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The map label for this gene is ilvB [H]

Identifier: 76817456

GI number: 76817456

Start: 2388755

End: 2390653

Strand: Direct

Name: ilvB [H]

Synonym: BURPS1710b_A1956

Alternate gene names: 76817456

Gene position: 2388755-2390653 (Clockwise)

Preceding gene: 76817690

Following gene: 76817935

Centisome position: 75.08

GC content: 66.46

Gene sequence:

>1899_bases
ATGCGCGATGCCCGAACCGCGCGATGCGCCGGTCTCGGCGTCGTCGGCCGCGGGAGGCGAACGTCGCTCGAGCCCGGTCC
CGCGGCGCGGATTGCGTCAACGAAGACATTCGAGCAATCGTTCGATCGTTCACGGGGCGCGCGACTTCGCCCATCCTTCC
ATCGCAGTTTCACCGGCCGAGCCACGATGAAAGCCTCAAACGCCATCGCCCGATTTCTCGCCGCGCACGACGTTCGACAT
TGTTTCGAGCTCGTCGGCGGAATGATCACGCATCTGCTCGACAGCTTCGCGGAAAGCGGGCGCTTTCAAATCGTGTCGAT
GCATCACGAGCAGGCCGCCGCCTTTGCGGCGGAGGGCGTCGCGCGGCGCTACATGGGGCGCAAGGTGGCCGTCGCGCTGG
GCACGAGCGGCCCGGGCGCGACGAATCTGATCACGGGCATCGGCAGTTGCTGGCTGGATTCCGTTCCGTGCGTGTTCATC
ACCGGGCAAGTCAATACGCACGAGCTGAAAGGCGAGCGGGCGATACGGCAGCAGGGTTTCCAGGAGCTCGACATCGTGCC
GATGGTGCGCTCGATCACCAAGCATGCGGTGCAAGTCAGCGACGCGAACGAACTGCTGCCGGCGCTGCACGGCGCGCTGT
CCGCGGCGCTGTCCGGCCGGCAGGGCCCCGTCCTCATCGACATTCCGAACGACGTGCAGCGCGCCGAGATCGCGGACGCC
GCTGTCGATCGATGGCTGGGCGAGCCGTTGCGCATCCGCGATCGATGCGAGCCCGGCGATCGCGACATCGACGCGCTGCG
CGAGCTGTGCCGCTCGTCCTCGCGGCCGCTCGTGTGCTTCGGCGGCGGCGCGCGCTGGGCGCCGTCGATGCCCGCGTGGA
TCGCCGCATTGGAGGACGCGCGGATTCCCTACGTCAGCACCTTGATGGGACACGAGCGCGTGCCCGCCGGCGCGCACTAT
TTCAACATGATCGGCGCGTACGGCAATCGGGAAGCGAACTGGGCCGTGCAGCACTGCGATCTGCTGATCGTGATCGGCGC
GCGTCTCGACGTGCGCCAGACCGGCGCGGACGTCGGCGATTTCGCGCGTCATGCGCGGGTCATTCAGATCGACATCGATC
CCGCTCAGTTGAACAACCGCATCAAGGTCGAGCAGGCCTTGTGCTGTGACGCGGAATCGTTCTTTCGGCGGTTTGCCGTG
CGGCGCGATACGTTCGCCGGCATCCGGCCGGATTGGGCGGACCAGCTCGCCACGCTGAGAACGGCGCATGCCCGCAACGA
GTACCCGGACTGGAACATCAGCCCCGGCGTCGTGTTCGCGCGCCTGAACGAGGCGATGGCCGGCAAGGCGGTTCACTACG
TGTGCGACGTGGGCAATCATCAAATGTGGGCCGCGCAGGGCCTTCGGCTGGGCGCGACCCAAGCCGTCCACTACAGCGGC
GGCATGGGCGCGATGGGTTTCGCGCTGCCGACCGCGATCGGCATCGCGTGCAGCGGCGACGGCGGCGGCAAGACCGTCGT
GATCACGGGCGACGGCAGCCTGCAGGTGAACGTGCAGGAGCTCGATACGCTGAGCCGGCTGCAACTCGATGTGGCCATCG
TGGTGATGAACAATTATTCGCTCGGCATGGTCAAGAATTTTCAGGACATGTATTTCGACGGCAAGAACATCTCGACCAAG
CAAGGCTATAGCTGCCCGTCGTTCGTCGCGCTCGCGCGCGCCTATGGCATCGAGAGCATGACGGTCGCCGCGCCGGCCGA
GCTGCAACGGGCGATCGACCGGGTGGCGGGCTCGCGCCGGCCGTTGCTCGTCGAAATCGCGATGCCGGAGGCGACGGAGT
GTCGGCCCCGGCTCGCCTTCGGCCGAAAGCTCGACGATCAGTATCCGAAACTCGATTAA

Upstream 100 bases:

>100_bases
GTGCGGCTGCGCGCGCAACTGCTGGGTATCGTCAAGGACGGCGCTTGAGTCGTCATTGCGGTATGCGTCGAGACTCCCGG
CGCGGACGGGCGTCGGCCGG

Downstream 100 bases:

>100_bases
GCGCCGCCGGCATGCGCGCCGCAAGCGGCGCGGGCAATGCGCCGCGTGCGGCGCCCGCTCGCGATCTGCCTCGTGTTCAG
ACCGATGCGTCGCGGCTGCC

Product: acetolactate synthase large subunit

Products: NA

Alternate protein names: AHAS; Acetohydroxy-acid synthase large subunit; ALS; Vegetative protein 105; VEG105 [H]

Number of amino acids: Translated: 632; Mature: 632

Protein sequence:

>632_residues
MRDARTARCAGLGVVGRGRRTSLEPGPAARIASTKTFEQSFDRSRGARLRPSFHRSFTGRATMKASNAIARFLAAHDVRH
CFELVGGMITHLLDSFAESGRFQIVSMHHEQAAAFAAEGVARRYMGRKVAVALGTSGPGATNLITGIGSCWLDSVPCVFI
TGQVNTHELKGERAIRQQGFQELDIVPMVRSITKHAVQVSDANELLPALHGALSAALSGRQGPVLIDIPNDVQRAEIADA
AVDRWLGEPLRIRDRCEPGDRDIDALRELCRSSSRPLVCFGGGARWAPSMPAWIAALEDARIPYVSTLMGHERVPAGAHY
FNMIGAYGNREANWAVQHCDLLIVIGARLDVRQTGADVGDFARHARVIQIDIDPAQLNNRIKVEQALCCDAESFFRRFAV
RRDTFAGIRPDWADQLATLRTAHARNEYPDWNISPGVVFARLNEAMAGKAVHYVCDVGNHQMWAAQGLRLGATQAVHYSG
GMGAMGFALPTAIGIACSGDGGGKTVVITGDGSLQVNVQELDTLSRLQLDVAIVVMNNYSLGMVKNFQDMYFDGKNISTK
QGYSCPSFVALARAYGIESMTVAAPAELQRAIDRVAGSRRPLLVEIAMPEATECRPRLAFGRKLDDQYPKLD

Sequences:

>Translated_632_residues
MRDARTARCAGLGVVGRGRRTSLEPGPAARIASTKTFEQSFDRSRGARLRPSFHRSFTGRATMKASNAIARFLAAHDVRH
CFELVGGMITHLLDSFAESGRFQIVSMHHEQAAAFAAEGVARRYMGRKVAVALGTSGPGATNLITGIGSCWLDSVPCVFI
TGQVNTHELKGERAIRQQGFQELDIVPMVRSITKHAVQVSDANELLPALHGALSAALSGRQGPVLIDIPNDVQRAEIADA
AVDRWLGEPLRIRDRCEPGDRDIDALRELCRSSSRPLVCFGGGARWAPSMPAWIAALEDARIPYVSTLMGHERVPAGAHY
FNMIGAYGNREANWAVQHCDLLIVIGARLDVRQTGADVGDFARHARVIQIDIDPAQLNNRIKVEQALCCDAESFFRRFAV
RRDTFAGIRPDWADQLATLRTAHARNEYPDWNISPGVVFARLNEAMAGKAVHYVCDVGNHQMWAAQGLRLGATQAVHYSG
GMGAMGFALPTAIGIACSGDGGGKTVVITGDGSLQVNVQELDTLSRLQLDVAIVVMNNYSLGMVKNFQDMYFDGKNISTK
QGYSCPSFVALARAYGIESMTVAAPAELQRAIDRVAGSRRPLLVEIAMPEATECRPRLAFGRKLDDQYPKLD
>Mature_632_residues
MRDARTARCAGLGVVGRGRRTSLEPGPAARIASTKTFEQSFDRSRGARLRPSFHRSFTGRATMKASNAIARFLAAHDVRH
CFELVGGMITHLLDSFAESGRFQIVSMHHEQAAAFAAEGVARRYMGRKVAVALGTSGPGATNLITGIGSCWLDSVPCVFI
TGQVNTHELKGERAIRQQGFQELDIVPMVRSITKHAVQVSDANELLPALHGALSAALSGRQGPVLIDIPNDVQRAEIADA
AVDRWLGEPLRIRDRCEPGDRDIDALRELCRSSSRPLVCFGGGARWAPSMPAWIAALEDARIPYVSTLMGHERVPAGAHY
FNMIGAYGNREANWAVQHCDLLIVIGARLDVRQTGADVGDFARHARVIQIDIDPAQLNNRIKVEQALCCDAESFFRRFAV
RRDTFAGIRPDWADQLATLRTAHARNEYPDWNISPGVVFARLNEAMAGKAVHYVCDVGNHQMWAAQGLRLGATQAVHYSG
GMGAMGFALPTAIGIACSGDGGGKTVVITGDGSLQVNVQELDTLSRLQLDVAIVVMNNYSLGMVKNFQDMYFDGKNISTK
QGYSCPSFVALARAYGIESMTVAAPAELQRAIDRVAGSRRPLLVEIAMPEATECRPRLAFGRKLDDQYPKLD

Specific function: Valine and isoleucine biosynthesis; first step. [C]

COG id: COG0028

COG function: function code EH; Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TPP enzyme family [H]

Homologues:

Organism=Homo sapiens, GI93004078, Length=591, Percent_Identity=23.3502538071066, Blast_Score=122, Evalue=1e-27,
Organism=Homo sapiens, GI21361361, Length=540, Percent_Identity=25, Blast_Score=102, Evalue=2e-21,
Organism=Escherichia coli, GI87081685, Length=580, Percent_Identity=31.3793103448276, Blast_Score=249, Evalue=4e-67,
Organism=Escherichia coli, GI1790104, Length=578, Percent_Identity=32.6989619377163, Blast_Score=242, Evalue=6e-65,
Organism=Escherichia coli, GI1786717, Length=587, Percent_Identity=27.427597955707, Blast_Score=186, Evalue=3e-48,
Organism=Escherichia coli, GI1787096, Length=548, Percent_Identity=25.9124087591241, Blast_Score=128, Evalue=1e-30,
Organism=Escherichia coli, GI1788716, Length=566, Percent_Identity=23.321554770318, Blast_Score=92, Evalue=7e-20,
Organism=Caenorhabditis elegans, GI17542570, Length=524, Percent_Identity=25.1908396946565, Blast_Score=99, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI17531299, Length=439, Percent_Identity=24.1457858769932, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17531301, Length=446, Percent_Identity=24.8878923766816, Blast_Score=80, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6323755, Length=633, Percent_Identity=29.8578199052133, Blast_Score=240, Evalue=4e-64,
Organism=Drosophila melanogaster, GI19922626, Length=584, Percent_Identity=24.3150684931507, Blast_Score=136, Evalue=5e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012846
- InterPro:   IPR012000
- InterPro:   IPR012001
- InterPro:   IPR011766 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF00205 TPP_enzyme_M; PF02776 TPP_enzyme_N [H]

EC number: =2.2.1.6 [H]

Molecular weight: Translated: 68748; Mature: 68748

Theoretical pI: Translated: 8.44; Mature: 8.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRDARTARCAGLGVVGRGRRTSLEPGPAARIASTKTFEQSFDRSRGARLRPSFHRSFTGR
CCCCCCCHHHCCCEECCCCCCCCCCCCCHHHCCHHHHHHHHHHCCCCCCCCHHHHCCCCC
ATMKASNAIARFLAAHDVRHCFELVGGMITHLLDSFAESGRFQIVSMHHEQAAAFAAEGV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECHHHHHHHHHHHH
ARRYMGRKVAVALGTSGPGATNLITGIGSCWLDSVPCVFITGQVNTHELKGERAIRQQGF
HHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEECCCCHHHHCCHHHHHHCCC
QELDIVPMVRSITKHAVQVSDANELLPALHGALSAALSGRQGPVLIDIPNDVQRAEIADA
HHCCHHHHHHHHHHHHEEECCHHHHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHH
AVDRWLGEPLRIRDRCEPGDRDIDALRELCRSSSRPLVCFGGGARWAPSMPAWIAALEDA
HHHHHCCCCCEECCCCCCCCCCHHHHHHHHHCCCCCEEEECCCCCCCCCCCHHHHHHHCC
RIPYVSTLMGHERVPAGAHYFNMIGAYGNREANWAVQHCDLLIVIGARLDVRQTGADVGD
CCCHHHHHHCCCCCCCCHHHHHHHHCCCCCCCCCHHHHCCEEEEECCCEEHHHCCCCHHH
FARHARVIQIDIDPAQLNNRIKVEQALCCDAESFFRRFAVRRDTFAGIRPDWADQLATLR
HHHCCEEEEEECCHHHHCCEEEEHHHHHCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHH
TAHARNEYPDWNISPGVVFARLNEAMAGKAVHYVCDVGNHQMWAAQGLRLGATQAVHYSG
HHHHCCCCCCCCCCCCEEEEHHHHHHHCCEEEEEEECCCCEEEHHCCCEECCCEEEEECC
GMGAMGFALPTAIGIACSGDGGGKTVVITGDGSLQVNVQELDTLSRLQLDVAIVVMNNYS
CCCHHHHHHHHHHEEEECCCCCCEEEEEECCCCEEEEHHHHHHHHHHEEEEEEEEECCCC
LGMVKNFQDMYFDGKNISTKQGYSCPSFVALARAYGIESMTVAAPAELQRAIDRVAGSRR
CCHHHCHHHHEECCCCCCCCCCCCCHHHHHHHHHHCCCCEEECCHHHHHHHHHHHHCCCC
PLLVEIAMPEATECRPRLAFGRKLDDQYPKLD
CEEEEEECCCCCCCCCHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MRDARTARCAGLGVVGRGRRTSLEPGPAARIASTKTFEQSFDRSRGARLRPSFHRSFTGR
CCCCCCCHHHCCCEECCCCCCCCCCCCCHHHCCHHHHHHHHHHCCCCCCCCHHHHCCCCC
ATMKASNAIARFLAAHDVRHCFELVGGMITHLLDSFAESGRFQIVSMHHEQAAAFAAEGV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECHHHHHHHHHHHH
ARRYMGRKVAVALGTSGPGATNLITGIGSCWLDSVPCVFITGQVNTHELKGERAIRQQGF
HHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEECCCCHHHHCCHHHHHHCCC
QELDIVPMVRSITKHAVQVSDANELLPALHGALSAALSGRQGPVLIDIPNDVQRAEIADA
HHCCHHHHHHHHHHHHEEECCHHHHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHH
AVDRWLGEPLRIRDRCEPGDRDIDALRELCRSSSRPLVCFGGGARWAPSMPAWIAALEDA
HHHHHCCCCCEECCCCCCCCCCHHHHHHHHHCCCCCEEEECCCCCCCCCCCHHHHHHHCC
RIPYVSTLMGHERVPAGAHYFNMIGAYGNREANWAVQHCDLLIVIGARLDVRQTGADVGD
CCCHHHHHHCCCCCCCCHHHHHHHHCCCCCCCCCHHHHCCEEEEECCCEEHHHCCCCHHH
FARHARVIQIDIDPAQLNNRIKVEQALCCDAESFFRRFAVRRDTFAGIRPDWADQLATLR
HHHCCEEEEEECCHHHHCCEEEEHHHHHCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHH
TAHARNEYPDWNISPGVVFARLNEAMAGKAVHYVCDVGNHQMWAAQGLRLGATQAVHYSG
HHHHCCCCCCCCCCCCEEEEHHHHHHHCCEEEEEEECCCCEEEHHCCCEECCCEEEEECC
GMGAMGFALPTAIGIACSGDGGGKTVVITGDGSLQVNVQELDTLSRLQLDVAIVVMNNYS
CCCHHHHHHHHHHEEEECCCCCCEEEEEECCCCEEEEHHHHHHHHHHEEEEEEEEECCCC
LGMVKNFQDMYFDGKNISTKQGYSCPSFVALARAYGIESMTVAAPAELQRAIDRVAGSRR
CCHHHCHHHHEECCCCCCCCCCCCCHHHHHHHHHHCCCCEEECCHHHHHHHHHHHHCCCC
PLLVEIAMPEATECRPRLAFGRKLDDQYPKLD
CEEEEEECCCCCCCCCHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969504; 9384377; 1577690; 9298659 [H]