Click here to switch to the map view.

The map label for this gene is fabF [H]

Identifier: 255961264

GI number: 255961264

Start: 4692390

End: 4693667

Strand: Reverse

Name: fabF [H]

Synonym: Pfl01_4155

Alternate gene names: 255961264

Gene position: 4693667-4692390 (Counterclockwise)

Preceding gene: 77460377

Following gene: 77460375

Centisome position: 72.9

GC content: 62.68

Gene sequence:

>1278_bases
ATGCAAAGTCGTCATTTGAAAAAGGAGAGTGCTGTGTCGCGTAGACGCGTCGTAGTCACCGGTATGGGTATGTTGTCGCC
ACTGGGCACGGATGTGCCGAGCAGTTGGCAGGGCATTCTGGCTGGCCGCAGTGGCATTGGTCTGATCGAACACACCGACC
TTTCTGCCTATTCCACCCGCTTTGGCGGCTCGGTAAAGGGCTTCAATGTCGAGGAATACCTGTCGGTCAAGGAAGCGCGC
AAGCTCGACCTGTTCATTCAGTACGGTCTGGCGGCCGGCTTTCAAGCCGTACGCAATGCCGGTCTGGAAGTCACCGATGC
CAACCGTGAACGCATCGGCGTGGCCATGGGGTCGGGTATCGGCGGTCTGACCAACATCGAAGAAACCAGCCGCACCCTGC
ACGAGACTGGCCCACGCCGGATTTCTCCGTTCTTTGTGCCTGGCTCGATCATCAATATGATTTCCGGTTTCCTGTCCATC
CACCTGGGTGCACAGGGGCCTAACTATGCCATCGCCACGGCGTGTACCACCGGTACGCACTGCATCGGCATGGCGGCGCG
CAACATCATGTACGACGAAGCCGACGTGATGATTGCCGGCGGTGCCGAGATGGCCGCGTGCGGTCTGGGCATGGGCGGCT
TCGGTGCTTCCCGTGCGCTGTCGACCCGCAACGACGAGCCGACCCGCGCCAGCCGTCCGTGGGACAAGGGCCGTGACGGC
TTCGTGCTGTCCGACGGCGCCGGTGCGCTGGTGCTCGAAGAGCTCGAGCACGCCAAGGCCCGTGGCGCGACCATCTACGC
CGAGCTGATCGGTTTCGGCACCAGTGGCGACGCCTTCCACATGACTTCGCCACCCGCCGACGGCGCCGGTGCTGCACGCT
GCATCACCAACGCGCTGCGCGATGCGAAGATCAACGTCGATCAAGTTCAATACATCAACGCCCACGGCACTTCGACCCCG
GCCGGCGACCTTGCCGAAGCCAACGCGATCAAGTCGGTGTTCGGTGATCACGCCTACAAACTGGCAGTCAGCTCCACCAA
GTCCATGACCGGTCACCTGCTGGGTGCGGCGGGCGCGGTCGAGGCGATCTTCAGCGTCCTGGCGATCAACAGCCAGGTGG
CGCCACCGACCATCAACCTCGAAGAGCCGGACGAAGGCTGCGACCTCGATTTCGTGCCGCACACCGCGCGCAATATGGAT
ATCGATGTCGTGCTGTCCAACTCGTTCGGGTTTGGCGGCACCAACGGCACGCTGGCGTTCCGTCGGTTCGCCGGCTGA

Upstream 100 bases:

>100_bases
CTACGTTACTAGCCACCAGGCGTAATAGTTTGTAATCGTTGCTTGCTGTCATGGAAAAACCGCACTGCCATCATGGCGTG
CGGTTTTTTCTTTAGGCCTG

Downstream 100 bases:

>100_bases
TGGACTGCTGGGTCGACGGTCTGCCGGCTGACGCTCTGTCGCTGAAAGATCGCGGCCTGGCTTACGGCGACGGTCTGTTC
GAGACCATCGCCGTGCGAGG

Product: 3-oxoacyl-(acyl carrier protein) synthase II

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 425; Mature: 425

Protein sequence:

>425_residues
MQSRHLKKESAVSRRRVVVTGMGMLSPLGTDVPSSWQGILAGRSGIGLIEHTDLSAYSTRFGGSVKGFNVEEYLSVKEAR
KLDLFIQYGLAAGFQAVRNAGLEVTDANRERIGVAMGSGIGGLTNIEETSRTLHETGPRRISPFFVPGSIINMISGFLSI
HLGAQGPNYAIATACTTGTHCIGMAARNIMYDEADVMIAGGAEMAACGLGMGGFGASRALSTRNDEPTRASRPWDKGRDG
FVLSDGAGALVLEELEHAKARGATIYAELIGFGTSGDAFHMTSPPADGAGAARCITNALRDAKINVDQVQYINAHGTSTP
AGDLAEANAIKSVFGDHAYKLAVSSTKSMTGHLLGAAGAVEAIFSVLAINSQVAPPTINLEEPDEGCDLDFVPHTARNMD
IDVVLSNSFGFGGTNGTLAFRRFAG

Sequences:

>Translated_425_residues
MQSRHLKKESAVSRRRVVVTGMGMLSPLGTDVPSSWQGILAGRSGIGLIEHTDLSAYSTRFGGSVKGFNVEEYLSVKEAR
KLDLFIQYGLAAGFQAVRNAGLEVTDANRERIGVAMGSGIGGLTNIEETSRTLHETGPRRISPFFVPGSIINMISGFLSI
HLGAQGPNYAIATACTTGTHCIGMAARNIMYDEADVMIAGGAEMAACGLGMGGFGASRALSTRNDEPTRASRPWDKGRDG
FVLSDGAGALVLEELEHAKARGATIYAELIGFGTSGDAFHMTSPPADGAGAARCITNALRDAKINVDQVQYINAHGTSTP
AGDLAEANAIKSVFGDHAYKLAVSSTKSMTGHLLGAAGAVEAIFSVLAINSQVAPPTINLEEPDEGCDLDFVPHTARNMD
IDVVLSNSFGFGGTNGTLAFRRFAG
>Mature_425_residues
MQSRHLKKESAVSRRRVVVTGMGMLSPLGTDVPSSWQGILAGRSGIGLIEHTDLSAYSTRFGGSVKGFNVEEYLSVKEAR
KLDLFIQYGLAAGFQAVRNAGLEVTDANRERIGVAMGSGIGGLTNIEETSRTLHETGPRRISPFFVPGSIINMISGFLSI
HLGAQGPNYAIATACTTGTHCIGMAARNIMYDEADVMIAGGAEMAACGLGMGGFGASRALSTRNDEPTRASRPWDKGRDG
FVLSDGAGALVLEELEHAKARGATIYAELIGFGTSGDAFHMTSPPADGAGAARCITNALRDAKINVDQVQYINAHGTSTP
AGDLAEANAIKSVFGDHAYKLAVSSTKSMTGHLLGAAGAVEAIFSVLAINSQVAPPTINLEEPDEGCDLDFVPHTARNMD
IDVVLSNSFGFGGTNGTLAFRRFAG

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates and may function to supply the octanoic substrates for lipoic acid biosynthes

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=419, Percent_Identity=45.1073985680191, Blast_Score=340, Evalue=2e-93,
Organism=Homo sapiens, GI223972627, Length=171, Percent_Identity=51.4619883040936, Blast_Score=162, Evalue=6e-40,
Organism=Homo sapiens, GI41872631, Length=407, Percent_Identity=24.3243243243243, Blast_Score=79, Evalue=1e-14,
Organism=Escherichia coli, GI1787337, Length=413, Percent_Identity=65.1331719128329, Blast_Score=517, Evalue=1e-148,
Organism=Escherichia coli, GI1788663, Length=415, Percent_Identity=39.5180722891566, Blast_Score=253, Evalue=2e-68,
Organism=Caenorhabditis elegans, GI71983541, Length=413, Percent_Identity=38.7409200968523, Blast_Score=279, Evalue=2e-75,
Organism=Caenorhabditis elegans, GI71983535, Length=257, Percent_Identity=43.579766536965, Blast_Score=209, Evalue=2e-54,
Organism=Caenorhabditis elegans, GI212642053, Length=359, Percent_Identity=26.1838440111421, Blast_Score=110, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI17550940, Length=422, Percent_Identity=22.9857819905213, Blast_Score=100, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6320904, Length=451, Percent_Identity=36.3636363636364, Blast_Score=266, Evalue=3e-72,
Organism=Drosophila melanogaster, GI24644341, Length=431, Percent_Identity=42.2273781902552, Blast_Score=314, Evalue=7e-86,
Organism=Drosophila melanogaster, GI221330659, Length=401, Percent_Identity=25.1870324189526, Blast_Score=103, Evalue=3e-22,
Organism=Drosophila melanogaster, GI19920632, Length=401, Percent_Identity=25.1870324189526, Blast_Score=103, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24581345, Length=406, Percent_Identity=23.1527093596059, Blast_Score=92, Evalue=6e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 44475; Mature: 44475

Theoretical pI: Translated: 6.29; Mature: 6.29

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQSRHLKKESAVSRRRVVVTGMGMLSPLGTDVPSSWQGILAGRSGIGLIEHTDLSAYSTR
CCCCCCCHHHHHHHCEEEEECCCHHCCCCCCCCCCCHHHEECCCCCCEEEECCCHHHHHH
FGGSVKGFNVEEYLSVKEARKLDLFIQYGLAAGFQAVRNAGLEVTDANRERIGVAMGSGI
CCCCCCCCCHHHHHHHHHHHHHEEHEEHHHHHHHHHHHHCCCEEECCCCCEEEEEECCCC
GGLTNIEETSRTLHETGPRRISPFFVPGSIINMISGFLSIHLGAQGPNYAIATACTTGTH
CCCCCHHHHHHHHHHCCCCCCCCEECCHHHHHHHHHHHEEEECCCCCCEEEEEEECCCCH
CIGMAARNIMYDEADVMIAGGAEMAACGLGMGGFGASRALSTRNDEPTRASRPWDKGRDG
HHHHHHHHHEECCCCEEEECCCHHHHHCCCCCCCCCHHCCCCCCCCCCCCCCCCCCCCCC
FVLSDGAGALVLEELEHAKARGATIYAELIGFGTSGDAFHMTSPPADGAGAARCITNALR
EEEECCCCHHHHHHHHHHHHCCCEEEEEHHCCCCCCCEEEECCCCCCCCHHHHHHHHHHH
DAKINVDQVQYINAHGTSTPAGDLAEANAIKSVFGDHAYKLAVSSTKSMTGHLLGAAGAV
HCCCCHHHEEEEECCCCCCCCCCHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHH
EAIFSVLAINSQVAPPTINLEEPDEGCDLDFVPHTARNMDIDVVLSNSFGFGGTNGTLAF
HHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCEEE
RRFAG
EECCC
>Mature Secondary Structure
MQSRHLKKESAVSRRRVVVTGMGMLSPLGTDVPSSWQGILAGRSGIGLIEHTDLSAYSTR
CCCCCCCHHHHHHHCEEEEECCCHHCCCCCCCCCCCHHHEECCCCCCEEEECCCHHHHHH
FGGSVKGFNVEEYLSVKEARKLDLFIQYGLAAGFQAVRNAGLEVTDANRERIGVAMGSGI
CCCCCCCCCHHHHHHHHHHHHHEEHEEHHHHHHHHHHHHCCCEEECCCCCEEEEEECCCC
GGLTNIEETSRTLHETGPRRISPFFVPGSIINMISGFLSIHLGAQGPNYAIATACTTGTH
CCCCCHHHHHHHHHHCCCCCCCCEECCHHHHHHHHHHHEEEECCCCCCEEEEEEECCCCH
CIGMAARNIMYDEADVMIAGGAEMAACGLGMGGFGASRALSTRNDEPTRASRPWDKGRDG
HHHHHHHHHEECCCCEEEECCCHHHHHCCCCCCCCCHHCCCCCCCCCCCCCCCCCCCCCC
FVLSDGAGALVLEELEHAKARGATIYAELIGFGTSGDAFHMTSPPADGAGAARCITNALR
EEEECCCCHHHHHHHHHHHHCCCEEEEEHHCCCCCCCEEEECCCCCCCCHHHHHHHHHHH
DAKINVDQVQYINAHGTSTPAGDLAEANAIKSVFGDHAYKLAVSSTKSMTGHLLGAAGAV
HCCCCHHHEEEEECCCCCCCCCCHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHH
EAIFSVLAINSQVAPPTINLEEPDEGCDLDFVPHTARNMDIDVVLSNSFGFGGTNGTLAF
HHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCEEE
RRFAG
EECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8550484 [H]