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The map label for this gene is ilvY [H]

Identifier: 75908969

GI number: 75908969

Start: 3397712

End: 3399610

Strand: Direct

Name: ilvY [H]

Synonym: Ava_2757

Alternate gene names: 75908969

Gene position: 3397712-3399610 (Clockwise)

Preceding gene: 75908968

Following gene: 75908972

Centisome position: 53.38

GC content: 47.34

Gene sequence:

>1899_bases
GTGACTGTGAGCTTGCCTTCCCCGACTAGTCCCTCACAAACAGAGAAACATACTCAGTCTGTTAATTCGCCATCGGTGGT
TGTGACACCACAACGGGTAACTGGTGGCTTCGCGCTACTTGATAGCCTGCTGCGCCACGGTGTTGAGTATATCTTTGGTT
ATCCTGGTGGGGCGATTCTGCCGATTTATGATGATCTGTATAAGGTGGAAGCAACTGGCAGCCTTAAACATATTCTAGTG
AGACACGAACAAGGGGCAGCTCATGCTGCTGATGGTTATGCTCGTGCAACCGGAAAAGTAGGTGTATGCTTTGGTACTTC
TGGGCCTGGGGCAACTAACTTGGTGACAGGAATCGCTACAGCCTATATGGATTCGATTCCAATGGTGATTGTCACTGGGC
AAGTACCCCGGAAAATGATCGGTACAGATGCGTTCCAAGAAACCGATATCTACGGTATTACTCTACCCATCGTTAAGCAT
TCCTATGTAGTGCGTGACCCCCAAGATATGGCGCGAATTGTGGCAGAAGCGTTCCACATCGCCAGCACAGGCCGTCCAGG
GCCAGTGTTAATTGATGTGCCTAAAGATGTGGCTTTTGAACAATTTGATTATGTGCCTGTAGAACCAGGTTCAATTAAAT
TACGCGGATATCGCCCCACGGTGAAGGGGAATCCACGCCAAATTAACGCCGCGATTGAATTGATCCGCGAAAGCCGTCGT
CCTTTACTATACGTTGGTGGTGGAGCGATCGCATCCGGCGCTCATGCAGAAATTCAGGAACTCGCCGAATTATTTAATAT
CCCCGTCACTACCACCTTGATGGGTATCGGTGCTTTTGATGAACATCATCCTTTATCTTTGGGGATGTTGGGGATGCACG
GCACAGCTTACGCTAACTTTGCTGTGACTGATTGTGATTTGTTGATTTGCGTCGGTGCGAGGTTTGATGACCGCGTTACC
GGCAAATTAGATGAGTTTGCATCCCGCGCCAAAGTTATTCATATCGATATTGACCCCGCCGAAGTTGGTAAAAACCGCAT
TCCTGAAGTCCCTATTGTTGGCGATGTACGGAAAGTTTTACTTGATTTGTTGCGTCGTTGTAAACAAACAGGTGCCAAAA
ATACCCCCAACCAAAACCAAGAATGGCTCAACTTAATTAACCGTTGGCGGGAAGATTACCCTCTAGTAATTCCCCAACAT
CCAGACAGCATTCCCCCACAAGAAGTAATTGTGGAAGTTGGTAGTCAAGCACCCCATGCTTTCTACACCACGGATGTTGG
TCAACATCAAATGTGGGCAGCCCAATTCCTCAAGAACGGCCCCAGACGTTGGATTTCTAGCGCAGGCTTGGGAACGATGG
GTTTTGGTTTACCTGCCGCCATTGGCGCTAAAGTGGCCTTCCCAGATGAACAAGTAATCTGTATTAGCGGTGATGCCAGT
TTCCAAATGTGTCTGCAAGAGCTTGGCACTGCTTCACAATATGGAATAAATGTCAAGACCGTAATTTTAAATAACGGTTG
GCAAGGGATGGTACGCCAATGGCAGCAAGCCTTCCACGGCGAACGCTACTCCTGCTCAAATATGGAAGTAGGGATGCCAG
ATGTGGAGTTATTGGCAAAAGCCTACGGCATTAAGGGTATTGTAGTTACGCAAAGAGAGCAATTGAAAGATGCGATCGCT
CAAATGTTAGCCTACGATGGCCCAGTTATTTTGGATGTCCGCGTCACAAAAGACGAGAACTGTTACCCAATGGTAGCTCC
TGGTAAGAGTAATGCTCAAATGATTGGCTTACCAAAGCAACCACAAAGGACCAGTGTTGAACCAGTTTATTGCAGCCATT
GTGGTACGTCGAATTTACCTAATCACAATTTCTGTTCTGAATGTGGGACTAAGTTGTAA

Upstream 100 bases:

>100_bases
AAAGAAATTTAATTCATAATTTGATTGAACTTTTCTATTAATATTGAAGTACTGACTACAGAATTCCTGCATTAACTTAG
CTATCATCTGAGGTTTGACC

Downstream 100 bases:

>100_bases
TTCATTTGCAGTTACATAATTGATTGTGATGACGCAGGGTTTTATGTACCCTGCGTTTTTTTTCAACACAGGGAAAACCA
AAAAATAAACCATTTGTAGA

Product: acetolactate synthase 3 catalytic subunit

Products: NA

Alternate protein names: ALS; Acetohydroxy-acid synthase [H]

Number of amino acids: Translated: 632; Mature: 631

Protein sequence:

>632_residues
MTVSLPSPTSPSQTEKHTQSVNSPSVVVTPQRVTGGFALLDSLLRHGVEYIFGYPGGAILPIYDDLYKVEATGSLKHILV
RHEQGAAHAADGYARATGKVGVCFGTSGPGATNLVTGIATAYMDSIPMVIVTGQVPRKMIGTDAFQETDIYGITLPIVKH
SYVVRDPQDMARIVAEAFHIASTGRPGPVLIDVPKDVAFEQFDYVPVEPGSIKLRGYRPTVKGNPRQINAAIELIRESRR
PLLYVGGGAIASGAHAEIQELAELFNIPVTTTLMGIGAFDEHHPLSLGMLGMHGTAYANFAVTDCDLLICVGARFDDRVT
GKLDEFASRAKVIHIDIDPAEVGKNRIPEVPIVGDVRKVLLDLLRRCKQTGAKNTPNQNQEWLNLINRWREDYPLVIPQH
PDSIPPQEVIVEVGSQAPHAFYTTDVGQHQMWAAQFLKNGPRRWISSAGLGTMGFGLPAAIGAKVAFPDEQVICISGDAS
FQMCLQELGTASQYGINVKTVILNNGWQGMVRQWQQAFHGERYSCSNMEVGMPDVELLAKAYGIKGIVVTQREQLKDAIA
QMLAYDGPVILDVRVTKDENCYPMVAPGKSNAQMIGLPKQPQRTSVEPVYCSHCGTSNLPNHNFCSECGTKL

Sequences:

>Translated_632_residues
MTVSLPSPTSPSQTEKHTQSVNSPSVVVTPQRVTGGFALLDSLLRHGVEYIFGYPGGAILPIYDDLYKVEATGSLKHILV
RHEQGAAHAADGYARATGKVGVCFGTSGPGATNLVTGIATAYMDSIPMVIVTGQVPRKMIGTDAFQETDIYGITLPIVKH
SYVVRDPQDMARIVAEAFHIASTGRPGPVLIDVPKDVAFEQFDYVPVEPGSIKLRGYRPTVKGNPRQINAAIELIRESRR
PLLYVGGGAIASGAHAEIQELAELFNIPVTTTLMGIGAFDEHHPLSLGMLGMHGTAYANFAVTDCDLLICVGARFDDRVT
GKLDEFASRAKVIHIDIDPAEVGKNRIPEVPIVGDVRKVLLDLLRRCKQTGAKNTPNQNQEWLNLINRWREDYPLVIPQH
PDSIPPQEVIVEVGSQAPHAFYTTDVGQHQMWAAQFLKNGPRRWISSAGLGTMGFGLPAAIGAKVAFPDEQVICISGDAS
FQMCLQELGTASQYGINVKTVILNNGWQGMVRQWQQAFHGERYSCSNMEVGMPDVELLAKAYGIKGIVVTQREQLKDAIA
QMLAYDGPVILDVRVTKDENCYPMVAPGKSNAQMIGLPKQPQRTSVEPVYCSHCGTSNLPNHNFCSECGTKL
>Mature_631_residues
TVSLPSPTSPSQTEKHTQSVNSPSVVVTPQRVTGGFALLDSLLRHGVEYIFGYPGGAILPIYDDLYKVEATGSLKHILVR
HEQGAAHAADGYARATGKVGVCFGTSGPGATNLVTGIATAYMDSIPMVIVTGQVPRKMIGTDAFQETDIYGITLPIVKHS
YVVRDPQDMARIVAEAFHIASTGRPGPVLIDVPKDVAFEQFDYVPVEPGSIKLRGYRPTVKGNPRQINAAIELIRESRRP
LLYVGGGAIASGAHAEIQELAELFNIPVTTTLMGIGAFDEHHPLSLGMLGMHGTAYANFAVTDCDLLICVGARFDDRVTG
KLDEFASRAKVIHIDIDPAEVGKNRIPEVPIVGDVRKVLLDLLRRCKQTGAKNTPNQNQEWLNLINRWREDYPLVIPQHP
DSIPPQEVIVEVGSQAPHAFYTTDVGQHQMWAAQFLKNGPRRWISSAGLGTMGFGLPAAIGAKVAFPDEQVICISGDASF
QMCLQELGTASQYGINVKTVILNNGWQGMVRQWQQAFHGERYSCSNMEVGMPDVELLAKAYGIKGIVVTQREQLKDAIAQ
MLAYDGPVILDVRVTKDENCYPMVAPGKSNAQMIGLPKQPQRTSVEPVYCSHCGTSNLPNHNFCSECGTKL

Specific function: Valine and isoleucine biosynthesis; first step. [C]

COG id: COG0028

COG function: function code EH; Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TPP enzyme family [H]

Homologues:

Organism=Homo sapiens, GI93004078, Length=555, Percent_Identity=26.3063063063063, Blast_Score=168, Evalue=2e-41,
Organism=Homo sapiens, GI21361361, Length=596, Percent_Identity=26.3422818791946, Blast_Score=166, Evalue=5e-41,
Organism=Escherichia coli, GI87081685, Length=569, Percent_Identity=46.0456942003515, Blast_Score=516, Evalue=1e-147,
Organism=Escherichia coli, GI1790104, Length=576, Percent_Identity=42.8819444444444, Blast_Score=460, Evalue=1e-130,
Organism=Escherichia coli, GI1786717, Length=558, Percent_Identity=34.5878136200717, Blast_Score=318, Evalue=9e-88,
Organism=Escherichia coli, GI1787096, Length=547, Percent_Identity=28.1535648994516, Blast_Score=203, Evalue=3e-53,
Organism=Escherichia coli, GI1788716, Length=555, Percent_Identity=26.6666666666667, Blast_Score=173, Evalue=4e-44,
Organism=Caenorhabditis elegans, GI17531299, Length=591, Percent_Identity=26.2267343485618, Blast_Score=149, Evalue=4e-36,
Organism=Caenorhabditis elegans, GI17531301, Length=580, Percent_Identity=26.551724137931, Blast_Score=149, Evalue=5e-36,
Organism=Caenorhabditis elegans, GI17542570, Length=613, Percent_Identity=24.7960848287113, Blast_Score=140, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6323755, Length=628, Percent_Identity=42.0382165605096, Blast_Score=452, Evalue=1e-127,
Organism=Saccharomyces cerevisiae, GI6320816, Length=533, Percent_Identity=24.765478424015, Blast_Score=108, Evalue=3e-24,
Organism=Saccharomyces cerevisiae, GI6321524, Length=511, Percent_Identity=26.027397260274, Blast_Score=104, Evalue=4e-23,
Organism=Drosophila melanogaster, GI19922626, Length=578, Percent_Identity=26.4705882352941, Blast_Score=167, Evalue=2e-41,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012846
- InterPro:   IPR012000
- InterPro:   IPR012001
- InterPro:   IPR011766 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF00205 TPP_enzyme_M; PF02776 TPP_enzyme_N [H]

EC number: =2.2.1.6 [H]

Molecular weight: Translated: 68676; Mature: 68544

Theoretical pI: Translated: 6.69; Mature: 6.69

Prosite motif: PS00187 TPP_ENZYMES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVSLPSPTSPSQTEKHTQSVNSPSVVVTPQRVTGGFALLDSLLRHGVEYIFGYPGGAIL
CEECCCCCCCCCHHHHHHHCCCCCEEEEECHHHCCHHHHHHHHHHCCCCEEEECCCCEEE
PIYDDLYKVEATGSLKHILVRHEQGAAHAADGYARATGKVGVCFGTSGPGATNLVTGIAT
EEECCEEEEECCCCEEEEEEECCCCCCCCCCCHHCCCCCEEEEEECCCCCHHHHHHHHHH
AYMDSIPMVIVTGQVPRKMIGTDAFQETDIYGITLPIVKHSYVVRDPQDMARIVAEAFHI
HHHCCCCEEEEECCCCHHHHCCCCCCCCCEEEEEEHHEECEEEEECHHHHHHHHHHHHHH
ASTGRPGPVLIDVPKDVAFEQFDYVPVEPGSIKLRGYRPTVKGNPRQINAAIELIRESRR
HCCCCCCCEEEECCCCCCHHHCCCEECCCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCC
PLLYVGGGAIASGAHAEIQELAELFNIPVTTTLMGIGAFDEHHPLSLGMLGMHGTAYANF
CEEEECCCCCCCCCHHHHHHHHHHHCCCHHHHHEECCCCCCCCCCEEEEEECCCCEEEEE
AVTDCDLLICVGARFDDRVTGKLDEFASRAKVIHIDIDPAEVGKNRIPEVPIVGDVRKVL
EEECCEEEEEECCCCCCCCCCCHHHHHCCCEEEEEECCHHHHCCCCCCCCCCHHHHHHHH
LDLLRRCKQTGAKNTPNQNQEWLNLINRWREDYPLVIPQHPDSIPPQEVIVEVGSQAPHA
HHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCEEECCCCCCCCHHHHHHHHCCCCCCE
FYTTDVGQHQMWAAQFLKNGPRRWISSAGLGTMGFGLPAAIGAKVAFPDEQVICISGDAS
EEECCCCCHHHHHHHHHHCCHHHHHHHCCCCCCCCCCHHHHCCEEECCCCEEEEEECCCH
FQMCLQELGTASQYGINVKTVILNNGWQGMVRQWQQAFHGERYSCSNMEVGMPDVELLAK
HHHHHHHHCCCHHCCCEEEEEEEECCCHHHHHHHHHHHCCCCEECCCCCCCCCHHHHHHH
AYGIKGIVVTQREQLKDAIAQMLAYDGPVILDVRVTKDENCYPMVAPGKSNAQMIGLPKQ
HHCCCEEEECCHHHHHHHHHHHHHCCCCEEEEEEECCCCCCEEEECCCCCCCEEECCCCC
PQRTSVEPVYCSHCGTSNLPNHNFCSECGTKL
CCCCCCCCEEECCCCCCCCCCCCHHHHCCCCC
>Mature Secondary Structure 
TVSLPSPTSPSQTEKHTQSVNSPSVVVTPQRVTGGFALLDSLLRHGVEYIFGYPGGAIL
EECCCCCCCCCHHHHHHHCCCCCEEEEECHHHCCHHHHHHHHHHCCCCEEEECCCCEEE
PIYDDLYKVEATGSLKHILVRHEQGAAHAADGYARATGKVGVCFGTSGPGATNLVTGIAT
EEECCEEEEECCCCEEEEEEECCCCCCCCCCCHHCCCCCEEEEEECCCCCHHHHHHHHHH
AYMDSIPMVIVTGQVPRKMIGTDAFQETDIYGITLPIVKHSYVVRDPQDMARIVAEAFHI
HHHCCCCEEEEECCCCHHHHCCCCCCCCCEEEEEEHHEECEEEEECHHHHHHHHHHHHHH
ASTGRPGPVLIDVPKDVAFEQFDYVPVEPGSIKLRGYRPTVKGNPRQINAAIELIRESRR
HCCCCCCCEEEECCCCCCHHHCCCEECCCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCC
PLLYVGGGAIASGAHAEIQELAELFNIPVTTTLMGIGAFDEHHPLSLGMLGMHGTAYANF
CEEEECCCCCCCCCHHHHHHHHHHHCCCHHHHHEECCCCCCCCCCEEEEEECCCCEEEEE
AVTDCDLLICVGARFDDRVTGKLDEFASRAKVIHIDIDPAEVGKNRIPEVPIVGDVRKVL
EEECCEEEEEECCCCCCCCCCCHHHHHCCCEEEEEECCHHHHCCCCCCCCCCHHHHHHHH
LDLLRRCKQTGAKNTPNQNQEWLNLINRWREDYPLVIPQHPDSIPPQEVIVEVGSQAPHA
HHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCEEECCCCCCCCHHHHHHHHCCCCCCE
FYTTDVGQHQMWAAQFLKNGPRRWISSAGLGTMGFGLPAAIGAKVAFPDEQVICISGDAS
EEECCCCCHHHHHHHHHHCCHHHHHHHCCCCCCCCCCHHHHCCEEECCCCEEEEEECCCH
FQMCLQELGTASQYGINVKTVILNNGWQGMVRQWQQAFHGERYSCSNMEVGMPDVELLAK
HHHHHHHHCCCHHCCCEEEEEEEECCCHHHHHHHHHHHCCCCEECCCCCCCCCHHHHHHH
AYGIKGIVVTQREQLKDAIAQMLAYDGPVILDVRVTKDENCYPMVAPGKSNAQMIGLPKQ
HHCCCEEEECCHHHHHHHHHHHHHCCCCEEEEEEECCCCCCEEEECCCCCCCEEECCCCC
PQRTSVEPVYCSHCGTSNLPNHNFCSECGTKL
CCCCCCCCEEECCCCCCCCCCCCHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1512571 [H]