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The map label for this gene is rmd [H]

Identifier: 76817374

GI number: 76817374

Start: 1005605

End: 1006573

Strand: Direct

Name: rmd [H]

Synonym: BURPS1710b_A0759

Alternate gene names: 76817374

Gene position: 1005605-1006573 (Clockwise)

Preceding gene: 76817894

Following gene: 76817348

Centisome position: 31.61

GC content: 71.72

Gene sequence:

>969_bases
ATGAGACCTTCTGAGCCCGGCGCGCGGCGCGCGCTCGTCACCGGCATCGCGGGCTTCACCGGCCGCCACCTCGCCGCGCG
GCTCGAGGCGCACGGCTACGACGTGTGGGGCACGGTCGCGCCCGGGACCGACGTGCTCGGCGATCCGCTGCTGCGGCGCT
GGCGCTGCGTGAAGGCGGATCTGCTCGACGTCGACTCGCTGCATGCGGCGGTCGCCGACGCACGCCCGCACGCGGTCGTG
CATCTGGCCGCGCGCGCGCACGTCGCGCACGGCAATCCGCAGGACACCTACCTCGTCAACGTGGTCGGCACGCGCAACCT
GCTCGCGTCGCTCGCCGGCCTCGACGCGCGCCCGCACGCCGTGCTGCTCGCGAGCAGCGCGAACGTCTACGGCAACGCAT
CGACCGAGGTGCTCGACGAATCGGCGCCGCCGCAGCCCGCGAACGACTACGCGGTCAGCAAGCTCGCGATGGAATACATG
GCGAAGCTCTGGCTCGACCGGCTGCCGATCGTGATCGCGCGCCCGTTCAACTACACGGGCGTCGGCCAGAGCGAAGCGTA
TCTGCTGCCCAAGCTCGTCGCGCACTACGCGCGCGGCGAGCCGCGGATCGCGCTCGGCAATCTCGACGTGAGCCGCGATT
TCTCCGACGTGCGCGACGTCGTCGACGCCTACGCGCGGCTCATCGATGCCGCGCCCGTGGGCGAGACGTTCAACGTGTGC
GCGGAGCGCGGCTATGCGTTGAAGGAAGTGCTGGCGATGCTCGCGCGGATCGCGGGCTACGTGATCGACGTGAGCGTCGA
TCCGCGCTTCGTGCGCGCGAGCGAGGTGAAGAAGCTGGTGGGCTCGCGGCGCAAGCTGCGCGCGGCGATCGGCGACGCAC
GCCGCACGCCGCTCGACGAAACGCTGCGCTGGATGTACGGCGACATGCGCGCGGCGCTCGGCGCGCGCGAGGATCAGCCG
GCGAGCTGA

Upstream 100 bases:

>100_bases
GCGGACAAGGCGCGGGACAAGCTCGGCTGGGTGCCGAAGACGACGCTCGAGGCGCTCTGCCGGATGATGGTGGAGGCCGA
CCTCACGCGCAACCGTCATC

Downstream 100 bases:

>100_bases
GCGTCGATGCTCTTCGCGAGCGGCGACGGCGTGTCGCCCGTGTGCAGCGTCGTGACGGTCTCGATCAGCGCGATCCCGCA
CTCCGCTTCGGCAACGGGGT

Product: oxidoreductase Rmd

Products: NA

Alternate protein names: UDP-glucuronic acid epimerase [H]

Number of amino acids: Translated: 322; Mature: 322

Protein sequence:

>322_residues
MRPSEPGARRALVTGIAGFTGRHLAARLEAHGYDVWGTVAPGTDVLGDPLLRRWRCVKADLLDVDSLHAAVADARPHAVV
HLAARAHVAHGNPQDTYLVNVVGTRNLLASLAGLDARPHAVLLASSANVYGNASTEVLDESAPPQPANDYAVSKLAMEYM
AKLWLDRLPIVIARPFNYTGVGQSEAYLLPKLVAHYARGEPRIALGNLDVSRDFSDVRDVVDAYARLIDAAPVGETFNVC
AERGYALKEVLAMLARIAGYVIDVSVDPRFVRASEVKKLVGSRRKLRAAIGDARRTPLDETLRWMYGDMRAALGAREDQP
AS

Sequences:

>Translated_322_residues
MRPSEPGARRALVTGIAGFTGRHLAARLEAHGYDVWGTVAPGTDVLGDPLLRRWRCVKADLLDVDSLHAAVADARPHAVV
HLAARAHVAHGNPQDTYLVNVVGTRNLLASLAGLDARPHAVLLASSANVYGNASTEVLDESAPPQPANDYAVSKLAMEYM
AKLWLDRLPIVIARPFNYTGVGQSEAYLLPKLVAHYARGEPRIALGNLDVSRDFSDVRDVVDAYARLIDAAPVGETFNVC
AERGYALKEVLAMLARIAGYVIDVSVDPRFVRASEVKKLVGSRRKLRAAIGDARRTPLDETLRWMYGDMRAALGAREDQP
AS
>Mature_322_residues
MRPSEPGARRALVTGIAGFTGRHLAARLEAHGYDVWGTVAPGTDVLGDPLLRRWRCVKADLLDVDSLHAAVADARPHAVV
HLAARAHVAHGNPQDTYLVNVVGTRNLLASLAGLDARPHAVLLASSANVYGNASTEVLDESAPPQPANDYAVSKLAMEYM
AKLWLDRLPIVIARPFNYTGVGQSEAYLLPKLVAHYARGEPRIALGNLDVSRDFSDVRDVVDAYARLIDAAPVGETFNVC
AERGYALKEVLAMLARIAGYVIDVSVDPRFVRASEVKKLVGSRRKLRAAIGDARRTPLDETLRWMYGDMRAALGAREDQP
AS

Specific function: Biosynthesis of the slime polysaccharide colanic acid. First of the three steps in the biosynthesis of GDP-fucose from GDP-mannose. [C]

COG id: COG0451

COG function: function code MG; Nucleoside-diphosphate-sugar epimerases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family [H]

Homologues:

Organism=Homo sapiens, GI7657641, Length=247, Percent_Identity=27.5303643724696, Blast_Score=87, Evalue=2e-17,
Organism=Escherichia coli, GI1788366, Length=356, Percent_Identity=25, Blast_Score=75, Evalue=6e-15,
Organism=Escherichia coli, GI48994969, Length=253, Percent_Identity=27.6679841897233, Blast_Score=65, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17539422, Length=333, Percent_Identity=25.8258258258258, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI133901788, Length=333, Percent_Identity=25.8258258258258, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI133901786, Length=333, Percent_Identity=25.8258258258258, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17539424, Length=333, Percent_Identity=25.8258258258258, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI133901790, Length=333, Percent_Identity=25.8258258258258, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17507723, Length=333, Percent_Identity=24.3243243243243, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17568069, Length=267, Percent_Identity=25.8426966292135, Blast_Score=68, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR016040
- InterPro:   IPR008089 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =5.1.3.12 [H]

Molecular weight: Translated: 34886; Mature: 34886

Theoretical pI: Translated: 8.61; Mature: 8.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRPSEPGARRALVTGIAGFTGRHLAARLEAHGYDVWGTVAPGTDVLGDPLLRRWRCVKAD
CCCCCCCHHHHHHHHHHCCCHHHHHHHHHHCCCEEEEECCCCCCHHCCHHHHHHHHHHHH
LLDVDSLHAAVADARPHAVVHLAARAHVAHGNPQDTYLVNVVGTRNLLASLAGLDARPHA
HCCHHHHHHHHHCCCCCCEEEEHHHHHHCCCCCCCCEEEEECCHHHHHHHHHCCCCCCCE
VLLASSANVYGNASTEVLDESAPPQPANDYAVSKLAMEYMAKLWLDRLPIVIARPFNYTG
EEEEECCCCCCCCHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCC
VGQSEAYLLPKLVAHYARGEPRIALGNLDVSRDFSDVRDVVDAYARLIDAAPVGETFNVC
CCCCHHHHHHHHHHHHHCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHH
AERGYALKEVLAMLARIAGYVIDVSVDPRFVRASEVKKLVGSRRKLRAAIGDARRTPLDE
HHCCHHHHHHHHHHHHHHCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
TLRWMYGDMRAALGAREDQPAS
HHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MRPSEPGARRALVTGIAGFTGRHLAARLEAHGYDVWGTVAPGTDVLGDPLLRRWRCVKAD
CCCCCCCHHHHHHHHHHCCCHHHHHHHHHHCCCEEEEECCCCCCHHCCHHHHHHHHHHHH
LLDVDSLHAAVADARPHAVVHLAARAHVAHGNPQDTYLVNVVGTRNLLASLAGLDARPHA
HCCHHHHHHHHHCCCCCCEEEEHHHHHHCCCCCCCCEEEEECCHHHHHHHHHCCCCCCCE
VLLASSANVYGNASTEVLDESAPPQPANDYAVSKLAMEYMAKLWLDRLPIVIARPFNYTG
EEEEECCCCCCCCHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCC
VGQSEAYLLPKLVAHYARGEPRIALGNLDVSRDFSDVRDVVDAYARLIDAAPVGETFNVC
CCCCHHHHHHHHHHHHHCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHH
AERGYALKEVLAMLARIAGYVIDVSVDPRFVRASEVKKLVGSRRKLRAAIGDARRTPLDE
HHCCHHHHHHHHHHHHHHCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
TLRWMYGDMRAALGAREDQPAS
HHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9765575; 11481430 [H]