Click here to switch to the map view.

The map label for this gene is ispA [C]

Identifier: 75908916

GI number: 75908916

Start: 3341484

End: 3342413

Strand: Direct

Name: ispA [C]

Synonym: Ava_2704

Alternate gene names: 75908916

Gene position: 3341484-3342413 (Clockwise)

Preceding gene: 75908915

Following gene: 75908917

Centisome position: 52.49

GC content: 44.09

Gene sequence:

>930_bases
ATGGTAGCAGCTGATAACCTCCAGAAGATGTCAGAGGAAGCCAAATTTAATCTAGTAGCTTATCTTAAAGAGCGGCAAAA
ACTTTGTGAAGCGGCTTTGGATGAAGCCATACCTGTTATTTATCCAGAAAAAATTTATGAATCGATGCGCTACTCCTTAT
TAGCTGGAGGTAAGCGCTTGCGTCCGATTCTTTGTCTGGCTACTTCGGAAATGATGGGTGGAACAATCGAAATAGCTATG
CCAACAGCTTGCGCTGTGGAAATGATCCACACCATGTCTTTGATTCACGACGACTTGCCAGCAATGGATAACGACGATTA
CCGTCGCGGTATGCTGACGAATCACAAGGTATATGGTGATGATATTGCGATTTTGGCGGGAGATGGCTTATTAGCCTATG
CTTTCGAGTTCGTAGCTATCCGTACTCCTGAAAGCGTGCCTAGAGACCGAGTATTGCAGGTAGTAGCCCGATTGGGACGA
GCATTAGGAGCTGCTGGCTTGGTTGGGGGTCAAGTAGTTGACTTAGACTCAGAAGGGAAATCAGATATTTCCTTAGAAAC
GCTCAATTTTATTCATAATCACAAAACAGCAGCTCTTTTAGAAGCTTGTGTGGTCTGTGGCGGCATTTTAGCTGGGGCAT
CATCAGAAGATGTACAAAGACTTTCACGGTATTCTCAAAATATTGGGCTAGCATTTCAAATCATCGATGATATTCTTGAT
ATCACTTCTACTCAAGAGCAATTAGGCAAGACTGCGGGTAAAGACCTTTTAGCGAAGAAAGTCACCTATCCTAGCCTATG
GGGAATTGAACAATCACGGGTCAAAGCCCAACAGCTAATTGAAGCAGCTTGTGCAGAACTAGAACCATTTGGAGAAGATG
CACAGCCTCTGAAAGCGATCGCTCACTTCATCACTAGCCGTAATCACTAA

Upstream 100 bases:

>100_bases
GATTACTGAAGTATGAGTTAATCTTTCAGCTCCAGAGCATCTTAAAATTGTGACGTGTATGACAAACAGCCAAAAGCAAA
AAATTTAAGGAAATCTAAGA

Downstream 100 bases:

>100_bases
TCAAACATCTAGTTGTTGTGTTGGTTCCCAAGTATACGCAGGCGGAAAACAGTAAAAATAATTACCACTGACAACCGACA
ACTAACAACCGACAACTAAC

Product: farnesyl-diphosphate synthase

Products: NA

Alternate protein names: FPP synthase; (2E,6E)-farnesyl diphosphate synthase; Geranyltranstransferase [H]

Number of amino acids: Translated: 309; Mature: 309

Protein sequence:

>309_residues
MVAADNLQKMSEEAKFNLVAYLKERQKLCEAALDEAIPVIYPEKIYESMRYSLLAGGKRLRPILCLATSEMMGGTIEIAM
PTACAVEMIHTMSLIHDDLPAMDNDDYRRGMLTNHKVYGDDIAILAGDGLLAYAFEFVAIRTPESVPRDRVLQVVARLGR
ALGAAGLVGGQVVDLDSEGKSDISLETLNFIHNHKTAALLEACVVCGGILAGASSEDVQRLSRYSQNIGLAFQIIDDILD
ITSTQEQLGKTAGKDLLAKKVTYPSLWGIEQSRVKAQQLIEAACAELEPFGEDAQPLKAIAHFITSRNH

Sequences:

>Translated_309_residues
MVAADNLQKMSEEAKFNLVAYLKERQKLCEAALDEAIPVIYPEKIYESMRYSLLAGGKRLRPILCLATSEMMGGTIEIAM
PTACAVEMIHTMSLIHDDLPAMDNDDYRRGMLTNHKVYGDDIAILAGDGLLAYAFEFVAIRTPESVPRDRVLQVVARLGR
ALGAAGLVGGQVVDLDSEGKSDISLETLNFIHNHKTAALLEACVVCGGILAGASSEDVQRLSRYSQNIGLAFQIIDDILD
ITSTQEQLGKTAGKDLLAKKVTYPSLWGIEQSRVKAQQLIEAACAELEPFGEDAQPLKAIAHFITSRNH
>Mature_309_residues
MVAADNLQKMSEEAKFNLVAYLKERQKLCEAALDEAIPVIYPEKIYESMRYSLLAGGKRLRPILCLATSEMMGGTIEIAM
PTACAVEMIHTMSLIHDDLPAMDNDDYRRGMLTNHKVYGDDIAILAGDGLLAYAFEFVAIRTPESVPRDRVLQVVARLGR
ALGAAGLVGGQVVDLDSEGKSDISLETLNFIHNHKTAALLEACVVCGGILAGASSEDVQRLSRYSQNIGLAFQIIDDILD
ITSTQEQLGKTAGKDLLAKKVTYPSLWGIEQSRVKAQQLIEAACAELEPFGEDAQPLKAIAHFITSRNH

Specific function: Unknown

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI50659086, Length=246, Percent_Identity=29.6747967479675, Blast_Score=82, Evalue=4e-16,
Organism=Escherichia coli, GI1786623, Length=269, Percent_Identity=46.0966542750929, Blast_Score=187, Evalue=9e-49,
Organism=Escherichia coli, GI1789578, Length=248, Percent_Identity=33.0645161290323, Blast_Score=124, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI17505681, Length=189, Percent_Identity=30.1587301587302, Blast_Score=85, Evalue=5e-17,
Organism=Drosophila melanogaster, GI24651612, Length=234, Percent_Identity=29.0598290598291, Blast_Score=85, Evalue=5e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.10 [H]

Molecular weight: Translated: 33692; Mature: 33692

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: PS00723 POLYPRENYL_SYNTHET_1 ; PS00444 POLYPRENYL_SYNTHET_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVAADNLQKMSEEAKFNLVAYLKERQKLCEAALDEAIPVIYPEKIYESMRYSLLAGGKRL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCC
RPILCLATSEMMGGTIEIAMPTACAVEMIHTMSLIHDDLPAMDNDDYRRGMLTNHKVYGD
CHHHEEEHHHHCCCEEEEECCHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCCCEEECC
DIAILAGDGLLAYAFEFVAIRTPESVPRDRVLQVVARLGRALGAAGLVGGQVVDLDSEGK
CEEEEECCCHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCC
SDISLETLNFIHNHKTAALLEACVVCGGILAGASSEDVQRLSRYSQNIGLAFQIIDDILD
CCCHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHH
ITSTQEQLGKTAGKDLLAKKVTYPSLWGIEQSRVKAQQLIEAACAELEPFGEDAQPLKAI
HCCHHHHHHHHHHHHHHHHHCCCCHHCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
AHFITSRNH
HHHHHCCCC
>Mature Secondary Structure
MVAADNLQKMSEEAKFNLVAYLKERQKLCEAALDEAIPVIYPEKIYESMRYSLLAGGKRL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCC
RPILCLATSEMMGGTIEIAMPTACAVEMIHTMSLIHDDLPAMDNDDYRRGMLTNHKVYGD
CHHHEEEHHHHCCCEEEEECCHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCCCEEECC
DIAILAGDGLLAYAFEFVAIRTPESVPRDRVLQVVARLGRALGAAGLVGGQVVDLDSEGK
CEEEEECCCHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCC
SDISLETLNFIHNHKTAALLEACVVCGGILAGASSEDVQRLSRYSQNIGLAFQIIDDILD
CCCHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHH
ITSTQEQLGKTAGKDLLAKKVTYPSLWGIEQSRVKAQQLIEAACAELEPFGEDAQPLKAI
HCCHHHHHHHHHHHHHHHHHCCCCHHCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
AHFITSRNH
HHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8486607; 7918490 [H]