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The map label for this gene is 75908268

Identifier: 75908268

GI number: 75908268

Start: 2533158

End: 2535455

Strand: Direct

Name: 75908268

Synonym: Ava_2047

Alternate gene names: NA

Gene position: 2533158-2535455 (Clockwise)

Preceding gene: 75908265

Following gene: 75908271

Centisome position: 39.79

GC content: 42.3

Gene sequence:

>2298_bases
ATGCTTTTTAAAGTAAATGGACGAATTTACGAAGAAGAAAGCGGAGTAGGTATTGCTAATTTAGTTGTCGAAGCCTTTGA
TAAAGATATCCTCAAAAATGATAAACTTGGTCAAACAAAAACTGATCAAGATGGCAAGTTTGCGATTAATTATTCAGAAG
CAAATTTCAAAAGCGCATTAGAAAAGTTTGAAGGTAATCCCGATTTATATATCGTTGTTAAAACTCCAGACCTTGCCAAT
ATTTTGTATAGTAGTGAGAAGAATATCCGCCCTGATGCTAGTACAAACGAGCATTTCGACGTACCTATTCCGAAAACAAC
TTTAATAGCTTATCAAGAACGATCAACTCAAGAAAATAAACAACTATTAAAAATTCTGCTGGGGATGGCTTGGCTAGATG
GGGAACTCGAACCTGGAGAAAAAGAATATTTATCCAAAGTCGCAGCCCAAAAAAGATTAACTGAAGATGCAGAGATTAAA
AGTTTATTATCTGATAGTAAGCCAATACAGCCCCAGCAGTGTTTTGATTGGTTACAAGCTTATTTAGGCAAAAATCCTAG
CCCTTACAAATTTGAGGCTTTAGATGAAGTTTTAGAAAGCTTATTCACCAGTGGCGCAGAAATAGACGAACGAGAAAAAG
AAATGTTAGCGGCTTTTGCTGACAAAAATACTCGTCAAACGGTTCTCCAGGAAAGACTAGGCAGCATTTTCCTCGATCCA
GATTTCTTAGCTAAAGTCACTCCTGACACCCCAGATTCCCCTCAAACTGCCCGTAAAAACCTCAAAAAAGGCTTTGCTTA
TGCTCGTGTTCCCCAAGCAGTTTTAAGTAAACTCACATCTGCACAGTCTGATCCGCAAGTCAAGGAAGAATTAGCCCATC
GCTTTTTAACTCTCAACTATGCTCCAGTCCGCAAAGAAATTACGGCTGATAACCTAGAAGTGATCGGCAAACTACCACAA
GAGTTGTCAGGGACGTTTCTCCGGATTGGGCCGAACCCCCGCTTCGCTCCTTTGGGTCTTTATCATTGGTTTGATGGAGA
CGGTATGATTCACGGGGTACAAATTAAAAATGGTAAGGCCAGCTATCGTAATCGTTACGTTCGTACTGAAGGATGGAAGA
TTGAAGAAAAAGAAGGTCAAGCTATCTGGCCAGGATTGCTGAATCTACCCCGCTTCGATGAACCCCACGGCATTATGATG
AAAAATGTAGCCAATACCGCTTTAGTTTGGCATCACGGACGGTTACTCGCTCTTTGGGAAGGAGGCGAACCTTATGAAAT
TAGCCTTCCCAATTTAGACACTGTCGGTTCTTATACCTTTAATGAGCAGTTAACCTTCCCCTTTTGCGCCCACCCCAAAG
TCGATGCTAGAACCGGGGAAATGATGTTCTTTGGTTATCAACCCCTAACCAAGCCCTACGTTCAATATGGTATCGTCTCA
CCAGAAGGAAAAATTGTCAAAACCATACCAATTGACATTCCTTCTCCAATTAGTATGCACGACTTTGCTATTACGGAAAA
ATATACTATTTTCCTCGATATGCCTCTAGCCCTCAAACCGATGCGAGTTATGCAGGGCAAAGTTCCCCTCGTGTTTGAAC
GTAATAAACCGAGTCGTTTTGGTATTATTCCTCGGCATGGGGGAGAAATACGCTGGTTTACCGTGCCGAGCTGTATGGTC
TACCATGTAGTCAACGCCTATGAAGAAGGTAACGAGGTAATTTTAGTTGCCTATCGCATGGATTGGACACAACTATTTAT
CCCTGACAGAGAAAACGCCCTCGATTTTGTCAACACCGACACCTCGTCAGAAAAACTTGCCCCAGAAATGACGAAATTGT
ATCGTTGGCGGTTTAATCTTTCTACTGGTCAAGTCAAGGAGGAAATACTTGACAAAGACGAAATTTGTGAGTTCCCCCGC
ATCAACGATCGCTTAATTGGATGCAAGATGCGTTATGTGTACTCCGGAATCGGGGCTATGTATATGGAACGCCCGCTATT
TGATGGAGTCAAGAAGTATGACTTAGAATCCGGAACAGCGCAATCTGTTTATTTTGGTCGTGGACGCTTTGGTGGTGAAT
GTGTCTTTGCACCTCGTCCTGGTGGCAAAACTGAAGATGATGGATGGGTATTGACTTATATTTATGATGCCGTTAACAAG
CGATCGGAATTTATTGTGTTAGATGCCCAGAATATCACTGCTGAACCTGTCGCCCGTGTTATTCTTCCTCAAAGAGTTCC
CTTTGGCTTCCATTGTGAGTGGGTTTCTAGCGAGAAAATGGCAACCGCGAACAGATAG

Upstream 100 bases:

>100_bases
GTCGTTGTTTTTTGCGATCGGCAATAAGATAATGTGACTGCTCTCAAGATGGACTACCTTTACATAAACCGACTTAATTT
AAGAAGATAGGGGAATTGTT

Downstream 100 bases:

>100_bases
TTAAGGGTATTTATCTGAGGTTAGGGACTTCCAGATAAAAAAGGGCATTGCCCACCATATCCGGGTTTTGGTGGGCAATG
CCCACCCTACATATACTTAC

Product: retinal pigment epithelial membrane protein

Products: NA

Alternate protein names: ACO; 8'-apo-beta-carotenal 15,15'-oxygenase; Diox1 [H]

Number of amino acids: Translated: 765; Mature: 765

Protein sequence:

>765_residues
MLFKVNGRIYEEESGVGIANLVVEAFDKDILKNDKLGQTKTDQDGKFAINYSEANFKSALEKFEGNPDLYIVVKTPDLAN
ILYSSEKNIRPDASTNEHFDVPIPKTTLIAYQERSTQENKQLLKILLGMAWLDGELEPGEKEYLSKVAAQKRLTEDAEIK
SLLSDSKPIQPQQCFDWLQAYLGKNPSPYKFEALDEVLESLFTSGAEIDEREKEMLAAFADKNTRQTVLQERLGSIFLDP
DFLAKVTPDTPDSPQTARKNLKKGFAYARVPQAVLSKLTSAQSDPQVKEELAHRFLTLNYAPVRKEITADNLEVIGKLPQ
ELSGTFLRIGPNPRFAPLGLYHWFDGDGMIHGVQIKNGKASYRNRYVRTEGWKIEEKEGQAIWPGLLNLPRFDEPHGIMM
KNVANTALVWHHGRLLALWEGGEPYEISLPNLDTVGSYTFNEQLTFPFCAHPKVDARTGEMMFFGYQPLTKPYVQYGIVS
PEGKIVKTIPIDIPSPISMHDFAITEKYTIFLDMPLALKPMRVMQGKVPLVFERNKPSRFGIIPRHGGEIRWFTVPSCMV
YHVVNAYEEGNEVILVAYRMDWTQLFIPDRENALDFVNTDTSSEKLAPEMTKLYRWRFNLSTGQVKEEILDKDEICEFPR
INDRLIGCKMRYVYSGIGAMYMERPLFDGVKKYDLESGTAQSVYFGRGRFGGECVFAPRPGGKTEDDGWVLTYIYDAVNK
RSEFIVLDAQNITAEPVARVILPQRVPFGFHCEWVSSEKMATANR

Sequences:

>Translated_765_residues
MLFKVNGRIYEEESGVGIANLVVEAFDKDILKNDKLGQTKTDQDGKFAINYSEANFKSALEKFEGNPDLYIVVKTPDLAN
ILYSSEKNIRPDASTNEHFDVPIPKTTLIAYQERSTQENKQLLKILLGMAWLDGELEPGEKEYLSKVAAQKRLTEDAEIK
SLLSDSKPIQPQQCFDWLQAYLGKNPSPYKFEALDEVLESLFTSGAEIDEREKEMLAAFADKNTRQTVLQERLGSIFLDP
DFLAKVTPDTPDSPQTARKNLKKGFAYARVPQAVLSKLTSAQSDPQVKEELAHRFLTLNYAPVRKEITADNLEVIGKLPQ
ELSGTFLRIGPNPRFAPLGLYHWFDGDGMIHGVQIKNGKASYRNRYVRTEGWKIEEKEGQAIWPGLLNLPRFDEPHGIMM
KNVANTALVWHHGRLLALWEGGEPYEISLPNLDTVGSYTFNEQLTFPFCAHPKVDARTGEMMFFGYQPLTKPYVQYGIVS
PEGKIVKTIPIDIPSPISMHDFAITEKYTIFLDMPLALKPMRVMQGKVPLVFERNKPSRFGIIPRHGGEIRWFTVPSCMV
YHVVNAYEEGNEVILVAYRMDWTQLFIPDRENALDFVNTDTSSEKLAPEMTKLYRWRFNLSTGQVKEEILDKDEICEFPR
INDRLIGCKMRYVYSGIGAMYMERPLFDGVKKYDLESGTAQSVYFGRGRFGGECVFAPRPGGKTEDDGWVLTYIYDAVNK
RSEFIVLDAQNITAEPVARVILPQRVPFGFHCEWVSSEKMATANR
>Mature_765_residues
MLFKVNGRIYEEESGVGIANLVVEAFDKDILKNDKLGQTKTDQDGKFAINYSEANFKSALEKFEGNPDLYIVVKTPDLAN
ILYSSEKNIRPDASTNEHFDVPIPKTTLIAYQERSTQENKQLLKILLGMAWLDGELEPGEKEYLSKVAAQKRLTEDAEIK
SLLSDSKPIQPQQCFDWLQAYLGKNPSPYKFEALDEVLESLFTSGAEIDEREKEMLAAFADKNTRQTVLQERLGSIFLDP
DFLAKVTPDTPDSPQTARKNLKKGFAYARVPQAVLSKLTSAQSDPQVKEELAHRFLTLNYAPVRKEITADNLEVIGKLPQ
ELSGTFLRIGPNPRFAPLGLYHWFDGDGMIHGVQIKNGKASYRNRYVRTEGWKIEEKEGQAIWPGLLNLPRFDEPHGIMM
KNVANTALVWHHGRLLALWEGGEPYEISLPNLDTVGSYTFNEQLTFPFCAHPKVDARTGEMMFFGYQPLTKPYVQYGIVS
PEGKIVKTIPIDIPSPISMHDFAITEKYTIFLDMPLALKPMRVMQGKVPLVFERNKPSRFGIIPRHGGEIRWFTVPSCMV
YHVVNAYEEGNEVILVAYRMDWTQLFIPDRENALDFVNTDTSSEKLAPEMTKLYRWRFNLSTGQVKEEILDKDEICEFPR
INDRLIGCKMRYVYSGIGAMYMERPLFDGVKKYDLESGTAQSVYFGRGRFGGECVFAPRPGGKTEDDGWVLTYIYDAVNK
RSEFIVLDAQNITAEPVARVILPQRVPFGFHCEWVSSEKMATANR

Specific function: Cleaves a number of carotenals and carotenols in the all-trans configuration at the 15-15' double bond producing retinal or retinol, respectively. Also shows activity toward lycopenals and the corresponding alcohols. Does not cleave beta- carotene or lyco

COG id: COG3670

COG function: function code Q; Lignostilbene-alpha,beta-dioxygenase and related enzymes

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the carotenoid oxygenase family [H]

Homologues:

Organism=Homo sapiens, GI74027270, Length=507, Percent_Identity=25.6410256410256, Blast_Score=104, Evalue=4e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004294 [H]

Pfam domain/function: PF03055 RPE65 [H]

EC number: =1.14.99.41 [H]

Molecular weight: Translated: 86944; Mature: 86944

Theoretical pI: Translated: 5.65; Mature: 5.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLFKVNGRIYEEESGVGIANLVVEAFDKDILKNDKLGQTKTDQDGKFAINYSEANFKSAL
CEEEECCEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCHHHHHHH
EKFEGNPDLYIVVKTPDLANILYSSEKNIRPDASTNEHFDVPIPKTTLIAYQERSTQENK
HHHCCCCCEEEEEECCCHHHHHHCCCCCCCCCCCCCCEEECCCCCEEEEEEECCCCHHHH
QLLKILLGMAWLDGELEPGEKEYLSKVAAQKRLTEDAEIKSLLSDSKPIQPQQCFDWLQA
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCHHHHHHHHHH
YLGKNPSPYKFEALDEVLESLFTSGAEIDEREKEMLAAFADKNTRQTVLQERLGSIFLDP
HHCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHCCEEECC
DFLAKVTPDTPDSPQTARKNLKKGFAYARVPQAVLSKLTSAQSDPQVKEELAHRFLTLNY
HHHEEECCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHEEEECC
APVRKEITADNLEVIGKLPQELSGTFLRIGPNPRFAPLGLYHWFDGDGMIHGVQIKNGKA
CCCHHHCCCCCHHHHHCCCHHHCCCEEEECCCCCEEEEEEEEEECCCCEEEEEEEECCCH
SYRNRYVRTEGWKIEEKEGQAIWPGLLNLPRFDEPHGIMMKNVANTALVWHHGRLLALWE
HHHCCEEECCCCEEECCCCCEECCHHCCCCCCCCCCCCEEHHCCCEEEEEECCEEEEEEC
GGEPYEISLPNLDTVGSYTFNEQLTFPFCAHPKVDARTGEMMFFGYQPLTKPYVQYGIVS
CCCCEEEECCCCCCCCCEEECCCCCCCEECCCCCCCCCCCEEEECCCCCCCHHHHEEEEC
PEGKIVKTIPIDIPSPISMHDFAITEKYTIFLDMPLALKPMRVMQGKVPLVFERNKPSRF
CCCCEEEEEECCCCCCCCCCEEEEEEEEEEEEECCCCCCCHHHHCCCCCEEEECCCCCEE
GIIPRHGGEIRWFTVPSCMVYHVVNAYEEGNEVILVAYRMDWTQLFIPDRENALDFVNTD
EEECCCCCEEEEEECCHHHHHHHHHHHCCCCCEEEEEEECCCEEEECCCCCCCCEEECCC
TSSEKLAPEMTKLYRWRFNLSTGQVKEEILDKDEICEFPRINDRLIGCKMRYVYSGIGAM
CCCHHHHHHHHHHEEEEECCCHHHHHHHHCCHHHHCCCCCCCCEEEEEEHHHHHHHHHHH
YMERPLFDGVKKYDLESGTAQSVYFGRGRFGGECVFAPRPGGKTEDDGWVLTYIYDAVNK
HHHCHHHHCHHHHCCCCCCCCEEEEECCCCCCEEEECCCCCCCCCCCCEEEEEEEHHHCC
RSEFIVLDAQNITAEPVARVILPQRVPFGFHCEWVSSEKMATANR
CCCEEEEECCCCCHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCC
>Mature Secondary Structure
MLFKVNGRIYEEESGVGIANLVVEAFDKDILKNDKLGQTKTDQDGKFAINYSEANFKSAL
CEEEECCEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCHHHHHHH
EKFEGNPDLYIVVKTPDLANILYSSEKNIRPDASTNEHFDVPIPKTTLIAYQERSTQENK
HHHCCCCCEEEEEECCCHHHHHHCCCCCCCCCCCCCCEEECCCCCEEEEEEECCCCHHHH
QLLKILLGMAWLDGELEPGEKEYLSKVAAQKRLTEDAEIKSLLSDSKPIQPQQCFDWLQA
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCHHHHHHHHHH
YLGKNPSPYKFEALDEVLESLFTSGAEIDEREKEMLAAFADKNTRQTVLQERLGSIFLDP
HHCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHCCEEECC
DFLAKVTPDTPDSPQTARKNLKKGFAYARVPQAVLSKLTSAQSDPQVKEELAHRFLTLNY
HHHEEECCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHEEEECC
APVRKEITADNLEVIGKLPQELSGTFLRIGPNPRFAPLGLYHWFDGDGMIHGVQIKNGKA
CCCHHHCCCCCHHHHHCCCHHHCCCEEEECCCCCEEEEEEEEEECCCCEEEEEEEECCCH
SYRNRYVRTEGWKIEEKEGQAIWPGLLNLPRFDEPHGIMMKNVANTALVWHHGRLLALWE
HHHCCEEECCCCEEECCCCCEECCHHCCCCCCCCCCCCEEHHCCCEEEEEECCEEEEEEC
GGEPYEISLPNLDTVGSYTFNEQLTFPFCAHPKVDARTGEMMFFGYQPLTKPYVQYGIVS
CCCCEEEECCCCCCCCCEEECCCCCCCEECCCCCCCCCCCEEEECCCCCCCHHHHEEEEC
PEGKIVKTIPIDIPSPISMHDFAITEKYTIFLDMPLALKPMRVMQGKVPLVFERNKPSRF
CCCCEEEEEECCCCCCCCCCEEEEEEEEEEEEECCCCCCCHHHHCCCCCEEEECCCCCEE
GIIPRHGGEIRWFTVPSCMVYHVVNAYEEGNEVILVAYRMDWTQLFIPDRENALDFVNTD
EEECCCCCEEEEEECCHHHHHHHHHHHCCCCCEEEEEEECCCEEEECCCCCCCCEEECCC
TSSEKLAPEMTKLYRWRFNLSTGQVKEEILDKDEICEFPRINDRLIGCKMRYVYSGIGAM
CCCHHHHHHHHHHEEEEECCCHHHHHHHHCCHHHHCCCCCCCCEEEEEEHHHHHHHHHHH
YMERPLFDGVKKYDLESGTAQSVYFGRGRFGGECVFAPRPGGKTEDDGWVLTYIYDAVNK
HHHCHHHHCHHHHCCCCCCCCEEEEECCCCCCEEEECCCCCCCCCCCCEEEEEEEHHHCC
RSEFIVLDAQNITAEPVARVILPQRVPFGFHCEWVSSEKMATANR
CCCEEEEECCCCCHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]