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The map label for this gene is adk2 [H]

Identifier: 75908882

GI number: 75908882

Start: 3299845

End: 3300399

Strand: Direct

Name: adk2 [H]

Synonym: Ava_2670

Alternate gene names: 75908882

Gene position: 3299845-3300399 (Clockwise)

Preceding gene: 75908878

Following gene: 75908883

Centisome position: 51.84

GC content: 44.86

Gene sequence:

>555_bases
GTGAGATTAGTGGTTCTGGGAGGTTCAGGGTCGGGAAAAAGCACTCAAGCACAAAGGCTTTGCAGTCATTTAGGAATTAC
TCAGATTTCTACGGGCGAGATTTTACGGGAAGCCATTTCCCACCTGAGTGAATTAGGCCGTCAGGCCCAACCTTACATGG
TTAAAGGGGAACTAGTTCCTGACGAAATGATCATTGAATTAATCCGACTGCGGTTGAAAAAGTTTGATGTAAGTGATGGC
TGGGTTTTGGAAGGTTATCCGCGTACTGCCTTCCAAGCTGAAGAGTTGGACTTTTTGCTTGATGAGTTGGGGCAGAAATT
AGATTGGGCAATTTATTTACAAGTACCGGAAGCAGTTATGGTGAGTCGTTCTTTGGGGCGTTCTCTACCAGATGACCAAC
CTGAAATTGTGCAGCGTCGAGTAGAGATTTTTTACGATCGCACAGTTCCCATTTTAGAGTATTACGACCGTCGCCGCCGC
CTGTTGACAATTAACGGTGATCAAGCGCCAGAATTAGTGTTGCAAAACATCCTCAAACTACTTTTAGTAACTTAG

Upstream 100 bases:

>100_bases
CCCTGACTCATACTCTTTGGCTAAATGTTAGATTTCTGACGGGGTTGGGCAAAACAAATTTATTATGTTTTAAATATTAC
TGGTTGAGGAGTGAATTGTT

Downstream 100 bases:

>100_bases
AGTTTTTAGTTATAGCTAGGGACTGGGGACTGGGGACTGGGGACTGGGTGAAGGGTCTTGTTGCGTCTAGGTTGTATCAT
CTATTGATGTCCTAACACTA

Product: adenylate kinase

Products: NA

Alternate protein names: AK 2; ATP-AMP transphosphorylase 2 [H]

Number of amino acids: Translated: 184; Mature: 184

Protein sequence:

>184_residues
MRLVVLGGSGSGKSTQAQRLCSHLGITQISTGEILREAISHLSELGRQAQPYMVKGELVPDEMIIELIRLRLKKFDVSDG
WVLEGYPRTAFQAEELDFLLDELGQKLDWAIYLQVPEAVMVSRSLGRSLPDDQPEIVQRRVEIFYDRTVPILEYYDRRRR
LLTINGDQAPELVLQNILKLLLVT

Sequences:

>Translated_184_residues
MRLVVLGGSGSGKSTQAQRLCSHLGITQISTGEILREAISHLSELGRQAQPYMVKGELVPDEMIIELIRLRLKKFDVSDG
WVLEGYPRTAFQAEELDFLLDELGQKLDWAIYLQVPEAVMVSRSLGRSLPDDQPEIVQRRVEIFYDRTVPILEYYDRRRR
LLTINGDQAPELVLQNILKLLLVT
>Mature_184_residues
MRLVVLGGSGSGKSTQAQRLCSHLGITQISTGEILREAISHLSELGRQAQPYMVKGELVPDEMIIELIRLRLKKFDVSDG
WVLEGYPRTAFQAEELDFLLDELGQKLDWAIYLQVPEAVMVSRSLGRSLPDDQPEIVQRRVEIFYDRTVPILEYYDRRRR
LLTINGDQAPELVLQNILKLLLVT

Specific function: This small ubiquitous enzyme is essential for maintenance and cell growth [H]

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family [H]

Homologues:

Organism=Homo sapiens, GI4502013, Length=209, Percent_Identity=31.5789473684211, Blast_Score=120, Evalue=8e-28,
Organism=Homo sapiens, GI7524346, Length=209, Percent_Identity=31.5789473684211, Blast_Score=120, Evalue=9e-28,
Organism=Homo sapiens, GI4502011, Length=184, Percent_Identity=30.9782608695652, Blast_Score=101, Evalue=4e-22,
Organism=Homo sapiens, GI28144899, Length=180, Percent_Identity=32.2222222222222, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI28144897, Length=180, Percent_Identity=32.2222222222222, Blast_Score=99, Evalue=1e-21,
Organism=Homo sapiens, GI19923437, Length=203, Percent_Identity=29.064039408867, Blast_Score=96, Evalue=2e-20,
Organism=Homo sapiens, GI310110345, Length=203, Percent_Identity=30.0492610837438, Blast_Score=86, Evalue=2e-17,
Organism=Homo sapiens, GI53832003, Length=203, Percent_Identity=30.0492610837438, Blast_Score=86, Evalue=2e-17,
Organism=Homo sapiens, GI8051579, Length=203, Percent_Identity=30.0492610837438, Blast_Score=86, Evalue=2e-17,
Organism=Homo sapiens, GI53832001, Length=203, Percent_Identity=30.0492610837438, Blast_Score=86, Evalue=2e-17,
Organism=Homo sapiens, GI22749187, Length=204, Percent_Identity=28.921568627451, Blast_Score=81, Evalue=6e-16,
Organism=Homo sapiens, GI7706497, Length=190, Percent_Identity=24.2105263157895, Blast_Score=74, Evalue=5e-14,
Organism=Escherichia coli, GI1786680, Length=188, Percent_Identity=34.0425531914894, Blast_Score=114, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI17567503, Length=171, Percent_Identity=29.2397660818713, Blast_Score=97, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI17552384, Length=189, Percent_Identity=28.5714285714286, Blast_Score=94, Evalue=6e-20,
Organism=Caenorhabditis elegans, GI17533833, Length=183, Percent_Identity=25.6830601092896, Blast_Score=78, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI25147457, Length=187, Percent_Identity=28.3422459893048, Blast_Score=77, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17550688, Length=184, Percent_Identity=26.0869565217391, Blast_Score=76, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6320432, Length=213, Percent_Identity=28.6384976525822, Blast_Score=100, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6321018, Length=205, Percent_Identity=30.7317073170732, Blast_Score=97, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6322828, Length=184, Percent_Identity=27.1739130434783, Blast_Score=78, Evalue=9e-16,
Organism=Drosophila melanogaster, GI22026816, Length=208, Percent_Identity=29.3269230769231, Blast_Score=104, Evalue=4e-23,
Organism=Drosophila melanogaster, GI17737899, Length=203, Percent_Identity=28.5714285714286, Blast_Score=102, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24645822, Length=203, Percent_Identity=28.5714285714286, Blast_Score=102, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24663208, Length=171, Percent_Identity=30.9941520467836, Blast_Score=88, Evalue=3e-18,
Organism=Drosophila melanogaster, GI17647141, Length=171, Percent_Identity=30.9941520467836, Blast_Score=88, Evalue=3e-18,
Organism=Drosophila melanogaster, GI221459597, Length=190, Percent_Identity=26.8421052631579, Blast_Score=81, Evalue=3e-16,
Organism=Drosophila melanogaster, GI21356893, Length=190, Percent_Identity=26.8421052631579, Blast_Score=81, Evalue=3e-16,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000850 [H]

Pfam domain/function: PF00406 ADK [H]

EC number: =2.7.4.3 [H]

Molecular weight: Translated: 20991; Mature: 20991

Theoretical pI: Translated: 5.09; Mature: 5.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLVVLGGSGSGKSTQAQRLCSHLGITQISTGEILREAISHLSELGRQAQPYMVKGELVP
CEEEEEECCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEECCCCC
DEMIIELIRLRLKKFDVSDGWVLEGYPRTAFQAEELDFLLDELGQKLDWAIYLQVPEAVM
HHHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCHHHH
VSRSLGRSLPDDQPEIVQRRVEIFYDRTVPILEYYDRRRRLLTINGDQAPELVLQNILKL
HHHHHCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHCCCEEEEECCCCCHHHHHHHHHHH
LLVT
HHCC
>Mature Secondary Structure
MRLVVLGGSGSGKSTQAQRLCSHLGITQISTGEILREAISHLSELGRQAQPYMVKGELVP
CEEEEEECCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEECCCCC
DEMIIELIRLRLKKFDVSDGWVLEGYPRTAFQAEELDFLLDELGQKLDWAIYLQVPEAVM
HHHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCHHHH
VSRSLGRSLPDDQPEIVQRRVEIFYDRTVPILEYYDRRRRLLTINGDQAPELVLQNILKL
HHHHHCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHCCCEEEEECCCCCHHHHHHHHHHH
LLVT
HHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11759840 [H]