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The map label for this gene is pcaK [H]

Identifier: 76818192

GI number: 76818192

Start: 1886048

End: 1887403

Strand: Direct

Name: pcaK [H]

Synonym: BURPS1710b_A1558

Alternate gene names: 76818192

Gene position: 1886048-1887403 (Clockwise)

Preceding gene: 76819074

Following gene: 76818408

Centisome position: 59.28

GC content: 69.1

Gene sequence:

>1356_bases
ATGACCGATCTCGCGCGCCAGCTCGATGTGCAGCAGTTCATCGACGAACGGCGCTTTTCGCCCTATCAGTGGCTGATTCT
GATCCTGTGTTTTCTGATCGTCGCGGCGGACGGCTTCGACACCGCCGCGATCGGTTTCGTCGCGCCCGCGCTCGCCCAGC
AATGGCACGTGACGAAGGCCGCGCTGGGGCCGGTGATGAGCGCGGCGCTCGTCGGCCTCGCGCTCGGCGCGCTCGCGGCG
GGCCCGCTTGCCGACCGGATCGGCCGCAAGCGCGTGCTGGTGGGCTCGGTCGTGCTGTTCGGACTCTTCAGCATCGGCTG
CGCTTTCACGCAGTCGGTCACCGAGCTCGCGGTGCTGCGGCTGCTGACGGGGCTCGGGCTGGGCGCGGCGATGCCGAACG
CGACGACGCTGATGGCCGAGTATGCGCCGCACGCGAAACGCTCGTTTCTCGTCAACACGATGTTCTGCGGCTTTACGCTG
GGCTCGTCCGCGGGCGGCCTCGTCGCCGCCGCGCTGATTCCCGAGCACGGGTGGCGCAGCGTGTTCATCGTCGGCGGTAT
CGCGCCGCTTGCGCTCGGCGCGCTGCTGATCGCGCTGCCCGAATCGATCCGCTTCATGGTGCTGCGCGGCGCGCCGCACG
AGCGCATCGCCGCGGTGTTGCGCAGGATCGCGCCCGATGCGGCGTTCGACGGCGTGCGCTTCGTGCTGCACGACGATCGC
GGCGAGCAACGGCGCTCGGGCGCGGCCGTCGTGTTGTCGCCGCGCTATCGTGCGGGCACCGCGATGCTGTGGCTCACCTA
TTTCATGGGGCTGCTCGTCTACTATCTGATGACGAGCTGGCTGCCCACGCTGATTCGCGACACGGGATTCACCGTGCGCG
ACGCGGCGCTCGTCACCGCGCTGTTTCCGCTCGGCGGCGGCATCGGCGCGATTGCTTGCGGCTGGCTGATGGACCGCATC
GAGCCGCATCGCGTGATTGCGTTTACCTATGCGCTGACGGCGTTGTTCGTCTGGATGATCGGACTGCAGGCTGGGCACCT
CGCGTTGCTGGCGACCGTCGTGTTCGTCGCGGGCGTTTGCATGAACGGCGCGCAGTCGTCGCTGCCGGCGCTCGCGGCGG
CGTTCTATCCGACGAGCGGGCGCGCGACGGGCGTCGCATGGATGCTCGGCGTCGGGCGCTTTGGCGGCATTCTGGGCGCG
TTTTCGGGCGGCTTGCTGCTGCAGGCGCAGCTGGGATTCGGCACGATTTTCTCGATGCTCGCGGTGCCGGCGCTGATTGC
GGCGGGTGCGCTGATGGTCAAGCGTTCGGCGGCGTCGCGCGAGACGCAGCCGGATGCGCCGACACGAGCGGCGTGA

Upstream 100 bases:

>100_bases
CGGCGCGCCGGACGGCCGCCGCCCGTGCGCGACGACACGCGCCGGCATCGCATCGGCGCAGGACGCGAATGCGTCGACGA
CAACCCCAACGGAGACAGCA

Downstream 100 bases:

>100_bases
TCGGCGTGGTCGGCGGCGCGGGAATGCGCCGTCGCGGCGGCTGACGGGGCGCTCCGTTCAGGCCCCGTCATTCCTCGGCG
TCGTGGACTTTCGCGAAGTG

Product: 4-hydroxybenzoate transporter

Products: Proton [Cytoplasm]; 3-(3-hydroxyphenyl)propionate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 451; Mature: 450

Protein sequence:

>451_residues
MTDLARQLDVQQFIDERRFSPYQWLILILCFLIVAADGFDTAAIGFVAPALAQQWHVTKAALGPVMSAALVGLALGALAA
GPLADRIGRKRVLVGSVVLFGLFSIGCAFTQSVTELAVLRLLTGLGLGAAMPNATTLMAEYAPHAKRSFLVNTMFCGFTL
GSSAGGLVAAALIPEHGWRSVFIVGGIAPLALGALLIALPESIRFMVLRGAPHERIAAVLRRIAPDAAFDGVRFVLHDDR
GEQRRSGAAVVLSPRYRAGTAMLWLTYFMGLLVYYLMTSWLPTLIRDTGFTVRDAALVTALFPLGGGIGAIACGWLMDRI
EPHRVIAFTYALTALFVWMIGLQAGHLALLATVVFVAGVCMNGAQSSLPALAAAFYPTSGRATGVAWMLGVGRFGGILGA
FSGGLLLQAQLGFGTIFSMLAVPALIAAGALMVKRSAASRETQPDAPTRAA

Sequences:

>Translated_451_residues
MTDLARQLDVQQFIDERRFSPYQWLILILCFLIVAADGFDTAAIGFVAPALAQQWHVTKAALGPVMSAALVGLALGALAA
GPLADRIGRKRVLVGSVVLFGLFSIGCAFTQSVTELAVLRLLTGLGLGAAMPNATTLMAEYAPHAKRSFLVNTMFCGFTL
GSSAGGLVAAALIPEHGWRSVFIVGGIAPLALGALLIALPESIRFMVLRGAPHERIAAVLRRIAPDAAFDGVRFVLHDDR
GEQRRSGAAVVLSPRYRAGTAMLWLTYFMGLLVYYLMTSWLPTLIRDTGFTVRDAALVTALFPLGGGIGAIACGWLMDRI
EPHRVIAFTYALTALFVWMIGLQAGHLALLATVVFVAGVCMNGAQSSLPALAAAFYPTSGRATGVAWMLGVGRFGGILGA
FSGGLLLQAQLGFGTIFSMLAVPALIAAGALMVKRSAASRETQPDAPTRAA
>Mature_450_residues
TDLARQLDVQQFIDERRFSPYQWLILILCFLIVAADGFDTAAIGFVAPALAQQWHVTKAALGPVMSAALVGLALGALAAG
PLADRIGRKRVLVGSVVLFGLFSIGCAFTQSVTELAVLRLLTGLGLGAAMPNATTLMAEYAPHAKRSFLVNTMFCGFTLG
SSAGGLVAAALIPEHGWRSVFIVGGIAPLALGALLIALPESIRFMVLRGAPHERIAAVLRRIAPDAAFDGVRFVLHDDRG
EQRRSGAAVVLSPRYRAGTAMLWLTYFMGLLVYYLMTSWLPTLIRDTGFTVRDAALVTALFPLGGGIGAIACGWLMDRIE
PHRVIAFTYALTALFVWMIGLQAGHLALLATVVFVAGVCMNGAQSSLPALAAAFYPTSGRATGVAWMLGVGRFGGILGAF
SGGLLLQAQLGFGTIFSMLAVPALIAAGALMVKRSAASRETQPDAPTRAA

Specific function: Transporter for 4-hydroxybenzoate. Also required for chemotaxis to aromatic acids [H]

COG id: COG0477

COG function: function code GEPR; Permeases of the major facilitator superfamily

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family [H]

Homologues:

Organism=Homo sapiens, GI24308167, Length=431, Percent_Identity=24.8259860788863, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI7662270, Length=330, Percent_Identity=23.6363636363636, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI216548223, Length=329, Percent_Identity=24.9240121580547, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI166064021, Length=363, Percent_Identity=25.6198347107438, Blast_Score=70, Evalue=4e-12,
Organism=Homo sapiens, GI73695465, Length=330, Percent_Identity=23.6363636363636, Blast_Score=70, Evalue=5e-12,
Organism=Homo sapiens, GI8923870, Length=405, Percent_Identity=23.2098765432099, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI213021148, Length=442, Percent_Identity=23.7556561085973, Blast_Score=67, Evalue=3e-11,
Organism=Homo sapiens, GI262399383, Length=263, Percent_Identity=24.3346007604563, Blast_Score=66, Evalue=8e-11,
Organism=Escherichia coli, GI87081723, Length=433, Percent_Identity=36.9515011547344, Blast_Score=174, Evalue=8e-45,
Organism=Escherichia coli, GI87082231, Length=438, Percent_Identity=24.4292237442922, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI87082159, Length=397, Percent_Identity=25.9445843828715, Blast_Score=84, Evalue=3e-17,
Organism=Escherichia coli, GI1786229, Length=369, Percent_Identity=23.0352303523035, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1789152, Length=418, Percent_Identity=21.7703349282297, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1789207, Length=276, Percent_Identity=26.8115942028986, Blast_Score=68, Evalue=2e-12,
Organism=Escherichia coli, GI87082404, Length=395, Percent_Identity=21.2658227848101, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1789515, Length=326, Percent_Identity=22.6993865030675, Blast_Score=64, Evalue=3e-11,
Organism=Escherichia coli, GI1790463, Length=255, Percent_Identity=26.2745098039216, Blast_Score=62, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI32564663, Length=458, Percent_Identity=23.7991266375546, Blast_Score=101, Evalue=7e-22,
Organism=Caenorhabditis elegans, GI71991859, Length=361, Percent_Identity=23.5457063711911, Blast_Score=68, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71991854, Length=361, Percent_Identity=22.9916897506925, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6320595, Length=179, Percent_Identity=29.0502793296089, Blast_Score=64, Evalue=7e-11,
Organism=Drosophila melanogaster, GI24640198, Length=450, Percent_Identity=23.1111111111111, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24640196, Length=450, Percent_Identity=23.1111111111111, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24640200, Length=450, Percent_Identity=23.1111111111111, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI19922874, Length=266, Percent_Identity=27.4436090225564, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24656861, Length=457, Percent_Identity=24.945295404814, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24656866, Length=457, Percent_Identity=24.945295404814, Blast_Score=69, Evalue=5e-12,
Organism=Drosophila melanogaster, GI45550478, Length=457, Percent_Identity=24.945295404814, Blast_Score=69, Evalue=5e-12,
Organism=Drosophila melanogaster, GI28573097, Length=519, Percent_Identity=22.3506743737958, Blast_Score=66, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004746
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR005829 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 47489; Mature: 47358

Theoretical pI: Translated: 10.00; Mature: 10.00

Prosite motif: PS50850 MFS ; PS00216 SUGAR_TRANSPORT_1 ; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDLARQLDVQQFIDERRFSPYQWLILILCFLIVAADGFDTAAIGFVAPALAQQWHVTKA
CCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
ALGPVMSAALVGLALGALAAGPLADRIGRKRVLVGSVVLFGLFSIGCAFTQSVTELAVLR
HHHHHHHHHHHHHHHHHHHCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLTGLGLGAAMPNATTLMAEYAPHAKRSFLVNTMFCGFTLGSSAGGLVAAALIPEHGWRS
HHHHCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCCCCE
VFIVGGIAPLALGALLIALPESIRFMVLRGAPHERIAAVLRRIAPDAAFDGVRFVLHDDR
EEEECCHHHHHHHHHHHHCCHHHEEEEEECCCHHHHHHHHHHHCCCCCCCCEEEEEECCC
GEQRRSGAAVVLSPRYRAGTAMLWLTYFMGLLVYYLMTSWLPTLIRDTGFTVRDAALVTA
CCHHHCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
LFPLGGGIGAIACGWLMDRIEPHRVIAFTYALTALFVWMIGLQAGHLALLATVVFVAGVC
HHHCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
MNGAQSSLPALAAAFYPTSGRATGVAWMLGVGRFGGILGAFSGGLLLQAQLGFGTIFSML
HCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHH
AVPALIAAGALMVKRSAASRETQPDAPTRAA
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
TDLARQLDVQQFIDERRFSPYQWLILILCFLIVAADGFDTAAIGFVAPALAQQWHVTKA
CCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
ALGPVMSAALVGLALGALAAGPLADRIGRKRVLVGSVVLFGLFSIGCAFTQSVTELAVLR
HHHHHHHHHHHHHHHHHHHCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLTGLGLGAAMPNATTLMAEYAPHAKRSFLVNTMFCGFTLGSSAGGLVAAALIPEHGWRS
HHHHCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCCCCE
VFIVGGIAPLALGALLIALPESIRFMVLRGAPHERIAAVLRRIAPDAAFDGVRFVLHDDR
EEEECCHHHHHHHHHHHHCCHHHEEEEEECCCHHHHHHHHHHHCCCCCCCCEEEEEECCC
GEQRRSGAAVVLSPRYRAGTAMLWLTYFMGLLVYYLMTSWLPTLIRDTGFTVRDAALVTA
CCHHHCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
LFPLGGGIGAIACGWLMDRIEPHRVIAFTYALTALFVWMIGLQAGHLALLATVVFVAGVC
HHHCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
MNGAQSSLPALAAAFYPTSGRATGVAWMLGVGRFGGILGAFSGGLLLQAQLGFGTIFSML
HCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHH
AVPALIAAGALMVKRSAASRETQPDAPTRAA
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; 3-(3-hydroxyphenyl)propionate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + 3-(3-hydroxyphenyl)propionate [Periplasm] = Proton [Cytoplasm] + 3-(3-hydroxyphenyl)propionate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7961399 [H]