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The map label for this gene is zitB [H]

Identifier: 76818934

GI number: 76818934

Start: 1362417

End: 1363685

Strand: Direct

Name: zitB [H]

Synonym: BURPS1710b_A1090

Alternate gene names: 76818934

Gene position: 1362417-1363685 (Clockwise)

Preceding gene: 76819300

Following gene: 76818008

Centisome position: 42.82

GC content: 66.67

Gene sequence:

>1269_bases
ATGAGCGAATTCGAAAACGTCGCGTTCGGCGCGGGGCACGACCATGTCTTCCTCGGCGCGGCGCACGGGCAGAACGAACG
CCGGACCTGGACCGTCATCGCGCTGTGCACGGCGATGATGGTCGCGGAGATCGTCGGCGGCACGCTGTTCGGCTCGCTCG
CGCTCGTCGCGGACGGCCTGCACATGTCGACTCACGCGGGCGCGATGCTGATCGCGGCGCTCGCGTACACGTATGCACGC
CGGCACGCGAGCGATGCGCGCTTCGTGTTCGGCACGGGCAAGCTCGGCGACTTGGCCGGCTTCACGAGCGCGATCGTGCT
CGCGATGATCGCGCTACTCATCGCGTACGAAGCGATCGCACGATTCCTGTCGCCCGTTCCGATCCACTTCGACGAAGCGA
TCCCGATCGCCGTGCTCGGCCTGCTCGTGAACCTGGCGAGCGTGTGGCTGCTGAGCGGCGATCATCACGGCCACGGCCAT
CATCATGGGCACGCCGCCCATCATGCACACGGCGATGAAGCGCAGACGATTTCGACAGGCGCGGGCGTCTTCGCCGTATC
GATCTTCGAGGACGGCGTGCCGCCGGTATTCCGGATCTCACCCGCGGCAAAACAGGCATGCATCGCCGGCGCGCGAGCGA
CGATCACGACGATCCGCGCCGACGGATCGCATCAGACGTTCGACATGGCCGAGCGCGGCGACCGGCTGGAATCGATCGAT
GCGATCCCCGAGCCGCACGCGTTCACCGCGATCGTGCGATTGCACGGCTCCGAGCACTCGCTGACGTTCGTCGAGCACGA
ACACGCGCATCACCATGGGCATGGCGGCTCGAAGGACGTCACGGCGCGCGATCACAACATCCGGTCCGCGTATATTCACG
TCATCGCGGACGCAGCCGTCTCGGTGCTCGCGATCGTCGGGCTCGTGCTCGCGCGTGCGTTCGGCTGGATGTGGATGGAC
CCGCTCGCGGGCATCGTCGGCGCGCTCGTGATCGCGAACTGGTCGTACGGCCTGATGCGCGATACGAGCCGCATCCTCCT
CGACGTCAGTCCGGACACCCGCCTCGCCGACAATGTGCGCCGCTCGATCGAAAGCGGCGGAGATCGCGTCACCGATCTGC
ATGTATGGCGTCTGGGCCCCGGCCACATGAGCGCCGTCGTGTCCGTCGCGACGGGCGATCCGGCGCGCGACTCGCGCTTC
TACCACCAGTTGTTGAAGCGCTTCACGAGTTTGTCGCACGTGACCGTGGAAGTGCACTGCCGCGCCTGA

Upstream 100 bases:

>100_bases
GCACCTCGTCGATGCGGACACGGGCGACAATCACGAAGGCAGCGCGTCCGAACAGTTGATCGACGTCGTCCACAGCTATT
TCAGGTAAGCGGAGCGAGCG

Downstream 100 bases:

>100_bases
CGCGAAAGTAAAACGGCTGCCGTCGGCGACGGCTGCCGCACCGAGCCGAAGCGGCATCCGTCGCGGCAAGCACGCGCCGC
GAACACGCCCGCGCACCGCA

Product: putative cation efflux related membrane protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 422; Mature: 421

Protein sequence:

>422_residues
MSEFENVAFGAGHDHVFLGAAHGQNERRTWTVIALCTAMMVAEIVGGTLFGSLALVADGLHMSTHAGAMLIAALAYTYAR
RHASDARFVFGTGKLGDLAGFTSAIVLAMIALLIAYEAIARFLSPVPIHFDEAIPIAVLGLLVNLASVWLLSGDHHGHGH
HHGHAAHHAHGDEAQTISTGAGVFAVSIFEDGVPPVFRISPAAKQACIAGARATITTIRADGSHQTFDMAERGDRLESID
AIPEPHAFTAIVRLHGSEHSLTFVEHEHAHHHGHGGSKDVTARDHNIRSAYIHVIADAAVSVLAIVGLVLARAFGWMWMD
PLAGIVGALVIANWSYGLMRDTSRILLDVSPDTRLADNVRRSIESGGDRVTDLHVWRLGPGHMSAVVSVATGDPARDSRF
YHQLLKRFTSLSHVTVEVHCRA

Sequences:

>Translated_422_residues
MSEFENVAFGAGHDHVFLGAAHGQNERRTWTVIALCTAMMVAEIVGGTLFGSLALVADGLHMSTHAGAMLIAALAYTYAR
RHASDARFVFGTGKLGDLAGFTSAIVLAMIALLIAYEAIARFLSPVPIHFDEAIPIAVLGLLVNLASVWLLSGDHHGHGH
HHGHAAHHAHGDEAQTISTGAGVFAVSIFEDGVPPVFRISPAAKQACIAGARATITTIRADGSHQTFDMAERGDRLESID
AIPEPHAFTAIVRLHGSEHSLTFVEHEHAHHHGHGGSKDVTARDHNIRSAYIHVIADAAVSVLAIVGLVLARAFGWMWMD
PLAGIVGALVIANWSYGLMRDTSRILLDVSPDTRLADNVRRSIESGGDRVTDLHVWRLGPGHMSAVVSVATGDPARDSRF
YHQLLKRFTSLSHVTVEVHCRA
>Mature_421_residues
SEFENVAFGAGHDHVFLGAAHGQNERRTWTVIALCTAMMVAEIVGGTLFGSLALVADGLHMSTHAGAMLIAALAYTYARR
HASDARFVFGTGKLGDLAGFTSAIVLAMIALLIAYEAIARFLSPVPIHFDEAIPIAVLGLLVNLASVWLLSGDHHGHGHH
HGHAAHHAHGDEAQTISTGAGVFAVSIFEDGVPPVFRISPAAKQACIAGARATITTIRADGSHQTFDMAERGDRLESIDA
IPEPHAFTAIVRLHGSEHSLTFVEHEHAHHHGHGGSKDVTARDHNIRSAYIHVIADAAVSVLAIVGLVLARAFGWMWMDP
LAGIVGALVIANWSYGLMRDTSRILLDVSPDTRLADNVRRSIESGGDRVTDLHVWRLGPGHMSAVVSVATGDPARDSRFY
HQLLKRFTSLSHVTVEVHCRA

Specific function: Involved in zinc efflux across the cytoplasmic membrane, thus reducing zinc accumulation in the cytoplasm and rendering bacteria more resistant to zinc. It may contribute to zinc homeostasis at low concentrations of zinc [H]

COG id: COG1230

COG function: function code P; Co/Zn/Cd efflux system component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily [H]

Homologues:

Organism=Homo sapiens, GI52352803, Length=425, Percent_Identity=23.2941176470588, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI20070323, Length=139, Percent_Identity=30.2158273381295, Blast_Score=70, Evalue=4e-12,
Organism=Escherichia coli, GI1786966, Length=152, Percent_Identity=42.7631578947368, Blast_Score=89, Evalue=7e-19,
Organism=Caenorhabditis elegans, GI32564488, Length=129, Percent_Identity=31.7829457364341, Blast_Score=68, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6323899, Length=361, Percent_Identity=25.4847645429363, Blast_Score=88, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6320411, Length=117, Percent_Identity=32.4786324786325, Blast_Score=67, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002524 [H]

Pfam domain/function: PF01545 Cation_efflux [H]

EC number: NA

Molecular weight: Translated: 45207; Mature: 45076

Theoretical pI: Translated: 6.88; Mature: 6.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEFENVAFGAGHDHVFLGAAHGQNERRTWTVIALCTAMMVAEIVGGTLFGSLALVADGL
CCCCCCCEECCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
HMSTHAGAMLIAALAYTYARRHASDARFVFGTGKLGDLAGFTSAIVLAMIALLIAYEAIA
CCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHH
RFLSPVPIHFDEAIPIAVLGLLVNLASVWLLSGDHHGHGHHHGHAAHHAHGDEAQTISTG
HHHCCCCCCCCCCHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCCCCCCCCCEEECC
AGVFAVSIFEDGVPPVFRISPAAKQACIAGARATITTIRADGSHQTFDMAERGDRLESID
CCEEEEEEECCCCCCEEEECHHHHHHHHHCCCEEEEEEEECCCCCCCCHHHHCCHHHHHC
AIPEPHAFTAIVRLHGSEHSLTFVEHEHAHHHGHGGSKDVTARDHNIRSAYIHVIADAAV
CCCCCCCEEEEEEEECCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHH
SVLAIVGLVLARAFGWMWMDPLAGIVGALVIANWSYGLMRDTSRILLDVSPDTRLADNVR
HHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCHHHCCCCEEEEECCCCCHHHHHHH
RSIESGGDRVTDLHVWRLGPGHMSAVVSVATGDPARDSRFYHQLLKRFTSLSHVTVEVHC
HHHHCCCCEEEEEEEEEECCCHHHHEEEEECCCCCCHHHHHHHHHHHHCCCCEEEEEEEE
RA
CC
>Mature Secondary Structure 
SEFENVAFGAGHDHVFLGAAHGQNERRTWTVIALCTAMMVAEIVGGTLFGSLALVADGL
CCCCCCEECCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
HMSTHAGAMLIAALAYTYARRHASDARFVFGTGKLGDLAGFTSAIVLAMIALLIAYEAIA
CCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHH
RFLSPVPIHFDEAIPIAVLGLLVNLASVWLLSGDHHGHGHHHGHAAHHAHGDEAQTISTG
HHHCCCCCCCCCCHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCCCCCCCCCEEECC
AGVFAVSIFEDGVPPVFRISPAAKQACIAGARATITTIRADGSHQTFDMAERGDRLESID
CCEEEEEEECCCCCCEEEECHHHHHHHHHCCCEEEEEEEECCCCCCCCHHHHCCHHHHHC
AIPEPHAFTAIVRLHGSEHSLTFVEHEHAHHHGHGGSKDVTARDHNIRSAYIHVIADAAV
CCCCCCCEEEEEEEECCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHH
SVLAIVGLVLARAFGWMWMDPLAGIVGALVIANWSYGLMRDTSRILLDVSPDTRLADNVR
HHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCHHHCCCCEEEEECCCCCHHHHHHH
RSIESGGDRVTDLHVWRLGPGHMSAVVSVATGDPARDSRFYHQLLKRFTSLSHVTVEVHC
HHHHCCCCEEEEEEEEEECCCHHHHEEEEECCCCCCHHHHHHHHHHHHCCCCEEEEEEEE
RA
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]