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The map label for this gene is dapA [H]

Identifier: 75909812

GI number: 75909812

Start: 4499594

End: 4500478

Strand: Direct

Name: dapA [H]

Synonym: Ava_3607

Alternate gene names: 75909812

Gene position: 4499594-4500478 (Clockwise)

Preceding gene: 75909811

Following gene: 75909813

Centisome position: 70.68

GC content: 44.52

Gene sequence:

>885_bases
GTGGGAGATTTTGGCACAGTTTTAACCGCTATGATTACACCGTTCAAAGCGGACGGGAGTGTTAACTATGCTGTAGCGGC
AGAACTAGCAGCGCATTTAGTTGACAATGGTACAGACACATTGGTTGTGTGTGGTACAACTGGAGAATCACCCACCTTGA
GTTGGGATGAAGAATACAATTTATTTGTAGAAGTTTTGCAGACAGTAGCAGGCAAAGCCAAGGTAATAGCTGGATGTGGT
TCCAATTCCACCAAAGAAGCGATCGCAGCTACGCAAAAAGCAGCTAAAATAGGAGTACATGGTACTTTACAGGTTGTACC
TTACTACAACAAACCGCCACAAGCCGGACTATATCAGCACTTTCAGGCGATAGCGCAAGCCTGTCCAGACTTACCGCTAT
TGTTATACAACGTTCCTGGTCGTACTGGTCAAAATCTCAGTCCAGAGACAGTTGTGCGGTTAGCCGAAATCGACAATATT
ATTGGTGTTAAAGAAGCTAGTGGCAATCTCGACCAAGCGGGTGAAATCCGTCGCTCGACACCAAAAGAATTCCAGATTTA
CGCTGGAGATGATTCGTTAACCTTGCCCTTGTTAGCGATAGGGGCAAAGGGCGTAGTTAGTGTAGCTTCCCATTTGGTAG
GGAACCAACTACAACAGATGATTCAAGCTTTTAATTCCGGGCAAGTGACAGTCGCCAGTGATATTCATCTTCGACTCTTG
CCGTTGTTTAAAGCTTTATTTATCACTACAAATCCGATTCCCATTAAACAAGCACTAAAACTTCAAGGTTGGGAGGTTGG
TTCAACCCGTCCGCCCCTAAGTGATGCGGATGCGGAAGTCAGTCAAAAACTAGAAGCAGTAATGAAACATCTCAATTTAA
TCTAA

Upstream 100 bases:

>100_bases
AAGAAGCAACTGACCACCTTTGACCGAGGACTATTAGCAGTTAACTGGCAACTAACAACTAACAACTGACCACTGACAAA
CATAAAGGAGTAACAAAAGG

Downstream 100 bases:

>100_bases
TCACCAATATCTCAGGACTAGTTAAATTCTATTTGTCAAAACTGTATATCTATAACTAATGGGGTTTATTAGAAAAATCT
GATGATTAAAGTTTTATTAC

Product: dihydrodipicolinate synthase

Products: NA

Alternate protein names: DHDPS [H]

Number of amino acids: Translated: 294; Mature: 293

Protein sequence:

>294_residues
MGDFGTVLTAMITPFKADGSVNYAVAAELAAHLVDNGTDTLVVCGTTGESPTLSWDEEYNLFVEVLQTVAGKAKVIAGCG
SNSTKEAIAATQKAAKIGVHGTLQVVPYYNKPPQAGLYQHFQAIAQACPDLPLLLYNVPGRTGQNLSPETVVRLAEIDNI
IGVKEASGNLDQAGEIRRSTPKEFQIYAGDDSLTLPLLAIGAKGVVSVASHLVGNQLQQMIQAFNSGQVTVASDIHLRLL
PLFKALFITTNPIPIKQALKLQGWEVGSTRPPLSDADAEVSQKLEAVMKHLNLI

Sequences:

>Translated_294_residues
MGDFGTVLTAMITPFKADGSVNYAVAAELAAHLVDNGTDTLVVCGTTGESPTLSWDEEYNLFVEVLQTVAGKAKVIAGCG
SNSTKEAIAATQKAAKIGVHGTLQVVPYYNKPPQAGLYQHFQAIAQACPDLPLLLYNVPGRTGQNLSPETVVRLAEIDNI
IGVKEASGNLDQAGEIRRSTPKEFQIYAGDDSLTLPLLAIGAKGVVSVASHLVGNQLQQMIQAFNSGQVTVASDIHLRLL
PLFKALFITTNPIPIKQALKLQGWEVGSTRPPLSDADAEVSQKLEAVMKHLNLI
>Mature_293_residues
GDFGTVLTAMITPFKADGSVNYAVAAELAAHLVDNGTDTLVVCGTTGESPTLSWDEEYNLFVEVLQTVAGKAKVIAGCGS
NSTKEAIAATQKAAKIGVHGTLQVVPYYNKPPQAGLYQHFQAIAQACPDLPLLLYNVPGRTGQNLSPETVVRLAEIDNII
GVKEASGNLDQAGEIRRSTPKEFQIYAGDDSLTLPLLAIGAKGVVSVASHLVGNQLQQMIQAFNSGQVTVASDIHLRLLP
LFKALFITTNPIPIKQALKLQGWEVGSTRPPLSDADAEVSQKLEAVMKHLNLI

Specific function: Biosynthesis of diaminopimelate and lysine from aspartate semialdehyde; first step. [C]

COG id: COG0329

COG function: function code EM; Dihydrodipicolinate synthase/N-acetylneuraminate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHDPS family [H]

Homologues:

Organism=Homo sapiens, GI31543060, Length=276, Percent_Identity=28.6231884057971, Blast_Score=108, Evalue=4e-24,
Organism=Homo sapiens, GI13540533, Length=299, Percent_Identity=28.0936454849498, Blast_Score=101, Evalue=7e-22,
Organism=Escherichia coli, GI1788823, Length=292, Percent_Identity=41.4383561643836, Blast_Score=223, Evalue=1e-59,
Organism=Escherichia coli, GI87082415, Length=298, Percent_Identity=29.1946308724832, Blast_Score=128, Evalue=6e-31,
Organism=Escherichia coli, GI1786463, Length=283, Percent_Identity=28.6219081272085, Blast_Score=104, Evalue=7e-24,
Organism=Escherichia coli, GI1789620, Length=286, Percent_Identity=26.2237762237762, Blast_Score=100, Evalue=1e-22,

Paralogues:

None

Copy number: 840 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005263
- InterPro:   IPR002220
- InterPro:   IPR020625 [H]

Pfam domain/function: PF00701 DHDPS [H]

EC number: =4.2.1.52 [H]

Molecular weight: Translated: 31240; Mature: 31109

Theoretical pI: Translated: 5.61; Mature: 5.61

Prosite motif: PS00666 DHDPS_2 ; PS00430 TONB_DEPENDENT_REC_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGDFGTVLTAMITPFKADGSVNYAVAAELAAHLVDNGTDTLVVCGTTGESPTLSWDEEYN
CCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCHHHH
LFVEVLQTVAGKAKVIAGCGSNSTKEAIAATQKAAKIGVHGTLQVVPYYNKPPQAGLYQH
HHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCHHHHH
FQAIAQACPDLPLLLYNVPGRTGQNLSPETVVRLAEIDNIIGVKEASGNLDQAGEIRRST
HHHHHHHCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHCCC
PKEFQIYAGDDSLTLPLLAIGAKGVVSVASHLVGNQLQQMIQAFNSGQVTVASDIHLRLL
CCCEEEEECCCCCEEHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHH
PLFKALFITTNPIPIKQALKLQGWEVGSTRPPLSDADAEVSQKLEAVMKHLNLI
HHHHHHHHCCCCCCHHHHHHCCCEECCCCCCCCCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
GDFGTVLTAMITPFKADGSVNYAVAAELAAHLVDNGTDTLVVCGTTGESPTLSWDEEYN
CCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCHHHH
LFVEVLQTVAGKAKVIAGCGSNSTKEAIAATQKAAKIGVHGTLQVVPYYNKPPQAGLYQH
HHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCHHHHH
FQAIAQACPDLPLLLYNVPGRTGQNLSPETVVRLAEIDNIIGVKEASGNLDQAGEIRRST
HHHHHHHCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHCCC
PKEFQIYAGDDSLTLPLLAIGAKGVVSVASHLVGNQLQQMIQAFNSGQVTVASDIHLRLL
CCCEEEEECCCCCEEHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHH
PLFKALFITTNPIPIKQALKLQGWEVGSTRPPLSDADAEVSQKLEAVMKHLNLI
HHHHHHHHCCCCCCHHHHHHCCCEECCCCCCCCCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11759840 [H]