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The map label for this gene is pgi

Identifier: 75909912

GI number: 75909912

Start: 4615259

End: 4616845

Strand: Direct

Name: pgi

Synonym: Ava_3708

Alternate gene names: 75909912

Gene position: 4615259-4616845 (Clockwise)

Preceding gene: 75909911

Following gene: 75909914

Centisome position: 72.5

GC content: 45.94

Gene sequence:

>1587_bases
ATGGATGCGAAGGCACTTTGGCAACGATACCAAGAATGGTTATATTTCCACGAGGGATTAGGACTGTATCTAGATGTCAG
TCGGATGCGTTTTGATGATGCCTTCGTGAAGTCGTTGCTGCCGAAATTTGACAAAGCATTTGCGGATATGGCGGAATTAG
AAAAGGGTGCGATCGCCAATCCTGATGAGAACCGCATGGTGGGACACTATTGGCTACGGAACCCAGACTTAGCGCCCACG
CCAGAAATAGCCCAAGAAATTGTTCAAACCTTGGAACAAATTGAAGCTTTTGCGGAAAAAATCCAAACAGGTGCTATTCA
TCCTCCCAAAGCCAACCGCTTCACAGATATTATTTCTATTGGGATTGGTGGTTCTGCCCTCGGCCCCCAGTTTGTCGCTG
AAGCCCTCGCCCCAGAATTTCCACCCCTAAAAATTCACTTTATCGACAATACCGACCCCGCCGGCATTGACAAGATTCTC
ACCCACCTGCGGAATAATCTTGCCAGCACCCTGGTTTTAGTCATCTCCAAATCTGGAGGTACACCAGAACCCCGCAACGG
CATGATAGAAGTTAAAAAAGCCTACGCTGGACAAAATTTAGATTTTGCCCAGTATGCAGTAGCTATTACTAGTACTGGTA
GCAACCTAGACAAAGTAGCCCAAGCAGAAGGTTGGCTAGCAACATTTCCCATGTATGACTGGGTGGGTGGACGTACCTCG
GAAATGTCTTCTGTAGGGCTAGTTCCTGCGGCATTACAAGGCATTGATGTCCGTGCCATGCTAGAAGGTGCAAAAGAAAT
GGATGACGCTACACGCGTCCCAGAAGTGAAAAACAACCCTGCGGCTTTACTGGCTTTGTCTTGGTACTACTCTGGTAACG
GCAAGGGTGAAAAAGATATGGTTGTTTTACCCTATAAAGACAGCTTGCTGCTATTCAGCCGTTATTTGCAACAGCTAGTC
ATGGAATCTTTGGGTAAAGAAAAAGACTTAGACGGTAAAACTGTCTATCAGGGTATCGCCGTTTATGGTAACAAAGGCTC
AACAGACCAACACGCTTACGTCCAGCAGTTACGTGAAGGTGTACCGAATTTCTTTGCTACCTTAATCGAAGTTTTGGAAG
ACCGTAACGGCGCATCTCCAGAAATAGACCCTGGTGTAACATCGGGTGATTATCTGTCTGGTTTTCTGCTAGGAACCCGC
CAAGCTTTGTATGAAAATCAACGCGATTCCATTACAGTGACGATTCCCCAAGTTAACGCCCGTACCGTTGGGGCGTTAAT
TGCTTTGTATGAACGTACTGTTGGTTTATATGCGAGTTTGGTCAACATTAACGCCTACCATCAACCAGGGGTAGAAGCTG
GTAAAAAAGCTGCTGCTGTGATTCTGGATCTACAAACAAAAGTAGTAGGATTACTCCAAAAGGAGAAAACAGCCCTTTCT
TTAGAGCAAATTGCTGAGAAAATAGGTGCAGCCGACCAAGTTGAAGCAATTTACAAGATTTTGCGTCACCTCCAAGCTAA
TCAACGCGGCGTTGTCTTCCAAGGAAATTTGGGACAACCAAGCAGCTTGAAAGTGTCTATTAGCTGA

Upstream 100 bases:

>100_bases
AAGAAATTTTCAACACTTAAAACTGTATAAGACTAAGCAGGGGTGGCTCTAACCTTACATTACACTTGTTTTTGAAGGAC
ACTTTACTAGAGATTTCCCT

Downstream 100 bases:

>100_bases
TAACTTTCCGTAAAATACCCAACTCTTTGGGGACTGGGGACTGGGGACTGGGGACTGGGGACTGGGTAATAGGCAAAAGT
CAGAAGAAAAAATCTTTTAC

Product: glucose-6-phosphate isomerase

Products: NA

Alternate protein names: GPI; Phosphoglucose isomerase; PGI; Phosphohexose isomerase; PHI

Number of amino acids: Translated: 528; Mature: 528

Protein sequence:

>528_residues
MDAKALWQRYQEWLYFHEGLGLYLDVSRMRFDDAFVKSLLPKFDKAFADMAELEKGAIANPDENRMVGHYWLRNPDLAPT
PEIAQEIVQTLEQIEAFAEKIQTGAIHPPKANRFTDIISIGIGGSALGPQFVAEALAPEFPPLKIHFIDNTDPAGIDKIL
THLRNNLASTLVLVISKSGGTPEPRNGMIEVKKAYAGQNLDFAQYAVAITSTGSNLDKVAQAEGWLATFPMYDWVGGRTS
EMSSVGLVPAALQGIDVRAMLEGAKEMDDATRVPEVKNNPAALLALSWYYSGNGKGEKDMVVLPYKDSLLLFSRYLQQLV
MESLGKEKDLDGKTVYQGIAVYGNKGSTDQHAYVQQLREGVPNFFATLIEVLEDRNGASPEIDPGVTSGDYLSGFLLGTR
QALYENQRDSITVTIPQVNARTVGALIALYERTVGLYASLVNINAYHQPGVEAGKKAAAVILDLQTKVVGLLQKEKTALS
LEQIAEKIGAADQVEAIYKILRHLQANQRGVVFQGNLGQPSSLKVSIS

Sequences:

>Translated_528_residues
MDAKALWQRYQEWLYFHEGLGLYLDVSRMRFDDAFVKSLLPKFDKAFADMAELEKGAIANPDENRMVGHYWLRNPDLAPT
PEIAQEIVQTLEQIEAFAEKIQTGAIHPPKANRFTDIISIGIGGSALGPQFVAEALAPEFPPLKIHFIDNTDPAGIDKIL
THLRNNLASTLVLVISKSGGTPEPRNGMIEVKKAYAGQNLDFAQYAVAITSTGSNLDKVAQAEGWLATFPMYDWVGGRTS
EMSSVGLVPAALQGIDVRAMLEGAKEMDDATRVPEVKNNPAALLALSWYYSGNGKGEKDMVVLPYKDSLLLFSRYLQQLV
MESLGKEKDLDGKTVYQGIAVYGNKGSTDQHAYVQQLREGVPNFFATLIEVLEDRNGASPEIDPGVTSGDYLSGFLLGTR
QALYENQRDSITVTIPQVNARTVGALIALYERTVGLYASLVNINAYHQPGVEAGKKAAAVILDLQTKVVGLLQKEKTALS
LEQIAEKIGAADQVEAIYKILRHLQANQRGVVFQGNLGQPSSLKVSIS
>Mature_528_residues
MDAKALWQRYQEWLYFHEGLGLYLDVSRMRFDDAFVKSLLPKFDKAFADMAELEKGAIANPDENRMVGHYWLRNPDLAPT
PEIAQEIVQTLEQIEAFAEKIQTGAIHPPKANRFTDIISIGIGGSALGPQFVAEALAPEFPPLKIHFIDNTDPAGIDKIL
THLRNNLASTLVLVISKSGGTPEPRNGMIEVKKAYAGQNLDFAQYAVAITSTGSNLDKVAQAEGWLATFPMYDWVGGRTS
EMSSVGLVPAALQGIDVRAMLEGAKEMDDATRVPEVKNNPAALLALSWYYSGNGKGEKDMVVLPYKDSLLLFSRYLQQLV
MESLGKEKDLDGKTVYQGIAVYGNKGSTDQHAYVQQLREGVPNFFATLIEVLEDRNGASPEIDPGVTSGDYLSGFLLGTR
QALYENQRDSITVTIPQVNARTVGALIALYERTVGLYASLVNINAYHQPGVEAGKKAAAVILDLQTKVVGLLQKEKTALS
LEQIAEKIGAADQVEAIYKILRHLQANQRGVVFQGNLGQPSSLKVSIS

Specific function: Involved in glycolysis and in gluconeogenesis. [C]

COG id: COG0166

COG function: function code G; Glucose-6-phosphate isomerase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GPI family

Homologues:

Organism=Homo sapiens, GI18201905, Length=476, Percent_Identity=28.5714285714286, Blast_Score=148, Evalue=1e-35,
Organism=Homo sapiens, GI296080693, Length=476, Percent_Identity=26.2605042016807, Blast_Score=112, Evalue=1e-24,
Organism=Escherichia coli, GI1790457, Length=486, Percent_Identity=30.6584362139918, Blast_Score=162, Evalue=4e-41,
Organism=Caenorhabditis elegans, GI71996708, Length=440, Percent_Identity=28.1818181818182, Blast_Score=145, Evalue=5e-35,
Organism=Caenorhabditis elegans, GI71996703, Length=440, Percent_Identity=28.1818181818182, Blast_Score=144, Evalue=8e-35,
Organism=Saccharomyces cerevisiae, GI6319673, Length=481, Percent_Identity=27.027027027027, Blast_Score=140, Evalue=5e-34,
Organism=Drosophila melanogaster, GI24651916, Length=481, Percent_Identity=29.5218295218295, Blast_Score=158, Evalue=9e-39,
Organism=Drosophila melanogaster, GI24651914, Length=481, Percent_Identity=29.5218295218295, Blast_Score=158, Evalue=9e-39,
Organism=Drosophila melanogaster, GI17737445, Length=481, Percent_Identity=29.5218295218295, Blast_Score=158, Evalue=9e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): G6PI_ANAVT (Q3M6S3)

Other databases:

- EMBL:   CP000117
- RefSeq:   YP_324208.1
- ProteinModelPortal:   Q3M6S3
- SMR:   Q3M6S3
- STRING:   Q3M6S3
- GeneID:   3678794
- GenomeReviews:   CP000117_GR
- KEGG:   ava:Ava_3708
- NMPDR:   fig|240292.3.peg.4861
- eggNOG:   COG0166
- HOGENOM:   HBG285902
- OMA:   RTSITSA
- ProtClustDB:   PRK14096
- BioCyc:   AVAR240292:AVA_3708-MONOMER
- GO:   GO:0005737
- GO:   GO:0006094
- GO:   GO:0006096
- HAMAP:   MF_00473
- InterPro:   IPR001672
- InterPro:   IPR018189
- PANTHER:   PTHR11469
- PRINTS:   PR00662

Pfam domain/function: PF00342 PGI

EC number: =5.3.1.9

Molecular weight: Translated: 57744; Mature: 57744

Theoretical pI: Translated: 5.14; Mature: 5.14

Prosite motif: PS00765 P_GLUCOSE_ISOMERASE_1; PS00174 P_GLUCOSE_ISOMERASE_2; PS51463 P_GLUCOSE_ISOMERASE_3

Important sites: ACT_SITE 322-322 ACT_SITE 351-351 ACT_SITE 455-455

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDAKALWQRYQEWLYFHEGLGLYLDVSRMRFDDAFVKSLLPKFDKAFADMAELEKGAIAN
CCHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
PDENRMVGHYWLRNPDLAPTPEIAQEIVQTLEQIEAFAEKIQTGAIHPPKANRFTDIISI
CCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHEEEE
GIGGSALGPQFVAEALAPEFPPLKIHFIDNTDPAGIDKILTHLRNNLASTLVLVISKSGG
CCCCCCCCHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHEEEEEEECCCC
TPEPRNGMIEVKKAYAGQNLDFAQYAVAITSTGSNLDKVAQAEGWLATFPMYDWVGGRTS
CCCCCCCCEEEHHHHCCCCCCHHHEEEEEECCCCCHHHHHHCCCCEEECCCHHCCCCCCC
EMSSVGLVPAALQGIDVRAMLEGAKEMDDATRVPEVKNNPAALLALSWYYSGNGKGEKDM
CHHHCCCHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEEEECCCCCCCCE
VVLPYKDSLLLFSRYLQQLVMESLGKEKDLDGKTVYQGIAVYGNKGSTDQHAYVQQLREG
EEECCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCEEEECCCCCCHHHHHHHHHHHC
VPNFFATLIEVLEDRNGASPEIDPGVTSGDYLSGFLLGTRQALYENQRDSITVTIPQVNA
CHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCH
RTVGALIALYERTVGLYASLVNINAYHQPGVEAGKKAAAVILDLQTKVVGLLQKEKTALS
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCHHEEEEEEHHHHHHHHHHHHHHHHH
LEQIAEKIGAADQVEAIYKILRHLQANQRGVVFQGNLGQPSSLKVSIS
HHHHHHHHCCHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCEEEEEC
>Mature Secondary Structure
MDAKALWQRYQEWLYFHEGLGLYLDVSRMRFDDAFVKSLLPKFDKAFADMAELEKGAIAN
CCHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
PDENRMVGHYWLRNPDLAPTPEIAQEIVQTLEQIEAFAEKIQTGAIHPPKANRFTDIISI
CCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHEEEE
GIGGSALGPQFVAEALAPEFPPLKIHFIDNTDPAGIDKILTHLRNNLASTLVLVISKSGG
CCCCCCCCHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHEEEEEEECCCC
TPEPRNGMIEVKKAYAGQNLDFAQYAVAITSTGSNLDKVAQAEGWLATFPMYDWVGGRTS
CCCCCCCCEEEHHHHCCCCCCHHHEEEEEECCCCCHHHHHHCCCCEEECCCHHCCCCCCC
EMSSVGLVPAALQGIDVRAMLEGAKEMDDATRVPEVKNNPAALLALSWYYSGNGKGEKDM
CHHHCCCHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEEEECCCCCCCCE
VVLPYKDSLLLFSRYLQQLVMESLGKEKDLDGKTVYQGIAVYGNKGSTDQHAYVQQLREG
EEECCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCEEEECCCCCCHHHHHHHHHHHC
VPNFFATLIEVLEDRNGASPEIDPGVTSGDYLSGFLLGTRQALYENQRDSITVTIPQVNA
CHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCH
RTVGALIALYERTVGLYASLVNINAYHQPGVEAGKKAAAVILDLQTKVVGLLQKEKTALS
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCHHEEEEEEHHHHHHHHHHHHHHHHH
LEQIAEKIGAADQVEAIYKILRHLQANQRGVVFQGNLGQPSSLKVSIS
HHHHHHHHCCHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA