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The map label for this gene is yhcA [H]

Identifier: 76818025

GI number: 76818025

Start: 941911

End: 943326

Strand: Direct

Name: yhcA [H]

Synonym: BURPS1710b_A0707

Alternate gene names: 76818025

Gene position: 941911-943326 (Clockwise)

Preceding gene: 76817309

Following gene: 76819472

Centisome position: 29.6

GC content: 71.82

Gene sequence:

>1416_bases
ATGTCACCGTTGGCCGCCATGTCCGCTCGCTCACGCATCGCCGCTGTCTATCTGCTCGGCTTCTCGATCGACCTCGCGAA
CATGTTCGCGATCAACGCCGCGTATCCGGCGCTGCAGCGCGCGCTGCACGCGTCGGTCGCGCAGCTCGCGTGGGTCGGCA
ACGTCTACATGCTCGGGCTCACGGTCGTGATTCCGCTCGGCGCTTGGCTTGCGCACCGGTTCGGCGAGCGCAGGCTGCTC
ACGGCGTCGCTGCTCGTGTTCGCGCTCGGCAGCGCCGGCGCGGCGAGCGCGCCGTCGATCGGCGCGCTGCTCGCGTCGCG
GCTCGTGCAGGGGCTCGGCGGCGGTTTGCTGATTCCCGTCGGCCAGGCGATGACCTATCGCGCCTATCCGCGCGAAGCGC
GCGCCCGCCTCACGTCGATCGTGATGATGGTCGCGCTGCTCGTTCCCGCGGCCTCGCCCGCGCTCGGCGGCGTGATCGTC
GACCATGCATCGTGGCGCGTGGTGTTCTGGAGCATGCTCGCGCTCGCCGCGTCGACGTGCACGCTCGCGCTCGCATGGCT
GCCCGCCGACGTCGCGCGCGACGCGCCTCGCACGCTCGACGCGGCGGGCCTCGGCCTGAGCGCGGCCGCGCTCGTCGCGT
TGCTGCTCGGCCTCGCGTTCGCGAGCCGGCGCGGCGCGGGCGCGCCGGCGATCGCGATGCTCGCGCTCGCATGCACCGCC
GGCGTCGCGTATGTCCGGCACGCGCGCCGCTCGAGCGCGCCATTGCTCGATCTCGCGCTGCTCTCGCAGCCGCTCCTGCG
TGTCGGCGTCGTTATTTATCTGTGCGTGCCCGGCATTTTCACCGGCGTGAATCTGATCGCGTCGCTCTTTCTGCAAAACG
CGCTGGGGCTCGGCGCGACGCAGGTCGGCGCGCTGATGGTGCCGTGGGCCGCCGCGTCGTTCGCCGCGATCGCGACGACG
CGGCGCGCGTTCCCCGCGGTCGGCGCGCGGCCGCTGCTCGCATGCGGCGTTGTAGTCGACTGCATCGGCATCGCGCTGCT
CGCGACGCCGCTCGCGGCGCACGAGGCAGGCCGCGTGCTCGCCTACGTCGCGATGGGTTTCGGCGCGAGCCTCTGCACGA
GCACGTCGCAAACCGCCGCGTTTCTCGATGTGCCCGCCGACCGGATGGGCGAAGCGAGCGCGCTATGGAACATCAATCGC
CAATTGAGCTTCTGCCTGGGCGTCGCCGTGCTCGGCGGCATGCTCAATTTCCTGCTGGCAGCCGGCGGCGGCGACGCGCC
GCTCGCGTATCGCCGCTGCTTCGCGTTCGGCGCGCTGCTGACCCTGCTGCCGCTGCCGCTCGTCGCACGGCTCGGCTCGC
GTCGCGCCGCGGTCTCGCCGGCCGTTTCCGTGGACGCCCAATCGAATCGAACATGA

Upstream 100 bases:

>100_bases
AACTCACCATCGCGCCCTCGATTGTCAAAATTTTTCGATCAGTCTATCCGGGCAATCGGGCTGACGGCCCCGGATCGCGG
ACTTTACACTACGTCGCCCG

Downstream 100 bases:

>100_bases
ACGAACCGAACCCGTATTTTCAGGAAGTCGTCGACGCGCACGTCGACATCGAACGATGGCTGTCAGGCCGTGCCGAACAC
GGCCTGCTGCCCGCGTTGCT

Product: EmrB/QacA family drug resistance transporter

Products: Proton [Cytoplasm]; drug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 471; Mature: 470

Protein sequence:

>471_residues
MSPLAAMSARSRIAAVYLLGFSIDLANMFAINAAYPALQRALHASVAQLAWVGNVYMLGLTVVIPLGAWLAHRFGERRLL
TASLLVFALGSAGAASAPSIGALLASRLVQGLGGGLLIPVGQAMTYRAYPREARARLTSIVMMVALLVPAASPALGGVIV
DHASWRVVFWSMLALAASTCTLALAWLPADVARDAPRTLDAAGLGLSAAALVALLLGLAFASRRGAGAPAIAMLALACTA
GVAYVRHARRSSAPLLDLALLSQPLLRVGVVIYLCVPGIFTGVNLIASLFLQNALGLGATQVGALMVPWAAASFAAIATT
RRAFPAVGARPLLACGVVVDCIGIALLATPLAAHEAGRVLAYVAMGFGASLCTSTSQTAAFLDVPADRMGEASALWNINR
QLSFCLGVAVLGGMLNFLLAAGGGDAPLAYRRCFAFGALLTLLPLPLVARLGSRRAAVSPAVSVDAQSNRT

Sequences:

>Translated_471_residues
MSPLAAMSARSRIAAVYLLGFSIDLANMFAINAAYPALQRALHASVAQLAWVGNVYMLGLTVVIPLGAWLAHRFGERRLL
TASLLVFALGSAGAASAPSIGALLASRLVQGLGGGLLIPVGQAMTYRAYPREARARLTSIVMMVALLVPAASPALGGVIV
DHASWRVVFWSMLALAASTCTLALAWLPADVARDAPRTLDAAGLGLSAAALVALLLGLAFASRRGAGAPAIAMLALACTA
GVAYVRHARRSSAPLLDLALLSQPLLRVGVVIYLCVPGIFTGVNLIASLFLQNALGLGATQVGALMVPWAAASFAAIATT
RRAFPAVGARPLLACGVVVDCIGIALLATPLAAHEAGRVLAYVAMGFGASLCTSTSQTAAFLDVPADRMGEASALWNINR
QLSFCLGVAVLGGMLNFLLAAGGGDAPLAYRRCFAFGALLTLLPLPLVARLGSRRAAVSPAVSVDAQSNRT
>Mature_470_residues
SPLAAMSARSRIAAVYLLGFSIDLANMFAINAAYPALQRALHASVAQLAWVGNVYMLGLTVVIPLGAWLAHRFGERRLLT
ASLLVFALGSAGAASAPSIGALLASRLVQGLGGGLLIPVGQAMTYRAYPREARARLTSIVMMVALLVPAASPALGGVIVD
HASWRVVFWSMLALAASTCTLALAWLPADVARDAPRTLDAAGLGLSAAALVALLLGLAFASRRGAGAPAIAMLALACTAG
VAYVRHARRSSAPLLDLALLSQPLLRVGVVIYLCVPGIFTGVNLIASLFLQNALGLGATQVGALMVPWAAASFAAIATTR
RAFPAVGARPLLACGVVVDCIGIALLATPLAAHEAGRVLAYVAMGFGASLCTSTSQTAAFLDVPADRMGEASALWNINRQ
LSFCLGVAVLGGMLNFLLAAGGGDAPLAYRRCFAFGALLTLLPLPLVARLGSRRAAVSPAVSVDAQSNRT

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. EmrB family [H]

Homologues:

Organism=Escherichia coli, GI1790195, Length=421, Percent_Identity=27.0783847980998, Blast_Score=126, Evalue=3e-30,
Organism=Escherichia coli, GI87081983, Length=393, Percent_Identity=26.7175572519084, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI1788710, Length=390, Percent_Identity=24.8717948717949, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1788392, Length=407, Percent_Identity=25.0614250614251, Blast_Score=90, Evalue=4e-19,
Organism=Escherichia coli, GI1789042, Length=274, Percent_Identity=25.9124087591241, Blast_Score=87, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004638
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR001411 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 48239; Mature: 48108

Theoretical pI: Translated: 10.78; Mature: 10.78

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSPLAAMSARSRIAAVYLLGFSIDLANMFAINAAYPALQRALHASVAQLAWVGNVYMLGL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TVVIPLGAWLAHRFGERRLLTASLLVFALGSAGAASAPSIGALLASRLVQGLGGGLLIPV
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEC
GQAMTYRAYPREARARLTSIVMMVALLVPAASPALGGVIVDHASWRVVFWSMLALAASTC
CCCCEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHH
TLALAWLPADVARDAPRTLDAAGLGLSAAALVALLLGLAFASRRGAGAPAIAMLALACTA
HHHHHHCCHHHHCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
GVAYVRHARRSSAPLLDLALLSQPLLRVGVVIYLCVPGIFTGVNLIASLFLQNALGLGAT
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
QVGALMVPWAAASFAAIATTRRAFPAVGARPLLACGVVVDCIGIALLATPLAAHEAGRVL
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AYVAMGFGASLCTSTSQTAAFLDVPADRMGEASALWNINRQLSFCLGVAVLGGMLNFLLA
HHHHHHCCHHHHCCCCCCCEEEECCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AGGGDAPLAYRRCFAFGALLTLLPLPLVARLGSRRAAVSPAVSVDAQSNRT
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCEEECCCCCCC
>Mature Secondary Structure 
SPLAAMSARSRIAAVYLLGFSIDLANMFAINAAYPALQRALHASVAQLAWVGNVYMLGL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TVVIPLGAWLAHRFGERRLLTASLLVFALGSAGAASAPSIGALLASRLVQGLGGGLLIPV
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEC
GQAMTYRAYPREARARLTSIVMMVALLVPAASPALGGVIVDHASWRVVFWSMLALAASTC
CCCCEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHH
TLALAWLPADVARDAPRTLDAAGLGLSAAALVALLLGLAFASRRGAGAPAIAMLALACTA
HHHHHHCCHHHHCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
GVAYVRHARRSSAPLLDLALLSQPLLRVGVVIYLCVPGIFTGVNLIASLFLQNALGLGAT
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
QVGALMVPWAAASFAAIATTRRAFPAVGARPLLACGVVVDCIGIALLATPLAAHEAGRVL
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AYVAMGFGASLCTSTSQTAAFLDVPADRMGEASALWNINRQLSFCLGVAVLGGMLNFLLA
HHHHHHCCHHHHCCCCCCCEEEECCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AGGGDAPLAYRRCFAFGALLTLLPLPLVARLGSRRAAVSPAVSVDAQSNRT
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; drug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + drug [Cytoplasm] = Proton [Cytoplasm] + drug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377; 8969498 [H]