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The map label for this gene is tyrB2 [H]

Identifier: 162210117

GI number: 162210117

Start: 1632062

End: 1633279

Strand: Direct

Name: tyrB2 [H]

Synonym: BURPS1710b_A1321

Alternate gene names: 162210117

Gene position: 1632062-1633279 (Clockwise)

Preceding gene: 76819357

Following gene: 76818375

Centisome position: 51.29

GC content: 70.53

Gene sequence:

>1218_bases
ATGTTCGAACATCTTCCCGCCCACCCCGGCGACCCGATCCTGTCGCTGTTCCAGGCGTTTCAGCGCGATCCCGAGCCGCG
CAAGGTCAATCTGAGCATCGGCCTTTACTACGACGAAAACGGCGCCGTGCCGGTGCTCGACAGCGTGCGCGCGGCGGCGG
CGCGGCTGGCCGCGCGGGACGACGCCCACACGTATCTGCCGATGGAAGGCATGGCCGACTACCGGCGCGCGCTGCAGGCG
CTCGTGTTCGGCGCGAACAGCCCCGCGCTGCGCGAGCAGCGGATCGCGACCGTGCAGACGGTAGGCGGCTCCGGCGCGCT
GCGCCTCGGCGCGGATCTGCTCAAGCGCTATTTCCCCGACAGCGCGATCTGGATCGGCGATCCGACGTGGGACAACCACC
GCGTGCTGTTCGCCGCGGCGGGACTCGACGTGCATACGTATCCGTATTACGACGCGGCGACGAACGGCGTGCGCTTCGAC
GCGATGATGGCGACGCTCGACACGCTGCCCGCGCGCGCGATCGTGCTGCTGCAGCCGTGCTGCCACAACCCGACGGGCAT
CGATCTGTCGCGCGAGCAGTGGCGCGAGCTCGCCGCGCTGTGCGAGCGGCGCGCGCTGATTGCGTTTCTCGACATCGCGT
ATCAGGGCTTCGGCGACGGCCTCGACGACGACGCGTGGCCGATCCGCGCGATGGCCGATGCGGGGCTGCCCGTGTTTGTC
AGCCATTCGTTCTCGAAGAACTTCTCGCTGTACGGCGAACGCTGCGGCGGGCTGTCGATCGCATGCGCGAACGAACGCGA
GGCCGCACGGGTGCTGAGCCAGATCCAGGCGGGCGTGCGCCGCGTCTATTCGAGCCCGCCGCTGCACGGCGCGCGCCTCG
TCTCGACCGTGCTGAACGATCCGGCGCTCGCGCGGCAATGGGACCGCGACGTCGCCGCGATGCGGGCGCGAATCAAGCGG
ATGCGCACCGCGCTCGCCGCGCGGCTCGCGGCGCGCGTGCCCGGCGCGTCGTTCGACTATCTCGTCGAGCAGCGCGGGAT
GTTCAGCTACACGGGGCTCGCGCCCCATGAGGTCGACGCGCTGCGCGAGCACGACGGCGTCTATCTGCTGCGCTCCGGCC
GCGCATGCATCGCGGGGCTGAGCGATGCGAACGTCGACCATGTCGCGAACGCGATCGCCGCGGTGTTGAAGGCGCGGCGA
GCGCGCGCCGCGGCGTGA

Upstream 100 bases:

>100_bases
CCCGGAAGGCCGCCCGCGGCATGCCGGCGCGGCCCCGCGGCAAGGGGCCCGGCGCCGCGGCCGCGCCGCTGTTCCCGTCA
TCCGTCACCCTGTGTCCAAC

Downstream 100 bases:

>100_bases
TGCGCGCCGCGCGGGGCCTCGCGCCCGGCGCGCCGCCCGCCTCGCCCTCGCGGCGCACGCGGCTGCGGGCGGGCGAGCGA
ACGCCGCCGGCAAAACGCCG

Product: aromatic amino acid aminotransferase

Products: NA

Alternate protein names: ARAT; AROAT [H]

Number of amino acids: Translated: 405; Mature: 405

Protein sequence:

>405_residues
MFEHLPAHPGDPILSLFQAFQRDPEPRKVNLSIGLYYDENGAVPVLDSVRAAAARLAARDDAHTYLPMEGMADYRRALQA
LVFGANSPALREQRIATVQTVGGSGALRLGADLLKRYFPDSAIWIGDPTWDNHRVLFAAAGLDVHTYPYYDAATNGVRFD
AMMATLDTLPARAIVLLQPCCHNPTGIDLSREQWRELAALCERRALIAFLDIAYQGFGDGLDDDAWPIRAMADAGLPVFV
SHSFSKNFSLYGERCGGLSIACANEREAARVLSQIQAGVRRVYSSPPLHGARLVSTVLNDPALARQWDRDVAAMRARIKR
MRTALAARLAARVPGASFDYLVEQRGMFSYTGLAPHEVDALREHDGVYLLRSGRACIAGLSDANVDHVANAIAAVLKARR
ARAAA

Sequences:

>Translated_405_residues
MFEHLPAHPGDPILSLFQAFQRDPEPRKVNLSIGLYYDENGAVPVLDSVRAAAARLAARDDAHTYLPMEGMADYRRALQA
LVFGANSPALREQRIATVQTVGGSGALRLGADLLKRYFPDSAIWIGDPTWDNHRVLFAAAGLDVHTYPYYDAATNGVRFD
AMMATLDTLPARAIVLLQPCCHNPTGIDLSREQWRELAALCERRALIAFLDIAYQGFGDGLDDDAWPIRAMADAGLPVFV
SHSFSKNFSLYGERCGGLSIACANEREAARVLSQIQAGVRRVYSSPPLHGARLVSTVLNDPALARQWDRDVAAMRARIKR
MRTALAARLAARVPGASFDYLVEQRGMFSYTGLAPHEVDALREHDGVYLLRSGRACIAGLSDANVDHVANAIAAVLKARR
ARAAA
>Mature_405_residues
MFEHLPAHPGDPILSLFQAFQRDPEPRKVNLSIGLYYDENGAVPVLDSVRAAAARLAARDDAHTYLPMEGMADYRRALQA
LVFGANSPALREQRIATVQTVGGSGALRLGADLLKRYFPDSAIWIGDPTWDNHRVLFAAAGLDVHTYPYYDAATNGVRFD
AMMATLDTLPARAIVLLQPCCHNPTGIDLSREQWRELAALCERRALIAFLDIAYQGFGDGLDDDAWPIRAMADAGLPVFV
SHSFSKNFSLYGERCGGLSIACANEREAARVLSQIQAGVRRVYSSPPLHGARLVSTVLNDPALARQWDRDVAAMRARIKR
MRTALAARLAARVPGASFDYLVEQRGMFSYTGLAPHEVDALREHDGVYLLRSGRACIAGLSDANVDHVANAIAAVLKARR
ARAAA

Specific function: Biosynthesis of Phe, Tyr, Asp and Leu. [C]

COG id: COG1448

COG function: function code E; Aspartate/tyrosine/aromatic aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI73486658, Length=399, Percent_Identity=41.6040100250627, Blast_Score=343, Evalue=1e-94,
Organism=Homo sapiens, GI4504067, Length=400, Percent_Identity=40, Blast_Score=323, Evalue=1e-88,
Organism=Homo sapiens, GI117414139, Length=383, Percent_Identity=25.8485639686684, Blast_Score=167, Evalue=1e-41,
Organism=Escherichia coli, GI1790488, Length=397, Percent_Identity=58.6901763224181, Blast_Score=487, Evalue=1e-139,
Organism=Escherichia coli, GI1787159, Length=396, Percent_Identity=41.6666666666667, Blast_Score=341, Evalue=4e-95,
Organism=Caenorhabditis elegans, GI25147133, Length=397, Percent_Identity=39.5465994962217, Blast_Score=326, Evalue=1e-89,
Organism=Caenorhabditis elegans, GI71981858, Length=397, Percent_Identity=38.5390428211587, Blast_Score=321, Evalue=5e-88,
Organism=Caenorhabditis elegans, GI17569539, Length=405, Percent_Identity=39.0123456790123, Blast_Score=307, Evalue=5e-84,
Organism=Caenorhabditis elegans, GI17569537, Length=391, Percent_Identity=32.9923273657289, Blast_Score=215, Evalue=4e-56,
Organism=Caenorhabditis elegans, GI17550384, Length=276, Percent_Identity=35.5072463768116, Blast_Score=181, Evalue=8e-46,
Organism=Caenorhabditis elegans, GI25147136, Length=214, Percent_Identity=35.5140186915888, Blast_Score=167, Evalue=1e-41,
Organism=Saccharomyces cerevisiae, GI6323055, Length=407, Percent_Identity=37.3464373464373, Blast_Score=291, Evalue=2e-79,
Organism=Saccharomyces cerevisiae, GI6322743, Length=434, Percent_Identity=31.7972350230415, Blast_Score=224, Evalue=2e-59,
Organism=Drosophila melanogaster, GI24654046, Length=399, Percent_Identity=41.8546365914787, Blast_Score=323, Evalue=1e-88,
Organism=Drosophila melanogaster, GI19922362, Length=399, Percent_Identity=41.8546365914787, Blast_Score=323, Evalue=1e-88,
Organism=Drosophila melanogaster, GI24580970, Length=398, Percent_Identity=39.9497487437186, Blast_Score=315, Evalue=3e-86,
Organism=Drosophila melanogaster, GI24580972, Length=398, Percent_Identity=39.9497487437186, Blast_Score=315, Evalue=3e-86,
Organism=Drosophila melanogaster, GI19920542, Length=391, Percent_Identity=40.4092071611253, Blast_Score=314, Evalue=7e-86,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR000796
- InterPro:   IPR004838
- InterPro:   IPR015424
- InterPro:   IPR015421 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.57 [H]

Molecular weight: Translated: 44223; Mature: 44223

Theoretical pI: Translated: 7.89; Mature: 7.89

Prosite motif: PS00070 ALDEHYDE_DEHYDR_CYS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFEHLPAHPGDPILSLFQAFQRDPEPRKVNLSIGLYYDENGAVPVLDSVRAAAARLAARD
CCCCCCCCCCCHHHHHHHHHHCCCCCCEEEEEEEEEECCCCCCCHHHHHHHHHHHHHHCC
DAHTYLPMEGMADYRRALQALVFGANSPALREQRIATVQTVGGSGALRLGADLLKRYFPD
CCCEECCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHEEECCCCCHHHHHHHHHHHHCCC
SAIWIGDPTWDNHRVLFAAAGLDVHTYPYYDAATNGVRFDAMMATLDTLPARAIVLLQPC
CEEEECCCCCCCCEEEEEEECCCEECCCCCCCCCCCEEHHHHHHHHHHCCHHEEEEECCC
CHNPTGIDLSREQWRELAALCERRALIAFLDIAYQGFGDGLDDDAWPIRAMADAGLPVFV
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCCEEEE
SHSFSKNFSLYGERCGGLSIACANEREAARVLSQIQAGVRRVYSSPPLHGARLVSTVLND
ECCCCCCCHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCC
PALARQWDRDVAAMRARIKRMRTALAARLAARVPGASFDYLVEQRGMFSYTGLAPHEVDA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCEEECCCCCHHHHH
LREHDGVYLLRSGRACIAGLSDANVDHVANAIAAVLKARRARAAA
HHHCCCEEEEECCCEEEECCCCCCHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MFEHLPAHPGDPILSLFQAFQRDPEPRKVNLSIGLYYDENGAVPVLDSVRAAAARLAARD
CCCCCCCCCCCHHHHHHHHHHCCCCCCEEEEEEEEEECCCCCCCHHHHHHHHHHHHHHCC
DAHTYLPMEGMADYRRALQALVFGANSPALREQRIATVQTVGGSGALRLGADLLKRYFPD
CCCEECCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHEEECCCCCHHHHHHHHHHHHCCC
SAIWIGDPTWDNHRVLFAAAGLDVHTYPYYDAATNGVRFDAMMATLDTLPARAIVLLQPC
CEEEECCCCCCCCEEEEEEECCCEECCCCCCCCCCCEEHHHHHHHHHHCCHHEEEEECCC
CHNPTGIDLSREQWRELAALCERRALIAFLDIAYQGFGDGLDDDAWPIRAMADAGLPVFV
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCCEEEE
SHSFSKNFSLYGERCGGLSIACANEREAARVLSQIQAGVRRVYSSPPLHGARLVSTVLND
ECCCCCCCHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCC
PALARQWDRDVAAMRARIKRMRTALAARLAARVPGASFDYLVEQRGMFSYTGLAPHEVDA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCEEECCCCCHHHHH
LREHDGVYLLRSGRACIAGLSDANVDHVANAIAAVLKARRARAAA
HHHCCCEEEEECCCEEEECCCCCCHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3521591; 3907634; 8265357; 9278503; 3308851; 10417420 [H]