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The map label for this gene is murB

Identifier: 75908538

GI number: 75908538

Start: 2883519

End: 2884514

Strand: Direct

Name: murB

Synonym: Ava_2321

Alternate gene names: 75908538

Gene position: 2883519-2884514 (Clockwise)

Preceding gene: 75908537

Following gene: 75908539

Centisome position: 45.3

GC content: 46.18

Gene sequence:

>996_bases
ATGAAAATTTCCCAGGCAGTTGGAAACGCCTGTACAGTTCCTGCTTCCAATGTAGAGACACACAATAACAATCCTTCAAG
AGAAAGTAAAATTATTTACTTACCCGGTACTAATTGCGAGATTAAGTCTCAAGCTCTGTTATCCGCATTTACTTCTTATA
GAGTCGGGGGAGCAGCTGAACTGTATGTTGCCCCTCGCAATATAGAAGCATTGCAAGCCAGCCTCAAATATGCACAAGAG
CATAACCTCAGAGTAACAACTCTCGGTGCAGGTTCTAACTTGTTAGTGAGCGATCGCGGCATCTCAGGCTTGGTCATTGC
TACTCGTCATCTACGTTACAATCGTTTTGACCACCAAACCGGTCAAGTAACTGTAGCAGCCGGAGAATCAATTCCTAGTT
TGGCATGGGAAATAGCAAAGCTGGGATGGCAAGGGTTTGAGTGGGCTGTAGGTATCCCTGGAACCGTTGGTGGTGCTGTA
GTGATGAATGCCGGAGCGCATAATAGCTGTATCGCAGATATATTAGTTAGCGCTCAAGTACTTTCGCCTGATGGCACAAT
AGAAACACTCACTCCTGAAGAATTGGGTTATGGGTATCGTACTTCATTACTACAAGGTAGCAATCGCGTAGTCACCCAAG
CCACATTCCAACTGCAACCAGGCTTTGATCCTGCCTACATCACAGCCACAACCAGAGAACACAAGCAGATGCGGTTAACC
ACTCAACCCTACAACTTCCCCAGTTGTGGTAGTGTGTTCCGCAACCCCAAACCTTATTCGGCAGGCTGGTTAATCGAACA
ATCAGGATTAAAAGGCTATCAAATAGGTGGCGCACAAGTAGCGCATCTCCACGCTAATTTTATAGTTAATCGCGGAGGAG
CCAAAGCTAACGATATTTTCTGCCTCATCCGCCATATCCAGCAGGAAGTCCAAGAACGCTGGTCAATTTTATTAGAGCCA
GAAGTCAAAATGCTGGGTGAATTTCAGGCGGCGTGA

Upstream 100 bases:

>100_bases
TTTTATCTAAGCCAAGTGTTTACTTAGCAACAGTTTTATCGAAATTGCTGTAGTTGTACGGCAGATAAATGTAAAAATTT
CACAATTAATTGATGTAAAG

Downstream 100 bases:

>100_bases
GGAATGGGGTAATGCTGAGATAGGGCTATGGGAGTAATGCCAAGAAAAAAACATAGTTTTTGTTCTTGTCCTCCCATTTA
CCCCTCCCCAGTCCCTAAAG

Product: UDP-N-acetylenolpyruvoylglucosamine reductase

Products: NA

Alternate protein names: UDP-N-acetylmuramate dehydrogenase

Number of amino acids: Translated: 331; Mature: 331

Protein sequence:

>331_residues
MKISQAVGNACTVPASNVETHNNNPSRESKIIYLPGTNCEIKSQALLSAFTSYRVGGAAELYVAPRNIEALQASLKYAQE
HNLRVTTLGAGSNLLVSDRGISGLVIATRHLRYNRFDHQTGQVTVAAGESIPSLAWEIAKLGWQGFEWAVGIPGTVGGAV
VMNAGAHNSCIADILVSAQVLSPDGTIETLTPEELGYGYRTSLLQGSNRVVTQATFQLQPGFDPAYITATTREHKQMRLT
TQPYNFPSCGSVFRNPKPYSAGWLIEQSGLKGYQIGGAQVAHLHANFIVNRGGAKANDIFCLIRHIQQEVQERWSILLEP
EVKMLGEFQAA

Sequences:

>Translated_331_residues
MKISQAVGNACTVPASNVETHNNNPSRESKIIYLPGTNCEIKSQALLSAFTSYRVGGAAELYVAPRNIEALQASLKYAQE
HNLRVTTLGAGSNLLVSDRGISGLVIATRHLRYNRFDHQTGQVTVAAGESIPSLAWEIAKLGWQGFEWAVGIPGTVGGAV
VMNAGAHNSCIADILVSAQVLSPDGTIETLTPEELGYGYRTSLLQGSNRVVTQATFQLQPGFDPAYITATTREHKQMRLT
TQPYNFPSCGSVFRNPKPYSAGWLIEQSGLKGYQIGGAQVAHLHANFIVNRGGAKANDIFCLIRHIQQEVQERWSILLEP
EVKMLGEFQAA
>Mature_331_residues
MKISQAVGNACTVPASNVETHNNNPSRESKIIYLPGTNCEIKSQALLSAFTSYRVGGAAELYVAPRNIEALQASLKYAQE
HNLRVTTLGAGSNLLVSDRGISGLVIATRHLRYNRFDHQTGQVTVAAGESIPSLAWEIAKLGWQGFEWAVGIPGTVGGAV
VMNAGAHNSCIADILVSAQVLSPDGTIETLTPEELGYGYRTSLLQGSNRVVTQATFQLQPGFDPAYITATTREHKQMRLT
TQPYNFPSCGSVFRNPKPYSAGWLIEQSGLKGYQIGGAQVAHLHANFIVNRGGAKANDIFCLIRHIQQEVQERWSILLEP
EVKMLGEFQAA

Specific function: Cell wall formation

COG id: COG0812

COG function: function code M; UDP-N-acetylmuramate dehydrogenase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain

Homologues:

Organism=Escherichia coli, GI1790407, Length=327, Percent_Identity=26.605504587156, Blast_Score=87, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURB_ANAVT (Q3MAP7)

Other databases:

- EMBL:   CP000117
- RefSeq:   YP_322834.1
- ProteinModelPortal:   Q3MAP7
- SMR:   Q3MAP7
- STRING:   Q3MAP7
- GeneID:   3683591
- GenomeReviews:   CP000117_GR
- KEGG:   ava:Ava_2321
- NMPDR:   fig|240292.3.peg.201
- eggNOG:   COG0812
- HOGENOM:   HBG686573
- OMA:   ILIVPKH
- PhylomeDB:   Q3MAP7
- ProtClustDB:   PRK13905
- BioCyc:   AVAR240292:AVA_2321-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00037
- InterPro:   IPR016169
- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR003170
- InterPro:   IPR011601
- InterPro:   IPR006094
- Gene3D:   G3DSA:3.30.465.10
- Gene3D:   G3DSA:3.30.43.10
- Gene3D:   G3DSA:3.90.78.10
- PANTHER:   PTHR21071
- TIGRFAMs:   TIGR00179

Pfam domain/function: PF01565 FAD_binding_4; PF02873 MurB_C; SSF56176 FAD-binding_2; SSF56194 MurB_C

EC number: =1.1.1.158

Molecular weight: Translated: 35866; Mature: 35866

Theoretical pI: Translated: 7.93; Mature: 7.93

Prosite motif: PS51387 FAD_PCMH

Important sites: ACT_SITE 200-200 ACT_SITE 251-251 ACT_SITE 321-321

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKISQAVGNACTVPASNVETHNNNPSRESKIIYLPGTNCEIKSQALLSAFTSYRVGGAAE
CCCHHHCCCEEECCCCCCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCCEEE
LYVAPRNIEALQASLKYAQEHNLRVTTLGAGSNLLVSDRGISGLVIATRHLRYNRFDHQT
EEEECCCHHHHHHHHHHHHHCCEEEEEECCCCEEEEECCCCCEEEEEEEHHHCCCCCCCC
GQVTVAAGESIPSLAWEIAKLGWQGFEWAVGIPGTVGGAVVMNAGAHNSCIADILVSAQV
CEEEEEECCCCHHHHHHHHHCCCCCCEEEEECCCCCCCEEEEECCCCCHHHHHHHHHHEE
LSPDGTIETLTPEELGYGYRTSLLQGSNRVVTQATFQLQPGFDPAYITATTREHKQMRLT
ECCCCCEEECCHHHHCCCHHHHHHCCCCEEEEEEEEEECCCCCCEEEEEECCCCCEEEEE
TQPYNFPSCGSVFRNPKPYSAGWLIEQSGLKGYQIGGAQVAHLHANFIVNRGGAKANDIF
ECCCCCCCHHHHHCCCCCCCCCEEEECCCCCEEEECCEEEEEEEEEEEEECCCCCHHHHH
CLIRHIQQEVQERWSILLEPEVKMLGEFQAA
HHHHHHHHHHHHHHCEEECCCHHHHHCCCCC
>Mature Secondary Structure
MKISQAVGNACTVPASNVETHNNNPSRESKIIYLPGTNCEIKSQALLSAFTSYRVGGAAE
CCCHHHCCCEEECCCCCCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCCEEE
LYVAPRNIEALQASLKYAQEHNLRVTTLGAGSNLLVSDRGISGLVIATRHLRYNRFDHQT
EEEECCCHHHHHHHHHHHHHCCEEEEEECCCCEEEEECCCCCEEEEEEEHHHCCCCCCCC
GQVTVAAGESIPSLAWEIAKLGWQGFEWAVGIPGTVGGAVVMNAGAHNSCIADILVSAQV
CEEEEEECCCCHHHHHHHHHCCCCCCEEEEECCCCCCCEEEEECCCCCHHHHHHHHHHEE
LSPDGTIETLTPEELGYGYRTSLLQGSNRVVTQATFQLQPGFDPAYITATTREHKQMRLT
ECCCCCEEECCHHHHCCCHHHHHHCCCCEEEEEEEEEECCCCCCEEEEEECCCCCEEEEE
TQPYNFPSCGSVFRNPKPYSAGWLIEQSGLKGYQIGGAQVAHLHANFIVNRGGAKANDIF
ECCCCCCCHHHHHCCCCCCCCCEEEECCCCCEEEECCEEEEEEEEEEEEECCCCCHHHHH
CLIRHIQQEVQERWSILLEPEVKMLGEFQAA
HHHHHHHHHHHHHHCEEECCCHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA