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The map label for this gene is 75909914

Identifier: 75909914

GI number: 75909914

Start: 4618705

End: 4620096

Strand: Direct

Name: 75909914

Synonym: Ava_3710

Alternate gene names: NA

Gene position: 4618705-4620096 (Clockwise)

Preceding gene: 75909912

Following gene: 75909915

Centisome position: 72.56

GC content: 44.76

Gene sequence:

>1392_bases
ATGACTACAACAGCAGTCAATCCCTATCTAGAGGGTAATTTTGCACCTGTCCACGAAGAAATTACCACTGACACCTTAAA
AGTTATCGGCGAACTTCCCCCTGATTTATCAGGGATGTTTATCCGCAACGGCCCGAACCCTCAATGGACACCCATCGGAC
AATATCACTGGTTTGATGGTGATGGGATGTTACACGGTGTCAGAATTAGTAATGGTAAAGCTACTTATCGCAATCGCTAC
GTCCGCACTCAAAGATGGCAAATTGAACATGAGGCGGGTCAAGCCATCTGGACAGGATTTATGGAACCACCCCAGCCAGA
ACTCCCCAGTAGAAACACTGGAAATACTGCCCTTATCTGGCACGCGGGACAACTATTAGCATTATGGGAAGGCGGCGCGC
CCCATGCAATTCAAGTTCCTGATTTAGAAACTATTGGTGAGTACACCTACAATAACCAGCTAAGTTCTGCTTTTACCGCC
CATCCTAAGGTAGACCCAGCAACAGGGGAAATGATGTTTTTCGGCTACTCATTTGCACCACCATATCTGCATTACAGCGT
GGTTTCCGCCACCGGGGAATTGGTGAGAACAATACCTATAGATTTACCAATGGGGGTGATGATGCACGACTTTGCTATCA
CTGCCAACTACACAATTTTTATGGATTTGCCCTTGACCTTTAGTGTAGAACGGATGCAACGGGGAGAACCTATGCTAATG
TTTGAGAGCGATCGCCCTAGTCGCTTTGGTATTCTACCTCGTCATGGTGACAATAGTCATATTCGCTGGTTTACAGCTCC
ATCTTGCTACGTTTTCCACACTCTCAACGCCTACGAGGACAAAGACGAAGTAGTACTTTTTGCCTGTCCCATGCGTTCCA
CCACCGTCCTAGCTTCCCCAGATTCCCAAACAGACCCAGAAGCAGACATTCCCCGTTTACATCGTTGGCGCTTTAACCTC
AAAACTGGGAAAGTACATGAAGAAATGCTGGATGATGTCGCCTCAGAATTTCCCCGTATCAATGAAAATTTCTTAGGACA
AGCAACGAAATATGGCTACACTAGTCGGTTAGCAAAAGGTTCTATACCTTTGTTTGAGGGTTTAATTAAATACGACCTCA
GCAATGCTAAGTCCCAAAATTATGAATATGGACAAGGACGTTATGGGAGTGAAGCTGTTTTTGTACCTCGTCCTGGTGCA
ACAGTTGAAGATGATGGTTGGTTAATCACTTACGTTTATGATATTGGTGAGGATAGTTCTGAATTAGTTGTCATAAATGC
CCAAGATATTAATAGTGAACCGATAGCGCGAGTGCTACTTCCCCAACGAGTACCTTACGGTTTTCATGGTATCTGGGTTA
CTGAAGAACAGTTGAATTTTGGAAGAATATAA

Upstream 100 bases:

>100_bases
CGCCAACCTCAAATCATCCCTCCATAATGCAACGCCGAAAATGAAAGTGAGAGCGATCGCTAAGATGATAAAAGATTCAC
TCGCTCTCTAATCCAACACC

Downstream 100 bases:

>100_bases
TTACAGGTAGCTTTGCTACCTTTAAAGCTTTTCATCTGTGCGCGCAACGAAAATAGGTAGACTCGATAATATTAAAACTA
GGTGTTTAAATGACAATTAC

Product: retinal pigment epithelial membrane protein

Products: NA

Alternate protein names: ACO; 8'-apo-beta-carotenal 15,15'-oxygenase; Diox1 [H]

Number of amino acids: Translated: 463; Mature: 462

Protein sequence:

>463_residues
MTTTAVNPYLEGNFAPVHEEITTDTLKVIGELPPDLSGMFIRNGPNPQWTPIGQYHWFDGDGMLHGVRISNGKATYRNRY
VRTQRWQIEHEAGQAIWTGFMEPPQPELPSRNTGNTALIWHAGQLLALWEGGAPHAIQVPDLETIGEYTYNNQLSSAFTA
HPKVDPATGEMMFFGYSFAPPYLHYSVVSATGELVRTIPIDLPMGVMMHDFAITANYTIFMDLPLTFSVERMQRGEPMLM
FESDRPSRFGILPRHGDNSHIRWFTAPSCYVFHTLNAYEDKDEVVLFACPMRSTTVLASPDSQTDPEADIPRLHRWRFNL
KTGKVHEEMLDDVASEFPRINENFLGQATKYGYTSRLAKGSIPLFEGLIKYDLSNAKSQNYEYGQGRYGSEAVFVPRPGA
TVEDDGWLITYVYDIGEDSSELVVINAQDINSEPIARVLLPQRVPYGFHGIWVTEEQLNFGRI

Sequences:

>Translated_463_residues
MTTTAVNPYLEGNFAPVHEEITTDTLKVIGELPPDLSGMFIRNGPNPQWTPIGQYHWFDGDGMLHGVRISNGKATYRNRY
VRTQRWQIEHEAGQAIWTGFMEPPQPELPSRNTGNTALIWHAGQLLALWEGGAPHAIQVPDLETIGEYTYNNQLSSAFTA
HPKVDPATGEMMFFGYSFAPPYLHYSVVSATGELVRTIPIDLPMGVMMHDFAITANYTIFMDLPLTFSVERMQRGEPMLM
FESDRPSRFGILPRHGDNSHIRWFTAPSCYVFHTLNAYEDKDEVVLFACPMRSTTVLASPDSQTDPEADIPRLHRWRFNL
KTGKVHEEMLDDVASEFPRINENFLGQATKYGYTSRLAKGSIPLFEGLIKYDLSNAKSQNYEYGQGRYGSEAVFVPRPGA
TVEDDGWLITYVYDIGEDSSELVVINAQDINSEPIARVLLPQRVPYGFHGIWVTEEQLNFGRI
>Mature_462_residues
TTTAVNPYLEGNFAPVHEEITTDTLKVIGELPPDLSGMFIRNGPNPQWTPIGQYHWFDGDGMLHGVRISNGKATYRNRYV
RTQRWQIEHEAGQAIWTGFMEPPQPELPSRNTGNTALIWHAGQLLALWEGGAPHAIQVPDLETIGEYTYNNQLSSAFTAH
PKVDPATGEMMFFGYSFAPPYLHYSVVSATGELVRTIPIDLPMGVMMHDFAITANYTIFMDLPLTFSVERMQRGEPMLMF
ESDRPSRFGILPRHGDNSHIRWFTAPSCYVFHTLNAYEDKDEVVLFACPMRSTTVLASPDSQTDPEADIPRLHRWRFNLK
TGKVHEEMLDDVASEFPRINENFLGQATKYGYTSRLAKGSIPLFEGLIKYDLSNAKSQNYEYGQGRYGSEAVFVPRPGAT
VEDDGWLITYVYDIGEDSSELVVINAQDINSEPIARVLLPQRVPYGFHGIWVTEEQLNFGRI

Specific function: Cleaves a number of carotenals and carotenols in the all-trans configuration at the 15-15' double bond producing retinal or retinol, respectively. Also shows activity toward lycopenals and the corresponding alcohols. Does not cleave beta- carotene or lyco

COG id: COG3670

COG function: function code Q; Lignostilbene-alpha,beta-dioxygenase and related enzymes

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the carotenoid oxygenase family [H]

Homologues:

Organism=Homo sapiens, GI82617624, Length=519, Percent_Identity=23.8921001926782, Blast_Score=106, Evalue=5e-23,
Organism=Homo sapiens, GI82617628, Length=519, Percent_Identity=23.8921001926782, Blast_Score=106, Evalue=5e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004294 [H]

Pfam domain/function: PF03055 RPE65 [H]

EC number: =1.14.99.41 [H]

Molecular weight: Translated: 52326; Mature: 52194

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTTAVNPYLEGNFAPVHEEITTDTLKVIGELPPDLSGMFIRNGPNPQWTPIGQYHWFDG
CCCCCCCCEECCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCCCEEEECC
DGMLHGVRISNGKATYRNRYVRTQRWQIEHEAGQAIWTGFMEPPQPELPSRNTGNTALIW
CCEEEEEEECCCCCHHHHCEEEEEEEEEECCCCCEEEECCCCCCCCCCCCCCCCCEEEEE
HAGQLLALWEGGAPHAIQVPDLETIGEYTYNNQLSSAFTAHPKVDPATGEMMFFGYSFAP
ECCEEEEEECCCCCCEEECCCHHHHCCCCCCCCCCHHEECCCCCCCCCCCEEEEEEECCC
PYLHYSVVSATGELVRTIPIDLPMGVMMHDFAITANYTIFMDLPLTFSVERMQRGEPMLM
CHHEEEEECCCCCEEEEEECCCCCCCEEEEEEEEECEEEEEECCCEEEHHHHHCCCEEEE
FESDRPSRFGILPRHGDNSHIRWFTAPSCYVFHTLNAYEDKDEVVLFACPMRSTTVLASP
EECCCCCEEEEEECCCCCCEEEEEECCCEEEEEECCCCCCCCCEEEEEECCCCCEEEECC
DSQTDPEADIPRLHRWRFNLKTGKVHEEMLDDVASEFPRINENFLGQATKYGYTSRLAKG
CCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHCCCCCHHHCCCCCCCCCHHHHCCC
SIPLFEGLIKYDLSNAKSQNYEYGQGRYGSEAVFVPRPGATVEDDGWLITYVYDIGEDSS
CCHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCEEEEEEEECCCCCC
ELVVINAQDINSEPIARVLLPQRVPYGFHGIWVTEEQLNFGRI
CEEEEECCCCCCCCHHHHHCCCCCCCCEEEEEEECCCCCCCCC
>Mature Secondary Structure 
TTTAVNPYLEGNFAPVHEEITTDTLKVIGELPPDLSGMFIRNGPNPQWTPIGQYHWFDG
CCCCCCCEECCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCCCEEEECC
DGMLHGVRISNGKATYRNRYVRTQRWQIEHEAGQAIWTGFMEPPQPELPSRNTGNTALIW
CCEEEEEEECCCCCHHHHCEEEEEEEEEECCCCCEEEECCCCCCCCCCCCCCCCCEEEEE
HAGQLLALWEGGAPHAIQVPDLETIGEYTYNNQLSSAFTAHPKVDPATGEMMFFGYSFAP
ECCEEEEEECCCCCCEEECCCHHHHCCCCCCCCCCHHEECCCCCCCCCCCEEEEEEECCC
PYLHYSVVSATGELVRTIPIDLPMGVMMHDFAITANYTIFMDLPLTFSVERMQRGEPMLM
CHHEEEEECCCCCEEEEEECCCCCCCEEEEEEEEECEEEEEECCCEEEHHHHHCCCEEEE
FESDRPSRFGILPRHGDNSHIRWFTAPSCYVFHTLNAYEDKDEVVLFACPMRSTTVLASP
EECCCCCEEEEEECCCCCCEEEEEECCCEEEEEECCCCCCCCCEEEEEECCCCCEEEECC
DSQTDPEADIPRLHRWRFNLKTGKVHEEMLDDVASEFPRINENFLGQATKYGYTSRLAKG
CCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHCCCCCHHHCCCCCCCCCHHHHCCC
SIPLFEGLIKYDLSNAKSQNYEYGQGRYGSEAVFVPRPGATVEDDGWLITYVYDIGEDSS
CCHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCEEEEEEEECCCCCC
ELVVINAQDINSEPIARVLLPQRVPYGFHGIWVTEEQLNFGRI
CEEEEECCCCCCCCHHHHHCCCCCCCCEEEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]