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The map label for this gene is yhcA [H]

Identifier: 77456370

GI number: 77456370

Start: 170960

End: 172495

Strand: Direct

Name: yhcA [H]

Synonym: Pfl01_0142

Alternate gene names: 77456370

Gene position: 170960-172495 (Clockwise)

Preceding gene: 77456369

Following gene: 77456371

Centisome position: 2.66

GC content: 63.48

Gene sequence:

>1536_bases
ATGACATCCCTGACGGTCACGGCGCCGATTGCCACTGCCGCTCCGATGGCCGCCGCGCCACCGGTGTTCGGGGCGCGGAT
CATCATCGGTCTGGTCGGCGTGCTGCTGGCGGTGCTGGTGTCGGGTCTCAACGAGATGGTGACCAAGGTCGCCCTGGCCG
ACATTCGCGGCGCCCTGAGCATCGGTTACGACGAAGGCACCTGGCTGGTCGCCAGTTACACCGCGACCTCGGTGGCGGCC
ATGGCATTCGCGCCGTGGTGCTCGGTGACCTTTTCCCTGCGTCGCTTCACCCTGTGCGCCATCGGCGTGTTCACCCTGCT
CGGGGTGCTTTGCCCGTTCGCCCCGAACTACGAAAGCCTGCTGCTGATGCGCATCCTGCAAGGCTTGGCCGGTGGTGCGC
TACCGCCGATGCTGATGACCGTTGCCCTGCGTTTCCTACCGGCCAATATCAAACTGTATGGCCTCGCCGGTTATGCCCTG
ACCGCTACCTTCGGCCCCGGTCTCGGCACGCCGCTGGCCGGGTTGTGGACCGAATACGTCGGCTGGCAGTGGACGTTCTG
GCAAATCATCGTGCCGTGCCTGATTGCCATGGCGATGGTTGCCTGGGGCATTCCACAGGATCCGCTGCGTCTGGAACGCC
TCAATTCGTTCAACTGGAAAGGCCTGCTGCTGGGCTTTCCGGCGATCTGCATGCTGGTGATCGGCCTGTTGCAGGGCAAT
CGCCTGGACTGGTTCGAGTCGAACCTGATCTGCGCTTTGCTCGGCGCCGGTTCGCTGTTGCTGGTGGCGTTTCTGATCAA
TGAATGGTCGCAGCCGATTCCGTTTTTCAAGTTGCAGATGCTCGGCATCCGCAACCTGTCGTTCGCGCTGATGACGCTGG
CCGGGGTGCTGGTTGTGCTGCTGGCGGTGGTGCTGATTCCATCGAGTTACCTGGCTCAGGTTCAGGGTTACCGGCCGGTA
CAGACTGCGCCGATCATGTTGATCGCGGCATTGCCGCAGTTGATCGCGCTGCCGCTGGTGGCGGCGTTGTGCAACCTGCG
CTGGGTCGATTGTCGCTGGGTGCTCGGCATCGGCTTGGGCATGTTGACGCTCTCGTGTCTGGGCGGATCGCAGCTGACCT
CGGAATGGATTCGCGACGATTTCTATGTCCTGCAATGGCTGCAGATTTTCGGCCAGCCGATGGCGGTGCTGCCGTTGCTG
ATGCTGTCGACCGGCAGCATCCAGCCACAGGACGGGCCTTTCGCCTCGGCGTGGTTCAACACCGTAAAAGGTCTGGCGGC
GGTGGTCGCCACCGGCGTGATCGAGGCGCTGACCACTTCGCGCCTGCATTTTCACTCGACGATGCTGGTCGATCGCCTCG
GCAACTCGCCGCTGGCCGCCAGCAACGACCCCGGCCTCGCCCATCGCCTGCACGAACAGGCGGTGGTGCTGACTTCTTCG
GATCTTTATCTGTGCATGGCCGGCGTCGCGGTGGCGCTGATCCTGCTGATTCTCTGGCTGCCGACGCGGATCTATCCGCC
TCGCGCGCCAACCTGA

Upstream 100 bases:

>100_bases
ATTGCGTCCGGTGCACTTATAAACTGCCAAGAAGTCAATTTTCGTCAGCACTAAGCCCTACTACCATGCTCCGGTATTTT
TCCCTCCGGAGTTTGCCTGC

Downstream 100 bases:

>100_bases
CTGGAACAGAAGGTTTTTTATGACGACTCAAGCAAAGCAAAAACTCGCGGTGGCTGTGGCCGCTGCGCTGGCGGTCGGTG
TGCTGGTGTATCTGGCGATG

Product: major facilitator transporter

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 511; Mature: 510

Protein sequence:

>511_residues
MTSLTVTAPIATAAPMAAAPPVFGARIIIGLVGVLLAVLVSGLNEMVTKVALADIRGALSIGYDEGTWLVASYTATSVAA
MAFAPWCSVTFSLRRFTLCAIGVFTLLGVLCPFAPNYESLLLMRILQGLAGGALPPMLMTVALRFLPANIKLYGLAGYAL
TATFGPGLGTPLAGLWTEYVGWQWTFWQIIVPCLIAMAMVAWGIPQDPLRLERLNSFNWKGLLLGFPAICMLVIGLLQGN
RLDWFESNLICALLGAGSLLLVAFLINEWSQPIPFFKLQMLGIRNLSFALMTLAGVLVVLLAVVLIPSSYLAQVQGYRPV
QTAPIMLIAALPQLIALPLVAALCNLRWVDCRWVLGIGLGMLTLSCLGGSQLTSEWIRDDFYVLQWLQIFGQPMAVLPLL
MLSTGSIQPQDGPFASAWFNTVKGLAAVVATGVIEALTTSRLHFHSTMLVDRLGNSPLAASNDPGLAHRLHEQAVVLTSS
DLYLCMAGVAVALILLILWLPTRIYPPRAPT

Sequences:

>Translated_511_residues
MTSLTVTAPIATAAPMAAAPPVFGARIIIGLVGVLLAVLVSGLNEMVTKVALADIRGALSIGYDEGTWLVASYTATSVAA
MAFAPWCSVTFSLRRFTLCAIGVFTLLGVLCPFAPNYESLLLMRILQGLAGGALPPMLMTVALRFLPANIKLYGLAGYAL
TATFGPGLGTPLAGLWTEYVGWQWTFWQIIVPCLIAMAMVAWGIPQDPLRLERLNSFNWKGLLLGFPAICMLVIGLLQGN
RLDWFESNLICALLGAGSLLLVAFLINEWSQPIPFFKLQMLGIRNLSFALMTLAGVLVVLLAVVLIPSSYLAQVQGYRPV
QTAPIMLIAALPQLIALPLVAALCNLRWVDCRWVLGIGLGMLTLSCLGGSQLTSEWIRDDFYVLQWLQIFGQPMAVLPLL
MLSTGSIQPQDGPFASAWFNTVKGLAAVVATGVIEALTTSRLHFHSTMLVDRLGNSPLAASNDPGLAHRLHEQAVVLTSS
DLYLCMAGVAVALILLILWLPTRIYPPRAPT
>Mature_510_residues
TSLTVTAPIATAAPMAAAPPVFGARIIIGLVGVLLAVLVSGLNEMVTKVALADIRGALSIGYDEGTWLVASYTATSVAAM
AFAPWCSVTFSLRRFTLCAIGVFTLLGVLCPFAPNYESLLLMRILQGLAGGALPPMLMTVALRFLPANIKLYGLAGYALT
ATFGPGLGTPLAGLWTEYVGWQWTFWQIIVPCLIAMAMVAWGIPQDPLRLERLNSFNWKGLLLGFPAICMLVIGLLQGNR
LDWFESNLICALLGAGSLLLVAFLINEWSQPIPFFKLQMLGIRNLSFALMTLAGVLVVLLAVVLIPSSYLAQVQGYRPVQ
TAPIMLIAALPQLIALPLVAALCNLRWVDCRWVLGIGLGMLTLSCLGGSQLTSEWIRDDFYVLQWLQIFGQPMAVLPLLM
LSTGSIQPQDGPFASAWFNTVKGLAAVVATGVIEALTTSRLHFHSTMLVDRLGNSPLAASNDPGLAHRLHEQAVVLTSSD
LYLCMAGVAVALILLILWLPTRIYPPRAPT

Specific function: Translocase That Confers Resistance To Substances Of High Hydrophobicity. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. EmrB family [H]

Homologues:

Organism=Escherichia coli, GI1789042, Length=506, Percent_Identity=22.5296442687747, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI1788710, Length=494, Percent_Identity=23.8866396761134, Blast_Score=96, Evalue=5e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004638
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR001411 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 54914; Mature: 54783

Theoretical pI: Translated: 8.08; Mature: 8.08

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSLTVTAPIATAAPMAAAPPVFGARIIIGLVGVLLAVLVSGLNEMVTKVALADIRGALS
CCCEEEECCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHE
IGYDEGTWLVASYTATSVAAMAFAPWCSVTFSLRRFTLCAIGVFTLLGVLCPFAPNYESL
ECCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
LLMRILQGLAGGALPPMLMTVALRFLPANIKLYGLAGYALTATFGPGLGTPLAGLWTEYV
HHHHHHHHHCCCCCHHHHHHHHHHHHCCCEEEEEEECEEEEEECCCCCCCCHHHHHHHHH
GWQWTFWQIIVPCLIAMAMVAWGIPQDPLRLERLNSFNWKGLLLGFPAICMLVIGLLQGN
CCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCC
RLDWFESNLICALLGAGSLLLVAFLINEWSQPIPFFKLQMLGIRNLSFALMTLAGVLVVL
CCCHHHCCHHHHHHCCHHHHHHHHHHHHCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHH
LAVVLIPSSYLAQVQGYRPVQTAPIMLIAALPQLIALPLVAALCNLRWVDCRWVLGIGLG
HHHHHCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEECHHHHHHHHHH
MLTLSCLGGSQLTSEWIRDDFYVLQWLQIFGQPMAVLPLLMLSTGSIQPQDGPFASAWFN
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCHHHHHHH
TVKGLAAVVATGVIEALTTSRLHFHSTMLVDRLGNSPLAASNDPGLAHRLHEQAVVLTSS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCEEEEECC
DLYLCMAGVAVALILLILWLPTRIYPPRAPT
CHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
TSLTVTAPIATAAPMAAAPPVFGARIIIGLVGVLLAVLVSGLNEMVTKVALADIRGALS
CCEEEECCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHE
IGYDEGTWLVASYTATSVAAMAFAPWCSVTFSLRRFTLCAIGVFTLLGVLCPFAPNYESL
ECCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
LLMRILQGLAGGALPPMLMTVALRFLPANIKLYGLAGYALTATFGPGLGTPLAGLWTEYV
HHHHHHHHHCCCCCHHHHHHHHHHHHCCCEEEEEEECEEEEEECCCCCCCCHHHHHHHHH
GWQWTFWQIIVPCLIAMAMVAWGIPQDPLRLERLNSFNWKGLLLGFPAICMLVIGLLQGN
CCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCC
RLDWFESNLICALLGAGSLLLVAFLINEWSQPIPFFKLQMLGIRNLSFALMTLAGVLVVL
CCCHHHCCHHHHHHCCHHHHHHHHHHHHCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHH
LAVVLIPSSYLAQVQGYRPVQTAPIMLIAALPQLIALPLVAALCNLRWVDCRWVLGIGLG
HHHHHCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEECHHHHHHHHHH
MLTLSCLGGSQLTSEWIRDDFYVLQWLQIFGQPMAVLPLLMLSTGSIQPQDGPFASAWFN
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCHHHHHHH
TVKGLAAVVATGVIEALTTSRLHFHSTMLVDRLGNSPLAASNDPGLAHRLHEQAVVLTSS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCEEEEECC
DLYLCMAGVAVALILLILWLPTRIYPPRAPT
CHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377; 8969498 [H]