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The map label for this gene is guaB [C]

Identifier: 75908865

GI number: 75908865

Start: 3282092

End: 3283255

Strand: Direct

Name: guaB [C]

Synonym: Ava_2653

Alternate gene names: 75908865

Gene position: 3282092-3283255 (Clockwise)

Preceding gene: 75908859

Following gene: 75908866

Centisome position: 51.56

GC content: 46.65

Gene sequence:

>1164_bases
GTGGAAATTCAACTTGGGCGGGGAAAGACAGCTCGCAGAGCATATGGCATTGATGAAATTGCTCTAGTCCCCGGTAACAG
AACACTCGATCCGAGTTTAGCTGATACTCGGTGGAAAATTGGCAATATCGAGCGAGAAATCCCGATTATTGCCAGTGCAA
TGGATGGGGTTGTTGATGTCAAGATGGCGGTGCGTTTATCGCAACTTGGGGCATTAGGAGTTATCAACTTGGAAGGCATT
CAAACTCGTTATGCTGACCCAGAACCGATTTTAGATCGGATTGCTTCGGTAGGCAAAGATGAGTTTGTCTCTTTAATGCA
GGAGCTTTATGCCGAACCCATCAAACCAGAATTAATTACCAAGCGTATTCAAGAAATTAAAGAACAAGGTGGGATTGCAG
CTGTTAGTGCTACTCCAGTAGGAGCCAGCAAATATGGTGAGGTAGTAGCCCAAGCCGGGGCAGATTTATTTTTTATTCAA
GCTACGGTAGTTTCTACCGCCCACTTGTCACCAGAATCTGTAGTACCCCTGGATTTGGCTGAATTTTGCCGTTCTATGCC
AATTCCCGTAATTTTGGGTAACTGTGTGACATACGAAGTCACCTTGAACTTGTTAAAAGCTGGGGCGGCGGCTGTCTTAG
TAGGGATTGGCCCTGGTGCAGCTTGTACCTCTCGTGGGGTATTAGGTGTAGGAGTACCCCAAGCAACTGCGATCGCTGAT
TGCGCCGCCGCACGGGATGATTACTATCGGGAAACAGGTAATTATATCCCCATCATCGCTGATGGCGGTTTAATTACTGG
TGGTGATATTTGTAAATGTATTGCCTGTGGCGCTGACGGCGTAATGATCGGTTCTCCCTTTGCTAGAGCCGCCGAAGCTC
CAGGAAGAGGCTTCCATTGGGGTATGGCAACACCTAGCCCTGTATTGCCCCGTGGGACGCGGATTCGCGTCGGTACAACC
GGCACTCTTGAACAAATATTAACTGGGCCAGCCGGACTAGATGATGGTACTCATAACTTATTGGGAGCTTTAAAAACTAG
CATGGGTACTTTGGGAGCAAAAGATATTAAAGAAATGCAGCAAGTTGAAGTTGTAATTGCTCCTTCTTTGTTAACTGAGG
GCAAAGTTTACCAAAAAGCTCAACAATTAGGTATGGGTAAATAA

Upstream 100 bases:

>100_bases
CGTGCAACACGTAAACTTAGCCATCAATTAAAAAAAATCGCTGCAAACTATCTCACAATTTGATACCCTAGCTAGAACAG
AATTGAGAAAAGTTAACAGC

Downstream 100 bases:

>100_bases
AGGGAATAGGTAAAAGGGAATAGGGAATGGCGAATGATTAATTAGAAATAAATTTTTTAGTATGCCTTCTACCCTATCCC
GGATTACCAACTTTAAATTA

Product: inosine 5-monophosphate dehydrogenase

Products: xanthosine 5'-phosphate; NADH; H+

Alternate protein names: NA

Number of amino acids: Translated: 387; Mature: 387

Protein sequence:

>387_residues
MEIQLGRGKTARRAYGIDEIALVPGNRTLDPSLADTRWKIGNIEREIPIIASAMDGVVDVKMAVRLSQLGALGVINLEGI
QTRYADPEPILDRIASVGKDEFVSLMQELYAEPIKPELITKRIQEIKEQGGIAAVSATPVGASKYGEVVAQAGADLFFIQ
ATVVSTAHLSPESVVPLDLAEFCRSMPIPVILGNCVTYEVTLNLLKAGAAAVLVGIGPGAACTSRGVLGVGVPQATAIAD
CAAARDDYYRETGNYIPIIADGGLITGGDICKCIACGADGVMIGSPFARAAEAPGRGFHWGMATPSPVLPRGTRIRVGTT
GTLEQILTGPAGLDDGTHNLLGALKTSMGTLGAKDIKEMQQVEVVIAPSLLTEGKVYQKAQQLGMGK

Sequences:

>Translated_387_residues
MEIQLGRGKTARRAYGIDEIALVPGNRTLDPSLADTRWKIGNIEREIPIIASAMDGVVDVKMAVRLSQLGALGVINLEGI
QTRYADPEPILDRIASVGKDEFVSLMQELYAEPIKPELITKRIQEIKEQGGIAAVSATPVGASKYGEVVAQAGADLFFIQ
ATVVSTAHLSPESVVPLDLAEFCRSMPIPVILGNCVTYEVTLNLLKAGAAAVLVGIGPGAACTSRGVLGVGVPQATAIAD
CAAARDDYYRETGNYIPIIADGGLITGGDICKCIACGADGVMIGSPFARAAEAPGRGFHWGMATPSPVLPRGTRIRVGTT
GTLEQILTGPAGLDDGTHNLLGALKTSMGTLGAKDIKEMQQVEVVIAPSLLTEGKVYQKAQQLGMGK
>Mature_387_residues
MEIQLGRGKTARRAYGIDEIALVPGNRTLDPSLADTRWKIGNIEREIPIIASAMDGVVDVKMAVRLSQLGALGVINLEGI
QTRYADPEPILDRIASVGKDEFVSLMQELYAEPIKPELITKRIQEIKEQGGIAAVSATPVGASKYGEVVAQAGADLFFIQ
ATVVSTAHLSPESVVPLDLAEFCRSMPIPVILGNCVTYEVTLNLLKAGAAAVLVGIGPGAACTSRGVLGVGVPQATAIAD
CAAARDDYYRETGNYIPIIADGGLITGGDICKCIACGADGVMIGSPFARAAEAPGRGFHWGMATPSPVLPRGTRIRVGTT
GTLEQILTGPAGLDDGTHNLLGALKTSMGTLGAKDIKEMQQVEVVIAPSLLTEGKVYQKAQQLGMGK

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the IMPDH/GMPR family [H]

Homologues:

Organism=Homo sapiens, GI66933016, Length=154, Percent_Identity=35.7142857142857, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI156104880, Length=189, Percent_Identity=30.6878306878307, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI217035150, Length=154, Percent_Identity=35.0649350649351, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI217035146, Length=154, Percent_Identity=35.0649350649351, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI217035148, Length=154, Percent_Identity=35.0649350649351, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI217035152, Length=154, Percent_Identity=35.0649350649351, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI34328930, Length=154, Percent_Identity=35.0649350649351, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI34328928, Length=154, Percent_Identity=35.0649350649351, Blast_Score=80, Evalue=5e-15,
Organism=Homo sapiens, GI156616279, Length=154, Percent_Identity=35.0649350649351, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI50541954, Length=189, Percent_Identity=30.1587301587302, Blast_Score=76, Evalue=4e-14,
Organism=Homo sapiens, GI50541952, Length=189, Percent_Identity=30.1587301587302, Blast_Score=76, Evalue=4e-14,
Organism=Homo sapiens, GI50541948, Length=189, Percent_Identity=30.1587301587302, Blast_Score=76, Evalue=4e-14,
Organism=Homo sapiens, GI50541956, Length=189, Percent_Identity=30.1587301587302, Blast_Score=76, Evalue=5e-14,
Organism=Escherichia coli, GI1788855, Length=236, Percent_Identity=33.4745762711864, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1786293, Length=187, Percent_Identity=33.6898395721925, Blast_Score=80, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17560440, Length=203, Percent_Identity=31.5270935960591, Blast_Score=78, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI71994385, Length=179, Percent_Identity=32.9608938547486, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI71994389, Length=179, Percent_Identity=32.9608938547486, Blast_Score=77, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6322012, Length=130, Percent_Identity=34.6153846153846, Blast_Score=75, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6323464, Length=130, Percent_Identity=33.0769230769231, Blast_Score=72, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6323585, Length=154, Percent_Identity=29.2207792207792, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI28571163, Length=188, Percent_Identity=32.9787234042553, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24641071, Length=188, Percent_Identity=32.9787234042553, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24641073, Length=188, Percent_Identity=32.9787234042553, Blast_Score=84, Evalue=2e-16,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR001093
- InterPro:   IPR005992 [H]

Pfam domain/function: PF00478 IMPDH [H]

EC number: 1.1.1.205

Molecular weight: Translated: 40459; Mature: 40459

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIQLGRGKTARRAYGIDEIALVPGNRTLDPSLADTRWKIGNIEREIPIIASAMDGVVDV
CEEECCCCCCHHHHCCCCEEEEECCCCCCCCCCCCCCEECCCCCCCCCHHHHHHCCHHHH
KMAVRLSQLGALGVINLEGIQTRYADPEPILDRIASVGKDEFVSLMQELYAEPIKPELIT
HHHHHHHHCCCEEEEEECCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHCCCCHHHHH
KRIQEIKEQGGIAAVSATPVGASKYGEVVAQAGADLFFIQATVVSTAHLSPESVVPLDLA
HHHHHHHHCCCEEEEECCCCCHHHHHHHHHHCCCCEEEEEEEHHHHHCCCCCCCCCCCHH
EFCRSMPIPVILGNCVTYEVTLNLLKAGAAAVLVGIGPGAACTSRGVLGVGVPQATAIAD
HHHHCCCCCEEECCEEEEEHHHHHHHCCCEEEEEECCCCCHHHCCCEEEECCCCHHHHHH
CAAARDDYYRETGNYIPIIADGGLITGGDICKCIACGADGVMIGSPFARAAEAPGRGFHW
HHHHHHHHHHHCCCEEEEEECCCEEECCHHHHHEECCCCCEEECCCHHHHHCCCCCCEEC
GMATPSPVLPRGTRIRVGTTGTLEQILTGPAGLDDGTHNLLGALKTSMGTLGAKDIKEMQ
CCCCCCCCCCCCCEEEECCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHH
QVEVVIAPSLLTEGKVYQKAQQLGMGK
HEEEEEECHHHHCCHHHHHHHHHCCCC
>Mature Secondary Structure
MEIQLGRGKTARRAYGIDEIALVPGNRTLDPSLADTRWKIGNIEREIPIIASAMDGVVDV
CEEECCCCCCHHHHCCCCEEEEECCCCCCCCCCCCCCEECCCCCCCCCHHHHHHCCHHHH
KMAVRLSQLGALGVINLEGIQTRYADPEPILDRIASVGKDEFVSLMQELYAEPIKPELIT
HHHHHHHHCCCEEEEEECCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHCCCCHHHHH
KRIQEIKEQGGIAAVSATPVGASKYGEVVAQAGADLFFIQATVVSTAHLSPESVVPLDLA
HHHHHHHHCCCEEEEECCCCCHHHHHHHHHHCCCCEEEEEEEHHHHHCCCCCCCCCCCHH
EFCRSMPIPVILGNCVTYEVTLNLLKAGAAAVLVGIGPGAACTSRGVLGVGVPQATAIAD
HHHHCCCCCEEECCEEEEEHHHHHHHCCCEEEEEECCCCCHHHCCCEEEECCCCHHHHHH
CAAARDDYYRETGNYIPIIADGGLITGGDICKCIACGADGVMIGSPFARAAEAPGRGFHW
HHHHHHHHHHHCCCEEEEEECCCEEECCHHHHHEECCCCCEEECCCHHHHHCCCCCCEEC
GMATPSPVLPRGTRIRVGTTGTLEQILTGPAGLDDGTHNLLGALKTSMGTLGAKDIKEMQ
CCCCCCCCCCCCCEEEECCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHH
QVEVVIAPSLLTEGKVYQKAQQLGMGK
HEEEEEECHHHHCCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NAD+ [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: inosine 5'-phosphate; NAD+; H2O

Specific reaction: inosine 5'-phosphate + NAD+ + H2O = xanthosine 5'-phosphate + NADH + H+

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA