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The map label for this gene is hemD [H]

Identifier: 75909283

GI number: 75909283

Start: 3814354

End: 3815184

Strand: Direct

Name: hemD [H]

Synonym: Ava_3075

Alternate gene names: 75909283

Gene position: 3814354-3815184 (Clockwise)

Preceding gene: 75909278

Following gene: 75909285

Centisome position: 59.92

GC content: 34.9

Gene sequence:

>831_bases
ATGTCTAACTTGCTAACTGCATCTCACCAATTGCCCTTATACGGAAAAAGGATTTTAGTAACAGCGCCAAGAAACTACGC
TTCTAGGTTGTCTGCACAAATTATCTGCAAGGGTGGTTTACCGATTCTCATGCCCACGATAGAAACCTGCTATTTACCTA
ACTTTTCTCAATTAGATGCTGTTATCAGCTGCATAAATGAATTTGATTGGATTGCATTTACTAGTAGAAACGGCATCATA
GCATTTTTTGAACGTCTACATAATTTAGATATTTCTATAAATAAATTGCAAAATTGTCAATTATGTGCATTGGGGAAAGA
TATAGATGTTTTATTATCTTTGTTTGGTAGAGTAGATTTAATTCCTGACGAATCTAGCCCGGCGGGGATTGTGGCTAAAT
TTTCGCAAATACATGGAATTAGTAGACAAAAAATCTTAGTTCCAGTGCCAGAAGTTATAGGCATACCTGAGCCTAATATT
GTGCCTAATTTTATCAAGGATTTAGAAAAATTGGGTATGCAGGTGATTCGTGTACCTACATACATAACTCAATCTTTAGA
CAAAAATATTTACTCGGTGGAAATAAATTTAATTCAACAAGGCTTAATTGATGTGATTGCCTTTAGTAGTACCGCAGAAA
TCGAAAGTTTTTTAAAAATGTTTAACTCTAAAAATGAGTTTCAGCATTGTGTTGTTGCTTGTTTTGGCCCTTATACAGCC
GCCAACGCCCAAAAGTTAGGTCTGGATGTTTCTCTTGTGTCAACAGACTTTAGTTCTTTTGAAGGTTTCGTAGAAGCAAT
AGTAAAATTTTATATTGATAGTCCAACGTAA

Upstream 100 bases:

>100_bases
CAAAGATTGCGGCGCGGATATTTGCTAACACACTTAATCCCTTATTTTCAGCTTAACAACAACACACTATACAATTACGC
TGCTGATTCGATATTTGCCA

Downstream 100 bases:

>100_bases
TGCGATCGCCTATGTAATATCGTAAGCGATCGCAGTTCATCAAATATTTTGTATAATGAGCAAATATGCCCATTATAGAA
GCTAGTTAGCCAACAGCAGA

Product: uroporphyrinogen-III synthase

Products: NA

Alternate protein names: Uroporphyrinogen-III C-methyltransferase; Urogen III methylase; SUMT; Uroporphyrinogen III methylase; UROM; Uroporphyrinogen-III synthase; UROS; Hydroxymethylbilane hydrolyase [cyclizing]; Uroporphyrinogen-III cosynthase [H]

Number of amino acids: Translated: 276; Mature: 275

Protein sequence:

>276_residues
MSNLLTASHQLPLYGKRILVTAPRNYASRLSAQIICKGGLPILMPTIETCYLPNFSQLDAVISCINEFDWIAFTSRNGII
AFFERLHNLDISINKLQNCQLCALGKDIDVLLSLFGRVDLIPDESSPAGIVAKFSQIHGISRQKILVPVPEVIGIPEPNI
VPNFIKDLEKLGMQVIRVPTYITQSLDKNIYSVEINLIQQGLIDVIAFSSTAEIESFLKMFNSKNEFQHCVVACFGPYTA
ANAQKLGLDVSLVSTDFSSFEGFVEAIVKFYIDSPT

Sequences:

>Translated_276_residues
MSNLLTASHQLPLYGKRILVTAPRNYASRLSAQIICKGGLPILMPTIETCYLPNFSQLDAVISCINEFDWIAFTSRNGII
AFFERLHNLDISINKLQNCQLCALGKDIDVLLSLFGRVDLIPDESSPAGIVAKFSQIHGISRQKILVPVPEVIGIPEPNI
VPNFIKDLEKLGMQVIRVPTYITQSLDKNIYSVEINLIQQGLIDVIAFSSTAEIESFLKMFNSKNEFQHCVVACFGPYTA
ANAQKLGLDVSLVSTDFSSFEGFVEAIVKFYIDSPT
>Mature_275_residues
SNLLTASHQLPLYGKRILVTAPRNYASRLSAQIICKGGLPILMPTIETCYLPNFSQLDAVISCINEFDWIAFTSRNGIIA
FFERLHNLDISINKLQNCQLCALGKDIDVLLSLFGRVDLIPDESSPAGIVAKFSQIHGISRQKILVPVPEVIGIPEPNIV
PNFIKDLEKLGMQVIRVPTYITQSLDKNIYSVEINLIQQGLIDVIAFSSTAEIESFLKMFNSKNEFQHCVVACFGPYTAA
NAQKLGLDVSLVSTDFSSFEGFVEAIVKFYIDSPT

Specific function: May catalyze sequential reactions to synthesize uroporphyrinogen III from hydroxymethylbilane (HMB) and then precorrin-2, which are intermediate compounds in both vitamin B12 and siroheme biosyntheses [H]

COG id: COG1587

COG function: function code H; Uroporphyrinogen-III synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the precorrin methyltransferase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000878
- InterPro:   IPR003754
- InterPro:   IPR014777
- InterPro:   IPR014776
- InterPro:   IPR006366
- InterPro:   IPR003043 [H]

Pfam domain/function: PF02602 HEM4; PF00590 TP_methylase [H]

EC number: =2.1.1.107; =4.2.1.75 [H]

Molecular weight: Translated: 30564; Mature: 30433

Theoretical pI: Translated: 5.31; Mature: 5.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNLLTASHQLPLYGKRILVTAPRNYASRLSAQIICKGGLPILMPTIETCYLPNFSQLDA
CCCCCCCCCCCCCCCCEEEEECCCHHHHHCCEEEEECCCCCEEECCHHHHCCCCHHHHHH
VISCINEFDWIAFTSRNGIIAFFERLHNLDISINKLQNCQLCALGKDIDVLLSLFGRVDL
HHHHHHCCCEEEEECCCCHHHHHHHHHCCCCEEECCCCCEEEECCCCHHHHHHHHCCEEE
IPDESSPAGIVAKFSQIHGISRQKILVPVPEVIGIPEPNIVPNFIKDLEKLGMQVIRVPT
CCCCCCCCHHHHHHHHHCCCCCCEEEEECHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHH
YITQSLDKNIYSVEINLIQQGLIDVIAFSSTAEIESFLKMFNSKNEFQHCVVACFGPYTA
HHHHHHCCCEEEEEHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHEECCCCC
ANAQKLGLDVSLVSTDFSSFEGFVEAIVKFYIDSPT
CCHHHHCCEEEEECCCHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SNLLTASHQLPLYGKRILVTAPRNYASRLSAQIICKGGLPILMPTIETCYLPNFSQLDA
CCCCCCCCCCCCCCCEEEEECCCHHHHHCCEEEEECCCCCEEECCHHHHCCCCHHHHHH
VISCINEFDWIAFTSRNGIIAFFERLHNLDISINKLQNCQLCALGKDIDVLLSLFGRVDL
HHHHHHCCCEEEEECCCCHHHHHHHHHCCCCEEECCCCCEEEECCCCHHHHHHHHCCEEE
IPDESSPAGIVAKFSQIHGISRQKILVPVPEVIGIPEPNIVPNFIKDLEKLGMQVIRVPT
CCCCCCCCHHHHHHHHHCCCCCCEEEEECHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHH
YITQSLDKNIYSVEINLIQQGLIDVIAFSSTAEIESFLKMFNSKNEFQHCVVACFGPYTA
HHHHHHCCCEEEEEHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHEECCCCC
ANAQKLGLDVSLVSTDFSSFEGFVEAIVKFYIDSPT
CCHHHHCCEEEEECCCHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7665501 [H]