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The map label for this gene is srrB [H]

Identifier: 75910054

GI number: 75910054

Start: 4792438

End: 4793553

Strand: Direct

Name: srrB [H]

Synonym: Ava_3850

Alternate gene names: 75910054

Gene position: 4792438-4793553 (Clockwise)

Preceding gene: 75910049

Following gene: 75910055

Centisome position: 75.29

GC content: 42.29

Gene sequence:

>1116_bases
ATGCTAGCCCGGCGAACTAAATTACTATCCCAAAACTCATTTTTGGTAAAAGCCTCAGTCATCTTAGGGCTATTGATCAC
AGTGATTTCTATGGAGTTTTCTACGCCCACAGAATATGTATTTGGGTATCTTTATACTGGGCCAATTCTGTTAGCTAATC
ACTGGTTTGGACGTATAGCAACTTTATTGACGACATTTATTGCTGTATTTTTAACGATTGTGAATCTTTGGCTTCCAGAT
CATGAAGTGATTAGGTTTCCTACAGTCGCTAGTCGGACGATCGCCTGTATGTCCTTGATTGTAACAGGAATTTTAAGCGA
TCGCCTGCGTCATTCTCAAGAGGCGATCGCCCTCACCCGTGCCAAATTAGAATCACAGGAAGAATTAGTCAGACTGCGGG
AAGATTTTGCTTCTACTCTCACCCACGATTTGAAAACACCACTTTTGGGTGCTATTGAAACTCTCAAAGCTGTTCAACAA
GAAAAATTTGGTGCGGTATCATCAGCACAGCAGCCGGTGTTAGCCACAATTATCCGCAGCCATCAAACTTCTCTACAACT
CCTAGAAACTTTATTAGATATCTATCGCAATGATACAGAAGGTTTACAGCTAAATTTAATTCCTGTGGATTTAACCACCT
TGGCCGAGGAAGCAGCGAGTACACTAATTGATTTGGCTGCCAGTCGGCGAGTTCATATATCGTTTAATTATGGTGACTCT
GATTGGCGGCGATCGCTGTGGGTAAACGGTGACCCTCTGCAATTGCAACGGGTGTTGTATAATCTCCTAGTCAATGCTAT
CAATCATTCTCGGCGGGGCGATCGTGTAGAGGTTATATTAGAAACCCAAGCTTCCTATCAAGTAGTAAAAATTTCCGATA
CTGGCCCAGGTATTCAAGCAGAACAGTTTCCCCATTTATTTGAACGATTTTATCAAGGACATAGTGAACGCCAAGCCAAA
GGTTCAGGTTTAGGACTTTATTTATCTCGACAAATTATTGCAGCTCATAACGGTATAATTTGGGCAGAGAATAGAGTTCC
TACGGGTGCTATGTTTGCATTCAAATTGCCTGTTCTCCCATTTCAGCCCTCCTTATCTGCGTCAGATGGCTTCTAA

Upstream 100 bases:

>100_bases
ATTGAGAATACCTAAGTATCTGTAGGGTGGGCAATGCCCACCCTACGTATATCTTATAAATCAAATATGAGTTTTATAGC
CAAATCACAAGTTAATATAA

Downstream 100 bases:

>100_bases
CCCGGTAAAAATTCTGTTGGTTGAAGATGATGAACTCTTTCGCTTAGGCTTGCGCGTGCGATTACAACAAGAAGCAGGTT
TAGAAATTATTGCTGAGGCT

Product: periplasmic sensor signal transduction histidine kinase

Products: NA

Alternate protein names: Staphylococcal respiratory response protein B [H]

Number of amino acids: Translated: 371; Mature: 371

Protein sequence:

>371_residues
MLARRTKLLSQNSFLVKASVILGLLITVISMEFSTPTEYVFGYLYTGPILLANHWFGRIATLLTTFIAVFLTIVNLWLPD
HEVIRFPTVASRTIACMSLIVTGILSDRLRHSQEAIALTRAKLESQEELVRLREDFASTLTHDLKTPLLGAIETLKAVQQ
EKFGAVSSAQQPVLATIIRSHQTSLQLLETLLDIYRNDTEGLQLNLIPVDLTTLAEEAASTLIDLAASRRVHISFNYGDS
DWRRSLWVNGDPLQLQRVLYNLLVNAINHSRRGDRVEVILETQASYQVVKISDTGPGIQAEQFPHLFERFYQGHSERQAK
GSGLGLYLSRQIIAAHNGIIWAENRVPTGAMFAFKLPVLPFQPSLSASDGF

Sequences:

>Translated_371_residues
MLARRTKLLSQNSFLVKASVILGLLITVISMEFSTPTEYVFGYLYTGPILLANHWFGRIATLLTTFIAVFLTIVNLWLPD
HEVIRFPTVASRTIACMSLIVTGILSDRLRHSQEAIALTRAKLESQEELVRLREDFASTLTHDLKTPLLGAIETLKAVQQ
EKFGAVSSAQQPVLATIIRSHQTSLQLLETLLDIYRNDTEGLQLNLIPVDLTTLAEEAASTLIDLAASRRVHISFNYGDS
DWRRSLWVNGDPLQLQRVLYNLLVNAINHSRRGDRVEVILETQASYQVVKISDTGPGIQAEQFPHLFERFYQGHSERQAK
GSGLGLYLSRQIIAAHNGIIWAENRVPTGAMFAFKLPVLPFQPSLSASDGF
>Mature_371_residues
MLARRTKLLSQNSFLVKASVILGLLITVISMEFSTPTEYVFGYLYTGPILLANHWFGRIATLLTTFIAVFLTIVNLWLPD
HEVIRFPTVASRTIACMSLIVTGILSDRLRHSQEAIALTRAKLESQEELVRLREDFASTLTHDLKTPLLGAIETLKAVQQ
EKFGAVSSAQQPVLATIIRSHQTSLQLLETLLDIYRNDTEGLQLNLIPVDLTTLAEEAASTLIDLAASRRVHISFNYGDS
DWRRSLWVNGDPLQLQRVLYNLLVNAINHSRRGDRVEVILETQASYQVVKISDTGPGIQAEQFPHLFERFYQGHSERQAK
GSGLGLYLSRQIIAAHNGIIWAENRVPTGAMFAFKLPVLPFQPSLSASDGF

Specific function: Member of the two-component regulatory system srrA/srrB, which is involved in the global regulation of staphylococcal virulence factors in response to environmental oxygen levels. Probably phosphorylates srrA [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788393, Length=234, Percent_Identity=29.4871794871795, Blast_Score=96, Evalue=5e-21,
Organism=Escherichia coli, GI1789149, Length=254, Percent_Identity=29.1338582677165, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI145693157, Length=282, Percent_Identity=25.531914893617, Blast_Score=86, Evalue=6e-18,
Organism=Escherichia coli, GI1788713, Length=235, Percent_Identity=28.5106382978723, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1786783, Length=245, Percent_Identity=28.5714285714286, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1786912, Length=256, Percent_Identity=31.25, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1786600, Length=233, Percent_Identity=28.755364806867, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI87082128, Length=237, Percent_Identity=27.4261603375527, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI1790436, Length=242, Percent_Identity=26.8595041322314, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI1789808, Length=244, Percent_Identity=26.6393442622951, Blast_Score=72, Evalue=8e-14,
Organism=Escherichia coli, GI87081816, Length=267, Percent_Identity=24.3445692883895, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1788279, Length=206, Percent_Identity=29.6116504854369, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1790861, Length=293, Percent_Identity=24.2320819112628, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI48994928, Length=233, Percent_Identity=24.8927038626609, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI1788549, Length=243, Percent_Identity=27.1604938271605, Blast_Score=61, Evalue=1e-10,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 41451; Mature: 41451

Theoretical pI: Translated: 7.39; Mature: 7.39

Prosite motif: PS50109 HIS_KIN ; PS00430 TONB_DEPENDENT_REC_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLARRTKLLSQNSFLVKASVILGLLITVISMEFSTPTEYVFGYLYTGPILLANHWFGRIA
CCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCHHHHHHHHHHHHH
TLLTTFIAVFLTIVNLWLPDHEVIRFPTVASRTIACMSLIVTGILSDRLRHSQEAIALTR
HHHHHHHHHHHHHHHHHCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AKLESQEELVRLREDFASTLTHDLKTPLLGAIETLKAVQQEKFGAVSSAQQPVLATIIRS
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHH
HQTSLQLLETLLDIYRNDTEGLQLNLIPVDLTTLAEEAASTLIDLAASRRVHISFNYGDS
HHHHHHHHHHHHHHHCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHCCCEEEEEEECCCC
DWRRSLWVNGDPLQLQRVLYNLLVNAINHSRRGDRVEVILETQASYQVVKISDTGPGIQA
HHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCEEEEEEECCCCCCCH
EQFPHLFERFYQGHSERQAKGSGLGLYLSRQIIAAHNGIIWAENRVPTGAMFAFKLPVLP
HHHHHHHHHHHCCCCHHHCCCCCCCHHHHHHHHHHCCCEEEECCCCCCCCEEEEECCCCC
FQPSLSASDGF
CCCCCCCCCCC
>Mature Secondary Structure
MLARRTKLLSQNSFLVKASVILGLLITVISMEFSTPTEYVFGYLYTGPILLANHWFGRIA
CCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCHHHHHHHHHHHHH
TLLTTFIAVFLTIVNLWLPDHEVIRFPTVASRTIACMSLIVTGILSDRLRHSQEAIALTR
HHHHHHHHHHHHHHHHHCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AKLESQEELVRLREDFASTLTHDLKTPLLGAIETLKAVQQEKFGAVSSAQQPVLATIIRS
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHH
HQTSLQLLETLLDIYRNDTEGLQLNLIPVDLTTLAEEAASTLIDLAASRRVHISFNYGDS
HHHHHHHHHHHHHHHCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHCCCEEEEEEECCCC
DWRRSLWVNGDPLQLQRVLYNLLVNAINHSRRGDRVEVILETQASYQVVKISDTGPGIQA
HHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCEEEEEEECCCCCCCH
EQFPHLFERFYQGHSERQAKGSGLGLYLSRQIIAAHNGIIWAENRVPTGAMFAFKLPVLP
HHHHHHHHHHHCCCCHHHCCCCCCCHHHHHHHHHHCCCEEEECCCCCCCCEEEEECCCCC
FQPSLSASDGF
CCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA