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The map label for this gene is murC

Identifier: 75908537

GI number: 75908537

Start: 2881914

End: 2883398

Strand: Direct

Name: murC

Synonym: Ava_2320

Alternate gene names: 75908537

Gene position: 2881914-2883398 (Clockwise)

Preceding gene: 75908534

Following gene: 75908538

Centisome position: 45.27

GC content: 42.76

Gene sequence:

>1485_bases
ATGAATAATAGTGTAGATTTCGGCGGTAGACCATTTCATTTTATCGGAATCGGCGGTATAGGGATGTCTGCCCTGGCATA
CGTTCTTGCAAAACGCCAGTTGCCAGTGTCAGGTTCTGACCTTCGTCCTAATCATATTACGCGCAAGTTGGAATCTATCG
GCGCGCATATTTTTAGTAGACAAGAAGCGAGTAATCTTGAATTCTTTGGCTCTAAAGTTAGCTCTACTGAAATAGAATTA
AATACACAAGAAATGTTTCCGCTTGGCAAGTCAACATTGCCTCAAGTGGTTTGTTCAACAGCAATTAACTCGAATAATTT
AGAATACCAAGCAGCAATAGAATTAGGATGCCCAATTTTACATCGTTCAGATGTACTAGCGGCTTTAATTAACGATTATC
ATAGTGTTGCCGTAGCAGGAACTCATGGCAAAACGACAACTAGTAGCATGATTGGTTATATGTTACTAGAAGCGGGTTTA
GATCCAACAATCATTGTTGGTGGAGAAGTAAATGCTTGGGAAGGCAATGCCAGATTAGGACAAAGTCCTTATTTAGTAGC
TGAGGCAGACGAATCAGATGGCTCCCTGGTCAAACACGCTCCAGAAATTGGTATTATCACTAATATTGAATTAGATCATC
CTGACCATTACGACACCTTAGAAGAAGTCGTTGATATCTTTCAAACATTTGCCAAGGGTTGTAAAACCTTAATTGGTAGT
GTTGATTGTGCAACAGTGCGCGAGTTGCTTCGCACCGCCGCCAGCGATCGCCAACAACCAACTATCACTTATAGTCTTCA
TCAAGATACAGAAGCTGATTACACCGTTACTAATATTGACTGCCGTGCTGACGGTACCACTGCTTTAGTCTGGGAAAAAG
GCAAAGCATTAGGTGTACTGAAACTAAAATTACTCAGTCGTCATAATCTAAGTAATGCTCTAGCCGCAGTAGCTGTTGGT
CGTCTAGTGGGTCTAGAATTTGGGGAAATCGCCAAAGGTATCGCTGGTTTTGAAGGCGCAAGACGACGCTTTGAATTCCG
TGGCGAAGTCGATGGTATTACCTTCATAGATGATTACGCCCATCACCCCAGCGAAATCCGGGCTACATTGGCTGCTGCGA
GGCTTCAAGCTAGACCAGGACAAAGAGTAGTAGCTATCTTTCAACCCCACCGTTATAGTCGCACCTTGACCTTTTTAGAA
GAATTCTCTGAGTCTTTCAGTCATGCCGATTTGGTAGTACTGACTGATATTTACAGTGCAGGGGAGCCCAATTTAGGACT
AATTAGTGGTGAACAGTTGGCAGAAAAAATTGCTCAAGAACACCCACAGGTAGTTTATCAACCAACTTTATCTACAGTGT
GTGAGTATTTATTAAAAAATCTCCGCCCTGGTGACTTGGCTTTATTCCTGGGTGCAGGAAATTTAAATCAGGCAATTCCC
GAAATCATTACCACACTGTGCGAACCTGCGACAGCCACATTGTGA

Upstream 100 bases:

>100_bases
AAAAAGATATAGGAGTAGTTACAGTAAAAATCCAAATCCTGTTATGATACGCGTGTTATTTGTGATTGATGGTGTGGTGT
GGTGATAAGAGGAGTAATCA

Downstream 100 bases:

>100_bases
GGACACTCACCAATGAAGGCTTTTATCTAAGCCAAGTGTTTACTTAGCAACAGTTTTATCGAAATTGCTGTAGTTGTACG
GCAGATAAATGTAAAAATTT

Product: UDP-N-acetylmuramate--L-alanine ligase

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase

Number of amino acids: Translated: 494; Mature: 494

Protein sequence:

>494_residues
MNNSVDFGGRPFHFIGIGGIGMSALAYVLAKRQLPVSGSDLRPNHITRKLESIGAHIFSRQEASNLEFFGSKVSSTEIEL
NTQEMFPLGKSTLPQVVCSTAINSNNLEYQAAIELGCPILHRSDVLAALINDYHSVAVAGTHGKTTTSSMIGYMLLEAGL
DPTIIVGGEVNAWEGNARLGQSPYLVAEADESDGSLVKHAPEIGIITNIELDHPDHYDTLEEVVDIFQTFAKGCKTLIGS
VDCATVRELLRTAASDRQQPTITYSLHQDTEADYTVTNIDCRADGTTALVWEKGKALGVLKLKLLSRHNLSNALAAVAVG
RLVGLEFGEIAKGIAGFEGARRRFEFRGEVDGITFIDDYAHHPSEIRATLAAARLQARPGQRVVAIFQPHRYSRTLTFLE
EFSESFSHADLVVLTDIYSAGEPNLGLISGEQLAEKIAQEHPQVVYQPTLSTVCEYLLKNLRPGDLALFLGAGNLNQAIP
EIITTLCEPATATL

Sequences:

>Translated_494_residues
MNNSVDFGGRPFHFIGIGGIGMSALAYVLAKRQLPVSGSDLRPNHITRKLESIGAHIFSRQEASNLEFFGSKVSSTEIEL
NTQEMFPLGKSTLPQVVCSTAINSNNLEYQAAIELGCPILHRSDVLAALINDYHSVAVAGTHGKTTTSSMIGYMLLEAGL
DPTIIVGGEVNAWEGNARLGQSPYLVAEADESDGSLVKHAPEIGIITNIELDHPDHYDTLEEVVDIFQTFAKGCKTLIGS
VDCATVRELLRTAASDRQQPTITYSLHQDTEADYTVTNIDCRADGTTALVWEKGKALGVLKLKLLSRHNLSNALAAVAVG
RLVGLEFGEIAKGIAGFEGARRRFEFRGEVDGITFIDDYAHHPSEIRATLAAARLQARPGQRVVAIFQPHRYSRTLTFLE
EFSESFSHADLVVLTDIYSAGEPNLGLISGEQLAEKIAQEHPQVVYQPTLSTVCEYLLKNLRPGDLALFLGAGNLNQAIP
EIITTLCEPATATL
>Mature_494_residues
MNNSVDFGGRPFHFIGIGGIGMSALAYVLAKRQLPVSGSDLRPNHITRKLESIGAHIFSRQEASNLEFFGSKVSSTEIEL
NTQEMFPLGKSTLPQVVCSTAINSNNLEYQAAIELGCPILHRSDVLAALINDYHSVAVAGTHGKTTTSSMIGYMLLEAGL
DPTIIVGGEVNAWEGNARLGQSPYLVAEADESDGSLVKHAPEIGIITNIELDHPDHYDTLEEVVDIFQTFAKGCKTLIGS
VDCATVRELLRTAASDRQQPTITYSLHQDTEADYTVTNIDCRADGTTALVWEKGKALGVLKLKLLSRHNLSNALAAVAVG
RLVGLEFGEIAKGIAGFEGARRRFEFRGEVDGITFIDDYAHHPSEIRATLAAARLQARPGQRVVAIFQPHRYSRTLTFLE
EFSESFSHADLVVLTDIYSAGEPNLGLISGEQLAEKIAQEHPQVVYQPTLSTVCEYLLKNLRPGDLALFLGAGNLNQAIP
EIITTLCEPATATL

Specific function: Cell wall formation

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family

Homologues:

Organism=Escherichia coli, GI1786279, Length=500, Percent_Identity=35.2, Blast_Score=207, Evalue=1e-54,
Organism=Escherichia coli, GI1790680, Length=497, Percent_Identity=26.9617706237425, Blast_Score=160, Evalue=2e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURC_ANAVT (Q3MAP8)

Other databases:

- EMBL:   CP000117
- RefSeq:   YP_322833.1
- ProteinModelPortal:   Q3MAP8
- SMR:   Q3MAP8
- STRING:   Q3MAP8
- GeneID:   3683590
- GenomeReviews:   CP000117_GR
- KEGG:   ava:Ava_2320
- NMPDR:   fig|240292.3.peg.199
- eggNOG:   COG0773
- HOGENOM:   HBG476594
- OMA:   YQPHRYS
- PhylomeDB:   Q3MAP8
- ProtClustDB:   PRK00421
- BioCyc:   AVAR240292:AVA_2320-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00046
- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758
- Gene3D:   G3DSA:3.90.190.20
- Gene3D:   G3DSA:3.40.1190.10
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR01082

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M; SSF53244 Mur_ligase_C; SSF53623 Mur_ligase_cen

EC number: =6.3.2.8

Molecular weight: Translated: 53541; Mature: 53541

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNSVDFGGRPFHFIGIGGIGMSALAYVLAKRQLPVSGSDLRPNHITRKLESIGAHIFSR
CCCCCCCCCCCEEEEEECCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHC
QEASNLEFFGSKVSSTEIELNTQEMFPLGKSTLPQVVCSTAINSNNLEYQAAIELGCPIL
CCCCCHHHHCCCCCCCEEEECHHHHCCCCCHHHHHHHHHHHCCCCCCEEEEEEECCCCCH
HRSDVLAALINDYHSVAVAGTHGKTTTSSMIGYMLLEAGLDPTIIVGGEVNAWEGNARLG
HHHHHHHHHHHCHHEEEEECCCCCCHHHHHHHHHHHHCCCCCEEEECCEEECCCCCCCCC
QSPYLVAEADESDGSLVKHAPEIGIITNIELDHPDHYDTLEEVVDIFQTFAKGCKTLIGS
CCCEEEEECCCCCCCHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCC
VDCATVRELLRTAASDRQQPTITYSLHQDTEADYTVTNIDCRADGTTALVWEKGKALGVL
CCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCEEEEEEEECCCCCEEEEEECCCEEEHH
KLKLLSRHNLSNALAAVAVGRLVGLEFGEIAKGIAGFEGARRRFEFRGEVDGITFIDDYA
HHHHHHHCCHHHHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHEEECCCCCCEEEEHHHC
HHPSEIRATLAAARLQARPGQRVVAIFQPHRYSRTLTFLEEFSESFSHADLVVLTDIYSA
CCHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCCEEEEEEHHHC
GEPNLGLISGEQLAEKIAQEHPQVVYQPTLSTVCEYLLKNLRPGDLALFLGAGNLNQAIP
CCCCCEEECHHHHHHHHHHHCCCEEECCCHHHHHHHHHHHCCCCCEEEEEECCCHHHHHH
EIITTLCEPATATL
HHHHHHCCCCCCCC
>Mature Secondary Structure
MNNSVDFGGRPFHFIGIGGIGMSALAYVLAKRQLPVSGSDLRPNHITRKLESIGAHIFSR
CCCCCCCCCCCEEEEEECCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHC
QEASNLEFFGSKVSSTEIELNTQEMFPLGKSTLPQVVCSTAINSNNLEYQAAIELGCPIL
CCCCCHHHHCCCCCCCEEEECHHHHCCCCCHHHHHHHHHHHCCCCCCEEEEEEECCCCCH
HRSDVLAALINDYHSVAVAGTHGKTTTSSMIGYMLLEAGLDPTIIVGGEVNAWEGNARLG
HHHHHHHHHHHCHHEEEEECCCCCCHHHHHHHHHHHHCCCCCEEEECCEEECCCCCCCCC
QSPYLVAEADESDGSLVKHAPEIGIITNIELDHPDHYDTLEEVVDIFQTFAKGCKTLIGS
CCCEEEEECCCCCCCHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCC
VDCATVRELLRTAASDRQQPTITYSLHQDTEADYTVTNIDCRADGTTALVWEKGKALGVL
CCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCEEEEEEEECCCCCEEEEEECCCEEEHH
KLKLLSRHNLSNALAAVAVGRLVGLEFGEIAKGIAGFEGARRRFEFRGEVDGITFIDDYA
HHHHHHHCCHHHHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHEEECCCCCCEEEEHHHC
HHPSEIRATLAAARLQARPGQRVVAIFQPHRYSRTLTFLEEFSESFSHADLVVLTDIYSA
CCHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCCEEEEEEHHHC
GEPNLGLISGEQLAEKIAQEHPQVVYQPTLSTVCEYLLKNLRPGDLALFLGAGNLNQAIP
CCCCCEEECHHHHHHHHHHHCCCEEECCCHHHHHHHHHHHCCCCCEEEEEECCCHHHHHH
EIITTLCEPATATL
HHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA