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The map label for this gene is recQ [H]

Identifier: 75908334

GI number: 75908334

Start: 2614097

End: 2615542

Strand: Direct

Name: recQ [H]

Synonym: Ava_2113

Alternate gene names: 75908334

Gene position: 2614097-2615542 (Clockwise)

Preceding gene: 75908333

Following gene: 75908337

Centisome position: 41.07

GC content: 41.7

Gene sequence:

>1446_bases
ATGAATCCTCACAAAATAAAGGCTTGGGAAGAAGTTCGGACTACTTTTAAAGAGATTTGGGGTTACGAAGATTTCCGTCC
GCCACAAGGGGAAATTGTTGGCAGTTTATTATCCCGAAAAGATGCACTAATTATTATGCCTACCGGGGGCGGTAAATCAA
TTTGTTTTCAATTACCTGCACTATTACAAACAGGTTTAACTTTGGTAGTTTCCCCGTTGGTGGCGTTGATGGAGAATCAA
GTGCAAGAACTACTCCAACGCCAACAAAAAGCAGCACTATTGCATAGTGAGTTGTCCACATTTCAACGCCGCATAACTCT
ACAAGCATTAGAAAAACAACAACTAAGATTACTATATTTATCTCCTGAAACTTTATTAAGTCCACCAGTTTGGGAAAGAT
TATGTCAGCCACAACTGCAAATAAATGGCTTAATTTTAGATGAAGCCCATTGTTTAGTGCAGTGGGGTGAAACATTTCGC
CCGGCTTACCGCAGACTAGGGGCTGTTAGACCTGCATTGCTCAAACATAAACCACCAGGAACTAAAATCAGTATTGCTGC
GTTTACGGCTACGGCTGACCCCTCTGCACAACAAACTATTCAAACAGTTTTACAATTACAGCAACCAGATATTTTTCGCC
TCAATCCTTACCGTCCTAATTTGCATCCTACTGTCCGCATTGCTTGGACACCAAAGGGTAGGAAACAGCATTTAATCAAA
TTTATTCAAAATCGACCCCAACAAGCAGGATTAATTTACGTCCGCACCAGAAGAGATAGTGAAGACTTAGCTGTATGGCT
GTCACAAATGGGTTACGCCACAGCTAGTTATCATGCTGGATTAGGCGCAACAGAACGCCGGGAAGTAGAAGCCAAGTGGT
TAGGGGGAAAAATTCCCTTTGTGGTCTGTACCTGCGCTTTTGGAATGGGGATTAATAAGCCAGATGTGCGCTGGGTAGTC
CATTTTCACTCACCACACCTATTGTCTGAATATGTGCAAGAAATTGGTCGTGGGGGAAGGGATGGTAAACCAGCCGAGGC
GCTGACATTGGTGAGTGAACCTACAGGGTGGCTAGATGCAGAGGATAAACAAAGACAGGAGTTTTTTCAAGAGAAAATGC
GATCGCAACAACAAAAAGCCCAGCAATTAATCAAAAAACTACCACAGCAAGGCGAAATTAACTCTGTAACTAAACAATTT
CCTGATAGTGCTGTAGCCCTAGCCTTACTCCACAGCAGTGGTCAATTAAACTGGCTAGATCCTTTCAATTACAAAATAGA
ACACAAGGCCAAAAGTCAGCCATCAAAACAATTGCAGGCTACTAAACAAATGACTCAATATTTAAATACTAAACAATGTC
GCTGGCAATTTTTATTAAATGCTTTTGGGTTTGATAAAGAAGCAAATAACTGGCGTTGTGGACATTGCGATAATTGCCGA
AATTAA

Upstream 100 bases:

>100_bases
AATATTTGCCATAGAAACTGTCAGTAATATCTGAGAAAATTACTGAACCAATATCTAGATAGTAGAGTGTAAATTCAAAA
ATATTGCATCTACTACCTTC

Downstream 100 bases:

>100_bases
CTCATCCAGTAAGCTCATTCTTTTTGCCCTTAAATTTATCCCATAATGCGCGATGAGATGAATAACCAAATTCATCATTA
CGGGTTTCATATTGTTGAAT

Product: ATP-dependent DNA helicase RecQ

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 481; Mature: 481

Protein sequence:

>481_residues
MNPHKIKAWEEVRTTFKEIWGYEDFRPPQGEIVGSLLSRKDALIIMPTGGGKSICFQLPALLQTGLTLVVSPLVALMENQ
VQELLQRQQKAALLHSELSTFQRRITLQALEKQQLRLLYLSPETLLSPPVWERLCQPQLQINGLILDEAHCLVQWGETFR
PAYRRLGAVRPALLKHKPPGTKISIAAFTATADPSAQQTIQTVLQLQQPDIFRLNPYRPNLHPTVRIAWTPKGRKQHLIK
FIQNRPQQAGLIYVRTRRDSEDLAVWLSQMGYATASYHAGLGATERREVEAKWLGGKIPFVVCTCAFGMGINKPDVRWVV
HFHSPHLLSEYVQEIGRGGRDGKPAEALTLVSEPTGWLDAEDKQRQEFFQEKMRSQQQKAQQLIKKLPQQGEINSVTKQF
PDSAVALALLHSSGQLNWLDPFNYKIEHKAKSQPSKQLQATKQMTQYLNTKQCRWQFLLNAFGFDKEANNWRCGHCDNCR
N

Sequences:

>Translated_481_residues
MNPHKIKAWEEVRTTFKEIWGYEDFRPPQGEIVGSLLSRKDALIIMPTGGGKSICFQLPALLQTGLTLVVSPLVALMENQ
VQELLQRQQKAALLHSELSTFQRRITLQALEKQQLRLLYLSPETLLSPPVWERLCQPQLQINGLILDEAHCLVQWGETFR
PAYRRLGAVRPALLKHKPPGTKISIAAFTATADPSAQQTIQTVLQLQQPDIFRLNPYRPNLHPTVRIAWTPKGRKQHLIK
FIQNRPQQAGLIYVRTRRDSEDLAVWLSQMGYATASYHAGLGATERREVEAKWLGGKIPFVVCTCAFGMGINKPDVRWVV
HFHSPHLLSEYVQEIGRGGRDGKPAEALTLVSEPTGWLDAEDKQRQEFFQEKMRSQQQKAQQLIKKLPQQGEINSVTKQF
PDSAVALALLHSSGQLNWLDPFNYKIEHKAKSQPSKQLQATKQMTQYLNTKQCRWQFLLNAFGFDKEANNWRCGHCDNCR
N
>Mature_481_residues
MNPHKIKAWEEVRTTFKEIWGYEDFRPPQGEIVGSLLSRKDALIIMPTGGGKSICFQLPALLQTGLTLVVSPLVALMENQ
VQELLQRQQKAALLHSELSTFQRRITLQALEKQQLRLLYLSPETLLSPPVWERLCQPQLQINGLILDEAHCLVQWGETFR
PAYRRLGAVRPALLKHKPPGTKISIAAFTATADPSAQQTIQTVLQLQQPDIFRLNPYRPNLHPTVRIAWTPKGRKQHLIK
FIQNRPQQAGLIYVRTRRDSEDLAVWLSQMGYATASYHAGLGATERREVEAKWLGGKIPFVVCTCAFGMGINKPDVRWVV
HFHSPHLLSEYVQEIGRGGRDGKPAEALTLVSEPTGWLDAEDKQRQEFFQEKMRSQQQKAQQLIKKLPQQGEINSVTKQF
PDSAVALALLHSSGQLNWLDPFNYKIEHKAKSQPSKQLQATKQMTQYLNTKQCRWQFLLNAFGFDKEANNWRCGHCDNCR
N

Specific function: DNA helicase [H]

COG id: COG0514

COG function: function code L; Superfamily II DNA helicase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 helicase C-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI51242943, Length=350, Percent_Identity=39.7142857142857, Blast_Score=246, Evalue=2e-65,
Organism=Homo sapiens, GI51242947, Length=350, Percent_Identity=39.7142857142857, Blast_Score=246, Evalue=5e-65,
Organism=Homo sapiens, GI148612816, Length=350, Percent_Identity=39.7142857142857, Blast_Score=243, Evalue=3e-64,
Organism=Homo sapiens, GI4557365, Length=347, Percent_Identity=37.1757925072046, Blast_Score=219, Evalue=6e-57,
Organism=Homo sapiens, GI14591902, Length=347, Percent_Identity=34.5821325648415, Blast_Score=214, Evalue=1e-55,
Organism=Homo sapiens, GI14591904, Length=347, Percent_Identity=34.5821325648415, Blast_Score=214, Evalue=1e-55,
Organism=Homo sapiens, GI110735439, Length=337, Percent_Identity=33.2344213649852, Blast_Score=194, Evalue=2e-49,
Organism=Homo sapiens, GI169218196, Length=337, Percent_Identity=33.2344213649852, Blast_Score=193, Evalue=3e-49,
Organism=Homo sapiens, GI284005309, Length=355, Percent_Identity=36.3380281690141, Blast_Score=187, Evalue=3e-47,
Organism=Homo sapiens, GI301171475, Length=354, Percent_Identity=23.728813559322, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI87196351, Length=354, Percent_Identity=23.728813559322, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI301171467, Length=354, Percent_Identity=23.728813559322, Blast_Score=77, Evalue=5e-14,
Organism=Homo sapiens, GI169881239, Length=354, Percent_Identity=24.0112994350282, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI13514809, Length=354, Percent_Identity=24.0112994350282, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI38569505, Length=354, Percent_Identity=21.7514124293785, Blast_Score=66, Evalue=6e-11,
Organism=Homo sapiens, GI38569503, Length=354, Percent_Identity=21.7514124293785, Blast_Score=65, Evalue=1e-10,
Organism=Escherichia coli, GI48994977, Length=350, Percent_Identity=41.4285714285714, Blast_Score=256, Evalue=3e-69,
Organism=Escherichia coli, GI87082221, Length=374, Percent_Identity=25.1336898395722, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1787016, Length=353, Percent_Identity=24.929178470255, Blast_Score=72, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI17552866, Length=356, Percent_Identity=36.7977528089888, Blast_Score=219, Evalue=3e-57,
Organism=Caenorhabditis elegans, GI32564293, Length=342, Percent_Identity=34.5029239766082, Blast_Score=212, Evalue=3e-55,
Organism=Caenorhabditis elegans, GI71987997, Length=346, Percent_Identity=35.5491329479769, Blast_Score=209, Evalue=2e-54,
Organism=Caenorhabditis elegans, GI71987993, Length=346, Percent_Identity=35.5491329479769, Blast_Score=209, Evalue=2e-54,
Organism=Caenorhabditis elegans, GI25145561, Length=353, Percent_Identity=34.2776203966006, Blast_Score=204, Evalue=1e-52,
Organism=Caenorhabditis elegans, GI17510309, Length=359, Percent_Identity=26.1838440111421, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17510307, Length=359, Percent_Identity=26.1838440111421, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI71995514, Length=359, Percent_Identity=26.1838440111421, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI71995718, Length=405, Percent_Identity=23.4567901234568, Blast_Score=78, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI32565321, Length=395, Percent_Identity=23.2911392405063, Blast_Score=72, Evalue=9e-13,
Organism=Saccharomyces cerevisiae, GI6323844, Length=355, Percent_Identity=36.056338028169, Blast_Score=213, Evalue=5e-56,
Organism=Saccharomyces cerevisiae, GI6321360, Length=348, Percent_Identity=22.7011494252874, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24646066, Length=338, Percent_Identity=35.7988165680473, Blast_Score=215, Evalue=7e-56,
Organism=Drosophila melanogaster, GI24664226, Length=353, Percent_Identity=33.9943342776204, Blast_Score=200, Evalue=2e-51,
Organism=Drosophila melanogaster, GI62472181, Length=353, Percent_Identity=33.9943342776204, Blast_Score=197, Evalue=2e-50,
Organism=Drosophila melanogaster, GI24664230, Length=353, Percent_Identity=33.9943342776204, Blast_Score=197, Evalue=2e-50,
Organism=Drosophila melanogaster, GI21358123, Length=360, Percent_Identity=31.6666666666667, Blast_Score=162, Evalue=6e-40,
Organism=Drosophila melanogaster, GI24584994, Length=395, Percent_Identity=23.2911392405063, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI21355075, Length=347, Percent_Identity=21.9020172910663, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI17985987, Length=367, Percent_Identity=23.1607629427793, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI28575014, Length=346, Percent_Identity=22.8323699421965, Blast_Score=69, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR011545
- InterPro:   IPR004589
- InterPro:   IPR001650
- InterPro:   IPR014021 [H]

Pfam domain/function: PF00270 DEAD; PF00271 Helicase_C [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 54846; Mature: 54846

Theoretical pI: Translated: 9.98; Mature: 9.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPHKIKAWEEVRTTFKEIWGYEDFRPPQGEIVGSLLSRKDALIIMPTGGGKSICFQLPA
CCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHH
LLQTGLTLVVSPLVALMENQVQELLQRQQKAALLHSELSTFQRRITLQALEKQQLRLLYL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEE
SPETLLSPPVWERLCQPQLQINGLILDEAHCLVQWGETFRPAYRRLGAVRPALLKHKPPG
CCHHHCCCHHHHHHCCCCCEECCEEEECHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCC
TKISIAAFTATADPSAQQTIQTVLQLQQPDIFRLNPYRPNLHPTVRIAWTPKGRKQHLIK
CEEEEEEEEECCCCCHHHHHHHHHHHCCCCCEEECCCCCCCCCEEEEEECCCCHHHHHHH
FIQNRPQQAGLIYVRTRRDSEDLAVWLSQMGYATASYHAGLGATERREVEAKWLGGKIPF
HHHCCCCCCCEEEEEECCCHHHHHHHHHHHCCHHHHHHCCCCCCHHHHHHHHHCCCCCHH
VVCTCAFGMGINKPDVRWVVHFHSPHLLSEYVQEIGRGGRDGKPAEALTLVSEPTGWLDA
HHHHHHHHCCCCCCCCEEEEEECCCHHHHHHHHHHHCCCCCCCCHHHEEEEECCCCCCCC
EDKQRQEFFQEKMRSQQQKAQQLIKKLPQQGEINSVTKQFPDSAVALALLHSSGQLNWLD
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCHHHHHHHHHCCCCEECCC
PFNYKIEHKAKSQPSKQLQATKQMTQYLNTKQCRWQFLLNAFGFDKEANNWRCGHCDNCR
CCCCEECCCCCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
N
C
>Mature Secondary Structure
MNPHKIKAWEEVRTTFKEIWGYEDFRPPQGEIVGSLLSRKDALIIMPTGGGKSICFQLPA
CCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHH
LLQTGLTLVVSPLVALMENQVQELLQRQQKAALLHSELSTFQRRITLQALEKQQLRLLYL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEE
SPETLLSPPVWERLCQPQLQINGLILDEAHCLVQWGETFRPAYRRLGAVRPALLKHKPPG
CCHHHCCCHHHHHHCCCCCEECCEEEECHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCC
TKISIAAFTATADPSAQQTIQTVLQLQQPDIFRLNPYRPNLHPTVRIAWTPKGRKQHLIK
CEEEEEEEEECCCCCHHHHHHHHHHHCCCCCEEECCCCCCCCCEEEEEECCCCHHHHHHH
FIQNRPQQAGLIYVRTRRDSEDLAVWLSQMGYATASYHAGLGATERREVEAKWLGGKIPF
HHHCCCCCCCEEEEEECCCHHHHHHHHHHHCCHHHHHHCCCCCCHHHHHHHHHCCCCCHH
VVCTCAFGMGINKPDVRWVVHFHSPHLLSEYVQEIGRGGRDGKPAEALTLVSEPTGWLDA
HHHHHHHHCCCCCCCCEEEEEECCCHHHHHHHHHHHCCCCCCCCHHHEEEEECCCCCCCC
EDKQRQEFFQEKMRSQQQKAQQLIKKLPQQGEINSVTKQFPDSAVALALLHSSGQLNWLD
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCHHHHHHHHHCCCCEECCC
PFNYKIEHKAKSQPSKQLQATKQMTQYLNTKQCRWQFLLNAFGFDKEANNWRCGHCDNCR
CCCCEECCCCCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
N
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]