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The map label for this gene is hipA [H]

Identifier: 76819740

GI number: 76819740

Start: 834824

End: 836692

Strand: Direct

Name: hipA [H]

Synonym: BURPS1710b_A0635

Alternate gene names: 76819740

Gene position: 834824-836692 (Clockwise)

Preceding gene: 76817713

Following gene: 76819176

Centisome position: 26.24

GC content: 70.52

Gene sequence:

>1869_bases
ATGCCCCGCTCATCCGAAATACAGATTCAACCTTGTAAATTCTATTTACAGTGTATAAACTGTTTTTCTCGCATACAGGC
GAAAATTTGTATTCCAACCAGGTGCGCACATGGCCATCCTCATCGAGCACGAGATCAAGACACTCGGCCAGCTGCGGCCG
ATTCTGCGCGGCTTCCGCAAATCGGCCGGATTGACGCAGGCGATACTCGCGAGCCGCCTCGGCGTCACGCAGCAGACCTA
CGCGCAGTTCGAGGCGAACCCGGCGTCGGCGAGCGTCGAGCGGCTGTTCAAGGTGCTGCGCGCGCTCGACATCGAACTCA
CGCTCACGCTCACGCAGGTCTACGCCGCGCCCGCGGGCAAGGACAAGGGCGAGGTTGCGAAGACGGCCGCAGGCGCGCGC
GCGCGCGCGGGCGCGCGACGTGCCGTGCCGCCCGCGTCCGCGCCCGCTCCGAGCGCCGCCGGGCGCGCGCCCCGCCCCGC
CCGCAAGCGCGCCGCCCCGAAAAAGCGGGAGGACTGGTGAGCGCCCGCCGCGCACGCGCGACGCGCCTGCACCTGTGGAT
GAACGGCCTGCCCGTCGGCTACTGGGAGCACGCGCGCGACGGCGAGCGCCTTGTCTACTTCGACGAATGGATCGGCGATC
CGCAAGGCCGGCCGCTGTCGCTGTCGCTGCCGTTCACGCCGGGCAACCAGCCGTATCGCGGTCGGCTCGTCAGCGATTAT
TTCGACAACCTGCTGCCCGACAGCGAGCCGATCCGCCGGCGAATCGCGATGCGCTACCGCACGGGCGGCACGTCCGCGTT
CGCGCTGCTCGCGACGCTCGGCCGCGATTGCGTCGGCGCGCTGCAGATGCTGCCGCCCGACGAAGCGCCGGACGACATCG
AACGCATCCGCGGCCACGCGCTCGCCGACGCGGACATCGCGCGCCTGCTGCGCGAAGTCACGTCCGCGCCGCAGGCCGGC
CGGCACGCGCCGCTCGACGATCTGCGCCTGTCGATCGCCGGCGCGCAGGAGAAGACCGCGCTGCTGCGCCATCGCGGCCG
CTGGCTGCTGCCCGAAGGGAGCACGCCGACCACGCACATCCTGAAGCTGCCGCTCGGGCTCGTCGGCAACCGGCGCGCCG
ACATGCGCACGTCGGTCGAGAACGAATGGCTGTGCGCGCGGATCGTCGCCGCGTACGGGTTGCCCGTCGCGCGCTGCGAC
ATCGCTCAGTTCGACGATCAGAAAGCGCTCGTCGTCGAGCGCTTCGACCGCCGGCCGTCGCGCGACGCACGCTGGCTCCT
GCGGCTGCCGCAGGAAGACATGTGCCAGGCAACCGGCACGTCCGCGCTCGACAAATATCAGGCCGACGGCGGCCCCGGCA
TCGAGACGATCATGGAAGTGCTCGCCGGCTCCGAGCACGCGCGGGACGACCGCCGCGCGTTCTTCGCGGCGCAGATCGTG
TTCTGGCTGCTCGCCGCGACCGACGGCCACGCGAAGAACTTCAGCATCGCGCACCTGCCCGGCAACCGCTACCGTTCGAC
GCCGCTTTACGACGTGCTGTCCGCGCATCCGGTCATCGGCCGGGGCGCGAACCAGTTGCCCGCGCAGCGCGCGCGGCTCG
CGATGGGCGTGCGCGGCAAGCACATCCACTATCCGCTGCACCAGATCCGGCGGCGGCACTGGATCGCGCAGGGCCAGCGC
GTCGGCTTCGCGCCCGCCGACGTCGACGCGCTGATCGACACGCTGACCGCGCGCACCGCGGGCGTCGTCGACGCGGTGTC
GGCGCGGCTGCCGCGCGATTTTCCGCGCGACGTCGCCGATGCGATCTTCAGCGGAATGCTCGGCCTGAGCGCAAGGCTCG
CCGGCGACGCGGCCGCGCGCGCACCATGA

Upstream 100 bases:

>100_bases
CGATTCCAACGTCGGCAAGCGCCGCGAGCCGCGACAAAACGACTCGCCGCATGATTGGCCGCCGGCCGCACGCGACACGC
CCGCGCACCCAAAGAACAGC

Downstream 100 bases:

>100_bases
CGGGATGGCGCGGCCGCCGCCGCGCGCCGCGCCGTGCAATCGGCACGCAATCGCCGCTCAATCGCCGCACTCGGCCGGCA
TCGCCGGGCGGGCGCCGCAG

Product: hipA protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 622; Mature: 621

Protein sequence:

>622_residues
MPRSSEIQIQPCKFYLQCINCFSRIQAKICIPTRCAHGHPHRARDQDTRPAAADSARLPQIGRIDAGDTREPPRRHAADL
RAVRGEPGVGERRAAVQGAARARHRTHAHAHAGLRRARGQGQGRGCEDGRRRARARGRATCRAARVRARSERRRARAPPR
PQARRPEKAGGLVSARRARATRLHLWMNGLPVGYWEHARDGERLVYFDEWIGDPQGRPLSLSLPFTPGNQPYRGRLVSDY
FDNLLPDSEPIRRRIAMRYRTGGTSAFALLATLGRDCVGALQMLPPDEAPDDIERIRGHALADADIARLLREVTSAPQAG
RHAPLDDLRLSIAGAQEKTALLRHRGRWLLPEGSTPTTHILKLPLGLVGNRRADMRTSVENEWLCARIVAAYGLPVARCD
IAQFDDQKALVVERFDRRPSRDARWLLRLPQEDMCQATGTSALDKYQADGGPGIETIMEVLAGSEHARDDRRAFFAAQIV
FWLLAATDGHAKNFSIAHLPGNRYRSTPLYDVLSAHPVIGRGANQLPAQRARLAMGVRGKHIHYPLHQIRRRHWIAQGQR
VGFAPADVDALIDTLTARTAGVVDAVSARLPRDFPRDVADAIFSGMLGLSARLAGDAAARAP

Sequences:

>Translated_622_residues
MPRSSEIQIQPCKFYLQCINCFSRIQAKICIPTRCAHGHPHRARDQDTRPAAADSARLPQIGRIDAGDTREPPRRHAADL
RAVRGEPGVGERRAAVQGAARARHRTHAHAHAGLRRARGQGQGRGCEDGRRRARARGRATCRAARVRARSERRRARAPPR
PQARRPEKAGGLVSARRARATRLHLWMNGLPVGYWEHARDGERLVYFDEWIGDPQGRPLSLSLPFTPGNQPYRGRLVSDY
FDNLLPDSEPIRRRIAMRYRTGGTSAFALLATLGRDCVGALQMLPPDEAPDDIERIRGHALADADIARLLREVTSAPQAG
RHAPLDDLRLSIAGAQEKTALLRHRGRWLLPEGSTPTTHILKLPLGLVGNRRADMRTSVENEWLCARIVAAYGLPVARCD
IAQFDDQKALVVERFDRRPSRDARWLLRLPQEDMCQATGTSALDKYQADGGPGIETIMEVLAGSEHARDDRRAFFAAQIV
FWLLAATDGHAKNFSIAHLPGNRYRSTPLYDVLSAHPVIGRGANQLPAQRARLAMGVRGKHIHYPLHQIRRRHWIAQGQR
VGFAPADVDALIDTLTARTAGVVDAVSARLPRDFPRDVADAIFSGMLGLSARLAGDAAARAP
>Mature_621_residues
PRSSEIQIQPCKFYLQCINCFSRIQAKICIPTRCAHGHPHRARDQDTRPAAADSARLPQIGRIDAGDTREPPRRHAADLR
AVRGEPGVGERRAAVQGAARARHRTHAHAHAGLRRARGQGQGRGCEDGRRRARARGRATCRAARVRARSERRRARAPPRP
QARRPEKAGGLVSARRARATRLHLWMNGLPVGYWEHARDGERLVYFDEWIGDPQGRPLSLSLPFTPGNQPYRGRLVSDYF
DNLLPDSEPIRRRIAMRYRTGGTSAFALLATLGRDCVGALQMLPPDEAPDDIERIRGHALADADIARLLREVTSAPQAGR
HAPLDDLRLSIAGAQEKTALLRHRGRWLLPEGSTPTTHILKLPLGLVGNRRADMRTSVENEWLCARIVAAYGLPVARCDI
AQFDDQKALVVERFDRRPSRDARWLLRLPQEDMCQATGTSALDKYQADGGPGIETIMEVLAGSEHARDDRRAFFAAQIVF
WLLAATDGHAKNFSIAHLPGNRYRSTPLYDVLSAHPVIGRGANQLPAQRARLAMGVRGKHIHYPLHQIRRRHWIAQGQRV
GFAPADVDALIDTLTARTAGVVDAVSARLPRDFPRDVADAIFSGMLGLSARLAGDAAARAP

Specific function: Unbalanced or excessive expression of hipA is toxic to the cell [H]

COG id: COG3550

COG function: function code R; Uncharacterized protein related to capsule biosynthesis enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: To H.influenzae HI_0665 [H]

Homologues:

Organism=Escherichia coli, GI1787785, Length=443, Percent_Identity=39.5033860045147, Blast_Score=297, Evalue=2e-81,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012893
- InterPro:   IPR012894
- InterPro:   IPR017508 [H]

Pfam domain/function: PF07804 HipA_C; PF07805 HipA_N [H]

EC number: NA

Molecular weight: Translated: 68896; Mature: 68765

Theoretical pI: Translated: 11.43; Mature: 11.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPRSSEIQIQPCKFYLQCINCFSRIQAKICIPTRCAHGHPHRARDQDTRPAAADSARLPQ
CCCCCCEEEHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
IGRIDAGDTREPPRRHAADLRAVRGEPGVGERRAAVQGAARARHRTHAHAHAGLRRARGQ
CCCCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GQGRGCEDGRRRARARGRATCRAARVRARSERRRARAPPRPQARRPEKAGGLVSARRARA
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHCCHHHHHHHHH
TRLHLWMNGLPVGYWEHARDGERLVYFDEWIGDPQGRPLSLSLPFTPGNQPYRGRLVSDY
HEEEEEECCCCCCCHHCCCCCCEEEEEHHHCCCCCCCEEEEECCCCCCCCCCCCCCHHHH
FDNLLPDSEPIRRRIAMRYRTGGTSAFALLATLGRDCVGALQMLPPDEAPDDIERIRGHA
HHHHCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCC
LADADIARLLREVTSAPQAGRHAPLDDLRLSIAGAQEKTALLRHRGRWLLPEGSTPTTHI
CCHHHHHHHHHHHHCCCCCCCCCCHHHHHEEECCCHHHHHHHHHCCCEECCCCCCCCHHH
LKLPLGLVGNRRADMRTSVENEWLCARIVAAYGLPVARCDIAQFDDQKALVVERFDRRPS
HHCCHHHCCCCCHHHHHCCCCHHHHHHHHHHHCCCHHCCHHHHCCCCHHHHHHHHCCCCC
RDARWLLRLPQEDMCQATGTSALDKYQADGGPGIETIMEVLAGSEHARDDRRAFFAAQIV
CCHHHHHCCCHHHHHHHCCCHHHHHHCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHH
FWLLAATDGHAKNFSIAHLPGNRYRSTPLYDVLSAHPVIGRGANQLPAQRARLAMGVRGK
HHHHHCCCCCCCCEEEEECCCCCCCCCCHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCC
HIHYPLHQIRRRHWIAQGQRVGFAPADVDALIDTLTARTAGVVDAVSARLPRDFPRDVAD
EEECCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
AIFSGMLGLSARLAGDAAARAP
HHHHHHHHHHHHHCCCHHCCCC
>Mature Secondary Structure 
PRSSEIQIQPCKFYLQCINCFSRIQAKICIPTRCAHGHPHRARDQDTRPAAADSARLPQ
CCCCCEEEHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
IGRIDAGDTREPPRRHAADLRAVRGEPGVGERRAAVQGAARARHRTHAHAHAGLRRARGQ
CCCCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GQGRGCEDGRRRARARGRATCRAARVRARSERRRARAPPRPQARRPEKAGGLVSARRARA
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHCCHHHHHHHHH
TRLHLWMNGLPVGYWEHARDGERLVYFDEWIGDPQGRPLSLSLPFTPGNQPYRGRLVSDY
HEEEEEECCCCCCCHHCCCCCCEEEEEHHHCCCCCCCEEEEECCCCCCCCCCCCCCHHHH
FDNLLPDSEPIRRRIAMRYRTGGTSAFALLATLGRDCVGALQMLPPDEAPDDIERIRGHA
HHHHCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCC
LADADIARLLREVTSAPQAGRHAPLDDLRLSIAGAQEKTALLRHRGRWLLPEGSTPTTHI
CCHHHHHHHHHHHHCCCCCCCCCCHHHHHEEECCCHHHHHHHHHCCCEECCCCCCCCHHH
LKLPLGLVGNRRADMRTSVENEWLCARIVAAYGLPVARCDIAQFDDQKALVVERFDRRPS
HHCCHHHCCCCCHHHHHCCCCHHHHHHHHHHHCCCHHCCHHHHCCCCHHHHHHHHCCCCC
RDARWLLRLPQEDMCQATGTSALDKYQADGGPGIETIMEVLAGSEHARDDRRAFFAAQIV
CCHHHHHCCCHHHHHHHCCCHHHHHHCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHH
FWLLAATDGHAKNFSIAHLPGNRYRSTPLYDVLSAHPVIGRGANQLPAQRARLAMGVRGK
HHHHHCCCCCCCCEEEEECCCCCCCCCCHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCC
HIHYPLHQIRRRHWIAQGQRVGFAPADVDALIDTLTARTAGVVDAVSARLPRDFPRDVAD
EEECCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
AIFSGMLGLSARLAGDAAARAP
HHHHHHHHHHHHHCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1715862; 9278503; 8021189 [H]