Click here to switch to the map view.

The map label for this gene is ygbJ [H]

Identifier: 76818839

GI number: 76818839

Start: 607519

End: 608328

Strand: Direct

Name: ygbJ [H]

Synonym: BURPS1710b_A0438

Alternate gene names: 76818839

Gene position: 607519-608328 (Clockwise)

Preceding gene: 76819678

Following gene: 76817602

Centisome position: 19.09

GC content: 72.96

Gene sequence:

>810_bases
GTGCACGCATGCGACGTGCGCGAGGACGTGCTCGCCGCCTTCGCCGCCGAAGGCGGCGTGCGCTGCGCGACGCCCGCCGA
GCTGGGCGCGCTGTGCGGCGTCGTGGTCACGCTCGTCGTCAACGCGCAGCAGACGGACGCGGTGCTGTTCGGCGAGCAAG
GCGCCGCGGCCGCGATGCCGCGCGGCGGCGTCGTGATCTCGAGCGCGACGGTCGCGCCGGACTTCGCCGCGCAACTCGGC
GCGCGGCTCGCGGCGGCCGGCCTGCTGATGCTCGACGCGCCCGTGTCCGGCGGCGCCGCGCGCGCCGCCTCCGGCGAGAT
GACGATGATGACTTCCGGCCCCGCCGCCGCGTACGAAGCCTGCGGCGACGTGCTCGCCGCGATCGCGGGCAAGGTCTACC
GGCTCGGCGATGCGCACGGCGCGGGCTCGAAGGTGAAGATCATCAATCAGTTGCTGGCCGGCGTGCACATCGCGGCGGCG
GCCGAGGCGATGGCGCTCGGCTTGCGCGAAGGCGTCGACCCCGACGCGCTGTACGACGTGATCACGCACAGCGCCGGCAA
TTCGTGGATGTTCGAGAACCGCGTGCCGCACATCCTGAACGGCGACTACACGCCGCTGTCGGCGGTCGACATCTTCGTGA
AGGATCTCGGCCTCGTGCTCGACACCGCGCGCCGCAGCCAATTCCCGCTGCCGCTGTCGGCGACCGCGCACCAGATGTTC
ATGAGCGCGTCGAGCGCGGGCCACGGCGGCGAGGACGACTCGGCCGTCATCAAGACGTTCCCCGGCATCGCGCTGCCGGC
GCGCCGCTGA

Upstream 100 bases:

>100_bases
ACCGCGAACAAGGTTGACCATGTCACGCAATGTTGGAGTCATCGGGCTGGGTGCGATGGGCCTGGGGGTCGCGCGCTCGC
TGCTGCGCGCGGGCTTTCGT

Downstream 100 bases:

>100_bases
TTCACCGGAGTTGCCTGCCTCCATGAGCACCGATCAAGCCCTTCGCCCCCTGCTCGGCTGCATCGCCGACGATTTCACCG
GCGCGACCGATCTCGCGAAC

Product: 6-phosphogluconate dehydrogenase

Products: 2-hydroxy-3-oxopropanoate; NADH; NADPH; H+

Alternate protein names: NA

Number of amino acids: Translated: 269; Mature: 269

Protein sequence:

>269_residues
MHACDVREDVLAAFAAEGGVRCATPAELGALCGVVVTLVVNAQQTDAVLFGEQGAAAAMPRGGVVISSATVAPDFAAQLG
ARLAAAGLLMLDAPVSGGAARAASGEMTMMTSGPAAAYEACGDVLAAIAGKVYRLGDAHGAGSKVKIINQLLAGVHIAAA
AEAMALGLREGVDPDALYDVITHSAGNSWMFENRVPHILNGDYTPLSAVDIFVKDLGLVLDTARRSQFPLPLSATAHQMF
MSASSAGHGGEDDSAVIKTFPGIALPARR

Sequences:

>Translated_269_residues
MHACDVREDVLAAFAAEGGVRCATPAELGALCGVVVTLVVNAQQTDAVLFGEQGAAAAMPRGGVVISSATVAPDFAAQLG
ARLAAAGLLMLDAPVSGGAARAASGEMTMMTSGPAAAYEACGDVLAAIAGKVYRLGDAHGAGSKVKIINQLLAGVHIAAA
AEAMALGLREGVDPDALYDVITHSAGNSWMFENRVPHILNGDYTPLSAVDIFVKDLGLVLDTARRSQFPLPLSATAHQMF
MSASSAGHGGEDDSAVIKTFPGIALPARR
>Mature_269_residues
MHACDVREDVLAAFAAEGGVRCATPAELGALCGVVVTLVVNAQQTDAVLFGEQGAAAAMPRGGVVISSATVAPDFAAQLG
ARLAAAGLLMLDAPVSGGAARAASGEMTMMTSGPAAAYEACGDVLAAIAGKVYRLGDAHGAGSKVKIINQLLAGVHIAAA
AEAMALGLREGVDPDALYDVITHSAGNSWMFENRVPHILNGDYTPLSAVDIFVKDLGLVLDTARRSQFPLPLSATAHQMF
MSASSAGHGGEDDSAVIKTFPGIALPARR

Specific function: Unknown

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI23308751, Length=261, Percent_Identity=29.1187739463602, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI40556376, Length=247, Percent_Identity=24.2914979757085, Blast_Score=90, Evalue=2e-18,
Organism=Escherichia coli, GI1789092, Length=261, Percent_Identity=58.2375478927203, Blast_Score=261, Evalue=5e-71,
Organism=Escherichia coli, GI145693186, Length=252, Percent_Identity=31.3492063492063, Blast_Score=132, Evalue=2e-32,
Organism=Escherichia coli, GI1790315, Length=259, Percent_Identity=28.5714285714286, Blast_Score=107, Evalue=6e-25,
Organism=Escherichia coli, GI1786719, Length=241, Percent_Identity=26.1410788381743, Blast_Score=98, Evalue=7e-22,
Organism=Caenorhabditis elegans, GI17557316, Length=244, Percent_Identity=29.0983606557377, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24655230, Length=263, Percent_Identity=30.4182509505703, Blast_Score=124, Evalue=6e-29,
Organism=Drosophila melanogaster, GI19922568, Length=263, Percent_Identity=30.4182509505703, Blast_Score=124, Evalue=6e-29,
Organism=Drosophila melanogaster, GI28574115, Length=250, Percent_Identity=24, Blast_Score=84, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: 1.1.1.60

Molecular weight: Translated: 27250; Mature: 27250

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHACDVREDVLAAFAAEGGVRCATPAELGALCGVVVTLVVNAQQTDAVLFGEQGAAAAMP
CCCCHHHHHHHHHHHHCCCCEECCHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCC
RGGVVISSATVAPDFAAQLGARLAAAGLLMLDAPVSGGAARAASGEMTMMTSGPAAAYEA
CCCEEEECCCCCCHHHHHHHHHHHHHCEEEEECCCCCCCCCCCCCCEEEEECCCHHHHHH
CGDVLAAIAGKVYRLGDAHGAGSKVKIINQLLAGVHIAAAAEAMALGLREGVDPDALYDV
HHHHHHHHHHHHEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
ITHSAGNSWMFENRVPHILNGDYTPLSAVDIFVKDLGLVLDTARRSQFPLPLSATAHQMF
HHHCCCCCEEECCCCCHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
MSASSAGHGGEDDSAVIKTFPGIALPARR
HHHCCCCCCCCCCCHHHHHCCCCCCCCCC
>Mature Secondary Structure
MHACDVREDVLAAFAAEGGVRCATPAELGALCGVVVTLVVNAQQTDAVLFGEQGAAAAMP
CCCCHHHHHHHHHHHHCCCCEECCHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCC
RGGVVISSATVAPDFAAQLGARLAAAGLLMLDAPVSGGAARAASGEMTMMTSGPAAAYEA
CCCEEEECCCCCCHHHHHHHHHHHHHCEEEEECCCCCCCCCCCCCCEEEEECCCHHHHHH
CGDVLAAIAGKVYRLGDAHGAGSKVKIINQLLAGVHIAAAAEAMALGLREGVDPDALYDV
HHHHHHHHHHHHEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
ITHSAGNSWMFENRVPHILNGDYTPLSAVDIFVKDLGLVLDTARRSQFPLPLSATAHQMF
HHHCCCCCEEECCCCCHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
MSASSAGHGGEDDSAVIKTFPGIALPARR
HHHCCCCCCCCCCCHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (R)-glycerate; NAD+; NADP+

Specific reaction: (R)-glycerate + NAD(P)+ = 2-hydroxy-3-oxopropanoate + NAD(P)H + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9278503 [H]