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The map label for this gene is gmd [H]

Identifier: 76817894

GI number: 76817894

Start: 1004575

End: 1005618

Strand: Direct

Name: gmd [H]

Synonym: BURPS1710b_A0758

Alternate gene names: 76817894

Gene position: 1004575-1005618 (Clockwise)

Preceding gene: 76819774

Following gene: 76817374

Centisome position: 31.57

GC content: 65.13

Gene sequence:

>1044_bases
ATGACCCAAGCACGCAAGGCGATCATCACCGGGATAACGGGCCAGGACGGCGCTTATCTGGCGAAGCTGCTGCTCGACAA
GGGCTACGAAGTCGTCGGCACGTATCGCCGCACGAGCTCGGTGAACTTCTGGCGCATCGCCGAACTGGGCGTCGACAAGC
ATCCGTGCTTGACGCTCGTCGAGCACGATCTGACCGATCTCGGCTCGAGCCTGCGCCTCGTCGAGCGCACGCAGCCGCAC
GAGCTGTACAACCTCGCCGCGCAGAGCTTCGTCGGCGTATCGTTCGACCAGCCGGCGACGACGGCCGAAGTCACCGGCCT
CGGCGCGCTGCACCTGCTCGAGGCGATCCGCGTCGTGAACCCGAAGATCCGCTATTACCAGGCGTCGACGTCGGAGATGT
TCGGCAAGGTGCAGGCGATTCCGCAAATCGAGAGCACCCCGTTCTATCCGCGCAGCCCGTACGGCGTCGCGAAGCTGTTC
GCGCACTGGACGACGCTCAACTATCGCGAGTCGTACGGCATCTTCGGCTCGAGCGGGATCCTGTTCAATCACGAATCGCC
GCTGCGCGGCCGCGAGTTCGTCACGCGCAAAATCACCGATACCGTCGCGAAGATCAAGCTCGGCAAGGCGAGCCGGCTCG
AGCTCGGCAACCTGGGCGCCAAGCGCGACTGGGGCTTCGCGCTCGAGTACGTCGAAGGGATGTGGCGCATGCTGCAGGCG
GACGAGCCCGATACCTACGTGCTCGCGACGAACCGCACCGAGACGGTCCGCGATTTCGTGCGGATGGCGTTCGCGGCGGC
CGGCTATCAGCTCGAATGGAGCGGCAAGGGCGAGGACGAGCGCGGCATCGATACGGCGACGGGCAACGTGCTCGTATCGG
TGAATCCGAAGTTCTACCGGCCCGCCGAAGTCGATCTGCTGATCGGCTGCGCGGACAAGGCGCGGGACAAGCTCGGCTGG
GTGCCGAAGACGACGCTCGAGGCGCTCTGCCGGATGATGGTGGAGGCCGACCTCACGCGCAACCGTCATCATGAGACCTT
CTGA

Upstream 100 bases:

>100_bases
AGCGGCGCCTGACGCGCGGCGCGCCGCGGCAGGCGCTCGCGGGGGCCGCGCGCGCGTCCGCATGACCCGCTTCATTCCAT
CGTTCGATTAGGAAACCGCA

Downstream 100 bases:

>100_bases
GCCCGGCGCGCGGCGCGCGCTCGTCACCGGCATCGCGGGCTTCACCGGCCGCCACCTCGCCGCGCGGCTCGAGGCGCACG
GCTACGACGTGTGGGGCACG

Product: GDP-mannose 4,6-dehydratase

Products: NA

Alternate protein names: GDP-D-mannose dehydratase [H]

Number of amino acids: Translated: 347; Mature: 346

Protein sequence:

>347_residues
MTQARKAIITGITGQDGAYLAKLLLDKGYEVVGTYRRTSSVNFWRIAELGVDKHPCLTLVEHDLTDLGSSLRLVERTQPH
ELYNLAAQSFVGVSFDQPATTAEVTGLGALHLLEAIRVVNPKIRYYQASTSEMFGKVQAIPQIESTPFYPRSPYGVAKLF
AHWTTLNYRESYGIFGSSGILFNHESPLRGREFVTRKITDTVAKIKLGKASRLELGNLGAKRDWGFALEYVEGMWRMLQA
DEPDTYVLATNRTETVRDFVRMAFAAAGYQLEWSGKGEDERGIDTATGNVLVSVNPKFYRPAEVDLLIGCADKARDKLGW
VPKTTLEALCRMMVEADLTRNRHHETF

Sequences:

>Translated_347_residues
MTQARKAIITGITGQDGAYLAKLLLDKGYEVVGTYRRTSSVNFWRIAELGVDKHPCLTLVEHDLTDLGSSLRLVERTQPH
ELYNLAAQSFVGVSFDQPATTAEVTGLGALHLLEAIRVVNPKIRYYQASTSEMFGKVQAIPQIESTPFYPRSPYGVAKLF
AHWTTLNYRESYGIFGSSGILFNHESPLRGREFVTRKITDTVAKIKLGKASRLELGNLGAKRDWGFALEYVEGMWRMLQA
DEPDTYVLATNRTETVRDFVRMAFAAAGYQLEWSGKGEDERGIDTATGNVLVSVNPKFYRPAEVDLLIGCADKARDKLGW
VPKTTLEALCRMMVEADLTRNRHHETF
>Mature_346_residues
TQARKAIITGITGQDGAYLAKLLLDKGYEVVGTYRRTSSVNFWRIAELGVDKHPCLTLVEHDLTDLGSSLRLVERTQPHE
LYNLAAQSFVGVSFDQPATTAEVTGLGALHLLEAIRVVNPKIRYYQASTSEMFGKVQAIPQIESTPFYPRSPYGVAKLFA
HWTTLNYRESYGIFGSSGILFNHESPLRGREFVTRKITDTVAKIKLGKASRLELGNLGAKRDWGFALEYVEGMWRMLQAD
EPDTYVLATNRTETVRDFVRMAFAAAGYQLEWSGKGEDERGIDTATGNVLVSVNPKFYRPAEVDLLIGCADKARDKLGWV
PKTTLEALCRMMVEADLTRNRHHETF

Specific function: Biosynthesis of the slime polysaccharide colanic acid. First of the three steps in the biosynthesis of GDP-fucose from GDP-mannose. [C]

COG id: COG1089

COG function: function code M; GDP-D-mannose dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GDP-mannose 4,6-dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI4504031, Length=340, Percent_Identity=52.3529411764706, Blast_Score=352, Evalue=4e-97,
Organism=Escherichia coli, GI1788366, Length=356, Percent_Identity=49.7191011235955, Blast_Score=348, Evalue=2e-97,
Organism=Escherichia coli, GI48994969, Length=242, Percent_Identity=25.2066115702479, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17539424, Length=344, Percent_Identity=53.4883720930233, Blast_Score=362, Evalue=1e-100,
Organism=Caenorhabditis elegans, GI133901786, Length=344, Percent_Identity=53.4883720930233, Blast_Score=362, Evalue=1e-100,
Organism=Caenorhabditis elegans, GI133901788, Length=344, Percent_Identity=53.4883720930233, Blast_Score=362, Evalue=1e-100,
Organism=Caenorhabditis elegans, GI17539422, Length=344, Percent_Identity=53.4883720930233, Blast_Score=362, Evalue=1e-100,
Organism=Caenorhabditis elegans, GI133901790, Length=344, Percent_Identity=53.4883720930233, Blast_Score=362, Evalue=1e-100,
Organism=Caenorhabditis elegans, GI17507723, Length=339, Percent_Identity=54.5722713864307, Blast_Score=360, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24158427, Length=338, Percent_Identity=52.0710059171598, Blast_Score=350, Evalue=1e-96,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR006368
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =4.2.1.47 [H]

Molecular weight: Translated: 38878; Mature: 38747

Theoretical pI: Translated: 8.07; Mature: 8.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQARKAIITGITGQDGAYLAKLLLDKGYEVVGTYRRTSSVNFWRIAELGVDKHPCLTLV
CCCCCEEEEECCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCEEEEHCCCCCCCCHHHHH
EHDLTDLGSSLRLVERTQPHELYNLAAQSFVGVSFDQPATTAEVTGLGALHLLEAIRVVN
HHHHHHHCHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCHHHCCCHHHHHHHHHHHCC
PKIRYYQASTSEMFGKVQAIPQIESTPFYPRSPYGVAKLFAHWTTLNYRESYGIFGSSGI
CCEEEEECCHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHCCCCEECCCE
LFNHESPLRGREFVTRKITDTVAKIKLGKASRLELGNLGAKRDWGFALEYVEGMWRMLQA
EECCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHC
DEPDTYVLATNRTETVRDFVRMAFAAAGYQLEWSGKGEDERGIDTATGNVLVSVNPKFYR
CCCCEEEEECCCHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCEECCCCEEEEECCCEEC
PAEVDLLIGCADKARDKLGWVPKTTLEALCRMMVEADLTRNRHHETF
CCCEEEEEECCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
TQARKAIITGITGQDGAYLAKLLLDKGYEVVGTYRRTSSVNFWRIAELGVDKHPCLTLV
CCCCEEEEECCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCEEEEHCCCCCCCCHHHHH
EHDLTDLGSSLRLVERTQPHELYNLAAQSFVGVSFDQPATTAEVTGLGALHLLEAIRVVN
HHHHHHHCHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCHHHCCCHHHHHHHHHHHCC
PKIRYYQASTSEMFGKVQAIPQIESTPFYPRSPYGVAKLFAHWTTLNYRESYGIFGSSGI
CCEEEEECCHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHCCCCEECCCE
LFNHESPLRGREFVTRKITDTVAKIKLGKASRLELGNLGAKRDWGFALEYVEGMWRMLQA
EECCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHC
DEPDTYVLATNRTETVRDFVRMAFAAAGYQLEWSGKGEDERGIDTATGNVLVSVNPKFYR
CCCCEEEEECCCHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCEECCCCEEEEECCCEEC
PAEVDLLIGCADKARDKLGWVPKTTLEALCRMMVEADLTRNRHHETF
CCCEEEEEECCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10065558 [H]