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The map label for this gene is yciC [H]

Identifier: 75908169

GI number: 75908169

Start: 2422350

End: 2423399

Strand: Direct

Name: yciC [H]

Synonym: Ava_1948

Alternate gene names: 75908169

Gene position: 2422350-2423399 (Clockwise)

Preceding gene: 75908168

Following gene: 75908170

Centisome position: 38.05

GC content: 36.76

Gene sequence:

>1050_bases
ATGAATACACTAACCGCAGAAACAACCAGCATAATTCCTGAAATTCCCAAACGAGGAATGCCAGTTACAATCATTACTGG
CTTTTTAGGTAGTGGTAAAACAACTCTACTCAATCAAATTCTTAAAAATAAGCATGACTTAAAAGTAGCTGTTCTTGTCA
ATGAGTTCGGCGATATTAATATTGATAGCCAGTTATTAGTGTCTGTAGACCAAGATATGCTCGAACTAAGCAATGGTTGT
ATATGCTGCACTATCAATGATGGTCTAGTTGATGCTGTTTATCGGGTTTTGGAACGAGAAGAACGTATTGATTATTTAGT
TATTGAAACTACTGGCGTTGCTGACCCATTACCCATTATTTTAACATTTTTAGGTACAGAGCTTAGGGATTTGACAAACC
TTGATTCAATTTTGACGGTTGTAGATGCGGAAGCTTTTGAACCAACTCATTTCGAGAGCGAAGTTGCTTTAAAACAACTT
ACTTATGCAGATATTATCCTCCTGAACAAAACAGACTTGGCTACTGCGGAAAAAATTCAAGCATTAGAAGACTATATCCA
AACTGTCAAAGATAGTGCAAGAATCCTACATACCAAATATGGTGAGGTAGCTTTACCCTTAATTTTAGGTGTTGGCTTAA
CCTCAAAAGATGACTATACAACTGATGATGCAGAAGCTCCTCATGAACATAATCATGAGCATCATAGCCAAGACCATGAC
CATCATGAGCATCACCATCTTCATGAACACCACTCCCATCATTTAGATAATGATGGATTTGTTGCGGTATCTTTTCAGTC
TGATAGACCGTTTGATATTCATAAATTTGAGAATTTTCTCACAGAACAAATGCCCCAGAATGTGTTCCGAGCTAAGGGTA
TTTTGTGGTTTAGTGATAGTGAGTTACGCCATATATTTCAACTGAGTGGGCCTCGTTATAACTTACACGCCGATGAATGG
CATACTTTACCAAAGAACCAATTAGTTTTTATTGGTAGAAAATTGGAGACTCAGCAAATTTATACACAACTTAACAATTG
TTTGATATGA

Upstream 100 bases:

>100_bases
AAAACTCTCAAGTCTATTTGCTGAAATTGAATATACGTACATAGCCACAATTATTCAACAGCATCATTGATTTCATAGTT
CACAAACATCTCATCATCCT

Downstream 100 bases:

>100_bases
TTAAGAAGTGTTAAGTAATCAAACGACTCGGTTAATAGATTTTTGTCAATCTCTAACTATTAACTAACTCACAATCTCTA
CCAATTAAACGAAATAATAT

Product: cobalamin synthesis protein/P47K

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 349; Mature: 349

Protein sequence:

>349_residues
MNTLTAETTSIIPEIPKRGMPVTIITGFLGSGKTTLLNQILKNKHDLKVAVLVNEFGDINIDSQLLVSVDQDMLELSNGC
ICCTINDGLVDAVYRVLEREERIDYLVIETTGVADPLPIILTFLGTELRDLTNLDSILTVVDAEAFEPTHFESEVALKQL
TYADIILLNKTDLATAEKIQALEDYIQTVKDSARILHTKYGEVALPLILGVGLTSKDDYTTDDAEAPHEHNHEHHSQDHD
HHEHHHLHEHHSHHLDNDGFVAVSFQSDRPFDIHKFENFLTEQMPQNVFRAKGILWFSDSELRHIFQLSGPRYNLHADEW
HTLPKNQLVFIGRKLETQQIYTQLNNCLI

Sequences:

>Translated_349_residues
MNTLTAETTSIIPEIPKRGMPVTIITGFLGSGKTTLLNQILKNKHDLKVAVLVNEFGDINIDSQLLVSVDQDMLELSNGC
ICCTINDGLVDAVYRVLEREERIDYLVIETTGVADPLPIILTFLGTELRDLTNLDSILTVVDAEAFEPTHFESEVALKQL
TYADIILLNKTDLATAEKIQALEDYIQTVKDSARILHTKYGEVALPLILGVGLTSKDDYTTDDAEAPHEHNHEHHSQDHD
HHEHHHLHEHHSHHLDNDGFVAVSFQSDRPFDIHKFENFLTEQMPQNVFRAKGILWFSDSELRHIFQLSGPRYNLHADEW
HTLPKNQLVFIGRKLETQQIYTQLNNCLI
>Mature_349_residues
MNTLTAETTSIIPEIPKRGMPVTIITGFLGSGKTTLLNQILKNKHDLKVAVLVNEFGDINIDSQLLVSVDQDMLELSNGC
ICCTINDGLVDAVYRVLEREERIDYLVIETTGVADPLPIILTFLGTELRDLTNLDSILTVVDAEAFEPTHFESEVALKQL
TYADIILLNKTDLATAEKIQALEDYIQTVKDSARILHTKYGEVALPLILGVGLTSKDDYTTDDAEAPHEHNHEHHSQDHD
HHEHHHLHEHHSHHLDNDGFVAVSFQSDRPFDIHKFENFLTEQMPQNVFRAKGILWFSDSELRHIFQLSGPRYNLHADEW
HTLPKNQLVFIGRKLETQQIYTQLNNCLI

Specific function: May bind GTP. Might act as metal chaperone (Potential). Contributes to optimal growth under starvation for zinc [H]

COG id: COG0523

COG function: function code R; Putative GTPases (G3E family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 cobW C-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI126722884, Length=353, Percent_Identity=31.728045325779, Blast_Score=138, Evalue=6e-33,
Organism=Homo sapiens, GI33469141, Length=353, Percent_Identity=31.728045325779, Blast_Score=138, Evalue=8e-33,
Organism=Homo sapiens, GI223941779, Length=193, Percent_Identity=39.3782383419689, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI148727351, Length=353, Percent_Identity=31.728045325779, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI146231952, Length=355, Percent_Identity=31.2676056338028, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI223941776, Length=355, Percent_Identity=30.1408450704225, Blast_Score=121, Evalue=8e-28,
Organism=Homo sapiens, GI119120938, Length=131, Percent_Identity=41.9847328244275, Blast_Score=104, Evalue=1e-22,
Organism=Escherichia coli, GI87082430, Length=334, Percent_Identity=32.6347305389222, Blast_Score=128, Evalue=6e-31,
Organism=Escherichia coli, GI1788499, Length=182, Percent_Identity=35.1648351648352, Blast_Score=101, Evalue=8e-23,
Organism=Saccharomyces cerevisiae, GI6324356, Length=221, Percent_Identity=33.9366515837104, Blast_Score=116, Evalue=6e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003495
- InterPro:   IPR011629 [H]

Pfam domain/function: PF02492 cobW; PF07683 CobW_C [H]

EC number: NA

Molecular weight: Translated: 39628; Mature: 39628

Theoretical pI: Translated: 4.94; Mature: 4.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTLTAETTSIIPEIPKRGMPVTIITGFLGSGKTTLLNQILKNKHDLKVAVLVNEFGDIN
CCCCCCHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHHCCCCCEEEEEEEECCCCCC
IDSQLLVSVDQDMLELSNGCICCTINDGLVDAVYRVLEREERIDYLVIETTGVADPLPII
CCCHHEEHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHH
LTFLGTELRDLTNLDSILTVVDAEAFEPTHFESEVALKQLTYADIILLNKTDLATAEKIQ
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHEEEEEECCCCHHHHHHHH
ALEDYIQTVKDSARILHTKYGEVALPLILGVGLTSKDDYTTDDAEAPHEHNHEHHSQDHD
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
HHEHHHLHEHHSHHLDNDGFVAVSFQSDRPFDIHKFENFLTEQMPQNVFRAKGILWFSDS
CHHHHHHHHHHHCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCEEEECCH
ELRHIFQLSGPRYNLHADEWHTLPKNQLVFIGRKLETQQIYTQLNNCLI
HHHHHHHCCCCCEECCCHHHCCCCCCCEEEEECCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MNTLTAETTSIIPEIPKRGMPVTIITGFLGSGKTTLLNQILKNKHDLKVAVLVNEFGDIN
CCCCCCHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHHCCCCCEEEEEEEECCCCCC
IDSQLLVSVDQDMLELSNGCICCTINDGLVDAVYRVLEREERIDYLVIETTGVADPLPII
CCCHHEEHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHH
LTFLGTELRDLTNLDSILTVVDAEAFEPTHFESEVALKQLTYADIILLNKTDLATAEKIQ
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHEEEEEECCCCHHHHHHHH
ALEDYIQTVKDSARILHTKYGEVALPLILGVGLTSKDDYTTDDAEAPHEHNHEHHSQDHD
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
HHEHHHLHEHHSHHLDNDGFVAVSFQSDRPFDIHKFENFLTEQMPQNVFRAKGILWFSDS
CHHHHHHHHHHHCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCEEEECCH
ELRHIFQLSGPRYNLHADEWHTLPKNQLVFIGRKLETQQIYTQLNNCLI
HHHHHHHCCCCCEECCCHHHCCCCCCCEEEEECCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8969502; 9384377; 9811636 [H]