evalue=1e-30,
Organism=Drosophila melanogaster, GI281366397, Length=331, Percent_Identity=31.4199395770393, Blast_Score=128, Evalue=1e-29,
Organism=Drosophila melanogaster, GI281366395, Length=331, Percent_Identity=31.4199395770393, Blast_Score=128, Evalue=1e-29,
Organism=Drosophila melanogaster, GI24666163, Length=331, Percent_Identity=31.4199395770393, Blast_Score=128, Evalue=1e-29,
Organism=Drosophila melanogaster, GI24666175, Length=480, Percent_Identity=26.4583333333333, Blast_Score=126, Evalue=3e-29,
Organism=Drosophila melanogaster, GI24666109, Length=331, Percent_Identity=28.3987915407855, Blast_Score=112, Evalue=8e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017849
- InterPro:   IPR017850
- InterPro:   IPR000917 [H]

Pfam domain/function: PF00884 Sulfatase [H]

EC number: =3.1.6.1 [H]

Molecular weight: Translated: 59709; Mature: 59578

Theoretical pI: Translated: 5.22; Mature: 5.22

Prosite motif: PS00523 SULFATASE_1 ; PS00149 SULFATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPQRPNFLVILADDLGFSDIGAFGGEIATPNLDALANNGLRLTDFHTAPTCSPTRSMLLT
CCCCCCEEEEEECCCCCHHHHHCCCCCCCCCHHHHHCCCEEEEECCCCCCCCCCCCEEEE
GTDHHIAGIGTMAETLTPELIGKPGYEGYLNDRVVALPELLREAGYQTLMSGKWHLGLTA
CCCCCHHHHHHHHHHHCHHHHCCCCCCCCCCCCHHHHHHHHHHCCHHHHHCCCEEEEEEC
ELAPHARGFERSFSLLPGAANHYGFEPTYDEHTPGLLKSTPALYIEDDTFIDELPKDFYS
CCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHCCCEEEEECCHHHHHHHHHHHC
SDAFGDKLLQYLKERDQSRPFFAYLPFSAPHWPLQAPADIVEKYRGRYDAGPEVLRLERL
CCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCHHHHHHHCCCCCCCHHHHHHHHH
EKLKSLGLIEPDVEPHPLIKLTAQWGALSDEQKRISARAMEVYAAMVERMDWNIGRVVDY
HHHHHCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
LRQQGQLDNTFILFMSDNGAEGALLEAFPKFGPDLVTYLSQHYDNSLDNIGRANSYVWYG
HHHCCCCCCEEEEEEECCCCCCHHHHHHHCCCHHHHHHHHHHHCCHHHHCCCCCCEEEEC
PNWAQVATAPSRLFKAFTTEGGIRVPALLHYPQLPLKGQISHGFGTVMDITPTILDLAGV
CCHHHHHHHHHHHHHHHHCCCCEECCCEECCCCCCCCCCCCCCCCCHHCCHHHHHHHHCC
RHPGKQWHGKPVAPLRGKSWLGFLSGETAQVHDEHTVTGWELFGRRAIRQGQWKAVWIPG
CCCCHHCCCCCCCCCCCCCEEEEECCCCEEECCCCCCHHHHHHHHHHHHCCCEEEEEECC
PVGPATWQLYDLGSDPGEIHDLASSQPQKLEALIEHWQRYVEETGVILSESPFQPD
CCCCCEEEEEECCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCEEECCCCCCC
>Mature Secondary Structure 
PQRPNFLVILADDLGFSDIGAFGGEIATPNLDALANNGLRLTDFHTAPTCSPTRSMLLT
CCCCCEEEEEECCCCCHHHHHCCCCCCCCCHHHHHCCCEEEEECCCCCCCCCCCCEEEE
GTDHHIAGIGTMAETLTPELIGKPGYEGYLNDRVVALPELLREAGYQTLMSGKWHLGLTA
CCCCCHHHHHHHHHHHCHHHHCCCCCCCCCCCCHHHHHHHHHHCCHHHHHCCCEEEEEEC
ELAPHARGFERSFSLLPGAANHYGFEPTYDEHTPGLLKSTPALYIEDDTFIDELPKDFYS
CCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHCCCEEEEECCHHHHHHHHHHHC
SDAFGDKLLQYLKERDQSRPFFAYLPFSAPHWPLQAPADIVEKYRGRYDAGPEVLRLERL
CCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCHHHHHHHCCCCCCCHHHHHHHHH
EKLKSLGLIEPDVEPHPLIKLTAQWGALSDEQKRISARAMEVYAAMVERMDWNIGRVVDY
HHHHHCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
LRQQGQLDNTFILFMSDNGAEGALLEAFPKFGPDLVTYLSQHYDNSLDNIGRANSYVWYG
HHHCCCCCCEEEEEEECCCCCCHHHHHHHCCCHHHHHHHHHHHCCHHHHCCCCCCEEEEC
PNWAQVATAPSRLFKAFTTEGGIRVPALLHYPQLPLKGQISHGFGTVMDITPTILDLAGV
CCHHHHHHHHHHHHHHHHCCCCEECCCEECCCCCCCCCCCCCCCCCHHCCHHHHHHHHCC
RHPGKQWHGKPVAPLRGKSWLGFLSGETAQVHDEHTVTGWELFGRRAIRQGQWKAVWIPG
CCCCHHCCCCCCCCCCCCCEEEEECCCCEEECCCCCCHHHHHHHHHHHHCCCEEEEEECC
PVGPATWQLYDLGSDPGEIHDLASSQPQKLEALIEHWQRYVEETGVILSESPFQPD
CCCCCEEEEEECCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7744061; 10984043 [H]