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The map label for this gene is dnaA [H]

Identifier: 77456229

GI number: 77456229

Start: 565

End: 2088

Strand: Direct

Name: dnaA [H]

Synonym: Pfl01_0001

Alternate gene names: 77456229

Gene position: 565-2088 (Clockwise)

Preceding gene: NA

Following gene: 77456230

Centisome position: 0.01

GC content: 59.12

Gene sequence:

>1524_bases
GTGTCAGTGGAACTTTGGCAGCAGTGCGTGGAGCTTTTGCGCGAAGAGCTGCCTGCCCAACAATTCAACACCTGGATCCG
TCCACTACAGGTCGAAGCCGAAGGCGACGAGTTGCGCGTCTACGCACCGAACCGTTTTGTTCTGGACTGGGTCAACGAAA
AGTACCTGGGGCGCGTCCTTGAACTGCTGGATGAGCATGGCAACGGTCTCGCACCGTCGCTCTCCTTATTAATAGGCAGC
AAGCGCAGTTCGGCTCCTCGTGCCGCACCGAACGCACCGTTGGCTGCTGCGCAAGTGTCCCAGGCTCAGGCCAATGCCGC
GCCGGCCAGTGCGCCAGCACCAGCTCCGACGCCTGCGCCGACCAAGCGCACAACGCAGAAAACAGAAGAGATCAGTGAAG
AGCCGTCCCGCGACAGCTTCGATCCGATGGCTGGTGCCGCTTCGCAACAGGCCCCGGTTCGCGCCGAACAGCGCACCGTG
CAGGTCGAAGGCGCGCTCAAGCACACCAGCTACCTCAACCGCACCTTTACCTTCGAAAACTTTGTCGAAGGTAAATCCAA
CCAGCTCGCCCGTGCGGCGGCCTGGCAGGTGGCAGACAACCCGAAGCACGGCTACAACCCGCTCTTCCTTTATGGCGGCG
TAGGTCTGGGTAAGACGCACTTGATGCACGCGGTGGGTAACCACCTATTAAAGAAGAACCCGAATGCCAAGGTCGTGTAC
TTGCATTCCGAGCGTTTCGTGGCTGACATGGTCAAGGCGCTGCAACTGAACGCGATCAACGAGTTCAAGCGTTTCTACCG
TTCGGTGGACGCCCTGCTGATCGACGACATTCAGTTCTTCGCCCGCAAGGAACGTTCCCAGGAAGAGTTTTTCCACACCT
TCAACGCCCTGCTTGAAGGTGGCCAGCAGGTCATTCTCACCAGTGACCGCTACCCGAAAGAAATCGAAGGCCTTGAAGAG
CGCCTCAAATCCCGCTTCGGCTGGGGCCTGACGGTTGCCGTCGAGCCGCCGGAGCTGGAAACCCGCGTAGCGATCTTGAT
GAAGAAGGCCGACCAGGCCAAAGTCGAGTTGCCACACGATGCGGCGTTCTTCATTGCCCAGCGTATTCGCTCCAACGTCC
GTGAGCTGGAAGGCGCGCTGAAACGCGTGATCGCCCACTCGCACTTCATGGGCCGCGACATCACCATCGAGTTGATTCGC
GAATCCCTGAAAGACCTGTTGGCGCTGCAGGACAAACTGGTCTCTGTGGATAACATTCAGCGCACCGTCGCCGAGTACTA
CAAGATCAAGATCTCCGACTTGCTGTCCAAGCGCCGTTCGCGTTCGGTCGCTCGTCCGCGTCAGGTGGCCATGGCATTGT
CCAAGGAACTGACCAACCACAGCCTGCCGGAAATCGGCGATGTGTTTGGCGGCCGCGACCACACGACCGTGTTGCACGCC
TGCCGCAAGATCAACGAACTTAAGGAATCCGACGCGGACATCCGCGAGGACTACAAGAACCTGCTGCGTACACTGACCAC
TTGA

Upstream 100 bases:

>100_bases
ATCATGTCCACCGGGCAACCTGCATGTGGATAAGTGGACGACTGGCCGCTACAATGGCCGCTTGTTTTTGCCTCACCGGC
TTTCAACTTAGGGGATATCC

Downstream 100 bases:

>100_bases
TGAACACCAGCGCAGCTTATTAAGGCAAGGGACTAGACCATGCATTTCACCATTCAACGCGAAGCCCTGTTGAAACCCCT
GCAACTGGTCGCAGGCGTCG

Product: chromosomal replication initiation protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 507; Mature: 506

Protein sequence:

>507_residues
MSVELWQQCVELLREELPAQQFNTWIRPLQVEAEGDELRVYAPNRFVLDWVNEKYLGRVLELLDEHGNGLAPSLSLLIGS
KRSSAPRAAPNAPLAAAQVSQAQANAAPASAPAPAPTPAPTKRTTQKTEEISEEPSRDSFDPMAGAASQQAPVRAEQRTV
QVEGALKHTSYLNRTFTFENFVEGKSNQLARAAAWQVADNPKHGYNPLFLYGGVGLGKTHLMHAVGNHLLKKNPNAKVVY
LHSERFVADMVKALQLNAINEFKRFYRSVDALLIDDIQFFARKERSQEEFFHTFNALLEGGQQVILTSDRYPKEIEGLEE
RLKSRFGWGLTVAVEPPELETRVAILMKKADQAKVELPHDAAFFIAQRIRSNVRELEGALKRVIAHSHFMGRDITIELIR
ESLKDLLALQDKLVSVDNIQRTVAEYYKIKISDLLSKRRSRSVARPRQVAMALSKELTNHSLPEIGDVFGGRDHTTVLHA
CRKINELKESDADIREDYKNLLRTLTT

Sequences:

>Translated_507_residues
MSVELWQQCVELLREELPAQQFNTWIRPLQVEAEGDELRVYAPNRFVLDWVNEKYLGRVLELLDEHGNGLAPSLSLLIGS
KRSSAPRAAPNAPLAAAQVSQAQANAAPASAPAPAPTPAPTKRTTQKTEEISEEPSRDSFDPMAGAASQQAPVRAEQRTV
QVEGALKHTSYLNRTFTFENFVEGKSNQLARAAAWQVADNPKHGYNPLFLYGGVGLGKTHLMHAVGNHLLKKNPNAKVVY
LHSERFVADMVKALQLNAINEFKRFYRSVDALLIDDIQFFARKERSQEEFFHTFNALLEGGQQVILTSDRYPKEIEGLEE
RLKSRFGWGLTVAVEPPELETRVAILMKKADQAKVELPHDAAFFIAQRIRSNVRELEGALKRVIAHSHFMGRDITIELIR
ESLKDLLALQDKLVSVDNIQRTVAEYYKIKISDLLSKRRSRSVARPRQVAMALSKELTNHSLPEIGDVFGGRDHTTVLHA
CRKINELKESDADIREDYKNLLRTLTT
>Mature_506_residues
SVELWQQCVELLREELPAQQFNTWIRPLQVEAEGDELRVYAPNRFVLDWVNEKYLGRVLELLDEHGNGLAPSLSLLIGSK
RSSAPRAAPNAPLAAAQVSQAQANAAPASAPAPAPTPAPTKRTTQKTEEISEEPSRDSFDPMAGAASQQAPVRAEQRTVQ
VEGALKHTSYLNRTFTFENFVEGKSNQLARAAAWQVADNPKHGYNPLFLYGGVGLGKTHLMHAVGNHLLKKNPNAKVVYL
HSERFVADMVKALQLNAINEFKRFYRSVDALLIDDIQFFARKERSQEEFFHTFNALLEGGQQVILTSDRYPKEIEGLEER
LKSRFGWGLTVAVEPPELETRVAILMKKADQAKVELPHDAAFFIAQRIRSNVRELEGALKRVIAHSHFMGRDITIELIRE
SLKDLLALQDKLVSVDNIQRTVAEYYKIKISDLLSKRRSRSVARPRQVAMALSKELTNHSLPEIGDVFGGRDHTTVLHAC
RKINELKESDADIREDYKNLLRTLTT

Specific function: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box):5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phosph

COG id: COG0593

COG function: function code L; ATPase involved in DNA replication initiation

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dnaA family [H]

Homologues:

Organism=Escherichia coli, GI2367267, Length=510, Percent_Identity=63.921568627451, Blast_Score=649, Evalue=0.0,
Organism=Escherichia coli, GI226510964, Length=237, Percent_Identity=27.4261603375527, Blast_Score=77, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR001957
- InterPro:   IPR020591
- InterPro:   IPR018312
- InterPro:   IPR013159
- InterPro:   IPR013317
- InterPro:   IPR010921 [H]

Pfam domain/function: PF00308 Bac_DnaA; PF08299 Bac_DnaA_C [H]

EC number: NA

Molecular weight: Translated: 57010; Mature: 56878

Theoretical pI: Translated: 8.59; Mature: 8.59

Prosite motif: PS01008 DNAA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVELWQQCVELLREELPAQQFNTWIRPLQVEAEGDELRVYAPNRFVLDWVNEKYLGRVL
CCHHHHHHHHHHHHHHCCHHHHHHHHCCEEEEECCCEEEEECCCEEEEHHHCHHHHHHHH
ELLDEHGNGLAPSLSLLIGSKRSSAPRAAPNAPLAAAQVSQAQANAAPASAPAPAPTPAP
HHHHHCCCCCCCHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCC
TKRTTQKTEEISEEPSRDSFDPMAGAASQQAPVRAEQRTVQVEGALKHTSYLNRTFTFEN
CCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHEEEEHHHHHHHHHHHHHCCHHH
FVEGKSNQLARAAAWQVADNPKHGYNPLFLYGGVGLGKTHLMHAVGNHLLKKNPNAKVVY
HHCCCCCHHHHHHHHHCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHCCCCCEEEE
LHSERFVADMVKALQLNAINEFKRFYRSVDALLIDDIQFFARKERSQEEFFHTFNALLEG
EECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GQQVILTSDRYPKEIEGLEERLKSRFGWGLTVAVEPPELETRVAILMKKADQAKVELPHD
CCEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHCCCCCEECCCH
AAFFIAQRIRSNVRELEGALKRVIAHSHFMGRDITIELIRESLKDLLALQDKLVSVDNIQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
RTVAEYYKIKISDLLSKRRSRSVARPRQVAMALSKELTNHSLPEIGDVFGGRDHTTVLHA
HHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCHHHHHCCCCCHHHHHHH
CRKINELKESDADIREDYKNLLRTLTT
HHHHHHHHHCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SVELWQQCVELLREELPAQQFNTWIRPLQVEAEGDELRVYAPNRFVLDWVNEKYLGRVL
CHHHHHHHHHHHHHHCCHHHHHHHHCCEEEEECCCEEEEECCCEEEEHHHCHHHHHHHH
ELLDEHGNGLAPSLSLLIGSKRSSAPRAAPNAPLAAAQVSQAQANAAPASAPAPAPTPAP
HHHHHCCCCCCCHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCC
TKRTTQKTEEISEEPSRDSFDPMAGAASQQAPVRAEQRTVQVEGALKHTSYLNRTFTFEN
CCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHEEEEHHHHHHHHHHHHHCCHHH
FVEGKSNQLARAAAWQVADNPKHGYNPLFLYGGVGLGKTHLMHAVGNHLLKKNPNAKVVY
HHCCCCCHHHHHHHHHCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHCCCCCEEEE
LHSERFVADMVKALQLNAINEFKRFYRSVDALLIDDIQFFARKERSQEEFFHTFNALLEG
EECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GQQVILTSDRYPKEIEGLEERLKSRFGWGLTVAVEPPELETRVAILMKKADQAKVELPHD
CCEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHCCCCCEECCCH
AAFFIAQRIRSNVRELEGALKRVIAHSHFMGRDITIELIRESLKDLLALQDKLVSVDNIQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
RTVAEYYKIKISDLLSKRRSRSVARPRQVAMALSKELTNHSLPEIGDVFGGRDHTTVLHA
HHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCHHHHHCCCCCHHHHHHH
CRKINELKESDADIREDYKNLLRTLTT
HHHHHHHHHCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA