Click here to switch to the map view.

The map label for this gene is nadA

Identifier: 75908212

GI number: 75908212

Start: 2472129

End: 2473103

Strand: Direct

Name: nadA

Synonym: Ava_1991

Alternate gene names: 75908212

Gene position: 2472129-2473103 (Clockwise)

Preceding gene: 75908210

Following gene: 75908214

Centisome position: 38.83

GC content: 43.38

Gene sequence:

>975_bases
GTGTTTACCACTGCCTTTGCTCAACGGGAACAAACTCAACCAGGTGGACTACCACTAGATTTATTTGCTGCTATTGATAG
TCTGAAAAAAGAACTCAATGCGGTGATTTTGGCACATTATTATCAAGAGCCGGATATTCAAGATATTGCAGACTTTATAG
GCGATTCATTACAATTAGCTAGAGCCGCAGCCAAGACCAATGCAGATGTGATTGTCTTTGCTGGCGTTCATTTTATGGCA
GAGACAGCCAAGATTCTCAATCCTGAGAAATTGGTACTGTTACCAGATTTAAATGCGGGTTGTTCTCTAGCAGATAGTTG
TCCACCAAAAGAATTTGCCGCTTTTAAAGCAGCACATCCCGATCATTTAGTAGTTTCCTATATTAACTGCTCTGCTGAAA
TTAAAGCTATGAGCGATATTATCTGCACGAGTTCCAACGCCGTGAAGATTGTGCAGCAAATCCCTAAAGAACAGCCGATT
ATTTTTGCTCCTGACAGAAATTTGGGGCGTTATGTGATGGAACAGACGGGACGGGATTTAGTACTGTGGCAGGGTAGCTG
TTTGGTACATGAAACCTTCTCTGAGAAGAAGATTGTACAGTTAAAAGTTGCTCATCCCCAAGCCGAGGCGATCGCTCACC
CAGAATGTGAAAGCAGTGTCTTGCGTCACGCTAGTTTTATCGGCTCTACAGCAGCTTTACTCCAATACTGCCAAACAAGC
CCCAGCCAAGAATTTATTGTGGCGACTGAGCCAGGAATTATCCACCAAATGCAGAAACTAGCACCTAACAAGCATTTTAT
TCCTGCGCCGCCCATAAATAATTGTGCTTGCAATGAGTGTCCATTCATGCGGTTAAACACCCTAGAAAAACTCTACTGGG
CGATGAAAAATCGGACTCCGGAAATCACCATGTCAGAGGATATCCGTATTGCGGCTTTGCGACCAATGCAAAGAATGTTA
GAGATGAGTAATTAG

Upstream 100 bases:

>100_bases
TTGGACACTATTTCGGGGTATTAACCCGCCATCTATTTTTGGTAAAAACTACTATAATTAAATAACCAGACAAAATTTGT
AATAAAAAGTAACCCTAACT

Downstream 100 bases:

>100_bases
TCAATTAATTCTTATATTTTTTACAAATTAAATGGGGAAACGTGATTTCCCCATTTTCCATATCATCTCTGTTTTCCAAA
TCCTCAAATCTAAACATTCT

Product: quinolinate synthetase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 324; Mature: 324

Protein sequence:

>324_residues
MFTTAFAQREQTQPGGLPLDLFAAIDSLKKELNAVILAHYYQEPDIQDIADFIGDSLQLARAAAKTNADVIVFAGVHFMA
ETAKILNPEKLVLLPDLNAGCSLADSCPPKEFAAFKAAHPDHLVVSYINCSAEIKAMSDIICTSSNAVKIVQQIPKEQPI
IFAPDRNLGRYVMEQTGRDLVLWQGSCLVHETFSEKKIVQLKVAHPQAEAIAHPECESSVLRHASFIGSTAALLQYCQTS
PSQEFIVATEPGIIHQMQKLAPNKHFIPAPPINNCACNECPFMRLNTLEKLYWAMKNRTPEITMSEDIRIAALRPMQRML
EMSN

Sequences:

>Translated_324_residues
MFTTAFAQREQTQPGGLPLDLFAAIDSLKKELNAVILAHYYQEPDIQDIADFIGDSLQLARAAAKTNADVIVFAGVHFMA
ETAKILNPEKLVLLPDLNAGCSLADSCPPKEFAAFKAAHPDHLVVSYINCSAEIKAMSDIICTSSNAVKIVQQIPKEQPI
IFAPDRNLGRYVMEQTGRDLVLWQGSCLVHETFSEKKIVQLKVAHPQAEAIAHPECESSVLRHASFIGSTAALLQYCQTS
PSQEFIVATEPGIIHQMQKLAPNKHFIPAPPINNCACNECPFMRLNTLEKLYWAMKNRTPEITMSEDIRIAALRPMQRML
EMSN
>Mature_324_residues
MFTTAFAQREQTQPGGLPLDLFAAIDSLKKELNAVILAHYYQEPDIQDIADFIGDSLQLARAAAKTNADVIVFAGVHFMA
ETAKILNPEKLVLLPDLNAGCSLADSCPPKEFAAFKAAHPDHLVVSYINCSAEIKAMSDIICTSSNAVKIVQQIPKEQPI
IFAPDRNLGRYVMEQTGRDLVLWQGSCLVHETFSEKKIVQLKVAHPQAEAIAHPECESSVLRHASFIGSTAALLQYCQTS
PSQEFIVATEPGIIHQMQKLAPNKHFIPAPPINNCACNECPFMRLNTLEKLYWAMKNRTPEITMSEDIRIAALRPMQRML
EMSN

Specific function: Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate

COG id: COG0379

COG function: function code H; Quinolinate synthase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the quinolinate synthase A family. Type 2 subfamily

Homologues:

Organism=Escherichia coli, GI1786964, Length=310, Percent_Identity=42.9032258064516, Blast_Score=254, Evalue=5e-69,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NADA_ANAVT (Q3MBM3)

Other databases:

- EMBL:   CP000117
- RefSeq:   YP_322508.1
- ProteinModelPortal:   Q3MBM3
- SMR:   Q3MBM3
- STRING:   Q3MBM3
- GeneID:   3681418
- GenomeReviews:   CP000117_GR
- KEGG:   ava:Ava_1991
- NMPDR:   fig|240292.3.peg.3071
- eggNOG:   COG0379
- HOGENOM:   HBG291157
- OMA:   IAHPECE
- PhylomeDB:   Q3MBM3
- ProtClustDB:   PRK09375
- BioCyc:   AVAR240292:AVA_1991-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00568
- InterPro:   IPR003473
- InterPro:   IPR023066
- TIGRFAMs:   TIGR00550

Pfam domain/function: PF02445 NadA

EC number: =2.5.1.72

Molecular weight: Translated: 35887; Mature: 35887

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: NA

Important sites: BINDING 39-39 BINDING 56-56 BINDING 127-127 BINDING 144-144 BINDING 213-213 BINDING 230-230

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.1 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
6.5 %Cys+Met (Translated Protein)
3.1 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
6.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFTTAFAQREQTQPGGLPLDLFAAIDSLKKELNAVILAHYYQEPDIQDIADFIGDSLQLA
CCCCHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHEEEEHHCCCCCHHHHHHHHCCHHHHH
RAAAKTNADVIVFAGVHFMAETAKILNPEKLVLLPDLNAGCSLADSCPPKEFAAFKAAHP
HHHHHCCCCEEEEECHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHCCCC
DHLVVSYINCSAEIKAMSDIICTSSNAVKIVQQIPKEQPIIFAPDRNLGRYVMEQTGRDL
CCEEEEEECCCHHHHHHHHHHCCCCCHHHHHHHCCCCCCEEECCCCCHHHHHHHHCCCEE
VLWQGSCLVHETFSEKKIVQLKVAHPQAEAIAHPECESSVLRHASFIGSTAALLQYCQTS
EEEECCEEEEECCCCCEEEEEEECCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCC
PSQEFIVATEPGIIHQMQKLAPNKHFIPAPPINNCACNECPFMRLNTLEKLYWAMKNRTP
CCCCEEEEECCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCC
EITMSEDIRIAALRPMQRMLEMSN
CEEECCCEEEEHHHHHHHHHHCCC
>Mature Secondary Structure
MFTTAFAQREQTQPGGLPLDLFAAIDSLKKELNAVILAHYYQEPDIQDIADFIGDSLQLA
CCCCHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHEEEEHHCCCCCHHHHHHHHCCHHHHH
RAAAKTNADVIVFAGVHFMAETAKILNPEKLVLLPDLNAGCSLADSCPPKEFAAFKAAHP
HHHHHCCCCEEEEECHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHCCCC
DHLVVSYINCSAEIKAMSDIICTSSNAVKIVQQIPKEQPIIFAPDRNLGRYVMEQTGRDL
CCEEEEEECCCHHHHHHHHHHCCCCCHHHHHHHCCCCCCEEECCCCCHHHHHHHHCCCEE
VLWQGSCLVHETFSEKKIVQLKVAHPQAEAIAHPECESSVLRHASFIGSTAALLQYCQTS
EEEECCEEEEECCCCCEEEEEEECCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCC
PSQEFIVATEPGIIHQMQKLAPNKHFIPAPPINNCACNECPFMRLNTLEKLYWAMKNRTP
CCCCEEEEECCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCC
EITMSEDIRIAALRPMQRMLEMSN
CEEECCCEEEEHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA