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The map label for this gene is ndhA

Identifier: 75908926

GI number: 75908926

Start: 3351461

End: 3352579

Strand: Direct

Name: ndhA

Synonym: Ava_2714

Alternate gene names: 75908926

Gene position: 3351461-3352579 (Clockwise)

Preceding gene: 75908925

Following gene: 75908927

Centisome position: 52.65

GC content: 45.67

Gene sequence:

>1119_bases
ATGAATTCAGGAATTGACCTCCAAGGAACGTTTATTAAATCCCTAATGGATTTAGGAATCCCACCAGGAACAGCTAAAGC
GATTTGGATGCCTCTGCCCATGATCCTGATGCTGATTGGGGCGACGGTGGGCGTACTGGTTTGTGTTTGGCTAGAACGGA
AGATTTCGGCAGCCGCACAACAACGGATTGGCCCTGAATACATTGGGCCTTTGGGCTTGCTGGCTCCAGTAGCCGATGGT
CTCAAGCTGGTATTTAAAGAAGATATTGTACCGGCTCAAGCTGACCCTTGGCTATTTACCCTCGGCCCGATTCTTGTAGT
CTTGCCAGTATTTCTGTCTTATTTGATTGTTCCTTTTGGACAGAATATTGTCATTACTAACATAGGTACAGGGATATTCT
TGTGGATTGCTTTATCTAGCATCCAACCCATTGGCTTGTTAATGGCTGGCTACTCTTCCAATAACAAGTATTCTCTACTA
GGGGGTTTGCGAGCAGCAGCGCAATCAATTAGTTATGAAATTCCCTTGGCGCTGAGTGTGTTGGCGATCGTCATGATGTC
TAACAGCCTCAGTACTGTAGACATTGTTAACCAACAATCTGGCTACGGTATTTTGGGCTGGAATATTTGGCGACAACCCC
TTGGCTTTCTCATCTTTTGGATAGCGGCTTTGGCAGAATGTGAACGTTTGCCCTTCGACTTACCAGAAGCAGAAGAAGAA
TTAGTAGCAGGCTATCAAACTGAATACTCAGGGATGAAATTTGCGCTGTTCTACCTCAGTTCCTACGTTAACTTAGTCCT
GTCGGCTCTTTTGGTAGCAGTATTGTACTTGGGTGGTTGGGATTTTCCCATTCCCATCAATGTTTTGGCTAATTTGGTGG
GAGTCAGCGAAGCAAATCCTGTATTACAGGTGGTCAGCGCTGCCTTAGGTATCACCATGACCTTAGTCAAGGCTTACTTT
TTAGTATTTATCGCCATCCTCTTGCGTTGGACAGTACCACGGGTAAGGATTGACCAGTTGTTAGATTTAGGATGGAAGTT
TTTGTTACCAGTTGGCTTAGTGAACCTACTTTTAACCGCAGCCCTGAAACTGGCTTTTCCCGTCGCCTTCGGCGGGTAA

Upstream 100 bases:

>100_bases
AGGTGTCATCTCAGCAGAGATATTAATGGGTGTGGTTGCAGGTATTAGTTTAACTAATGATTGTAACTCGCCATGACTTG
ATGACTTAAAGAGCGAAAAC

Downstream 100 bases:

>100_bases
TCGGTGATCGGTAATCGGTAATGGAAAAATCATTACCAATTACCTGTTACCAATTACCAATTACCTCAAAAGAGTAGAGA
GACACAAAATGCTAAAGTTC

Product: NADH dehydrogenase subunit H

Products: NAD+; ubiquinol

Alternate protein names: NAD(P)H dehydrogenase I subunit 1; NDH-1 subunit 1; NDH-A

Number of amino acids: Translated: 372; Mature: 372

Protein sequence:

>372_residues
MNSGIDLQGTFIKSLMDLGIPPGTAKAIWMPLPMILMLIGATVGVLVCVWLERKISAAAQQRIGPEYIGPLGLLAPVADG
LKLVFKEDIVPAQADPWLFTLGPILVVLPVFLSYLIVPFGQNIVITNIGTGIFLWIALSSIQPIGLLMAGYSSNNKYSLL
GGLRAAAQSISYEIPLALSVLAIVMMSNSLSTVDIVNQQSGYGILGWNIWRQPLGFLIFWIAALAECERLPFDLPEAEEE
LVAGYQTEYSGMKFALFYLSSYVNLVLSALLVAVLYLGGWDFPIPINVLANLVGVSEANPVLQVVSAALGITMTLVKAYF
LVFIAILLRWTVPRVRIDQLLDLGWKFLLPVGLVNLLLTAALKLAFPVAFGG

Sequences:

>Translated_372_residues
MNSGIDLQGTFIKSLMDLGIPPGTAKAIWMPLPMILMLIGATVGVLVCVWLERKISAAAQQRIGPEYIGPLGLLAPVADG
LKLVFKEDIVPAQADPWLFTLGPILVVLPVFLSYLIVPFGQNIVITNIGTGIFLWIALSSIQPIGLLMAGYSSNNKYSLL
GGLRAAAQSISYEIPLALSVLAIVMMSNSLSTVDIVNQQSGYGILGWNIWRQPLGFLIFWIAALAECERLPFDLPEAEEE
LVAGYQTEYSGMKFALFYLSSYVNLVLSALLVAVLYLGGWDFPIPINVLANLVGVSEANPVLQVVSAALGITMTLVKAYF
LVFIAILLRWTVPRVRIDQLLDLGWKFLLPVGLVNLLLTAALKLAFPVAFGG
>Mature_372_residues
MNSGIDLQGTFIKSLMDLGIPPGTAKAIWMPLPMILMLIGATVGVLVCVWLERKISAAAQQRIGPEYIGPLGLLAPVADG
LKLVFKEDIVPAQADPWLFTLGPILVVLPVFLSYLIVPFGQNIVITNIGTGIFLWIALSSIQPIGLLMAGYSSNNKYSLL
GGLRAAAQSISYEIPLALSVLAIVMMSNSLSTVDIVNQQSGYGILGWNIWRQPLGFLIFWIAALAECERLPFDLPEAEEE
LVAGYQTEYSGMKFALFYLSSYVNLVLSALLVAVLYLGGWDFPIPINVLANLVGVSEANPVLQVVSAALGITMTLVKAYF
LVFIAILLRWTVPRVRIDQLLDLGWKFLLPVGLVNLLLTAALKLAFPVAFGG

Specific function: NDH-1 shuttles electrons from an unknown electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and/or the photosynthetic chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone

COG id: COG1005

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 1 (chain H)

Gene ontology:

Cell location: Cellular thylakoid membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 1 family

Homologues:

Organism=Homo sapiens, GI251831107, Length=306, Percent_Identity=33.3333333333333, Blast_Score=157, Evalue=1e-38,
Organism=Escherichia coli, GI1788618, Length=332, Percent_Identity=38.2530120481928, Blast_Score=224, Evalue=5e-60,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NU1C_ANAVT (Q3M9K9)

Other databases:

- EMBL:   CP000117
- RefSeq:   YP_323222.1
- STRING:   Q3M9K9
- GeneID:   3682212
- GenomeReviews:   CP000117_GR
- KEGG:   ava:Ava_2714
- NMPDR:   fig|240292.3.peg.1051
- eggNOG:   COG1005
- HOGENOM:   HBG727670
- OMA:   IFWICAL
- PhylomeDB:   Q3M9K9
- ProtClustDB:   PRK06076
- BioCyc:   AVAR240292:AVA_2714-MONOMER
- HAMAP:   MF_01350
- InterPro:   IPR023020
- InterPro:   IPR001694
- InterPro:   IPR018086
- PANTHER:   PTHR11432

Pfam domain/function: PF00146 NADHdh

EC number: 1.6.5.3

Molecular weight: Translated: 40263; Mature: 40263

Theoretical pI: Translated: 4.68; Mature: 4.68

Prosite motif: PS00667 COMPLEX1_ND1_1; PS00668 COMPLEX1_ND1_2

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x108666f4)-; HASH(0x109c7ef8)-; HASH(0x114ea4c4)-; HASH(0xfef9080)-; HASH(0xfd76908)-; HASH(0x115cb570)-; HASH(0xf302fc8)-; HASH(0xfbb0044)-; HASH(0xed0ee5c)-;

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSGIDLQGTFIKSLMDLGIPPGTAKAIWMPLPMILMLIGATVGVLVCVWLERKISAAAQ
CCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QRIGPEYIGPLGLLAPVADGLKLVFKEDIVPAQADPWLFTLGPILVVLPVFLSYLIVPFG
HCCCHHHHCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCC
QNIVITNIGTGIFLWIALSSIQPIGLLMAGYSSNNKYSLLGGLRAAAQSISYEIPLALSV
CCEEEEECCHHHHHHHHHHCCCHHHHHEECCCCCCCCHHHHHHHHHHHHCCCCCHHHHHH
LAIVMMSNSLSTVDIVNQQSGYGILGWNIWRQPLGFLIFWIAALAECERLPFDLPEAEEE
HHHHHHCCCCCCEEEEECCCCCEEECHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
LVAGYQTEYSGMKFALFYLSSYVNLVLSALLVAVLYLGGWDFPIPINVLANLVGVSEANP
HHHCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCH
VLQVVSAALGITMTLVKAYFLVFIAILLRWTVPRVRIDQLLDLGWKFLLPVGLVNLLLTA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALKLAFPVAFGG
HHHHHHHHCCCH
>Mature Secondary Structure
MNSGIDLQGTFIKSLMDLGIPPGTAKAIWMPLPMILMLIGATVGVLVCVWLERKISAAAQ
CCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QRIGPEYIGPLGLLAPVADGLKLVFKEDIVPAQADPWLFTLGPILVVLPVFLSYLIVPFG
HCCCHHHHCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCC
QNIVITNIGTGIFLWIALSSIQPIGLLMAGYSSNNKYSLLGGLRAAAQSISYEIPLALSV
CCEEEEECCHHHHHHHHHHCCCHHHHHEECCCCCCCCHHHHHHHHHHHHCCCCCHHHHHH
LAIVMMSNSLSTVDIVNQQSGYGILGWNIWRQPLGFLIFWIAALAECERLPFDLPEAEEE
HHHHHHCCCCCCEEEEECCCCCEEECHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
LVAGYQTEYSGMKFALFYLSSYVNLVLSALLVAVLYLGGWDFPIPINVLANLVGVSEANP
HHHCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCH
VLQVVSAALGITMTLVKAYFLVFIAILLRWTVPRVRIDQLLDLGWKFLLPVGLVNLLLTA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALKLAFPVAFGG
HHHHHHHHCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NADH; H+; ubiquinone

Specific reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA