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The map label for this gene is pntAA [H]

Identifier: 77456342

GI number: 77456342

Start: 115794

End: 116915

Strand: Reverse

Name: pntAA [H]

Synonym: Pfl01_0114

Alternate gene names: 77456342

Gene position: 116915-115794 (Counterclockwise)

Preceding gene: 77456344

Following gene: 77456341

Centisome position: 1.82

GC content: 62.12

Gene sequence:

>1122_bases
GTGCACATTGGTGTTCCTCTCGAAACCCAGACCGGTGAAACACGGGTTGCTGCAACCCCGGAAACCATTAAAAAGCTGAT
CAGCCAAGGTCATAAGGTCACTGTGCAAACCGGCGCCGGCGTTAAAGCCAGCGTTGTCGACAGTGCCTATGAAGCGGCAG
GCGCAACCATTGGCAGTGCCAATGACGCGTTTGGCGCCGAGCTGATTCTCAAAGTGGTCGCGCCAAGCGATGCCGAACTG
ACGCTGATCAAGCGCGGAACGGTGCTGGTGGGCATGCTCAACCCATTCAACAACGACACCATCGCAAAGATGGCCGAGTG
CGGGATTACCGCGTTTGCCCTGGAAGCGGCGCCACGTACCTCCCGGGCCCAGAGCCTCGACGTGCTGTCATCCCAGGCGA
ACATTGCCGGCTATAAGGCCGTGCTGCTGGCCGCTCATTACTATCCGCGCTTCATGCCGATGCTGATGACTGCTGCGGGC
ACCGTGAAAGCGGCGCGCGTGCTGATTCTGGGGGCTGGTGTGGCCGGGTTGCAGGCGATTGCCACGGCGAAACGTCTGGG
TGCCGTCATCGAAGCGTCCGACGTACGTCCGGCCGTGAAGGAACAGATCGAATCCCTCGGCGCCAAGTTCGTCGACGTGC
CTTACGAAACCGATGAAGAACGCGAATGCGCGGTCGGCGTCGGCGGTTACGCACGCCCGATGCCGGCGAGCTGGATGCAG
CGTCAGGCCCAAGCCGTGCACGAGCGCGCCAAGCAGGCTGACATCGTCATCACCACCGCACTGATACCGGGCCGCAAGGC
ACCGACGCTGTTGAGCGCGGACACCGTGGCGCAGATGAAACCCGGCTCGGTGGTCATCGACCTCGCTGCAGCCCAGGGTG
GCAACTGCCCGCTGACCGTGGCCGATCAGGTCGTGATCGAGAACGGCGTGACCATCGTCGGCCCGACCAACCTCGCCGGT
GAAGTCGCCGCAGACGCCTCGGCGCTGTATGCACGCAACCTGCTGGACTTCCTGAAGCTGGTCTTCACCAAAGAAGGCCA
GTTCGAAGTAAACCTCGAAGACGATATCGTCGCCGCGTGCCTGATGTGCCGCGACGGCCAAGTCATCCGCAAAAACGCCT
AA

Upstream 100 bases:

>100_bases
CGCCCCGCCCTGATTTGGCGGGATCGTGCTGATCGGCCGCCCCAGTCGCACCATCCGTAGTGCATGGGTTTACTCAATAA
GATCACGCAGGAGATTTGAC

Downstream 100 bases:

>100_bases
GCAGGGATTCAGACGATGGAAGAGCTTATCTCCCCCGGTATCTACAACCTGATCATCTTCGTGCTGGCGATTTATGTCGG
TTACCACGTGGTCTGGAACG

Product: NAD(P)(+) transhydrogenase

Products: NA

Alternate protein names: Nicotinamide nucleotide transhydrogenase subunit alpha 1; Proton-translocating transhydrogenase component 1; Pyridine nucleotide transhydrogenase subunit alpha 1; dI [H]

Number of amino acids: Translated: 373; Mature: 373

Protein sequence:

>373_residues
MHIGVPLETQTGETRVAATPETIKKLISQGHKVTVQTGAGVKASVVDSAYEAAGATIGSANDAFGAELILKVVAPSDAEL
TLIKRGTVLVGMLNPFNNDTIAKMAECGITAFALEAAPRTSRAQSLDVLSSQANIAGYKAVLLAAHYYPRFMPMLMTAAG
TVKAARVLILGAGVAGLQAIATAKRLGAVIEASDVRPAVKEQIESLGAKFVDVPYETDEERECAVGVGGYARPMPASWMQ
RQAQAVHERAKQADIVITTALIPGRKAPTLLSADTVAQMKPGSVVIDLAAAQGGNCPLTVADQVVIENGVTIVGPTNLAG
EVAADASALYARNLLDFLKLVFTKEGQFEVNLEDDIVAACLMCRDGQVIRKNA

Sequences:

>Translated_373_residues
MHIGVPLETQTGETRVAATPETIKKLISQGHKVTVQTGAGVKASVVDSAYEAAGATIGSANDAFGAELILKVVAPSDAEL
TLIKRGTVLVGMLNPFNNDTIAKMAECGITAFALEAAPRTSRAQSLDVLSSQANIAGYKAVLLAAHYYPRFMPMLMTAAG
TVKAARVLILGAGVAGLQAIATAKRLGAVIEASDVRPAVKEQIESLGAKFVDVPYETDEERECAVGVGGYARPMPASWMQ
RQAQAVHERAKQADIVITTALIPGRKAPTLLSADTVAQMKPGSVVIDLAAAQGGNCPLTVADQVVIENGVTIVGPTNLAG
EVAADASALYARNLLDFLKLVFTKEGQFEVNLEDDIVAACLMCRDGQVIRKNA
>Mature_373_residues
MHIGVPLETQTGETRVAATPETIKKLISQGHKVTVQTGAGVKASVVDSAYEAAGATIGSANDAFGAELILKVVAPSDAEL
TLIKRGTVLVGMLNPFNNDTIAKMAECGITAFALEAAPRTSRAQSLDVLSSQANIAGYKAVLLAAHYYPRFMPMLMTAAG
TVKAARVLILGAGVAGLQAIATAKRLGAVIEASDVRPAVKEQIESLGAKFVDVPYETDEERECAVGVGGYARPMPASWMQ
RQAQAVHERAKQADIVITTALIPGRKAPTLLSADTVAQMKPGSVVIDLAAAQGGNCPLTVADQVVIENGVTIVGPTNLAG
EVAADASALYARNLLDFLKLVFTKEGQFEVNLEDDIVAACLMCRDGQVIRKNA

Specific function: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane [H]

COG id: COG3288

COG function: function code C; NAD/NADP transhydrogenase alpha subunit

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AlaDH/PNT family [H]

Homologues:

Organism=Homo sapiens, GI122939155, Length=384, Percent_Identity=38.0208333333333, Blast_Score=253, Evalue=2e-67,
Organism=Homo sapiens, GI122939153, Length=384, Percent_Identity=38.0208333333333, Blast_Score=253, Evalue=2e-67,
Organism=Escherichia coli, GI1787887, Length=371, Percent_Identity=45.2830188679245, Blast_Score=308, Evalue=3e-85,
Organism=Caenorhabditis elegans, GI17550456, Length=369, Percent_Identity=41.1924119241192, Blast_Score=281, Evalue=3e-76,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007698
- InterPro:   IPR008142
- InterPro:   IPR008143
- InterPro:   IPR007886 [H]

Pfam domain/function: PF01262 AlaDh_PNT_C; PF05222 AlaDh_PNT_N [H]

EC number: =1.6.1.2 [H]

Molecular weight: Translated: 38950; Mature: 38950

Theoretical pI: Translated: 5.78; Mature: 5.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHIGVPLETQTGETRVAATPETIKKLISQGHKVTVQTGAGVKASVVDSAYEAAGATIGSA
CCCCCCCCCCCCCEEEEECHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHCCCCCCC
NDAFGAELILKVVAPSDAELTLIKRGTVLVGMLNPFNNDTIAKMAECGITAFALEAAPRT
CCCHHHHEEEEEECCCCCEEEEEECCEEEEEECCCCCCCHHHHHHHCCCEEEEEECCCCC
SRAQSLDVLSSQANIAGYKAVLLAAHYYPRFMPMLMTAAGTVKAARVLILGAGVAGLQAI
CHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHEEEEEEEECCHHHHHHH
ATAKRLGAVIEASDVRPAVKEQIESLGAKFVDVPYETDEERECAVGVGGYARPMPASWMQ
HHHHHHHHEEECCCCCHHHHHHHHHCCCEEEECCCCCCCCCCEEECCCCCCCCCCHHHHH
RQAQAVHERAKQADIVITTALIPGRKAPTLLSADTVAQMKPGSVVIDLAAAQGGNCPLTV
HHHHHHHHHHHCCCEEEEEEECCCCCCCCEEECCHHHHCCCCCEEEEEEECCCCCCCEEE
ADQVVIENGVTIVGPTNLAGEVAADASALYARNLLDFLKLVFTKEGQFEVNLEDDIVAAC
ECEEEEECCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCHHHHHHH
LMCRDGQVIRKNA
HHCCCCCEEECCC
>Mature Secondary Structure
MHIGVPLETQTGETRVAATPETIKKLISQGHKVTVQTGAGVKASVVDSAYEAAGATIGSA
CCCCCCCCCCCCCEEEEECHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHCCCCCCC
NDAFGAELILKVVAPSDAELTLIKRGTVLVGMLNPFNNDTIAKMAECGITAFALEAAPRT
CCCHHHHEEEEEECCCCCEEEEEECCEEEEEECCCCCCCHHHHHHHCCCEEEEEECCCCC
SRAQSLDVLSSQANIAGYKAVLLAAHYYPRFMPMLMTAAGTVKAARVLILGAGVAGLQAI
CHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHEEEEEEEECCHHHHHHH
ATAKRLGAVIEASDVRPAVKEQIESLGAKFVDVPYETDEERECAVGVGGYARPMPASWMQ
HHHHHHHHEEECCCCCHHHHHHHHHCCCEEEECCCCCCCCCCEEECCCCCCCCCCHHHHH
RQAQAVHERAKQADIVITTALIPGRKAPTLLSADTVAQMKPGSVVIDLAAAQGGNCPLTV
HHHHHHHHHHHCCCEEEEEEECCCCCCCCEEECCHHHHCCCCCEEEEEEECCCCCCCEEE
ADQVVIENGVTIVGPTNLAGEVAADASALYARNLLDFLKLVFTKEGQFEVNLEDDIVAAC
ECEEEEECCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCHHHHHHH
LMCRDGQVIRKNA
HHCCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8075801 [H]