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The map label for this gene is prlC [H]

Identifier: 76819768

GI number: 76819768

Start: 185972

End: 188041

Strand: Direct

Name: prlC [H]

Synonym: BURPS1710b_A0141

Alternate gene names: 76819768

Gene position: 185972-188041 (Clockwise)

Preceding gene: 76818747

Following gene: 76817623

Centisome position: 5.84

GC content: 65.65

Gene sequence:

>2070_bases
GTGACGCAGATAACATTAGCCAATCCCCTTCTGGATCGTTCTCAATTACCCCGCTTTGAATCAATTCGCGATTTCCATGT
ACGCCCCGCCATCGACGCGCTTCTGATTGATCTCGATAACGCGATATCGCGTGCCAGCGCAAAAAATTTGTCGCCGAATT
GGGGCAATGCGATTGAGCCGGTGAGTCTCGCGCTCGAATCGCTCGACTATGCGTGGGGCGCCGTCGCGCATCTCGTATCG
GTGCGCGATTGCGCGCCGTTGCGCGCCGCGTACGGAGCGTGCGCGGGACGGGTGTCGGCGGCGCTGTCGCGCTTTCGGCA
AAACGGCGCGCTGCTCGATCGCTATCGCGCGGTTGCCGCGTCGGCGGGCTTTCGCGCCCTCTCGCCCGAGCGGCGCCAGG
TCGTGCGCAACCTGATACGCGACGCCCGGCTCGCCGGTGCCGAATTGCCGCCGGGCCCGAGAGCGCGGCTGAACGAGCTG
CGCGAGCGCATCGCGCAGCTCGCCGCCGTGTACCAGGACAACATCGCGGACGCCACCCGCGCGTTCGCGCGCATCGTGAC
GACAGACGAGGAACTCGACGGCATCCCCGACTACGCGCGCGCGGCGGCCGCCCGACGCGCGGCCGCGGGCTTCGAATTCA
CACTGGATTTCGCGTCCTACCAGCCGGTCATGCAGTTCTCGACGTGCCGCGCGTTGCGCGAGGAAATGTATCGGGCGCGC
TCGACTCGCGCGTCGGAATTCGACGCGGCGGGCGCGAACGACGCCGCGCGGCGGGACAACGCGCCCGTCATGGCGGAAAT
TCTGAAACTGCGGCGCGAGCAAGCCGCGCTGCTCGGCTATCGCGATTTCGCCCAGATGTCGCTCGAGCACAAGATGGCGC
GCACCCCGGCGCGCGCGCGCGCGTTTCTCGAGCGCCTTCATCGGCGAGTGAGCCCGAAGGCGAGCCTCGAGTGGCAGGCG
CTGCAATCGTTCGCGCGCGCCGAGCTGGGCCTCGCCGACGTGCAGCCGTGGGACATCGCGTTCGTCGCCGAGCGCATGCG
CGAGCGGTGCTTCGGGGTTTCGACGCAGGACGTTCGCCGCTATTTCCCCGAACACGCGGTGCTGCGCGGGCTATTCGCGC
TCGTCGAAACGCTGTTCGACATCCGGATCCGCGCCGACGAAGGCAGCGTGTGGCATCAGGACGTGCGCCGATACCGGCTC
GAGACCCTGCGCGGCGAACCCGTCGCGCATCTCTACCTCGATCTGTATGCGCGCGACGGAAAACGCGAAGGCGCGTGGGC
GGCGAGCGGCCGCTCGCGCGGCACCGGCGCCGACGGCGCGATACGCACCCCCGTCGCCTATCTGATGTGCAACGTGGCCG
CGCCCGCCGCCGGCATGCCCGCGTGCTTCGCGTTCGATCAGGTCGTGACGCTGTTCCATGAAATGGGCCACTGTCTCCAT
CATATGCTGACCGGCGTGGCCGAAAGCGCGATATCCGGCACGAACGGCATCGAATGGGATGCAATCGAATTTCCGTCGCA
ATTCATGGAGCACTTCTGCTGGGATCCGGAGGTCGTTTCCACGCTCAGCGCCCATGTCGACACCGGCGAGCCATTACCGG
ACGCGATGTTCGAGCGCATGCTCGCGGCGCGTCATTTCAACCAGGGCATTGAAATGGCCCATCAGATCGCGCTGTCGATG
CTCGATATCGCTTTGCATTCCGGCGAATCAATAGAATCAGTCAATTCAATGCAAAACACGATGCATGAAATTTATCAAAA
ATATGAATTTACGCCGCTAGATCGGCGGGCGCGAAGCGCGAACACATTCAGCCACATCTTCTCCGGCGGTTATGCGGCGG
CCTATTACAGCTATCAATGGGCGCAGGTGCTCGCGGCCGATGCGTATGCGGCCGTCGAGGAAGCCCGCGCCGAGCACGCG
GACGCGGGCAAGCGCGAAGCCGGCATGCGCTATCGGAAGGAAGTGCTCGAGCCGGGCGGCAGCCGGCCCGCGCTCGATTC
GTTCGTCGCCTTCCGTGGCCGCGCGCCGAGCCTCGACGCGCTGCTGCGGCACTGCCGGATAGACCGCTAG

Upstream 100 bases:

>100_bases
AGTAACTGCAAGAACTAATAGGTAAAGCAACGTATCGCACTCCTTGCGTCTTCATACAATCATCGCTATCGTTCAGTGAC
ATTGAAAGAGGAGCGGATTC

Downstream 100 bases:

>100_bases
CCGCCGCCCGCCCGGAGTTCGCCGCCGGTGCGTCGTCTCCGGCGTCTGTAGCGGCGAGCGGCCCGGCGAGCGTGAAAGCC
CGCTGCGGCCGCTGCCGCCG

Product: oligopeptidase A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 689; Mature: 688

Protein sequence:

>689_residues
MTQITLANPLLDRSQLPRFESIRDFHVRPAIDALLIDLDNAISRASAKNLSPNWGNAIEPVSLALESLDYAWGAVAHLVS
VRDCAPLRAAYGACAGRVSAALSRFRQNGALLDRYRAVAASAGFRALSPERRQVVRNLIRDARLAGAELPPGPRARLNEL
RERIAQLAAVYQDNIADATRAFARIVTTDEELDGIPDYARAAAARRAAAGFEFTLDFASYQPVMQFSTCRALREEMYRAR
STRASEFDAAGANDAARRDNAPVMAEILKLRREQAALLGYRDFAQMSLEHKMARTPARARAFLERLHRRVSPKASLEWQA
LQSFARAELGLADVQPWDIAFVAERMRERCFGVSTQDVRRYFPEHAVLRGLFALVETLFDIRIRADEGSVWHQDVRRYRL
ETLRGEPVAHLYLDLYARDGKREGAWAASGRSRGTGADGAIRTPVAYLMCNVAAPAAGMPACFAFDQVVTLFHEMGHCLH
HMLTGVAESAISGTNGIEWDAIEFPSQFMEHFCWDPEVVSTLSAHVDTGEPLPDAMFERMLAARHFNQGIEMAHQIALSM
LDIALHSGESIESVNSMQNTMHEIYQKYEFTPLDRRARSANTFSHIFSGGYAAAYYSYQWAQVLAADAYAAVEEARAEHA
DAGKREAGMRYRKEVLEPGGSRPALDSFVAFRGRAPSLDALLRHCRIDR

Sequences:

>Translated_689_residues
MTQITLANPLLDRSQLPRFESIRDFHVRPAIDALLIDLDNAISRASAKNLSPNWGNAIEPVSLALESLDYAWGAVAHLVS
VRDCAPLRAAYGACAGRVSAALSRFRQNGALLDRYRAVAASAGFRALSPERRQVVRNLIRDARLAGAELPPGPRARLNEL
RERIAQLAAVYQDNIADATRAFARIVTTDEELDGIPDYARAAAARRAAAGFEFTLDFASYQPVMQFSTCRALREEMYRAR
STRASEFDAAGANDAARRDNAPVMAEILKLRREQAALLGYRDFAQMSLEHKMARTPARARAFLERLHRRVSPKASLEWQA
LQSFARAELGLADVQPWDIAFVAERMRERCFGVSTQDVRRYFPEHAVLRGLFALVETLFDIRIRADEGSVWHQDVRRYRL
ETLRGEPVAHLYLDLYARDGKREGAWAASGRSRGTGADGAIRTPVAYLMCNVAAPAAGMPACFAFDQVVTLFHEMGHCLH
HMLTGVAESAISGTNGIEWDAIEFPSQFMEHFCWDPEVVSTLSAHVDTGEPLPDAMFERMLAARHFNQGIEMAHQIALSM
LDIALHSGESIESVNSMQNTMHEIYQKYEFTPLDRRARSANTFSHIFSGGYAAAYYSYQWAQVLAADAYAAVEEARAEHA
DAGKREAGMRYRKEVLEPGGSRPALDSFVAFRGRAPSLDALLRHCRIDR
>Mature_688_residues
TQITLANPLLDRSQLPRFESIRDFHVRPAIDALLIDLDNAISRASAKNLSPNWGNAIEPVSLALESLDYAWGAVAHLVSV
RDCAPLRAAYGACAGRVSAALSRFRQNGALLDRYRAVAASAGFRALSPERRQVVRNLIRDARLAGAELPPGPRARLNELR
ERIAQLAAVYQDNIADATRAFARIVTTDEELDGIPDYARAAAARRAAAGFEFTLDFASYQPVMQFSTCRALREEMYRARS
TRASEFDAAGANDAARRDNAPVMAEILKLRREQAALLGYRDFAQMSLEHKMARTPARARAFLERLHRRVSPKASLEWQAL
QSFARAELGLADVQPWDIAFVAERMRERCFGVSTQDVRRYFPEHAVLRGLFALVETLFDIRIRADEGSVWHQDVRRYRLE
TLRGEPVAHLYLDLYARDGKREGAWAASGRSRGTGADGAIRTPVAYLMCNVAAPAAGMPACFAFDQVVTLFHEMGHCLHH
MLTGVAESAISGTNGIEWDAIEFPSQFMEHFCWDPEVVSTLSAHVDTGEPLPDAMFERMLAARHFNQGIEMAHQIALSML
DIALHSGESIESVNSMQNTMHEIYQKYEFTPLDRRARSANTFSHIFSGGYAAAYYSYQWAQVLAADAYAAVEEARAEHAD
AGKREAGMRYRKEVLEPGGSRPALDSFVAFRGRAPSLDALLRHCRIDR

Specific function: May play a specific role in the degradation of signal peptides after they are released from precursor forms of secreted proteins. Can cleave N-acetyl-L-Ala(4) [H]

COG id: COG0339

COG function: function code E; Zn-dependent oligopeptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M3 family [H]

Homologues:

Organism=Homo sapiens, GI4507491, Length=566, Percent_Identity=28.4452296819788, Blast_Score=237, Evalue=3e-62,
Organism=Homo sapiens, GI14149738, Length=608, Percent_Identity=27.1381578947368, Blast_Score=229, Evalue=7e-60,
Organism=Homo sapiens, GI156105687, Length=420, Percent_Identity=27.6190476190476, Blast_Score=161, Evalue=2e-39,
Organism=Escherichia coli, GI1789913, Length=687, Percent_Identity=39.7379912663755, Blast_Score=500, Evalue=1e-142,
Organism=Escherichia coli, GI1787819, Length=694, Percent_Identity=29.5389048991354, Blast_Score=252, Evalue=6e-68,
Organism=Caenorhabditis elegans, GI71999758, Length=492, Percent_Identity=24.1869918699187, Blast_Score=114, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI32565901, Length=432, Percent_Identity=21.9907407407407, Blast_Score=82, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6319793, Length=674, Percent_Identity=25.6676557863501, Blast_Score=238, Evalue=3e-63,
Organism=Saccharomyces cerevisiae, GI6322715, Length=575, Percent_Identity=24.1739130434783, Blast_Score=137, Evalue=5e-33,
Organism=Drosophila melanogaster, GI21356111, Length=572, Percent_Identity=28.1468531468531, Blast_Score=231, Evalue=1e-60,
Organism=Drosophila melanogaster, GI20129717, Length=425, Percent_Identity=27.7647058823529, Blast_Score=164, Evalue=2e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001567 [H]

Pfam domain/function: PF01432 Peptidase_M3 [H]

EC number: =3.4.24.70 [H]

Molecular weight: Translated: 76766; Mature: 76635

Theoretical pI: Translated: 7.32; Mature: 7.32

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQITLANPLLDRSQLPRFESIRDFHVRPAIDALLIDLDNAISRASAKNLSPNWGNAIEP
CCEEECCCCHHCHHCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHH
VSLALESLDYAWGAVAHLVSVRDCAPLRAAYGACAGRVSAALSRFRQNGALLDRYRAVAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
SAGFRALSPERRQVVRNLIRDARLAGAELPPGPRARLNELRERIAQLAAVYQDNIADATR
HCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
AFARIVTTDEELDGIPDYARAAAARRAAAGFEFTLDFASYQPVMQFSTCRALREEMYRAR
HHHHHHCCCHHHCCCCHHHHHHHHHHHHCCCEEEEEHHHCCHHHHHHHHHHHHHHHHHHH
STRASEFDAAGANDAARRDNAPVMAEILKLRREQAALLGYRDFAQMSLEHKMARTPARAR
HCCCCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHH
AFLERLHRRVSPKASLEWQALQSFARAELGLADVQPWDIAFVAERMRERCFGVSTQDVRR
HHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHH
YFPEHAVLRGLFALVETLFDIRIRADEGSVWHQDVRRYRLETLRGEPVAHLYLDLYARDG
HCCHHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCC
KREGAWAASGRSRGTGADGAIRTPVAYLMCNVAAPAAGMPACFAFDQVVTLFHEMGHCLH
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHH
HMLTGVAESAISGTNGIEWDAIEFPSQFMEHFCWDPEVVSTLSAHVDTGEPLPDAMFERM
HHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCHHHHHHHH
LAARHFNQGIEMAHQIALSMLDIALHSGESIESVNSMQNTMHEIYQKYEFTPLDRRARSA
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
NTFSHIFSGGYAAAYYSYQWAQVLAADAYAAVEEARAEHADAGKREAGMRYRKEVLEPGG
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCC
SRPALDSFVAFRGRAPSLDALLRHCRIDR
CCCHHHHHHHHCCCCCCHHHHHHHHCCCC
>Mature Secondary Structure 
TQITLANPLLDRSQLPRFESIRDFHVRPAIDALLIDLDNAISRASAKNLSPNWGNAIEP
CEEECCCCHHCHHCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHH
VSLALESLDYAWGAVAHLVSVRDCAPLRAAYGACAGRVSAALSRFRQNGALLDRYRAVAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
SAGFRALSPERRQVVRNLIRDARLAGAELPPGPRARLNELRERIAQLAAVYQDNIADATR
HCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
AFARIVTTDEELDGIPDYARAAAARRAAAGFEFTLDFASYQPVMQFSTCRALREEMYRAR
HHHHHHCCCHHHCCCCHHHHHHHHHHHHCCCEEEEEHHHCCHHHHHHHHHHHHHHHHHHH
STRASEFDAAGANDAARRDNAPVMAEILKLRREQAALLGYRDFAQMSLEHKMARTPARAR
HCCCCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHH
AFLERLHRRVSPKASLEWQALQSFARAELGLADVQPWDIAFVAERMRERCFGVSTQDVRR
HHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHH
YFPEHAVLRGLFALVETLFDIRIRADEGSVWHQDVRRYRLETLRGEPVAHLYLDLYARDG
HCCHHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCC
KREGAWAASGRSRGTGADGAIRTPVAYLMCNVAAPAAGMPACFAFDQVVTLFHEMGHCLH
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHH
HMLTGVAESAISGTNGIEWDAIEFPSQFMEHFCWDPEVVSTLSAHVDTGEPLPDAMFERM
HHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCHHHHHHHH
LAARHFNQGIEMAHQIALSMLDIALHSGESIESVNSMQNTMHEIYQKYEFTPLDRRARSA
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
NTFSHIFSGGYAAAYYSYQWAQVLAADAYAAVEEARAEHADAGKREAGMRYRKEVLEPGG
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCC
SRPALDSFVAFRGRAPSLDALLRHCRIDR
CCCHHHHHHHHCCCCCCHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]