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The map label for this gene is yvaE [H]

Identifier: 75909285

GI number: 75909285

Start: 3816079

End: 3816399

Strand: Direct

Name: yvaE [H]

Synonym: Ava_3077

Alternate gene names: 75909285

Gene position: 3816079-3816399 (Clockwise)

Preceding gene: 75909283

Following gene: 75909286

Centisome position: 59.95

GC content: 33.96

Gene sequence:

>321_bases
ATGTCTACAAGTTTAGTTTACTTGCTGATGGCAATTATATTTGAAGTTTCCGGCACCACCTGCATGAAATTATCAGATGG
TTTTAATAAATTGACACCTTCTATTTTGATATTTGTATTTTATGGACTTTGTTTTACTTTCCAGACACTATCCCTCAAAA
ATATTGACATTAGTATTGCTTACTCTGTTTGGGCAGGTTTAGGAACTGCTTTAATTGCTGGTGTTGGTCTAATTTGGTTT
CGTGAATCCATGACGCTAGTTAAGTTTATCTCTATGACTTTAATTATCGTGGGAGTAGTTGGCATAAATTCAGGGAAATA
A

Upstream 100 bases:

>100_bases
TAGCAGAAATGTGAAAAATAAATTTATAAGCTATTTAGATAGCAACATGATTTATTTTTGCTGATAATACATTTTGCTTT
TGTAAAAAATACATCACAAT

Downstream 100 bases:

>100_bases
AAACTCTACCCACAAGGGGATCGAGTTTTGTCAGTGGTCAGTGGTCAGTGGCAAAGATATGTAAAAACTACTCCATGTGA
GGGTTGGGGTATTAGACCAG

Product: small multidrug resistance protein

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 106; Mature: 105

Protein sequence:

>106_residues
MSTSLVYLLMAIIFEVSGTTCMKLSDGFNKLTPSILIFVFYGLCFTFQTLSLKNIDISIAYSVWAGLGTALIAGVGLIWF
RESMTLVKFISMTLIIVGVVGINSGK

Sequences:

>Translated_106_residues
MSTSLVYLLMAIIFEVSGTTCMKLSDGFNKLTPSILIFVFYGLCFTFQTLSLKNIDISIAYSVWAGLGTALIAGVGLIWF
RESMTLVKFISMTLIIVGVVGINSGK
>Mature_105_residues
STSLVYLLMAIIFEVSGTTCMKLSDGFNKLTPSILIFVFYGLCFTFQTLSLKNIDISIAYSVWAGLGTALIAGVGLIWFR
ESMTLVKFISMTLIIVGVVGINSGK

Specific function: Multidrug Transporter. Confers Resistance To A Wide Range Of Toxic Compounds By Removing Them For The Cells. The Efflux Is Coupled To An Influx Of Protons. Probably Prevents The Incorporation Of Methyl VIologen Into Cells. Involved In Ethidium Bromide Ef

COG id: COG2076

COG function: function code P; Membrane transporters of cations and cationic drugs

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the small multidrug resistance (SMR) protein family [H]

Homologues:

Organism=Escherichia coli, GI1786755, Length=98, Percent_Identity=39.7959183673469, Blast_Score=63, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000390 [H]

Pfam domain/function: PF00893 Multi_Drug_Res [H]

EC number: NA

Molecular weight: Translated: 11514; Mature: 11383

Theoretical pI: Translated: 8.73; Mature: 8.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
6.6 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTSLVYLLMAIIFEVSGTTCMKLSDGFNKLTPSILIFVFYGLCFTFQTLSLKNIDISIA
CCHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCEECCCEEEHH
YSVWAGLGTALIAGVGLIWFRESMTLVKFISMTLIIVGVVGINSGK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
STSLVYLLMAIIFEVSGTTCMKLSDGFNKLTPSILIFVFYGLCFTFQTLSLKNIDISIA
CHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCEECCCEEEHH
YSVWAGLGTALIAGVGLIWFRESMTLVKFISMTLIIVGVVGINSGK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]