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The map label for this gene is gcvT [H]

Identifier: 75908972

GI number: 75908972

Start: 3401547

End: 3402677

Strand: Direct

Name: gcvT [H]

Synonym: Ava_2760

Alternate gene names: 75908972

Gene position: 3401547-3402677 (Clockwise)

Preceding gene: 75908969

Following gene: 75908973

Centisome position: 53.44

GC content: 46.6

Gene sequence:

>1131_bases
GTGGCTAATCAAAAAGACACTGCCGAAACCTTAGCGAGAACTCCTTTGTATCAACTGAGTCTAGAACTCAACGCCCGTTT
GACCAGCTTTGGCGGGTGGGAAATGCCAGTACAATTCAGTGGGATTACCCGCGAACACGAAGCAGTGAGAAATGCTGCTG
GGATGTTTGACATATCTCACATGGGGAAATTTACCCTCCAAGGTAAAAACCTGATTTCTCAACTCCAAGGTTTAGTTCCT
TCAGACTTGAGTAGGTTGCAACCAGGACAAGCCCAATACACCGTGTTGTTAAACCCCCAAGGAGGAATCATTGACGATAT
CATTGTCTACTACCAAGGTGAAGACAACAGTGGTATGCAACAGGCATTTATCATCGTCAACGCAGCCACCACCAGTAAAG
ACAAAGCATGGATACTGTCACACCTTGACCAAAATCAGGTGCAATTCCAAGACATATCACTAGCAAAAGTCTTAATTGCC
GTCCAAGGGCCAAAAGCCATTGACTATCTCCAGCCTTTTGTGCAGCAAAATTTACAACCAATCAAAGCCTTCGGACATCT
AGGAGCCACAGTACTAGGTCAAGCAGGTTTTATAGCCCGTACAGGTTACACCGGGGAAGATGGCTTTGAGATTTTGTTAG
ACCCAGAAGTGGGAGTGGAGTTATGGCGTAGTTTATCTAATGCAGGTGTCATTCCCTGTGGCTTAGGTGCAAGAGATACC
CTGAGGCTAGAAGCAGCTATGGCACTCTACGGTCAAGACATCAATGACAACACCACTCCTCTAGAAGCTGGGTTAGGGTG
GTTAGTTCATTTGGATACCAAAGGAGATTTTATTGGTCGGTCAGTTTTAGAACAACAAAAGGCCACAGGAGTAAAACGCC
GCCTCATAGGTTTGCAAGCCCAAGGACGTAACATCGCCCGTCATGGTTACCAAGTTCTCTCAGACGGTAAAGTAGTAGGC
GAAGTGACTAGCGGTACTCTATCGCCTACACTAGGTCATCCCGTTGCTTTAGCCTACGTCCCCAGCAAACTAGCAAAAGT
TGGTCAACCCCTAGAAGTCGAAATTCGCGGTAAAGCATACCCAGCCGTTGTAGTTAAGCGACCATTTTATCGTTCAAGTC
AGAAGGGCTAG

Upstream 100 bases:

>100_bases
GTAGAAAATCGTGGGTAAGACAATTTCTCACTCCCTATTAATTGAAACCATCACGTAGGATATTAAATGTTGAAGTGCGA
TCGCATAAGCAAAACTATCT

Downstream 100 bases:

>100_bases
AAAATCACGATTAGGGTAAGCAGAGGGTCTAAAGAGCGAAAATTTAGCCTATCTCCAGCCCCCAATCTAAAAATCAATGT
TGACCTACTGAATGTGTTGT

Product: glycine cleavage system aminomethyltransferase T

Products: NA

Alternate protein names: Glycine cleavage system T protein [H]

Number of amino acids: Translated: 376; Mature: 375

Protein sequence:

>376_residues
MANQKDTAETLARTPLYQLSLELNARLTSFGGWEMPVQFSGITREHEAVRNAAGMFDISHMGKFTLQGKNLISQLQGLVP
SDLSRLQPGQAQYTVLLNPQGGIIDDIIVYYQGEDNSGMQQAFIIVNAATTSKDKAWILSHLDQNQVQFQDISLAKVLIA
VQGPKAIDYLQPFVQQNLQPIKAFGHLGATVLGQAGFIARTGYTGEDGFEILLDPEVGVELWRSLSNAGVIPCGLGARDT
LRLEAAMALYGQDINDNTTPLEAGLGWLVHLDTKGDFIGRSVLEQQKATGVKRRLIGLQAQGRNIARHGYQVLSDGKVVG
EVTSGTLSPTLGHPVALAYVPSKLAKVGQPLEVEIRGKAYPAVVVKRPFYRSSQKG

Sequences:

>Translated_376_residues
MANQKDTAETLARTPLYQLSLELNARLTSFGGWEMPVQFSGITREHEAVRNAAGMFDISHMGKFTLQGKNLISQLQGLVP
SDLSRLQPGQAQYTVLLNPQGGIIDDIIVYYQGEDNSGMQQAFIIVNAATTSKDKAWILSHLDQNQVQFQDISLAKVLIA
VQGPKAIDYLQPFVQQNLQPIKAFGHLGATVLGQAGFIARTGYTGEDGFEILLDPEVGVELWRSLSNAGVIPCGLGARDT
LRLEAAMALYGQDINDNTTPLEAGLGWLVHLDTKGDFIGRSVLEQQKATGVKRRLIGLQAQGRNIARHGYQVLSDGKVVG
EVTSGTLSPTLGHPVALAYVPSKLAKVGQPLEVEIRGKAYPAVVVKRPFYRSSQKG
>Mature_375_residues
ANQKDTAETLARTPLYQLSLELNARLTSFGGWEMPVQFSGITREHEAVRNAAGMFDISHMGKFTLQGKNLISQLQGLVPS
DLSRLQPGQAQYTVLLNPQGGIIDDIIVYYQGEDNSGMQQAFIIVNAATTSKDKAWILSHLDQNQVQFQDISLAKVLIAV
QGPKAIDYLQPFVQQNLQPIKAFGHLGATVLGQAGFIARTGYTGEDGFEILLDPEVGVELWRSLSNAGVIPCGLGARDTL
RLEAAMALYGQDINDNTTPLEAGLGWLVHLDTKGDFIGRSVLEQQKATGVKRRLIGLQAQGRNIARHGYQVLSDGKVVGE
VTSGTLSPTLGHPVALAYVPSKLAKVGQPLEVEIRGKAYPAVVVKRPFYRSSQKG

Specific function: The glycine cleavage system catalyzes the degradation of glycine [H]

COG id: COG0404

COG function: function code E; Glycine cleavage system T protein (aminomethyltransferase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvT family [H]

Homologues:

Organism=Homo sapiens, GI44662838, Length=369, Percent_Identity=36.3143631436314, Blast_Score=216, Evalue=3e-56,
Organism=Homo sapiens, GI257796258, Length=355, Percent_Identity=35.4929577464789, Blast_Score=203, Evalue=3e-52,
Organism=Homo sapiens, GI257796254, Length=366, Percent_Identity=33.879781420765, Blast_Score=175, Evalue=6e-44,
Organism=Homo sapiens, GI257796256, Length=309, Percent_Identity=36.2459546925566, Blast_Score=171, Evalue=9e-43,
Organism=Homo sapiens, GI24797151, Length=383, Percent_Identity=30.5483028720627, Blast_Score=156, Evalue=3e-38,
Organism=Homo sapiens, GI197927446, Length=324, Percent_Identity=28.3950617283951, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI21361378, Length=324, Percent_Identity=28.3950617283951, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI194306651, Length=322, Percent_Identity=27.0186335403727, Blast_Score=98, Evalue=1e-20,
Organism=Escherichia coli, GI1789272, Length=375, Percent_Identity=40.8, Blast_Score=247, Evalue=1e-66,
Organism=Caenorhabditis elegans, GI17560118, Length=379, Percent_Identity=33.7730870712401, Blast_Score=187, Evalue=6e-48,
Organism=Caenorhabditis elegans, GI32563613, Length=408, Percent_Identity=25.2450980392157, Blast_Score=102, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI71994052, Length=375, Percent_Identity=24.8, Blast_Score=92, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI71994045, Length=375, Percent_Identity=24.8, Blast_Score=92, Evalue=4e-19,
Organism=Saccharomyces cerevisiae, GI6320222, Length=385, Percent_Identity=36.3636363636364, Blast_Score=201, Evalue=1e-52,
Organism=Drosophila melanogaster, GI20129441, Length=377, Percent_Identity=36.0742705570292, Blast_Score=214, Evalue=9e-56,
Organism=Drosophila melanogaster, GI20130091, Length=366, Percent_Identity=25.6830601092896, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI28571104, Length=287, Percent_Identity=27.8745644599303, Blast_Score=97, Evalue=2e-20,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013977
- InterPro:   IPR006222
- InterPro:   IPR006223
- InterPro:   IPR022903 [H]

Pfam domain/function: PF01571 GCV_T; PF08669 GCV_T_C [H]

EC number: =2.1.2.10 [H]

Molecular weight: Translated: 40775; Mature: 40644

Theoretical pI: Translated: 7.78; Mature: 7.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANQKDTAETLARTPLYQLSLELNARLTSFGGWEMPVQFSGITREHEAVRNAAGMFDISH
CCCCHHHHHHHHHCCCEEEEEEECEEEECCCCEECCEEECCCCHHHHHHHHHCCCEEHHH
MGKFTLQGKNLISQLQGLVPSDLSRLQPGQAQYTVLLNPQGGIIDDIIVYYQGEDNSGMQ
CCCEEECHHHHHHHHHCCCHHHHHHCCCCCCEEEEEECCCCCCEEEEEEEEECCCCCCCE
QAFIIVNAATTSKDKAWILSHLDQNQVQFQDISLAKVLIAVQGPKAIDYLQPFVQQNLQP
EEEEEEEECCCCCCHHHHHHHCCCCCEEEHHHHEEEEEEEECCCCHHHHHHHHHHCCCHH
IKAFGHLGATVLGQAGFIARTGYTGEDGFEILLDPEVGVELWRSLSNAGVIPCGLGARDT
HHHHHHCCHHHHCCCCEEEECCCCCCCCCEEEECCHHHHHHHHHHHCCCCEECCCCCCCH
LRLEAAMALYGQDINDNTTPLEAGLGWLVHLDTKGDFIGRSVLEQQKATGVKRRLIGLQA
HHHHHHHHHHCCCCCCCCCCHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCC
QGRNIARHGYQVLSDGKVVGEVTSGTLSPTLGHPVALAYVPSKLAKVGQPLEVEIRGKAY
CCCHHHHHCHHHHCCCEEEEEECCCCCCCCCCCCEEEEECCHHHHHCCCCEEEEECCCCC
PAVVVKRPFYRSSQKG
CEEEEECCCCCCCCCC
>Mature Secondary Structure 
ANQKDTAETLARTPLYQLSLELNARLTSFGGWEMPVQFSGITREHEAVRNAAGMFDISH
CCCHHHHHHHHHCCCEEEEEEECEEEECCCCEECCEEECCCCHHHHHHHHHCCCEEHHH
MGKFTLQGKNLISQLQGLVPSDLSRLQPGQAQYTVLLNPQGGIIDDIIVYYQGEDNSGMQ
CCCEEECHHHHHHHHHCCCHHHHHHCCCCCCEEEEEECCCCCCEEEEEEEEECCCCCCCE
QAFIIVNAATTSKDKAWILSHLDQNQVQFQDISLAKVLIAVQGPKAIDYLQPFVQQNLQP
EEEEEEEECCCCCCHHHHHHHCCCCCEEEHHHHEEEEEEEECCCCHHHHHHHHHHCCCHH
IKAFGHLGATVLGQAGFIARTGYTGEDGFEILLDPEVGVELWRSLSNAGVIPCGLGARDT
HHHHHHCCHHHHCCCCEEEECCCCCCCCCEEEECCHHHHHHHHHHHCCCCEECCCCCCCH
LRLEAAMALYGQDINDNTTPLEAGLGWLVHLDTKGDFIGRSVLEQQKATGVKRRLIGLQA
HHHHHHHHHHCCCCCCCCCCHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCC
QGRNIARHGYQVLSDGKVVGEVTSGTLSPTLGHPVALAYVPSKLAKVGQPLEVEIRGKAY
CCCHHHHHCHHHHCCCEEEEEECCCCCCCCCCCCEEEEECCHHHHHCCCCEEEEECCCCC
PAVVVKRPFYRSSQKG
CEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11759840 [H]